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Radiation therapy of Kaposi's sarcoma
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RADIATIONTHERAPY OF KAPOSI’S SARCOMA
Tri D. Nguyen, M.D.*, and John T. Farekas, M.D. Department of Radiation Therapy and Nuclear Medicine Thomas Jefferson University Hospital Philadelphia, Pennsylvania C. Jules Rominger, M.D. Department of Radiation Therapy and Nuclear Medicine Mercy Catholic Medical Center, Misericordia Division Philadelphia, Pennsylvania Between 1950 and 1978, 27 cases of Kaposi's sarcoma were diagnosed. Sixteen of these 27 patients received radiation therapy, of whom 15 are evaluakle for radiation response, with median follow-up of 5 years. Treatment modalities include superficial, orthovoltage, megavoltage photons, and superficial electrons. Small field techniques with protracted fractionation were utilized for treatment in the majority of A total of 92 anatomic sites were irradiated with 85 lothe cases. cated within the skin of the lower extremities. Each site was analyzed with regards to treatment modality, response in tumor size, bleeding, pain, local pigmentation and duration of relief. Of the 85 evalwable individual lesions (15 patients), a complete response was noted in 62%, relief of pain in 88% and recession of bleeding in 94%. A ret dose of 1000 or greater is associated with a higher rate of local tumor control as compared,to lower time-dose fractionation schemes. Poor local response appears to be predictive of later regrowth. A higher failure rate seems associated with the use of electron beam therapy. Although several patients have survived for periods of up to 20 years without manifesting visceral involvement, half of the cases developed lymphedema, presumably by sarcomatous engorgement of deep lymphatic channels, causing serious morbidity and responding poorly to systemic chemotherapy.
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A METHOD FOR INSERTING125 IODINE SEEDSINTO VICRYL (R)
ABSORBABLE SUTURE IN PREPARATION FOR PERMANENT IMPLANTATION INTO TUMORS
Bernice Palos, B.S.*; Alvaro Martinez, M.D.; Donald Goffinet, M.D., and Donna Pooler Division of Radiation Therapy Stanford University Medical Center Stanford, California The use of Vicryl absorbable sutures as carriers for radioactive 125 Iodine seeds significantly increases the versatility of the permanent implant. It is invaluable for intra-operative implantation of previously inaccessible tumors (intra-thoracic and intra-abdominal) and tumor beds when surgical margins are not clear. Over 100 patients have been implanted with 125 Iodine sutures at this institution. The implant effect on local control and survival has been very encouraging.
09
RADIATIONTHERAPY OF KAPOSI’S SARCOMA
Tri D. Nguyen, M.D.*, and John T. Farekas, M.D. Department of Radiation Therapy and Nuclear Medicine Thomas Jefferson University Hospital Philadelphia, Pennsylvania C. Jules Rominger, M.D. Department of Radiation Therapy and Nuclear Medicine Mercy Catholic Medical Center, Misericordia Division Philadelphia, Pennsylvania Between 1950 and 1978, 27 cases of Kaposi's sarcoma were diagnosed. Sixteen of these 27 patients received radiation therapy, of whom 15 are evaluakle for radiation response, with median follow-up of 5 years. Treatment modalities include superficial, orthovoltage, megavoltage photons, and superficial electrons. Small field techniques with protracted fractionation were utilized for treatment in the majority of A total of 92 anatomic sites were irradiated with 85 lothe cases. cated within the skin of the lower extremities. Each site was analyzed with regards to treatment modality, response in tumor size, bleeding, pain, local pigmentation and duration of relief. Of the 85 evalwable individual lesions (15 patients), a complete response was noted in 62%, relief of pain in 88% and recession of bleeding in 94%. A ret dose of 1000 or greater is associated with a higher rate of local tumor control as compared,to lower time-dose fractionation schemes. Poor local response appears to be predictive of later regrowth. A higher failure rate seems associated with the use of electron beam therapy. Although several patients have survived for periods of up to 20 years without manifesting visceral involvement, half of the cases developed lymphedema, presumably by sarcomatous engorgement of deep lymphatic channels, causing serious morbidity and responding poorly to systemic chemotherapy.
(go)
A METHOD FOR INSERTING125 IODINE SEEDSINTO VICRYL (R)
ABSORBABLE SUTURE IN PREPARATION FOR PERMANENT IMPLANTATION INTO TUMORS
Bernice Palos, B.S.*; Alvaro Martinez, M.D.; Donald Goffinet, M.D., and Donna Pooler Division of Radiation Therapy Stanford University Medical Center Stanford, California The use of Vicryl absorbable sutures as carriers for radioactive 125 Iodine seeds significantly increases the versatility of the permanent implant. It is invaluable for intra-operative implantation of previously inaccessible tumors (intra-thoracic and intra-abdominal) and tumor beds when surgical margins are not clear. Over 100 patients have been implanted with 125 Iodine sutures at this institution. The implant effect on local control and survival has been very encouraging.
09