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QS306. Resistance of Microsatellite (MSI) Human Colorectal Cancers (CRC) to Histone Deacetylase Inhibitor (HDACI) Mediated Differentiation is Regulated at the Epigenetic Level
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ASSOCIATION FOR ACADEMIC SURGERY AND SOCIETY OF UNIVERSITY SURGEONS—ABSTRACTS
QS297. OPIOID GROWTH FACTOR INHIBITS CELL REPLICATION AND DNA SYNTHESIS OF HEPATOCELLULAR CANCER IN VITRO THROUGH A RECEPTOR MEDIATED MECHANISM. D. M. Avella Patino, H. R. Tagaram, E. T. Kimchi, P. J. McLaughlin, I. S. Zagon, K. F. Staveley-O’Carroll; Penn State University College of Medicine, Hershey, PA QS298. A VEGFR1/CXCR4 POSITIVE PHENOTYPE CHARACTERIZES PANCREATIC CANCER CELLS THAT METASTASIZE TO LYMPH NODES. J. B. Fleming1, S. Dineen2, Y. Kang1, R. A. Brekken2; 1MD Anderson Cancer Center, Houston, TX; 2UT Southwestern Medical Center, Dallas, TX QS299. MUC1 NUCLEAR TRANSLOCATION IS AUGMENTED BY HER-2-NEU AMPLIFICATION. Z. Yuan1, X. Liu1, J. Kahn2, S. Mangray1, M. Chung1; 1Rhode Island Hospital, Brown University, Providence, RI; 2Warren Alpert Medical School of Brown University, Providence, RI QS300. C-MET INHIBITION POTENTIATES GEMCITABINEINDUCED PANCREATIC CANCER CELL DEATH. Y. Zhang, X. Zhang, Z. Cao, S. J. Hughes; University of Pittsburgh School of Medicine, Pittsburgh, PA QS301. A SMALL MOLECULE INHIBITOR OF C-MET SENSITIZES ESOPHAGEAL ADENOCARCINOMA TO CHEMOTHERAPY. X. Zhang, S. J. Hughes; University of Pittsburgh School of Medicine, Pittsburgh, PA QS302. GATA6 SYNERGIZES WITH BETA CATENIN TO ACTIVATE THE WNT PATHWAY IN COLORECTAL CANCER. N. Belaguli, M. Rigi, M. Zhang, F. Ayanbule, A. Sarkar, D. H. Berger; Baylor College of Medicine, Houston, TX QS303. ZM336372 SUPPRESSES GROWTH IN OVARIAN CANCER CELL LINES BY PHOSPHORYLATION OF GSK-3. N. L. Seiler, M. Kunnimalaiyaan, L. Krichevsky, S. L. Rose; University of Wisconsin, Madison, WI QS304. MICRORNA-21 (MIR-21) IS OVEREXPRESSED IN ESOPHAGEAL ADENOCARCINOMA AND A POTENTIAL PREDICTOR OF PROGRESSION IN BARRETT’S ESOPHAGUS. M. E. Dillhoff, J. Liu, W. Frankel, M. Bloomston; Ohio State University, Columbus, OH QS305. THE ROLE OF ACTIVATING RET-PROTOONCOGENE MUTATIONS IN SPORADIC NEOPLASMS OF THE GASTRO-ENTERO-PANCREATIC AXIS. F. Rueckert, H. Goergens, H. Schackert, G. Fitze, H. Saeger, C. Pilarsky, R. Gruetzmann; University Hospital Dresden, Dresden, Germany QS306. RESISTANCE OF MICROSATELLITE (MSI) HUMAN COLORECTAL CANCERS (CRC) TO HISTONE DEACETYLASE INHIBITOR (HDACI) MEDIATED DIFFERENTIATION IS REGULATED AT THE EPIGENETIC LEVEL. A. Azarbayejani1, J. Shin1, J. Ady1, N. Ahmed2, T. Weber3, J. Mariadason2; 1 Department of Surgery, Albert Einstein College of Medicine, Bronx, NY; 2Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY; 3Department of Surgery and Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY QS307. HYPERBARIC OXYGEN THERAPY FOR TREATMENT OF RADIATION TISSUE INJURY. G. A. Perdrizet1, B.
Allen2, A. Babigian2; 1Morristown Memorial Hosp, Morristown, NJ; 2 Hartford Hospital, Hartford, CT QS308. BLOCKADE OF THE GRM1 RECEPTOR RESULTS IN DECREASED MIGRATION, INVASION, AND PROLIFERATION IN MELANOMA. M. N. Le1, J. L. Chan2, S. Chan3, J. Goydos1; 1 Robert Wood Johnson University Hospital/UMDNJ, New Brunswick, NJ; 2Cancer Insitute of New Jersey/UMDNJ, New Brunswick, NJ; 3Rutgers, The State University of New Jersey, New Brunswick, NJ QS309. BOMBESIN AND EPIDERMAL GROWTH FACTOR INREASE BREAST CANCER CELL MIGRATION AND INTERLEUKIN-8 EXPRESSION. C. Chao, C. M. Townsend, Jr., M. R. Hellmich; University of TX Medical Branch, Galveston, TX QS310. POSTTRANSCRIPTIONAL REGULATION OF GATA6 EXPRESSION IN COLON CANCER. N. Belaguli, M. Aftab, M. Zhang, F. Ayanbule, M. Rigi, A. Sakar, D. H. Berger; Baylor College of Medicine, Houston, TX QS311. DUAL EXPRESSION LENTIVIRAL VECTORS FOR CONCURRENT RNA INTERFERENCE AND RESCUE: REGULATION OF RESCUE TRANSGENE EXPRESSION BY ALTERATION OF CLONING SITE AND POSITIONAL EFFECT. N. V. Sankpal, T. P. Fleming, W. E. Gillanders; Washington Universtiy School of Medicine, Saint Louis, MO QS312. OPHTHALMIC ACID AND GLUTATHIONE CONCENTRATION IN SECONDARY LIVER TUMORS SUBSISTENCE AND GROWTH. J. R. Sanabria1, R. Abbas1, S. Kombu2, H. Brunengraber1; 1University Hospitals-Case Medical Center & Case Western Reserve University, Cleveland, OH; 2Case Western Reserve University, Cleveland, OH
ONCOLOGY 13: UPPER GI-CLINICAL QS313. CHEMORADIATION AND SALVAGE ESOPHAGECTOMY FOR TREATMENT OF RESECTABLE ESOPHAGEAL CANCER. K. Onodera, S. Miyazaki, S. Satomi; Tohoku University School of Medicine, Sendai, Japan QS314. TGF-ALPHA LEVELS AS POTENTIAL BIOMARKER FOR HIGH GRADE INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM. C. Doyle, C. Schmidt, M. Yip-Schneider; Indiana University School of Medicine, Indianapolis, IN QS315. HEPATIC RADIOFREQUENCY ABLATION ELEVATES PRO-CANCER CYTOKINES. S. P. Dineen1, J. E. Toombs1, E. E. Moore2, W. L. Biffl2, R. A. Brekken1, C. C. Barnett, Jr.2; 1University of Texas Southwestern Medical Center, Dallas, TX; 2 University of Colorado, Denver, CO QS316. PREDICTORS OF LONG-TERM SURVIVAL AFTER DISTAL PANCREATECTOMY FOR PANCREATIC ADENOCARCINOMA. H. Nathan, C. R. Goodwin, J. L. Cameron, J. M. Winter, S. K. Reddy, B. H. Edil, T. M. Pawlik, R. D. Schulick, M. A. Choti, C. L. Wolfgang; The Johns Hopkins University School of Medicine, Baltimore, MD QS317. TRENDS IN CLINICOPATHOLOGIC CHARACTERISTICS AND PROGNOSTIC PREDICTORS OF SURVIVAL OUTCOME IN BLACK PATIENTS WITH GASTRIC CARCINOMA:
ASSOCIATION FOR ACADEMIC SURGERY AND SOCIETY OF UNIVERSITY SURGEONS—ABSTRACTS
QS297. OPIOID GROWTH FACTOR INHIBITS CELL REPLICATION AND DNA SYNTHESIS OF HEPATOCELLULAR CANCER IN VITRO THROUGH A RECEPTOR MEDIATED MECHANISM. D. M. Avella Patino, H. R. Tagaram, E. T. Kimchi, P. J. McLaughlin, I. S. Zagon, K. F. Staveley-O’Carroll; Penn State University College of Medicine, Hershey, PA QS298. A VEGFR1/CXCR4 POSITIVE PHENOTYPE CHARACTERIZES PANCREATIC CANCER CELLS THAT METASTASIZE TO LYMPH NODES. J. B. Fleming1, S. Dineen2, Y. Kang1, R. A. Brekken2; 1MD Anderson Cancer Center, Houston, TX; 2UT Southwestern Medical Center, Dallas, TX QS299. MUC1 NUCLEAR TRANSLOCATION IS AUGMENTED BY HER-2-NEU AMPLIFICATION. Z. Yuan1, X. Liu1, J. Kahn2, S. Mangray1, M. Chung1; 1Rhode Island Hospital, Brown University, Providence, RI; 2Warren Alpert Medical School of Brown University, Providence, RI QS300. C-MET INHIBITION POTENTIATES GEMCITABINEINDUCED PANCREATIC CANCER CELL DEATH. Y. Zhang, X. Zhang, Z. Cao, S. J. Hughes; University of Pittsburgh School of Medicine, Pittsburgh, PA QS301. A SMALL MOLECULE INHIBITOR OF C-MET SENSITIZES ESOPHAGEAL ADENOCARCINOMA TO CHEMOTHERAPY. X. Zhang, S. J. Hughes; University of Pittsburgh School of Medicine, Pittsburgh, PA QS302. GATA6 SYNERGIZES WITH BETA CATENIN TO ACTIVATE THE WNT PATHWAY IN COLORECTAL CANCER. N. Belaguli, M. Rigi, M. Zhang, F. Ayanbule, A. Sarkar, D. H. Berger; Baylor College of Medicine, Houston, TX QS303. ZM336372 SUPPRESSES GROWTH IN OVARIAN CANCER CELL LINES BY PHOSPHORYLATION OF GSK-3. N. L. Seiler, M. Kunnimalaiyaan, L. Krichevsky, S. L. Rose; University of Wisconsin, Madison, WI QS304. MICRORNA-21 (MIR-21) IS OVEREXPRESSED IN ESOPHAGEAL ADENOCARCINOMA AND A POTENTIAL PREDICTOR OF PROGRESSION IN BARRETT’S ESOPHAGUS. M. E. Dillhoff, J. Liu, W. Frankel, M. Bloomston; Ohio State University, Columbus, OH QS305. THE ROLE OF ACTIVATING RET-PROTOONCOGENE MUTATIONS IN SPORADIC NEOPLASMS OF THE GASTRO-ENTERO-PANCREATIC AXIS. F. Rueckert, H. Goergens, H. Schackert, G. Fitze, H. Saeger, C. Pilarsky, R. Gruetzmann; University Hospital Dresden, Dresden, Germany QS306. RESISTANCE OF MICROSATELLITE (MSI) HUMAN COLORECTAL CANCERS (CRC) TO HISTONE DEACETYLASE INHIBITOR (HDACI) MEDIATED DIFFERENTIATION IS REGULATED AT THE EPIGENETIC LEVEL. A. Azarbayejani1, J. Shin1, J. Ady1, N. Ahmed2, T. Weber3, J. Mariadason2; 1 Department of Surgery, Albert Einstein College of Medicine, Bronx, NY; 2Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY; 3Department of Surgery and Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY QS307. HYPERBARIC OXYGEN THERAPY FOR TREATMENT OF RADIATION TISSUE INJURY. G. A. Perdrizet1, B.
Allen2, A. Babigian2; 1Morristown Memorial Hosp, Morristown, NJ; 2 Hartford Hospital, Hartford, CT QS308. BLOCKADE OF THE GRM1 RECEPTOR RESULTS IN DECREASED MIGRATION, INVASION, AND PROLIFERATION IN MELANOMA. M. N. Le1, J. L. Chan2, S. Chan3, J. Goydos1; 1 Robert Wood Johnson University Hospital/UMDNJ, New Brunswick, NJ; 2Cancer Insitute of New Jersey/UMDNJ, New Brunswick, NJ; 3Rutgers, The State University of New Jersey, New Brunswick, NJ QS309. BOMBESIN AND EPIDERMAL GROWTH FACTOR INREASE BREAST CANCER CELL MIGRATION AND INTERLEUKIN-8 EXPRESSION. C. Chao, C. M. Townsend, Jr., M. R. Hellmich; University of TX Medical Branch, Galveston, TX QS310. POSTTRANSCRIPTIONAL REGULATION OF GATA6 EXPRESSION IN COLON CANCER. N. Belaguli, M. Aftab, M. Zhang, F. Ayanbule, M. Rigi, A. Sakar, D. H. Berger; Baylor College of Medicine, Houston, TX QS311. DUAL EXPRESSION LENTIVIRAL VECTORS FOR CONCURRENT RNA INTERFERENCE AND RESCUE: REGULATION OF RESCUE TRANSGENE EXPRESSION BY ALTERATION OF CLONING SITE AND POSITIONAL EFFECT. N. V. Sankpal, T. P. Fleming, W. E. Gillanders; Washington Universtiy School of Medicine, Saint Louis, MO QS312. OPHTHALMIC ACID AND GLUTATHIONE CONCENTRATION IN SECONDARY LIVER TUMORS SUBSISTENCE AND GROWTH. J. R. Sanabria1, R. Abbas1, S. Kombu2, H. Brunengraber1; 1University Hospitals-Case Medical Center & Case Western Reserve University, Cleveland, OH; 2Case Western Reserve University, Cleveland, OH
ONCOLOGY 13: UPPER GI-CLINICAL QS313. CHEMORADIATION AND SALVAGE ESOPHAGECTOMY FOR TREATMENT OF RESECTABLE ESOPHAGEAL CANCER. K. Onodera, S. Miyazaki, S. Satomi; Tohoku University School of Medicine, Sendai, Japan QS314. TGF-ALPHA LEVELS AS POTENTIAL BIOMARKER FOR HIGH GRADE INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM. C. Doyle, C. Schmidt, M. Yip-Schneider; Indiana University School of Medicine, Indianapolis, IN QS315. HEPATIC RADIOFREQUENCY ABLATION ELEVATES PRO-CANCER CYTOKINES. S. P. Dineen1, J. E. Toombs1, E. E. Moore2, W. L. Biffl2, R. A. Brekken1, C. C. Barnett, Jr.2; 1University of Texas Southwestern Medical Center, Dallas, TX; 2 University of Colorado, Denver, CO QS316. PREDICTORS OF LONG-TERM SURVIVAL AFTER DISTAL PANCREATECTOMY FOR PANCREATIC ADENOCARCINOMA. H. Nathan, C. R. Goodwin, J. L. Cameron, J. M. Winter, S. K. Reddy, B. H. Edil, T. M. Pawlik, R. D. Schulick, M. A. Choti, C. L. Wolfgang; The Johns Hopkins University School of Medicine, Baltimore, MD QS317. TRENDS IN CLINICOPATHOLOGIC CHARACTERISTICS AND PROGNOSTIC PREDICTORS OF SURVIVAL OUTCOME IN BLACK PATIENTS WITH GASTRIC CARCINOMA: