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Quantitative cytometry as a tool for toxicity assessment
Toxicology in Vitro 24 (2010) 2059
Contents lists available at ScienceDirect
Toxicology in Vitro journal homepage: www.elsevier.com/locate/toxinvit
Editorial
Quantitative cytometry as a tool for toxicity assessment (27th annual workshop of the Scandinavian Society for Cell Toxicology) 1. Introduction Quantitative cytometry as a tool for toxicity assessment was the motto of the 27th annual workshop of the Scandinavian Society for Cell Toxicology (SSCT). The workshop was held, maybe as a little surprise, in the Czech Republic, in a small spa Lázneˇ Sedmihorky, during nice Indian summer days in September 16–22, 2009. The SSCT was established in 1983 primarily as a discussion platform for cell toxicologists from Nordic countries. Nevertheless, very soon the activities crossed the boarder of Scandinavia and annual workshops already took place in Germany, United Kingdom, and Estonia. During the meeting of the SSCT Board in Grinda, Sweden, in 2006 it was decided to organise the 27th workshop in the Czech Republic and Prof. Zuzana Cˇervinková and Prof. Miroslav Cˇervinka from the Charles University Faculty of Medicine in Hradec Kralove were appointed as the local organisers. The local organisers adopted traditional characteristics of the SSCT workshops: close to the nature. The workshop venue was in the Bohemian Paradise in the National natural protected park; in the quiet resort Lazne Sedmihorky. But not only natural beauties supported the success of the meeting. In the first place, the scientific program and the participants themselves created a constructive and friendly atmosphere. Together, there were 41 participants from 11 European countries, participants from the Czech Republic represented less than 45% of all participants. The workshop started with the invited lecture of Prof. Ada Kolman ‘‘Bjorn Ekwall, an outstanding Swedish cell toxicologist”. Next morning, the scientific programme started with the Björn Ekwall Memorial Award Lecture. In 2009 the award was given to Prof. Annalaura Stammati, a research director of the Instituto Supeiore di Sanita, Rome, Italy. Prof. Stammati presented her invited lecture about ‘‘The evolution of in vitro toxicology research at ISS from 1979 to 2009”. The workshop had the following main topics: mechanisms of toxicity, toxicity testing in vitro, application of in vitro assays in regulatory toxicology. There was also a series of special sessions under the heading ‘‘Methods of Cell Toxicology” this time focused on ‘‘Quantitative cytometry as a tool for toxicity assessment”. Peter ´ Brien from the University College in Dublin (Ireland) presented a O very educative presentation about ‘‘High Content Analysis”. The programme continued with a presentation about ‘‘The use of time-lapse microscope-assisted cytometry for characterisation of toxic effects on cell cultures”. In subsequent sessions many interesting presentations highlighted the importance of in vitro models for toxicity assessment. The poster session was organised as guided presentation and discussion.
0887-2333/$ - see front matter Ó 2010 Elsevier Ltd. All rights reserved. doi:10.1016/j.tiv.2010.08.018
At the end of the meeting another essential part of the SSCT workshops took place – SSCT Young Scientists Awards for the best oral and poster presentations were given. This year winners were: Tomáš Roušar (University Pardubice, Czech Republic) for his talk about ‘‘Study of acetaminophen hepatotoxicity in vitro – role of glutathione reductase inhibition” (with his co-authors O. Kucˇera, P. ˇ ková, H. Lotková, V. Muzˇáková a Z. Cˇervinková). Parˇík, P. Stan Sibylle Brenner (Institute of Toxicology, Kiel, Germany) for her poster presentation ‘‘Lasting effects of preceding culture conditions on the susceptibility of C6 cell to peroxide induced oxidative stress” (with her co-authors M. Gülden, E. Masser and H. Seiberts). The General Assembly held during the workshop appointed Ada Kolman as a honorary member of the Scandinavian Society for Cell Toxicology. During the Assembly and also on many occasions during the workshop participants highly appreciated both scientific and social milieu during this event. For these reasons we have to acknowledge small group of local organisers, based on academicians and students of the Charles University, Faculty of Medicine in Hradec Kralove. With help of these enthusiastic people it was possible to cope with economical part of this event even though the number of industrial sponsors was rather limited. Finally, all participants appreciated decision of the SSCT Board to organise this annual workshop of the Scandinavian Scientific Society in the central Europe. In the current special issue of Toxicology in vitro you can find nine articles representing topics discussed during the 27th SSCT workshop. Miroslav Cˇervinka Emil Rudolf Medical Biology and Genetics Charles University Faculty of Medicine, Hradec Kralove, Czech Republic
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Bas Blaauboer Utrecht University, Institute for Risk Assessment Sciences, Division of Toxicology, P.O. Box 80.177, Utrecht 3508 TD, The Netherlands ⇑ Tel.: +31 30 2535330; fax: +31 30 2535077 E-mail address: [email protected] (Bas Blaauboer) Available online 6 September 2010
Contents lists available at ScienceDirect
Toxicology in Vitro journal homepage: www.elsevier.com/locate/toxinvit
Editorial
Quantitative cytometry as a tool for toxicity assessment (27th annual workshop of the Scandinavian Society for Cell Toxicology) 1. Introduction Quantitative cytometry as a tool for toxicity assessment was the motto of the 27th annual workshop of the Scandinavian Society for Cell Toxicology (SSCT). The workshop was held, maybe as a little surprise, in the Czech Republic, in a small spa Lázneˇ Sedmihorky, during nice Indian summer days in September 16–22, 2009. The SSCT was established in 1983 primarily as a discussion platform for cell toxicologists from Nordic countries. Nevertheless, very soon the activities crossed the boarder of Scandinavia and annual workshops already took place in Germany, United Kingdom, and Estonia. During the meeting of the SSCT Board in Grinda, Sweden, in 2006 it was decided to organise the 27th workshop in the Czech Republic and Prof. Zuzana Cˇervinková and Prof. Miroslav Cˇervinka from the Charles University Faculty of Medicine in Hradec Kralove were appointed as the local organisers. The local organisers adopted traditional characteristics of the SSCT workshops: close to the nature. The workshop venue was in the Bohemian Paradise in the National natural protected park; in the quiet resort Lazne Sedmihorky. But not only natural beauties supported the success of the meeting. In the first place, the scientific program and the participants themselves created a constructive and friendly atmosphere. Together, there were 41 participants from 11 European countries, participants from the Czech Republic represented less than 45% of all participants. The workshop started with the invited lecture of Prof. Ada Kolman ‘‘Bjorn Ekwall, an outstanding Swedish cell toxicologist”. Next morning, the scientific programme started with the Björn Ekwall Memorial Award Lecture. In 2009 the award was given to Prof. Annalaura Stammati, a research director of the Instituto Supeiore di Sanita, Rome, Italy. Prof. Stammati presented her invited lecture about ‘‘The evolution of in vitro toxicology research at ISS from 1979 to 2009”. The workshop had the following main topics: mechanisms of toxicity, toxicity testing in vitro, application of in vitro assays in regulatory toxicology. There was also a series of special sessions under the heading ‘‘Methods of Cell Toxicology” this time focused on ‘‘Quantitative cytometry as a tool for toxicity assessment”. Peter ´ Brien from the University College in Dublin (Ireland) presented a O very educative presentation about ‘‘High Content Analysis”. The programme continued with a presentation about ‘‘The use of time-lapse microscope-assisted cytometry for characterisation of toxic effects on cell cultures”. In subsequent sessions many interesting presentations highlighted the importance of in vitro models for toxicity assessment. The poster session was organised as guided presentation and discussion.
0887-2333/$ - see front matter Ó 2010 Elsevier Ltd. All rights reserved. doi:10.1016/j.tiv.2010.08.018
At the end of the meeting another essential part of the SSCT workshops took place – SSCT Young Scientists Awards for the best oral and poster presentations were given. This year winners were: Tomáš Roušar (University Pardubice, Czech Republic) for his talk about ‘‘Study of acetaminophen hepatotoxicity in vitro – role of glutathione reductase inhibition” (with his co-authors O. Kucˇera, P. ˇ ková, H. Lotková, V. Muzˇáková a Z. Cˇervinková). Parˇík, P. Stan Sibylle Brenner (Institute of Toxicology, Kiel, Germany) for her poster presentation ‘‘Lasting effects of preceding culture conditions on the susceptibility of C6 cell to peroxide induced oxidative stress” (with her co-authors M. Gülden, E. Masser and H. Seiberts). The General Assembly held during the workshop appointed Ada Kolman as a honorary member of the Scandinavian Society for Cell Toxicology. During the Assembly and also on many occasions during the workshop participants highly appreciated both scientific and social milieu during this event. For these reasons we have to acknowledge small group of local organisers, based on academicians and students of the Charles University, Faculty of Medicine in Hradec Kralove. With help of these enthusiastic people it was possible to cope with economical part of this event even though the number of industrial sponsors was rather limited. Finally, all participants appreciated decision of the SSCT Board to organise this annual workshop of the Scandinavian Scientific Society in the central Europe. In the current special issue of Toxicology in vitro you can find nine articles representing topics discussed during the 27th SSCT workshop. Miroslav Cˇervinka Emil Rudolf Medical Biology and Genetics Charles University Faculty of Medicine, Hradec Kralove, Czech Republic
⇑
Bas Blaauboer Utrecht University, Institute for Risk Assessment Sciences, Division of Toxicology, P.O. Box 80.177, Utrecht 3508 TD, The Netherlands ⇑ Tel.: +31 30 2535330; fax: +31 30 2535077 E-mail address: [email protected] (Bas Blaauboer) Available online 6 September 2010