- Email: [email protected]
RACIAL DIFFERENCES IN LEFT VENTRICULAR RECOVERY IN PATIENTS WITH PERIPARTUM CARDIOMYOPATHY ASSESSED BY GLOBAL LONGITUDINAL STRAIN
1463 JACC March 21, 2017 Volume 69, Issue 11
Non Invasive Imaging (Echocardiography, Nuclear, PET, MR and CT) RACIAL DIFFERENCES IN LEFT VENTRICULAR RECOVERY IN PATIENTS WITH PERIPARTUM CARDIOMYOPATHY ASSESSED BY GLOBAL LONGITUDINAL STRAIN Poster Contributions Poster Hall, Hall C Friday, March 17, 2017, 10:00 a.m.-10:45 a.m. Session Title: Novel Echocardiographic Methods for Assessing Cardiac Function Abstract Category: 28. Non Invasive Imaging: Echo Presentation Number: 1120-234 Authors: Masataka Sugahara, Dennis McNamara, Joan Briller, Leslie Cooper, Julie Damp, Mark Drazner, James Fett, Eileen Hsich, Navin Rajagopalan, John Gorcsan, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Background: Racial differences between Black and Non-black women with peripertum cardiomyopathy (PPCM) have been observed. The aim was to test the hypothesis that racial differences in degree of left ventricular (LV) dysfunction at presentation and recovery occur in PPCM using strain imaging. Methods: We studied 100 PPCM patients in the multicenter Investigation in Pregnancy Associated Cardiomyopathy study [LV ejection fraction (EF) <45% within 2 months of delivery]. Speckle tracking echo from 3 apical views for global longitudinal strain (GLS) was done at entry, 6-month-follow and 1-year. Patients with lack of LV recovery were predefined as LVEF < 50% at 1 year, death, heart transplant or LV assist device (LVAD). Results: PPCM patients with Black race had greater degree of LV dysfunction at each time point: LVEF was 31.7±1.8%* vs.35.9±1.1% at entry, *p=0.048; 47.0±2.2%* vs. 53.0±1.4% at 6 mo, *p=0.024; and 47.6±2.2%* vs. 55.4±1.3% at 1 year, *p=0.003. GLS (absolute values) was also lower in Black vs. Non-black patients: 10.0±0.8%* vs. 12.4±0.5% at entry, *p=0.014; 16.5±1.0%* vs. 19.0±0.6% at 6 mo., p=0.040*; 16.8±1.1%* vs. 19.4±0.6% at 1 yr, p=0.043). Conclusions: Racial differences in degree of LV dysfunction and recovery were observed in PPCM with Black patients having comparatively greater LV dysfunction by both EF and GLS.
Non Invasive Imaging (Echocardiography, Nuclear, PET, MR and CT) RACIAL DIFFERENCES IN LEFT VENTRICULAR RECOVERY IN PATIENTS WITH PERIPARTUM CARDIOMYOPATHY ASSESSED BY GLOBAL LONGITUDINAL STRAIN Poster Contributions Poster Hall, Hall C Friday, March 17, 2017, 10:00 a.m.-10:45 a.m. Session Title: Novel Echocardiographic Methods for Assessing Cardiac Function Abstract Category: 28. Non Invasive Imaging: Echo Presentation Number: 1120-234 Authors: Masataka Sugahara, Dennis McNamara, Joan Briller, Leslie Cooper, Julie Damp, Mark Drazner, James Fett, Eileen Hsich, Navin Rajagopalan, John Gorcsan, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Background: Racial differences between Black and Non-black women with peripertum cardiomyopathy (PPCM) have been observed. The aim was to test the hypothesis that racial differences in degree of left ventricular (LV) dysfunction at presentation and recovery occur in PPCM using strain imaging. Methods: We studied 100 PPCM patients in the multicenter Investigation in Pregnancy Associated Cardiomyopathy study [LV ejection fraction (EF) <45% within 2 months of delivery]. Speckle tracking echo from 3 apical views for global longitudinal strain (GLS) was done at entry, 6-month-follow and 1-year. Patients with lack of LV recovery were predefined as LVEF < 50% at 1 year, death, heart transplant or LV assist device (LVAD). Results: PPCM patients with Black race had greater degree of LV dysfunction at each time point: LVEF was 31.7±1.8%* vs.35.9±1.1% at entry, *p=0.048; 47.0±2.2%* vs. 53.0±1.4% at 6 mo, *p=0.024; and 47.6±2.2%* vs. 55.4±1.3% at 1 year, *p=0.003. GLS (absolute values) was also lower in Black vs. Non-black patients: 10.0±0.8%* vs. 12.4±0.5% at entry, *p=0.014; 16.5±1.0%* vs. 19.0±0.6% at 6 mo., p=0.040*; 16.8±1.1%* vs. 19.4±0.6% at 1 yr, p=0.043). Conclusions: Racial differences in degree of LV dysfunction and recovery were observed in PPCM with Black patients having comparatively greater LV dysfunction by both EF and GLS.