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Radiation physics and chemistry of biomolecules. Recent developments
Radiation Physics and Chemistry 128 (2016) 1–2
Contents lists available at ScienceDirect
Radiation Physics and Chemistry journal homepage: www.elsevier.com/locate/radphyschem
Preface
Radiation physics and chemistry of biomolecules. Recent developments
A chapter of the book “Radiation chemistry. From basics to application in materials and life sciences (EDP Science, Paris, France, 2008)” was devoted to the state-of-the-art in the research on ionizing radiation (IR) effects on biomolecules. An update, eight years later, seemed pertinent enough to the editors of this journal who accepted to dedicate a Special Issue to the latest developments in this area of high interest for cancer radiotherapy, nuclear workers’ radioprotection and food radiosterilisation. We sincerely thank them and the authors who accepted to present reviews of their most recent work. Obviously, only a small part of the research in the fascinating domain of molecular radiobiology can be covered here. Some articles are presenting the contribution of biophysical models and computational techniques to the understanding of IR effects on molecules such as DNA and proteins, or on larger systems such as chromatin, chromosomes and even cells (Nikjoo et al., Štěpán & Davídková, Ballarini & Carante, and Nikitaki et al.). In these papers, as well as in many others, several qualities of IR are compared in order to explain the observed differences of effects. The damages induced by the low energy electrons and new techniques involved in their study are discussed in great detail (Sanche and Fromm & Boulanouar). The chemistry behind the IR induced damages (single or clustered), studied in many laboratories around the world is presented in several papers (Cadet & Wagner, Sevilla et al., Chatgilialoglu et al., and Greenberg). One of them addresses a very useful comparison between the effects of IR and UV exposure on DNA (Ravanat & Douki). The majority of the papers in this Special Issue is dealing with DNA and this reflects the real situation: damages of DNA are more studied than those of other biomolecules. This is due to the role of DNA as main support of hereditary information. Nevertheless, more and more studies are outlining the influence of epigenetic factors on mutagenesis and cell death. Therefore the development of research on effects of IR on partners of DNA such as proteins is necessary. Some papers presented here are already discussing the IR effects on some proteins and protein-DNA complexes (Scuderi et al., Rodacka et al., and Bury et al.). Concerning the damages of DNA, the enzyme-driven repair processes taking place in the cell are of crucial importance for cell faith. New techniques such as the single molecule fluorescence imaging (Lee & Wallace) are applied to the study of repair process. The possible use of nanoparticles as radiomodifiers is discussed in two papers (Krokosz et al. and Brun & Sicard-Roselli). Finally, we would like to apologize for not being able to invite papers from all the very good laboratories dealing today with the effects of IR on biomolecules. In spite of the space limitation, we hope that this issue will succeed drawing, at least partially, a realistic picture of the current state of this research field in 2016. Guest Editor Melanie Spotheim-Maurizot
http://dx.doi.org/10.1016/j.radphyschem.2016.09.011 0969-806X/& 2016 Published by Elsevier Ltd.
2
Preface / Radiation Physics and Chemistry 128 (2016) 1–2
List of articles Nikjoo, H., Taleei, R., Liamsuwan, T., Liljequist, D., Emfietzoglou, D., 2016. Perspectives in radiation biophysics: from radiation track structure simulation to mechanistic models of DNA damage and repair. Radiat. Phys. Chem. 128, 2–9. Štěpán, Václav, Davídková, Marie, 2016. Understanding radiation damage on sub-cellular scale using RADAMOL simulation tool. Radiat. Phys. Chem. 128, 10–16. Ballarini, Francesca, Carante, Mario P., 2016. Chromosome aberrations and cell death by ionizing radiation: evolution of a biophysical model. Radiat. Phys. Chem. 128, 17–24. Nikitaki, Zacharenia, Nikolov, Vladimir, Mavragani, Ifigeneia V., Plante, Ianik, Emfietzoglou, Dimitris, Iliakis, George, Georgakilas, Alexandros G., 2016. Non-DSB clustered DNA lesions. Does theory colocalize with the experiment? Radiat. Phys. Chem. 128, 25–34. Sanche, Léon, 2016. Interaction of low energy electrons with DNA: applications to cancer radiation therapy. Radiat. Phys. Chem. 128, 35–42. Fromm, Michel, Boulanouar, Omar, 2016. Low energy electrons and ultra-soft X-rays irradiation of plasmid DNA. Technical innovations. Radiat. Phys. Chem. 128, 43–52. Cadet, Jean, Wagner, J. Richard, 2016. Radiation-induced damage to cellular DNA: chemical nature and mechanisms of lesion formation. Radiat. Phys. Chem. 128, 53–58. Sevilla, Michael D., Becker, David, Kumar, Anil, Adhikary, Amitava, 2016. Gamma and ion-beam irradiation of DNA: free radical mechanisms, electron effects, and radiation chemical track structure. Radiat. Phys. Chem. 128, 59–73. Chatgilialoglu, Chryssostomos, Krokidis, Marios G., Papadopoulos, Kyriakos, Terzidis, Michael A., 2016. Purine 5′,8-cyclo-2′-deoxynucleoside lesions in irradiated DNA. Radiat. Phys. Chem. 128, 74–80. Greenberg, Marc M., 2016. Pyrimidine nucleobase radical reactivity in DNA and RNA. Radiat. Phys. Chem. 128, 81–90. Ravanat, Jean-Luc, Douki, Thierry, 2016. UV and ionizing radiations induced DNA damage, differences and similarities. Radiat. Phys. Chem. 128, 91–101. Scuderi, Debora, Bergès, Jacqueline, Oliveira, Pedrode, Houée-Levin, Chantal, 2016. Methionine one-electron oxidation: coherent contributions from radiolysis, IRMPD spectroscopy, DFT calculations and electrochemistry. Radiat. Phys. Chem. 128, 102–110. Rodacka, Aleksandra, Gerszon, Joanna, Puchala, Mieczyslaw, Bartosz, Grzegorz, 2016. Radiation-induced inactivation of enzymes – molecular mechanism based on inactivation of dehydrogenases. Radiat. Phys. Chem. 128, 111–116. Bury, Charles S., Carmichael, Ian, McGeehan, John E., Garman, Elspeth F., 2016. Radiation damage with in nucleoprotein complexes studied by macromolecular X-ray crystallography. Radiat. Phys. Chem. 128, 117–124. Lee, Andrea J., Wallace, Susan S., 2016. Visualizing the search for radiation-damaged DNA bases in real time. Radiat. Phys. Chem. 128, 125– 132. Brun, Emilie, Sicard-Roselli, Cécile, 2016. Actual questions raised by nanoparticle radiosensitization. Radiat. Phys. Chem. 128, 133–141. Krokosz, Anita, Lichota, Anna, Nowak, Katarzyna E., Grebowski, Jacek, 2016. Carbon nanoparticles as possible radioprotectors in biological systems. Radiat. Phys. Chem. 128, 142–149.
Contents lists available at ScienceDirect
Radiation Physics and Chemistry journal homepage: www.elsevier.com/locate/radphyschem
Preface
Radiation physics and chemistry of biomolecules. Recent developments
A chapter of the book “Radiation chemistry. From basics to application in materials and life sciences (EDP Science, Paris, France, 2008)” was devoted to the state-of-the-art in the research on ionizing radiation (IR) effects on biomolecules. An update, eight years later, seemed pertinent enough to the editors of this journal who accepted to dedicate a Special Issue to the latest developments in this area of high interest for cancer radiotherapy, nuclear workers’ radioprotection and food radiosterilisation. We sincerely thank them and the authors who accepted to present reviews of their most recent work. Obviously, only a small part of the research in the fascinating domain of molecular radiobiology can be covered here. Some articles are presenting the contribution of biophysical models and computational techniques to the understanding of IR effects on molecules such as DNA and proteins, or on larger systems such as chromatin, chromosomes and even cells (Nikjoo et al., Štěpán & Davídková, Ballarini & Carante, and Nikitaki et al.). In these papers, as well as in many others, several qualities of IR are compared in order to explain the observed differences of effects. The damages induced by the low energy electrons and new techniques involved in their study are discussed in great detail (Sanche and Fromm & Boulanouar). The chemistry behind the IR induced damages (single or clustered), studied in many laboratories around the world is presented in several papers (Cadet & Wagner, Sevilla et al., Chatgilialoglu et al., and Greenberg). One of them addresses a very useful comparison between the effects of IR and UV exposure on DNA (Ravanat & Douki). The majority of the papers in this Special Issue is dealing with DNA and this reflects the real situation: damages of DNA are more studied than those of other biomolecules. This is due to the role of DNA as main support of hereditary information. Nevertheless, more and more studies are outlining the influence of epigenetic factors on mutagenesis and cell death. Therefore the development of research on effects of IR on partners of DNA such as proteins is necessary. Some papers presented here are already discussing the IR effects on some proteins and protein-DNA complexes (Scuderi et al., Rodacka et al., and Bury et al.). Concerning the damages of DNA, the enzyme-driven repair processes taking place in the cell are of crucial importance for cell faith. New techniques such as the single molecule fluorescence imaging (Lee & Wallace) are applied to the study of repair process. The possible use of nanoparticles as radiomodifiers is discussed in two papers (Krokosz et al. and Brun & Sicard-Roselli). Finally, we would like to apologize for not being able to invite papers from all the very good laboratories dealing today with the effects of IR on biomolecules. In spite of the space limitation, we hope that this issue will succeed drawing, at least partially, a realistic picture of the current state of this research field in 2016. Guest Editor Melanie Spotheim-Maurizot
http://dx.doi.org/10.1016/j.radphyschem.2016.09.011 0969-806X/& 2016 Published by Elsevier Ltd.
2
Preface / Radiation Physics and Chemistry 128 (2016) 1–2
List of articles Nikjoo, H., Taleei, R., Liamsuwan, T., Liljequist, D., Emfietzoglou, D., 2016. Perspectives in radiation biophysics: from radiation track structure simulation to mechanistic models of DNA damage and repair. Radiat. Phys. Chem. 128, 2–9. Štěpán, Václav, Davídková, Marie, 2016. Understanding radiation damage on sub-cellular scale using RADAMOL simulation tool. Radiat. Phys. Chem. 128, 10–16. Ballarini, Francesca, Carante, Mario P., 2016. Chromosome aberrations and cell death by ionizing radiation: evolution of a biophysical model. Radiat. Phys. Chem. 128, 17–24. Nikitaki, Zacharenia, Nikolov, Vladimir, Mavragani, Ifigeneia V., Plante, Ianik, Emfietzoglou, Dimitris, Iliakis, George, Georgakilas, Alexandros G., 2016. Non-DSB clustered DNA lesions. Does theory colocalize with the experiment? Radiat. Phys. Chem. 128, 25–34. Sanche, Léon, 2016. Interaction of low energy electrons with DNA: applications to cancer radiation therapy. Radiat. Phys. Chem. 128, 35–42. Fromm, Michel, Boulanouar, Omar, 2016. Low energy electrons and ultra-soft X-rays irradiation of plasmid DNA. Technical innovations. Radiat. Phys. Chem. 128, 43–52. Cadet, Jean, Wagner, J. Richard, 2016. Radiation-induced damage to cellular DNA: chemical nature and mechanisms of lesion formation. Radiat. Phys. Chem. 128, 53–58. Sevilla, Michael D., Becker, David, Kumar, Anil, Adhikary, Amitava, 2016. Gamma and ion-beam irradiation of DNA: free radical mechanisms, electron effects, and radiation chemical track structure. Radiat. Phys. Chem. 128, 59–73. Chatgilialoglu, Chryssostomos, Krokidis, Marios G., Papadopoulos, Kyriakos, Terzidis, Michael A., 2016. Purine 5′,8-cyclo-2′-deoxynucleoside lesions in irradiated DNA. Radiat. Phys. Chem. 128, 74–80. Greenberg, Marc M., 2016. Pyrimidine nucleobase radical reactivity in DNA and RNA. Radiat. Phys. Chem. 128, 81–90. Ravanat, Jean-Luc, Douki, Thierry, 2016. UV and ionizing radiations induced DNA damage, differences and similarities. Radiat. Phys. Chem. 128, 91–101. Scuderi, Debora, Bergès, Jacqueline, Oliveira, Pedrode, Houée-Levin, Chantal, 2016. Methionine one-electron oxidation: coherent contributions from radiolysis, IRMPD spectroscopy, DFT calculations and electrochemistry. Radiat. Phys. Chem. 128, 102–110. Rodacka, Aleksandra, Gerszon, Joanna, Puchala, Mieczyslaw, Bartosz, Grzegorz, 2016. Radiation-induced inactivation of enzymes – molecular mechanism based on inactivation of dehydrogenases. Radiat. Phys. Chem. 128, 111–116. Bury, Charles S., Carmichael, Ian, McGeehan, John E., Garman, Elspeth F., 2016. Radiation damage with in nucleoprotein complexes studied by macromolecular X-ray crystallography. Radiat. Phys. Chem. 128, 117–124. Lee, Andrea J., Wallace, Susan S., 2016. Visualizing the search for radiation-damaged DNA bases in real time. Radiat. Phys. Chem. 128, 125– 132. Brun, Emilie, Sicard-Roselli, Cécile, 2016. Actual questions raised by nanoparticle radiosensitization. Radiat. Phys. Chem. 128, 133–141. Krokosz, Anita, Lichota, Anna, Nowak, Katarzyna E., Grebowski, Jacek, 2016. Carbon nanoparticles as possible radioprotectors in biological systems. Radiat. Phys. Chem. 128, 142–149.