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Quantitative Measurement of Changes in Human Lung Density Following Irradiation
Literature Reviews probability of pelvic disease control may benefit from extended field irradiation.
161
MOVING-STRIP ABDOMINO-PELVICRADIOTHERAPY AFTER CIS-PLATINUM-BASEDCHEMOTHERAPYAND SECOND-LOOKOPERATION A Feasibility Study in Advanced Ovarian Cancer
QUANTITATIVEMEASUREMENTOF CHANGES IN HUMAN LUNG DENSITY FOLLOWING IRRADIATION K. Mah and J. Van Dyk The Department of Medical Biophysics, University of Toronto, and the Ontario Cancer Institute, 500 Sherbourne Street, Toronto, Ontario, Canada M4X 1K9 Radiotherapy and Oncology, Journal of the European Society for Therapeutic Radiology and Oncology,
Vol. 11 (1988), pp. 169-179 In a prospective clinical study, a dose-response relationship for the incidence of acute radiation-induced pulmonary damage in patients undergoing partial lung, conventional fractionated radiotherapy was established. In this study, Computed Tomography (C.T.) was used to monitor the lung density changes due to radiation before and at pre-selected times up to 6 months following the initiation of radiotherapy. Lung densities were assessed separately in the irradiated and non-irradiated regions. In the 54 patients studied, 36 demonstrated visible postirradiation lung damage on C.T. The mean relative increase in average lung density was 0.20 ? 0.10 in the irradiated regions and 0.02 + 0.09 in the non-irradiated lung volume. For the 18 patients without visible damage, the mean relative changes were 0.00 + 0.09 and 0.05 + 0.07 for the irradiated and non-irradiated regions respectively. The results suggest an increase in average lung density of 5% or greater is associated with the visible detection of pulmonary damage.
A. Falcone, S. Chiara, P. Franzone, V. Vitale, D. Scarpati, M. Bruzzone, F. Camino, and P. F. Conte Instituto Nazionale per la Ricerca sul Cancro (A.F., S.C., P.F., V.V., M.B., P.F.C.), Instituto di Radiologia dell’universita di Genova (D.S.), Genova; and Ospedale Ginecologico “S. Anna” (F.C.), Torino, Italy American Journal qf Clinical Oncology, 1 l( 1): 16-20, 1988
From February 1984 to August 1986, 16 patients with histologically confirmed diagnosis of ovarian carcinoma Stage II-IV, who completed 6 to 12 courses of a cis-platinumbased combination chemotherapy received abdomino-pelvie radiotherapy with the moving strip technique. Post-operative chemotherapy consisted of cis-platinum 50 mg/sm and cyclophosphamide 600 mg/sm (P.C.) in four patients, and P.C. and adriamycin 45 mg/sm (P.A.C.) in 12 patients every 28 days.Toxicity was moderate; predominantly nausea, vomiting and alopecia. Moving strip therapy consisted of four patients being treated with an isocentric technique described by Dembo et al.“. Each strip was irradiated isocentrically ten times to a total dose of 2,250 cGy. The remaining twelve patients were treated according to the technique of Deklos et aLI2 fixed source-skin distance. Each strip was irradiated eight times with a total dose of 2,250 cGy. No pelvic boost was given. Liver was not shielded and kidneys were shielded in the posterior field only with lead five em blocks. Data collected indicated that this therapeutic approach is feasible with acceptable toxicities, but its therapeutic value remains questionable.
161
MOVING-STRIP ABDOMINO-PELVICRADIOTHERAPY AFTER CIS-PLATINUM-BASEDCHEMOTHERAPYAND SECOND-LOOKOPERATION A Feasibility Study in Advanced Ovarian Cancer
QUANTITATIVEMEASUREMENTOF CHANGES IN HUMAN LUNG DENSITY FOLLOWING IRRADIATION K. Mah and J. Van Dyk The Department of Medical Biophysics, University of Toronto, and the Ontario Cancer Institute, 500 Sherbourne Street, Toronto, Ontario, Canada M4X 1K9 Radiotherapy and Oncology, Journal of the European Society for Therapeutic Radiology and Oncology,
Vol. 11 (1988), pp. 169-179 In a prospective clinical study, a dose-response relationship for the incidence of acute radiation-induced pulmonary damage in patients undergoing partial lung, conventional fractionated radiotherapy was established. In this study, Computed Tomography (C.T.) was used to monitor the lung density changes due to radiation before and at pre-selected times up to 6 months following the initiation of radiotherapy. Lung densities were assessed separately in the irradiated and non-irradiated regions. In the 54 patients studied, 36 demonstrated visible postirradiation lung damage on C.T. The mean relative increase in average lung density was 0.20 ? 0.10 in the irradiated regions and 0.02 + 0.09 in the non-irradiated lung volume. For the 18 patients without visible damage, the mean relative changes were 0.00 + 0.09 and 0.05 + 0.07 for the irradiated and non-irradiated regions respectively. The results suggest an increase in average lung density of 5% or greater is associated with the visible detection of pulmonary damage.
A. Falcone, S. Chiara, P. Franzone, V. Vitale, D. Scarpati, M. Bruzzone, F. Camino, and P. F. Conte Instituto Nazionale per la Ricerca sul Cancro (A.F., S.C., P.F., V.V., M.B., P.F.C.), Instituto di Radiologia dell’universita di Genova (D.S.), Genova; and Ospedale Ginecologico “S. Anna” (F.C.), Torino, Italy American Journal qf Clinical Oncology, 1 l( 1): 16-20, 1988
From February 1984 to August 1986, 16 patients with histologically confirmed diagnosis of ovarian carcinoma Stage II-IV, who completed 6 to 12 courses of a cis-platinumbased combination chemotherapy received abdomino-pelvie radiotherapy with the moving strip technique. Post-operative chemotherapy consisted of cis-platinum 50 mg/sm and cyclophosphamide 600 mg/sm (P.C.) in four patients, and P.C. and adriamycin 45 mg/sm (P.A.C.) in 12 patients every 28 days.Toxicity was moderate; predominantly nausea, vomiting and alopecia. Moving strip therapy consisted of four patients being treated with an isocentric technique described by Dembo et al.“. Each strip was irradiated isocentrically ten times to a total dose of 2,250 cGy. The remaining twelve patients were treated according to the technique of Deklos et aLI2 fixed source-skin distance. Each strip was irradiated eight times with a total dose of 2,250 cGy. No pelvic boost was given. Liver was not shielded and kidneys were shielded in the posterior field only with lead five em blocks. Data collected indicated that this therapeutic approach is feasible with acceptable toxicities, but its therapeutic value remains questionable.