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Quality of life and inflammation among bereaved individuals and controls
Abstracts / Brain, Behavior, and Immunity 66 (2017) e1–e42
60–92). Three principal components were identified (PC1-PC3). PC1 (49% variance explained) was characterized by indicators of NK cell exhaustion (NK56dim: NKG2C+, FCRc-, NKG2C + CD57+, NKG2C + FCRc-, and FCRc-CD57+). PC2 (23% variance explained) was characterized by indicators of T cell senescence (CD8+: CD28-, CD57+, and CD56+). PC3 (10% variance explained) was characterized by NK56dimCD57+. Using PCA results, we examined relationships between the principal components and relevant descriptive and physical health variables that may affect immunological aging. PC1-PC3 were not significantly associated with chronological age, and PC1 and PC2 did not significantly differ by sex. However, males were significantly higher than females on PC3 (F(1,106) = 7.19, p = 0.009). In addition, PC1 and PC2 were significantly associated with cytomegalovirus titers (PC1: b(SE) = 2.77(1.27), p = 0.002; PC2: b(SE) = 5.98(2.13), p = 0.006). Immunological aging may be driven less by chronological age (i.e., years lived) and more by overall health status and androgens. Furthermore, latent viral infections, particularly cytomegalovirus, may drive cellular aging in both NK and T cell dimensions in older adults. http://dx.doi.org/10.1016/j.bbi.2017.07.101
Abstract # 1970 Quality of life and inflammation among bereaved individuals and controls D. Chirinos a, P. Le a, A. Ramiz a, C. Heijnen b, C. Fagundes a,b,c a Rice University, Bioscience Research Collaborative, Rm 773, MS-142, 6100 Main Street, Houston, Texas 77005-1892, Houston, Texas 77098, USA b MD Anderson Cancer Center, USA c Baylor College of Medicine, USA
Spousal bereavement is associated with an increased risk of mortality. The pathways involved in this association are not well understood; however, inflammation has been implicated as an important factor. In this study, we aimed to examine the cross-sectional association between dimensions of quality of life and inflammation, and explore the moderating role of bereavement in these associations. Participants included 46 bereaved individuals and 60 controls with a mean age of 65.15 (SD = 15.00). Inflammation was measured using C-reactive protein (CRP). Dimensions of quality of life were measured using subscales of the Short Form Health Survey-36 (Physical functioning, role limitations, emotional limitations, energy and fatigue, mental health, social role functioning, bodily pain and general health). After controlling for participant age, gender, race, ethnicity, education, income, smoking, alcohol use, obesity, and comorbid conditions, worse perceived general health was associated with increased inflammation among bereaved individuals and controls (B = 0.016, p = 0.026). Further, there was a significant moderating effect of bereavement in the association between inflammation and physical functioning (Binteraction = 0.019, p = 0.047), role limitations (B interaction = 0.016, p = 0.005), energy and fatigue (B interaction = 0.026, p = 0.033), mental health (B interaction = 0.038, p = 0.005), and social role functioning (B interaction = 0.026, p = 0.015). Associations between lower scores on these subscales and increased inflammation were present among bereaved individuals, only. This is the first study to examine the role of bereavement on the association between quality of life and inflammation. http://dx.doi.org/10.1016/j.bbi.2017.07.102
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Abstract # 1972 An iPod-based adaptation of MBSR for lung cancer: Associations of usage with depression and behavioral and endocrine circadian markers S.E. Sephton a,b, E. Cash a,b, L. Zimmaro a, W.N. Rebholz a, C. Albert a, C. Siwik a, K. Phillips a, P. Salmon a a
University of Louisville, 2301 South Third Street, Louisville, Kentucky 40292, USA b James Graham Brown Cancer Center, USA Depressive symptoms are common in lung cancer. In turn, depression and disrupted circadian rhythms predict early mortality in several cancer types, including lung cancer. Mindfulness-based StressReduction (MBSR) shows promise for depression treatment but lacks feasibility for those with socioeconomic disadvantage or functional disability precluding group attendance. We piloted an iPod-based adaptation of MBSR for cancer patients. We explored patient factors related to intervention use; and associations of usage with depressive symptoms, rest activity rhythms, and cortisol rhythms. Participants reported distress and depressive symptoms. They wore actigraphs and collected waking and bedtime saliva for cortisol assessment over 10 days. A subsequent interview oriented them to mindfulness. They were given iPods with MBSR didactic and meditation practice tracks. Follow-up data were collected at three months. Alpha = 0.10 was adopted for this pilot. The sample (n = 65, 67% female, 78% non– Hispanic white) averaged 23 months post-diagnosis, mostly with advanced or metastatic disease. Thirty-eight participants provided follow-up data, and 24 returned iPods. Usage was not linked with baseline demographic, medical, or psychological factors. Stronger baseline rest-activity and cortisol rhythms emerged as predictors of subsequent intervention use. Usage (total minutes, tracks played) was linked with reduction of depression and bedtime cortisol. It’s interesting that rhythms, not clinical factors/symptoms, predicted iPod use. Future research should continue to explore the potential of simple media-based interventions to alleviate psychological symptoms in patients with advancing cancer. http://dx.doi.org/10.1016/j.bbi.2017.07.103
Abstract # 1973 Anxiety levels parallel changes in inflammation over time in ovarian cancer patients J.S. Armer a, A. Schrepf b, M.G. Cuneo a, D. Christensen a, P.H. Thaker c, G.M. Slavich d, M.J. Goodheart a, S.W. Cole d, A.K. Sood e, S.K. Lutgendorf a a
University of Iowa, Iowa City, USA University of Michigan, USA c Washington University School of Medicine, USA d University of California, Los Angeles, USA e UT MD Anderson Comprehensive Cancer Center, USA b
Although extensive research has documented a relationship between depression and inflammation, links between anxiety and inflammation are less well-characterized. Among ovarian cancer patients, who generally have a poor prognosis, 29%–38% have significant anxiety at diagnosis. However, little is known about the relationship of anxiety with inflammation, which often supports tumor progression in ovarian cancer. To address this issue, we examined changes in anxiety over time in ovarian cancer patients following primary treatment, and associations of anxiety with inflammation and inflammatory control. Participants (n = 373) completed
60–92). Three principal components were identified (PC1-PC3). PC1 (49% variance explained) was characterized by indicators of NK cell exhaustion (NK56dim: NKG2C+, FCRc-, NKG2C + CD57+, NKG2C + FCRc-, and FCRc-CD57+). PC2 (23% variance explained) was characterized by indicators of T cell senescence (CD8+: CD28-, CD57+, and CD56+). PC3 (10% variance explained) was characterized by NK56dimCD57+. Using PCA results, we examined relationships between the principal components and relevant descriptive and physical health variables that may affect immunological aging. PC1-PC3 were not significantly associated with chronological age, and PC1 and PC2 did not significantly differ by sex. However, males were significantly higher than females on PC3 (F(1,106) = 7.19, p = 0.009). In addition, PC1 and PC2 were significantly associated with cytomegalovirus titers (PC1: b(SE) = 2.77(1.27), p = 0.002; PC2: b(SE) = 5.98(2.13), p = 0.006). Immunological aging may be driven less by chronological age (i.e., years lived) and more by overall health status and androgens. Furthermore, latent viral infections, particularly cytomegalovirus, may drive cellular aging in both NK and T cell dimensions in older adults. http://dx.doi.org/10.1016/j.bbi.2017.07.101
Abstract # 1970 Quality of life and inflammation among bereaved individuals and controls D. Chirinos a, P. Le a, A. Ramiz a, C. Heijnen b, C. Fagundes a,b,c a Rice University, Bioscience Research Collaborative, Rm 773, MS-142, 6100 Main Street, Houston, Texas 77005-1892, Houston, Texas 77098, USA b MD Anderson Cancer Center, USA c Baylor College of Medicine, USA
Spousal bereavement is associated with an increased risk of mortality. The pathways involved in this association are not well understood; however, inflammation has been implicated as an important factor. In this study, we aimed to examine the cross-sectional association between dimensions of quality of life and inflammation, and explore the moderating role of bereavement in these associations. Participants included 46 bereaved individuals and 60 controls with a mean age of 65.15 (SD = 15.00). Inflammation was measured using C-reactive protein (CRP). Dimensions of quality of life were measured using subscales of the Short Form Health Survey-36 (Physical functioning, role limitations, emotional limitations, energy and fatigue, mental health, social role functioning, bodily pain and general health). After controlling for participant age, gender, race, ethnicity, education, income, smoking, alcohol use, obesity, and comorbid conditions, worse perceived general health was associated with increased inflammation among bereaved individuals and controls (B = 0.016, p = 0.026). Further, there was a significant moderating effect of bereavement in the association between inflammation and physical functioning (Binteraction = 0.019, p = 0.047), role limitations (B interaction = 0.016, p = 0.005), energy and fatigue (B interaction = 0.026, p = 0.033), mental health (B interaction = 0.038, p = 0.005), and social role functioning (B interaction = 0.026, p = 0.015). Associations between lower scores on these subscales and increased inflammation were present among bereaved individuals, only. This is the first study to examine the role of bereavement on the association between quality of life and inflammation. http://dx.doi.org/10.1016/j.bbi.2017.07.102
e27
Abstract # 1972 An iPod-based adaptation of MBSR for lung cancer: Associations of usage with depression and behavioral and endocrine circadian markers S.E. Sephton a,b, E. Cash a,b, L. Zimmaro a, W.N. Rebholz a, C. Albert a, C. Siwik a, K. Phillips a, P. Salmon a a
University of Louisville, 2301 South Third Street, Louisville, Kentucky 40292, USA b James Graham Brown Cancer Center, USA Depressive symptoms are common in lung cancer. In turn, depression and disrupted circadian rhythms predict early mortality in several cancer types, including lung cancer. Mindfulness-based StressReduction (MBSR) shows promise for depression treatment but lacks feasibility for those with socioeconomic disadvantage or functional disability precluding group attendance. We piloted an iPod-based adaptation of MBSR for cancer patients. We explored patient factors related to intervention use; and associations of usage with depressive symptoms, rest activity rhythms, and cortisol rhythms. Participants reported distress and depressive symptoms. They wore actigraphs and collected waking and bedtime saliva for cortisol assessment over 10 days. A subsequent interview oriented them to mindfulness. They were given iPods with MBSR didactic and meditation practice tracks. Follow-up data were collected at three months. Alpha = 0.10 was adopted for this pilot. The sample (n = 65, 67% female, 78% non– Hispanic white) averaged 23 months post-diagnosis, mostly with advanced or metastatic disease. Thirty-eight participants provided follow-up data, and 24 returned iPods. Usage was not linked with baseline demographic, medical, or psychological factors. Stronger baseline rest-activity and cortisol rhythms emerged as predictors of subsequent intervention use. Usage (total minutes, tracks played) was linked with reduction of depression and bedtime cortisol. It’s interesting that rhythms, not clinical factors/symptoms, predicted iPod use. Future research should continue to explore the potential of simple media-based interventions to alleviate psychological symptoms in patients with advancing cancer. http://dx.doi.org/10.1016/j.bbi.2017.07.103
Abstract # 1973 Anxiety levels parallel changes in inflammation over time in ovarian cancer patients J.S. Armer a, A. Schrepf b, M.G. Cuneo a, D. Christensen a, P.H. Thaker c, G.M. Slavich d, M.J. Goodheart a, S.W. Cole d, A.K. Sood e, S.K. Lutgendorf a a
University of Iowa, Iowa City, USA University of Michigan, USA c Washington University School of Medicine, USA d University of California, Los Angeles, USA e UT MD Anderson Comprehensive Cancer Center, USA b
Although extensive research has documented a relationship between depression and inflammation, links between anxiety and inflammation are less well-characterized. Among ovarian cancer patients, who generally have a poor prognosis, 29%–38% have significant anxiety at diagnosis. However, little is known about the relationship of anxiety with inflammation, which often supports tumor progression in ovarian cancer. To address this issue, we examined changes in anxiety over time in ovarian cancer patients following primary treatment, and associations of anxiety with inflammation and inflammatory control. Participants (n = 373) completed