Pulsatile luteinizing hormone release in postmenopausal women: Effect of chronic bromocriptine administration

166 Pulmtik 111teinhhg hormone release ln postmenopausal women: Effect of cbronk bromocriptioe admhistration Gambacciani M; Melis GB; Paoletti AM; et al Deportment of Obstetrics and Gynecology, University of piso; 56100 piscr, Italy J. CLIN. ENDGCRINOL. MBTAB.; 65/3 (465468)/1987/ Pulsatile LH release was studied in 28 healthy postmenopausal women by obtaining blood samples every 5 min for 4 h either basally or after 30 days of bromocriptine @CT; 3.75 mg/day; n = 14) or placebo (n = 14) administration. Basally, mean plasma LH levels were 46.3 f 3.5 ( f SE) and 53.4 f 4.6 mIU/ml in the BCT and placebo groups, respectively. Mean LH pulse frequencies were 4.2 f 0.3 and 4.0 f 0.4 pulses/4 h. mean pulse amplitudes were 19.2 f 1.9 and 20.1 f 1.5 mIU/ml. and mean interpulse intervals were 54.3 f 3.1 and 54.6 f: 3.2 min in the two groups, respectively. BCT administration induced no significant changes in mean plasma LH levels, but it significantly (P < 0.01) decreased LH pulse frequency (1.7 f 0.3 pulses/4 h) and amplitude (12.7 f 0.8 mIU/ml) and signiikantly (P < 0.01) increased mean interpulse interval (126.1 f 17.5 min). Placebo administration did not induce any signifkxnt changes in pulsatilc LH release. These results demonstrate that in postmenopausal women LH secretion is &choral. and BCT administration can blunt LH pulsatility, suggesting dopaminergic regulation of the GnRH-LH pulse generator.

Metary fat and b-t cancer in the National Health and Nutrition Examination Survey I Epidemiologk Follow-up Study Jones DY; Schatzkin A; Green SB; et al Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health and Human Services, Bethesda, MD 20892, United States of America J. NATL. CANCER INST.; 79/3 (465-471)/1987/ The relationship between dietary fat intake and breast cancer incidence was examined in the National Health and Nutrition Examination Survey I (NHANES I) Epidemiologic Follow-up Study cohort. This cohort is derived from adults (325 yr) examined in the NHANES I (1970-75) cross-sectional survey of the U.S. population and provides a mean follow-up time of 10 years. An analytic sample of 5,485 women, including 99 breast cancer cases (34 premenopausal and 65 postmenopausal at NHANES I baseline), was examined for associations with dietary intake of fat, percent energy from fat, total energy, saturated fat, polyunsaturated fat, monounsaturated fat, and cholesterol on the basis of a 24-h recall administered at the baseline NHANES I examination. No significant differences in dietary fat intake between cases and non-cases were evident when mean intakes for each group were compared. For total fat (g) and saturated fat (g). a significant inverse association was indicated in proportional hazards analyses. Adjustment of fat for total energy intake resulted in a smaller effect that was no longer statistically signIfIcant. Adjustment for accepted breast cancer risk factors did not change these Endings. This prospective study of a sample from the U.S. population does not support the hypothesis that high dietary fat intake increases breast cancer risk. Indeed, some lower risk associated with high fat intake may be indicated, although this result may be influenced by methodologic problems with the dietary assessment.

Methods and clinical applications of total body absorptiometry Nuti R; Righi 0, Martini 0; et al Istituto di Clinica Medica Generale, Universita de& Studi di Siena, I-53100 Siena, Ita& J. NUCL. MED. ALLIED SCI.; 31/2 (213-221)/1987/ Dual-photon absorptiometry (DPA) was used to measure bone mineral of the total body and of different anatomical segments of the skeleton. The source was 153 Gadolinium (1 Ci) with principal photopeaks at 44 and 100 keV. The entire body was scanned in a rectilinear raster pattern (transverse