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Pulmonary scar cancer: An analysis of 38 cases
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or surgery. Its value is most significant in the management of benign lesions.
11,
REVIEWS
Malignant Mesothelioma of the Pleura Report of 63 Patients Received at the Norwegian Radium Hospital 1966 - 83. Thorud, E., Telhaug, R., Loeb, M., H~st, H. General Department, The Norwegian Radium Hospital, Oslo, Norway. Sixtyone men and 2 women with a mean age of 61 years were seen at NRH 1966 - 83. Most patients had disease beyond the local pleura; stage I: 17, II: 31, III: 3, IV: 12. The median duration of symptoms was 5 months, however, with a wide range. 51/63 had pleural effusion. Most (50/63) patients had radiotherapy, while 22/63 had chemotherapy with different cytotoxic drugs. Radiotherapy was often given as opposing hemithorax fields. Nineteen patients received radiation doses higher than corresponding to a CRE value of 1500. This group had a median survival of ll months, while the group that had lower doses had a median survival of 5 months. Many of the patients in the latter group were in poor condition. The overall 23 years survival was close to zero. Twentythree patients could be evaluated for effect of therapy on the neoplastic tissue. Eight had objective effect, and this group had a median survival of 16 months. Malignant mesothelioma is a lethal disease. Both radiation therapy and chemotherapy have objective effect on the neoplastic tissue only to a minor extent, such treatment is often associated with heavy side effects, and it is doubtful whether it improves survival of the patients. However, radiation therapy may play a role in the palliation of pain and pleural effusion.
Bronchioloalveolar Carcinoma of Lung. Its Clinical, Radiological and Pathological Significances. Huang, X.-M., Bai, Y.-X., Song, H.-F. General Hospital of Pla, BeiJing, People's Republic of China. Among 410 cases of lung cancers treated surgically in our hospital from 1965-1984, there are 82 cases of bronchioloalveolar carcinoma. Clinically: (i) the bronchioloalveolar carcinoma (BAC) has the highest rate of resection 95.12%, as compared to 91.23% in squamous cell carcinoma and 84.8% in adenocarcinoma of the lung as a whole. (2) It has better prognosis with a 5-year survival rate: 34.48% better than the rest of adenocarcinoma in our series: 20.83%.
Radiologically: (I) In the nodular form, lobulation, spiculation, vacuole sign and its hazy border are the most characteristic signs. (2) In addition, pseudocolor photographs are also of definite value in the diagnosis. Pathologically: (i) The carcinoma cells of BAC grow in a row along the intact alveolar wall and does not destroy the alveolar septa and the outline of the alveoli remains. (2) There is apparent transition of cancer cells present between the cancer cells originating from the bronchiolar epithelium and the cancer cells from the alveolar epithelium. We concluded that BAC, is not a rare form of lung cancer, it occurs 20% in our series of surgically treated cases. Though it is a subgroup of adenocarcinoma in WHO classification, but it should be considered as a distinct clinical entity.
Pulmonary Scar Cancer: An Analysis of 38 Cases. W~, H.S., KOO, K.S., Ling, Z.Q., Huang, O.L., Wu, S.F., Wu, S.C., Chow, Y.C., Sun, T.K., Rong, Z.B., Cheng, W.H., Gao, C.X., Wang, J.M. Shanghai Chest Hospital, Shanghai, China. Among 750 cases of lung cancer resected (Jan. 1980 through Dec. 1982), there were 38 cases of pulmonary scar cancer (PSC) being 5.1% of all lung cancers during the same period and 16.1% of all peripheral types. The highrisk age was 50-60 years old, and the ratio of male to female was 3.8:1. Seventy-one per cent had the past history of various chronic lung diseases, including tuberculosis (31.6%), inflammation (21.1%), and infarction (15.8%). Preoperative x-ray films showed spiculations (80%), lobulations (71%), pleural indentations (34%), tail or rabbit-ear signs (29%), and beam signs (13%). Preoperative sputum examinations revealed 40.5% positive cytology. Operatively, 95% of cases received lobectomy; the operative mortaliry was 5%. The histopathological concludions were: adenocarcinoma (76.3%), squamous (21.1%), and mixed type (2.6%). pTNM: I (47%), II (29%), and III (24%). Follow-up of the resected cases (life table) showed three- and four-year survival rates of 54.4% and 38.9%, respectively. One case was lost; the follow-up rate was 97%. PSC is rare. Reviewing over 600 cases reported in world literature and 53 cases in Chinese literature, the authors made detailed discussions regarding definition, incidence, etiology, histopathogenesis, cardinal symptoms and signs, x-ray manifestations, criteria in making pathological conclusions, treatment, and prognosis.
Bronchogenic Carcinoma in Patients 40 and Under. Antkowiak, J.G., Regal, A.-M., Takita, H. Roswell Part Memorial Institute, Buffalo, N.Y., U.S.A. A retrospective study was done on iii patients, age 40 and under, who were diagnosed histologically to have bronchogenic carcinoma between
or surgery. Its value is most significant in the management of benign lesions.
11,
REVIEWS
Malignant Mesothelioma of the Pleura Report of 63 Patients Received at the Norwegian Radium Hospital 1966 - 83. Thorud, E., Telhaug, R., Loeb, M., H~st, H. General Department, The Norwegian Radium Hospital, Oslo, Norway. Sixtyone men and 2 women with a mean age of 61 years were seen at NRH 1966 - 83. Most patients had disease beyond the local pleura; stage I: 17, II: 31, III: 3, IV: 12. The median duration of symptoms was 5 months, however, with a wide range. 51/63 had pleural effusion. Most (50/63) patients had radiotherapy, while 22/63 had chemotherapy with different cytotoxic drugs. Radiotherapy was often given as opposing hemithorax fields. Nineteen patients received radiation doses higher than corresponding to a CRE value of 1500. This group had a median survival of ll months, while the group that had lower doses had a median survival of 5 months. Many of the patients in the latter group were in poor condition. The overall 23 years survival was close to zero. Twentythree patients could be evaluated for effect of therapy on the neoplastic tissue. Eight had objective effect, and this group had a median survival of 16 months. Malignant mesothelioma is a lethal disease. Both radiation therapy and chemotherapy have objective effect on the neoplastic tissue only to a minor extent, such treatment is often associated with heavy side effects, and it is doubtful whether it improves survival of the patients. However, radiation therapy may play a role in the palliation of pain and pleural effusion.
Bronchioloalveolar Carcinoma of Lung. Its Clinical, Radiological and Pathological Significances. Huang, X.-M., Bai, Y.-X., Song, H.-F. General Hospital of Pla, BeiJing, People's Republic of China. Among 410 cases of lung cancers treated surgically in our hospital from 1965-1984, there are 82 cases of bronchioloalveolar carcinoma. Clinically: (i) the bronchioloalveolar carcinoma (BAC) has the highest rate of resection 95.12%, as compared to 91.23% in squamous cell carcinoma and 84.8% in adenocarcinoma of the lung as a whole. (2) It has better prognosis with a 5-year survival rate: 34.48% better than the rest of adenocarcinoma in our series: 20.83%.
Radiologically: (I) In the nodular form, lobulation, spiculation, vacuole sign and its hazy border are the most characteristic signs. (2) In addition, pseudocolor photographs are also of definite value in the diagnosis. Pathologically: (i) The carcinoma cells of BAC grow in a row along the intact alveolar wall and does not destroy the alveolar septa and the outline of the alveoli remains. (2) There is apparent transition of cancer cells present between the cancer cells originating from the bronchiolar epithelium and the cancer cells from the alveolar epithelium. We concluded that BAC, is not a rare form of lung cancer, it occurs 20% in our series of surgically treated cases. Though it is a subgroup of adenocarcinoma in WHO classification, but it should be considered as a distinct clinical entity.
Pulmonary Scar Cancer: An Analysis of 38 Cases. W~, H.S., KOO, K.S., Ling, Z.Q., Huang, O.L., Wu, S.F., Wu, S.C., Chow, Y.C., Sun, T.K., Rong, Z.B., Cheng, W.H., Gao, C.X., Wang, J.M. Shanghai Chest Hospital, Shanghai, China. Among 750 cases of lung cancer resected (Jan. 1980 through Dec. 1982), there were 38 cases of pulmonary scar cancer (PSC) being 5.1% of all lung cancers during the same period and 16.1% of all peripheral types. The highrisk age was 50-60 years old, and the ratio of male to female was 3.8:1. Seventy-one per cent had the past history of various chronic lung diseases, including tuberculosis (31.6%), inflammation (21.1%), and infarction (15.8%). Preoperative x-ray films showed spiculations (80%), lobulations (71%), pleural indentations (34%), tail or rabbit-ear signs (29%), and beam signs (13%). Preoperative sputum examinations revealed 40.5% positive cytology. Operatively, 95% of cases received lobectomy; the operative mortaliry was 5%. The histopathological concludions were: adenocarcinoma (76.3%), squamous (21.1%), and mixed type (2.6%). pTNM: I (47%), II (29%), and III (24%). Follow-up of the resected cases (life table) showed three- and four-year survival rates of 54.4% and 38.9%, respectively. One case was lost; the follow-up rate was 97%. PSC is rare. Reviewing over 600 cases reported in world literature and 53 cases in Chinese literature, the authors made detailed discussions regarding definition, incidence, etiology, histopathogenesis, cardinal symptoms and signs, x-ray manifestations, criteria in making pathological conclusions, treatment, and prognosis.
Bronchogenic Carcinoma in Patients 40 and Under. Antkowiak, J.G., Regal, A.-M., Takita, H. Roswell Part Memorial Institute, Buffalo, N.Y., U.S.A. A retrospective study was done on iii patients, age 40 and under, who were diagnosed histologically to have bronchogenic carcinoma between