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PT271 Prevalence of Metabolic Syndrome in Patients with HIV in the Era of Highly Active Antiretroviral Therapy
PT270
analysis found an association between treatment with the protease inhibitor, darunavir and Metabolic Syndrome. (OR 3.32 with 95% confidence interval between 1.54 and 7.15). Conclusion: We found a high prevalence of Metabolic syndrome and obesity in HIV patients. Metabolic Syndrome was associated with the use of the protease inhibitor darunavir. Hypertension was the most common co-morbidity found while symptomatic coronary artery disease was relatively uncommon in this cohort. Disclosure of Interest: None Declared
Excess metabolic and cardiovascukar risks among females health workers compared with males Abiodun M. Adeoye*1, Adewole Adebiyi1, Ayodele Falase1 1 Department of Medicine, University of Ibadan/Unversity College Hospital, Ibadan, Nigeria
PT274
Introduction: Metabolic syndrome (MS) is a major health concern in the world because it is associated with significant cardiovascular morbidity and mortality. Studies have suggested that there may be differences in the prevalence of metabolic syndrome by occupation type and gender. Few data exist on the prevalence of metabolic syndrome and gender disparities among hospital personnel in Nigeria. Objectives: This study aimed to investigate the prevalence of metabolic syndrome among Nigerian health workers and determine whether the prevalence differed according to occupation and gender. Methods: A total of 256 core hospital workers, including nurses and physicians, comprising 84 (32.8%) males and 172 (67.2%) females were recruited. Baseline clinical and demographic characteristics were obtained from the subjects using a structured questionnaire. Metabolic syndrome (MS) was defined according to the International Diabetic Federation (IDF) criteria, by the presence of waist circumference 94 cm in men and 80 cm in women and any two of the following characteristics: triglycerides 150 mg/dl; HDL cholesterol <40 mg/dl in men and <50 mg/dl in women; blood pressure 130/85 mm Hg; and fasting glucose 100 mg/dl. Proportions were compared using the chi square test or Fisher’s exact test. Results: The mean age of the participants was 42.03 (9.4) years. The overall prevalence of metabolic syndrome was 24.2%. Participants with metabolic syndrome were older and heavier with higher mean systolic blood pressure and fasting plasma glucose when compared with subjects without MS. Compared with males, females had a higher frequency of metabolic syndrome (34.9% vs 2.4%, p<0.0001). Total cholesterol was higher among the physicians compared with nurses (182.7(19.71) vs 171.4(15.63) p<0.001) Blood pressure measurements were comparable across the occupational groups. Nurses were found to have greater frequency of metabolic syndrome when compared with physicians (40.2% vs 4.8%, p<0.0001). Conclusion: This study has revealed excess female gender influence on the proportional distribution of metabolic syndrome. The high prevalence of MS among core health workers who should serve as models of health is of concern. Lifestyle modification changes through workplace health promotion programs addressing risk factors for metabolic syndrome are needed. Disclosure of Interest: None Declared
Flavia De Conti Cartolano1, Patricia A. de Lima1, Caroline Pappiani1, Antonio Augusto F. Carioca1, Nagila Raquel T. Damasceno*1 1 School of Public Health, University of Sao Paulo, São Paulo, Brazil
Brazilian adults with Metabolic Syndrome Show Higher Atherogenic Risk Linked to Particle Size of Lipoproteins
Introduction: Despite of reduced mortality for cardiovascular diseases (CVD) observed in United States in the last years, these remain the major cause of morbi-mortality in the world. The high prevalence of CVD is related increased incidence of Metabolic Syndrome (MetS). MetS is accepted with constellation of classical cardiovascular risk factors (waist circumference, insulin resistance, imbalance of lipid and hypertension), however, the impact of physical changes of lipoprotein (size and concentration) are not includes in this criteria. Objectives: Evaluate the possible association between MetS and size and concentration of LDL and HDL in individual adults in Brazil. Methods: From a subsample (n¼287) of the CARDIONUTRI study, a cross-sectional sample including patients of both genders and ages between 30-74 years was selected. Complete clinical, socio-demographic and familial history disease data were performed by validated methods. Blood samples were collected after 12h of fasting and from the plasma lipid profile (total cholesterol, LDL, HDL and TG, APO AI, APO B) and lipoprotein subclasses (size and concentration) were monitored. The particle size of LDL and HDL were analyzed by Lipoprint SystemÒ (Quantimetrix Corporation). The classification of the metabolic syndrome was performed as proposed by IDF. Statistical analysis was performed by Statistical Package for the Social Sciences Ò (SPSS) version 17.0, at significant level of p<0.05. Results: The results indicated a predominance of females in the sample (63.4%), but equally distributed between groups with and without MetS. The MetS group had higher TG level (p<0.001) and lower levels of LDL (p<0.05), HDL (p<0.001) and Apo AI (p<0.001), with no difference in the amount of Apo B. In addition, the MetS group showed a higher proportion of small (p<0.001) and intermediate (p<0.001) HDL, smaller particle size LDL (p<0.001) and higher proportion of small LDL (p<0.001). No difference was found in the proportion of large LDL between the two groups.
PT271 Prevalence of Metabolic Syndrome in Patients with HIV in the Era of Highly Active Antiretroviral Therapy Bernardo Lombo*1, Irma Fotjadhi1, Sreedhar Ravi1, Marjorie Golden2, Michael Virata2, Martha Lievano3, Jose Diez4, Andre Ghantous1, Thomas Donohue1 1 Cardiology, 2Infectious Diseases, Yale New Haven Hospital, Yale University, New Haven, United States, 3Nutrition, Universidad Javeriana, Bogota, Colombia, 4Cardiology, Baylor College of Medicine, Houston, United States Introduction: Since the introduction of Highly Active Antiretroviral Therapy (HAART) as the standard of care for HIV disease, there has been a precipitous decline in the death rate due to HIV/AIDS. HAART can induce significant metabolic complications including dyslipidemia and insulin resistance. Objectives: The purpose of this study was to report the prevalence of Metabolic Syndrome in HIV infected patients in the Era of Highly Active Antiretroviral Therapy. Methods: A retrospective cross-sectional observational study of 259 patients with HIV infection from an urban community hospital was performed. Metabolic Syndrome prevalence was defined using the International Diabetes Federation (IDF) and U.S. National Cholesterol Education Program Adult Treatment Panel III (ATPIII) criteria. Study patients were between the ages 18 and 81 and were included irrespective of race, duration of diagnosis, or duration of HAART. Patients who had been hospitalized within the previous month were excluded from the study. Results: Mean patient age was 49.6 9.7 and mean Body Mass Index was 28.6 10 kg/m2. The prevalence of Metabolic Syndrome was 27% using IDF criteria and 26% using ATP-III criteria. In patients with Metabolic syndrome by IDF, 54% were women, with a mean duration of HIV infection of 12.6 6 yrs, and mean duration of HAART of 9 5 yrs. Hypertension was present in 55.6 %, coronary artery disease in 5.6%, and obesity in 66.7% of patients. In patients with Metabolic syndrome by ATP-III, 43% were women, mean duration of HIV infection was 11.8 6.2 yrs, and mean duration of HAART was 8.9 5.7 yrs. Hypertension was present in 57.4%, coronary artery disease in 5.9%, and obesity in 51.5 % of patients. Logistic regression
GHEART Vol 9/1S/2014
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Conclusion: Individuals with MetS showed increased atherogenic risk linked to worse lipid profile, with more small particles of LDL and small HDL. Financial support: FAPESP (2011/15026-0 / 2011/12523-2, 2011/14556-5, 2011/ 15590-2, 2012/03775-0), INCT-FCx, NAP-FCx e CNPq. Disclosure of Interest: None Declared
PT275 Prevalence of metabolic syndrome according to three Criteria in hypertensive population in a rural hospital setting Umar G. Adamu*1, Okon I. Ibok1, Ikenna Umenze1, O. M. Olaniyi1 Department of medicine, Federal Medical Centre, Bida, Nigeria
1
Introduction: : Metabolic syndrome is the occurrence of several cardiovascular risk factors in individuals. Several criteria have been proposed to determine its prevalence.
e219
POSTER ABSTRACTS
suggests that a gender specific approach to clinical care is not only highly effective but also efficient in promoting gender responsiveness to health and wellness, and could shape response to disease burden, assessment and diagnosis, and available health care options. Disclosure of Interest: None Declared
analysis found an association between treatment with the protease inhibitor, darunavir and Metabolic Syndrome. (OR 3.32 with 95% confidence interval between 1.54 and 7.15). Conclusion: We found a high prevalence of Metabolic syndrome and obesity in HIV patients. Metabolic Syndrome was associated with the use of the protease inhibitor darunavir. Hypertension was the most common co-morbidity found while symptomatic coronary artery disease was relatively uncommon in this cohort. Disclosure of Interest: None Declared
Excess metabolic and cardiovascukar risks among females health workers compared with males Abiodun M. Adeoye*1, Adewole Adebiyi1, Ayodele Falase1 1 Department of Medicine, University of Ibadan/Unversity College Hospital, Ibadan, Nigeria
PT274
Introduction: Metabolic syndrome (MS) is a major health concern in the world because it is associated with significant cardiovascular morbidity and mortality. Studies have suggested that there may be differences in the prevalence of metabolic syndrome by occupation type and gender. Few data exist on the prevalence of metabolic syndrome and gender disparities among hospital personnel in Nigeria. Objectives: This study aimed to investigate the prevalence of metabolic syndrome among Nigerian health workers and determine whether the prevalence differed according to occupation and gender. Methods: A total of 256 core hospital workers, including nurses and physicians, comprising 84 (32.8%) males and 172 (67.2%) females were recruited. Baseline clinical and demographic characteristics were obtained from the subjects using a structured questionnaire. Metabolic syndrome (MS) was defined according to the International Diabetic Federation (IDF) criteria, by the presence of waist circumference 94 cm in men and 80 cm in women and any two of the following characteristics: triglycerides 150 mg/dl; HDL cholesterol <40 mg/dl in men and <50 mg/dl in women; blood pressure 130/85 mm Hg; and fasting glucose 100 mg/dl. Proportions were compared using the chi square test or Fisher’s exact test. Results: The mean age of the participants was 42.03 (9.4) years. The overall prevalence of metabolic syndrome was 24.2%. Participants with metabolic syndrome were older and heavier with higher mean systolic blood pressure and fasting plasma glucose when compared with subjects without MS. Compared with males, females had a higher frequency of metabolic syndrome (34.9% vs 2.4%, p<0.0001). Total cholesterol was higher among the physicians compared with nurses (182.7(19.71) vs 171.4(15.63) p<0.001) Blood pressure measurements were comparable across the occupational groups. Nurses were found to have greater frequency of metabolic syndrome when compared with physicians (40.2% vs 4.8%, p<0.0001). Conclusion: This study has revealed excess female gender influence on the proportional distribution of metabolic syndrome. The high prevalence of MS among core health workers who should serve as models of health is of concern. Lifestyle modification changes through workplace health promotion programs addressing risk factors for metabolic syndrome are needed. Disclosure of Interest: None Declared
Flavia De Conti Cartolano1, Patricia A. de Lima1, Caroline Pappiani1, Antonio Augusto F. Carioca1, Nagila Raquel T. Damasceno*1 1 School of Public Health, University of Sao Paulo, São Paulo, Brazil
Brazilian adults with Metabolic Syndrome Show Higher Atherogenic Risk Linked to Particle Size of Lipoproteins
Introduction: Despite of reduced mortality for cardiovascular diseases (CVD) observed in United States in the last years, these remain the major cause of morbi-mortality in the world. The high prevalence of CVD is related increased incidence of Metabolic Syndrome (MetS). MetS is accepted with constellation of classical cardiovascular risk factors (waist circumference, insulin resistance, imbalance of lipid and hypertension), however, the impact of physical changes of lipoprotein (size and concentration) are not includes in this criteria. Objectives: Evaluate the possible association between MetS and size and concentration of LDL and HDL in individual adults in Brazil. Methods: From a subsample (n¼287) of the CARDIONUTRI study, a cross-sectional sample including patients of both genders and ages between 30-74 years was selected. Complete clinical, socio-demographic and familial history disease data were performed by validated methods. Blood samples were collected after 12h of fasting and from the plasma lipid profile (total cholesterol, LDL, HDL and TG, APO AI, APO B) and lipoprotein subclasses (size and concentration) were monitored. The particle size of LDL and HDL were analyzed by Lipoprint SystemÒ (Quantimetrix Corporation). The classification of the metabolic syndrome was performed as proposed by IDF. Statistical analysis was performed by Statistical Package for the Social Sciences Ò (SPSS) version 17.0, at significant level of p<0.05. Results: The results indicated a predominance of females in the sample (63.4%), but equally distributed between groups with and without MetS. The MetS group had higher TG level (p<0.001) and lower levels of LDL (p<0.05), HDL (p<0.001) and Apo AI (p<0.001), with no difference in the amount of Apo B. In addition, the MetS group showed a higher proportion of small (p<0.001) and intermediate (p<0.001) HDL, smaller particle size LDL (p<0.001) and higher proportion of small LDL (p<0.001). No difference was found in the proportion of large LDL between the two groups.
PT271 Prevalence of Metabolic Syndrome in Patients with HIV in the Era of Highly Active Antiretroviral Therapy Bernardo Lombo*1, Irma Fotjadhi1, Sreedhar Ravi1, Marjorie Golden2, Michael Virata2, Martha Lievano3, Jose Diez4, Andre Ghantous1, Thomas Donohue1 1 Cardiology, 2Infectious Diseases, Yale New Haven Hospital, Yale University, New Haven, United States, 3Nutrition, Universidad Javeriana, Bogota, Colombia, 4Cardiology, Baylor College of Medicine, Houston, United States Introduction: Since the introduction of Highly Active Antiretroviral Therapy (HAART) as the standard of care for HIV disease, there has been a precipitous decline in the death rate due to HIV/AIDS. HAART can induce significant metabolic complications including dyslipidemia and insulin resistance. Objectives: The purpose of this study was to report the prevalence of Metabolic Syndrome in HIV infected patients in the Era of Highly Active Antiretroviral Therapy. Methods: A retrospective cross-sectional observational study of 259 patients with HIV infection from an urban community hospital was performed. Metabolic Syndrome prevalence was defined using the International Diabetes Federation (IDF) and U.S. National Cholesterol Education Program Adult Treatment Panel III (ATPIII) criteria. Study patients were between the ages 18 and 81 and were included irrespective of race, duration of diagnosis, or duration of HAART. Patients who had been hospitalized within the previous month were excluded from the study. Results: Mean patient age was 49.6 9.7 and mean Body Mass Index was 28.6 10 kg/m2. The prevalence of Metabolic Syndrome was 27% using IDF criteria and 26% using ATP-III criteria. In patients with Metabolic syndrome by IDF, 54% were women, with a mean duration of HIV infection of 12.6 6 yrs, and mean duration of HAART of 9 5 yrs. Hypertension was present in 55.6 %, coronary artery disease in 5.6%, and obesity in 66.7% of patients. In patients with Metabolic syndrome by ATP-III, 43% were women, mean duration of HIV infection was 11.8 6.2 yrs, and mean duration of HAART was 8.9 5.7 yrs. Hypertension was present in 57.4%, coronary artery disease in 5.9%, and obesity in 51.5 % of patients. Logistic regression
GHEART Vol 9/1S/2014
j
March, 2014
j
POSTER/2014 WCC Posters
Conclusion: Individuals with MetS showed increased atherogenic risk linked to worse lipid profile, with more small particles of LDL and small HDL. Financial support: FAPESP (2011/15026-0 / 2011/12523-2, 2011/14556-5, 2011/ 15590-2, 2012/03775-0), INCT-FCx, NAP-FCx e CNPq. Disclosure of Interest: None Declared
PT275 Prevalence of metabolic syndrome according to three Criteria in hypertensive population in a rural hospital setting Umar G. Adamu*1, Okon I. Ibok1, Ikenna Umenze1, O. M. Olaniyi1 Department of medicine, Federal Medical Centre, Bida, Nigeria
1
Introduction: : Metabolic syndrome is the occurrence of several cardiovascular risk factors in individuals. Several criteria have been proposed to determine its prevalence.
e219
POSTER ABSTRACTS
suggests that a gender specific approach to clinical care is not only highly effective but also efficient in promoting gender responsiveness to health and wellness, and could shape response to disease burden, assessment and diagnosis, and available health care options. Disclosure of Interest: None Declared