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Radiation therapy in carcinoma of the nasopharynx
1286
Radiation Oncology 0 Biology 0 Physics
mediastinum and supraclavicular mOre of the poor prognostic none of the twelve patients tes test we do not recommend at the time of diagnosis.
RADIATION
B.E. Amendold,
September 1981, Volume 7, Number 9
lymph nodes should be considered if one or factors are present at the time of diagnosis. As had any manifestation of their disease in the orchiectomy if the testes are normal to palpation
THERAPY
IN CARCINOMA
M.D., J.H. Thrall, and C. Kanellitsas,
OF THE NASOPHARYNX
M.D., Ph.D.
M.A.
Amen dola,
Oepartment of Radiolo Division of Rad:;;ioi,';;rap University of Michigan %s edical Center, ,
M.D.
fi I 48109
Between January 1365 and December 1977, 59 patients with squamous cell carcinoma of the nasopharynx were seen at the University of Michigan Hospital. Of these patients, 40 received treatment in the Department of Radiation Therapy. There were 28 males and 12 females. The age range was 10 to 82 years with an average of 52. All patients were restaged accordiny to the AJC Classification; there were 3 patients in stage II; 18
in stage All
III
and 19 in stage
IV.
patients were treated with Cobalt-60, parallel opposed portals to a maximum dose of 6600 rads. No attempt was made to treat the lower neck; except in 6 patients with massive adenopathy in which the ipsilateral lower neck was treated. There was no dose reduction at the spinal cord tolerance in any case. There was no evidence of myelopathy in any of the survivors. The 3 and 5 year survivals were 13/40 (32%) and 6/40 (15%) respectively. The average survival for patients who died was 8 months. The most common cause of local treatment failure was tumor recurrence in the anterior aspect of the nasopharynx. Review of port films in this series revealed that this portion of the nasopharynx was not systematically included in every case. We conclude that anterior extension is common in nasopharyngeal carcinoma and that wider anterior margins from lateral portals or the addition of an anterior portal is necessary to prevent local recurrence.
PITUITARY
ADENOMAS:
B.E. Amendola,
WEN IS RADIATION THERAPY INDICATED?
M.D., J.H. Thrall, M.D., and C. Kanellitsas, Ph.D.
M.A.
Amendola,
Department of Radiology, Division of Radiation Therapy, University of Michigan Medical Center, Ann Arbor, MI
M.D.,
48109
The role of Radiation Therapy in the control of the tumors of the piA retrospective review was conducted of 214 patients tuitary is analyzed. with adenomas of the hypophysis seen at the University of Michigan Hospital Twenty two out of 214 patients did between January 1965 and December 1978. not receive any type of treatment and 27 craniophaynyicmas were excluded Seventy three patients were treated by surgery alone. Sixfrom the study. ty two received radiation therapy alone and 56 received a combination of Radiation was delivered by means of bilatsurgery and radiation therapy. eral opposed fields using Cobalt-60, 4000 rads in 4 weeks, 5 fractions per week. Crude local control for patients eligible for 5 and 10 year follow up was studied. Of the patients treated with surgery alone, 5 year local control was achieved in 30 patients out of 50 (60X), 10 year local control was achieved in 12 out of 27 (44%). Of the 56 pdtients treated by a combination of surgery and radiation, 34 out of 44 (74%) were alive and free of disease at 5 years, and 22 out of 33 (66%) at 10 years.
Radiation Oncology 0 Biology 0 Physics
mediastinum and supraclavicular mOre of the poor prognostic none of the twelve patients tes test we do not recommend at the time of diagnosis.
RADIATION
B.E. Amendold,
September 1981, Volume 7, Number 9
lymph nodes should be considered if one or factors are present at the time of diagnosis. As had any manifestation of their disease in the orchiectomy if the testes are normal to palpation
THERAPY
IN CARCINOMA
M.D., J.H. Thrall, and C. Kanellitsas,
OF THE NASOPHARYNX
M.D., Ph.D.
M.A.
Amen dola,
Oepartment of Radiolo Division of Rad:;;ioi,';;rap University of Michigan %s edical Center, ,
M.D.
fi I 48109
Between January 1365 and December 1977, 59 patients with squamous cell carcinoma of the nasopharynx were seen at the University of Michigan Hospital. Of these patients, 40 received treatment in the Department of Radiation Therapy. There were 28 males and 12 females. The age range was 10 to 82 years with an average of 52. All patients were restaged accordiny to the AJC Classification; there were 3 patients in stage II; 18
in stage All
III
and 19 in stage
IV.
patients were treated with Cobalt-60, parallel opposed portals to a maximum dose of 6600 rads. No attempt was made to treat the lower neck; except in 6 patients with massive adenopathy in which the ipsilateral lower neck was treated. There was no dose reduction at the spinal cord tolerance in any case. There was no evidence of myelopathy in any of the survivors. The 3 and 5 year survivals were 13/40 (32%) and 6/40 (15%) respectively. The average survival for patients who died was 8 months. The most common cause of local treatment failure was tumor recurrence in the anterior aspect of the nasopharynx. Review of port films in this series revealed that this portion of the nasopharynx was not systematically included in every case. We conclude that anterior extension is common in nasopharyngeal carcinoma and that wider anterior margins from lateral portals or the addition of an anterior portal is necessary to prevent local recurrence.
PITUITARY
ADENOMAS:
B.E. Amendola,
WEN IS RADIATION THERAPY INDICATED?
M.D., J.H. Thrall, M.D., and C. Kanellitsas, Ph.D.
M.A.
Amendola,
Department of Radiology, Division of Radiation Therapy, University of Michigan Medical Center, Ann Arbor, MI
M.D.,
48109
The role of Radiation Therapy in the control of the tumors of the piA retrospective review was conducted of 214 patients tuitary is analyzed. with adenomas of the hypophysis seen at the University of Michigan Hospital Twenty two out of 214 patients did between January 1965 and December 1978. not receive any type of treatment and 27 craniophaynyicmas were excluded Seventy three patients were treated by surgery alone. Sixfrom the study. ty two received radiation therapy alone and 56 received a combination of Radiation was delivered by means of bilatsurgery and radiation therapy. eral opposed fields using Cobalt-60, 4000 rads in 4 weeks, 5 fractions per week. Crude local control for patients eligible for 5 and 10 year follow up was studied. Of the patients treated with surgery alone, 5 year local control was achieved in 30 patients out of 50 (60X), 10 year local control was achieved in 12 out of 27 (44%). Of the 56 pdtients treated by a combination of surgery and radiation, 34 out of 44 (74%) were alive and free of disease at 5 years, and 22 out of 33 (66%) at 10 years.