230
Radiation
Oncology,
Biology, Physics
Volume 21,
Supplement1
1075 ACIJTE TOXlClTY AND VOWMETWC IN PROSTATE CANCER. Culbert H. Vihyakumar
CDMPARISON
S. Awan A. Low N.
Department of Radiation Oncology. M&ad
OF DIFFERENTTECHNIQUES
IN PATIENTS TREATED WDH BADICAL RADKIT?iEf?APY
Chen GPI BaeseNniveraity
of Cbkegn Ceoter fer Radiathn Therapy
purwsS:tl ) To compare acum irradiim hduced lower intestine1 (LB and genitoudnary [GUI toxhiliea among 3 groups of patientz (aftmated wirb convsotiaul lGroup I), Ibhomputerizsd tomography 1tXl based IGroup ll) or (cl beam’s sye view fBEVI based planning 4Gmup 1lllL (21 To~~tDxidtyOD~ZWdriz~ud~of~iation.U)Touvlyuony~aldi~n~h~rd~ofp~~to~t in prostam spedfh antigen (PSAI bvdr. for racial diffaacs &bt~mhe psthnts WM eligibh for such aoal~aist 15,39, sod dbpatisnts mspectitiY h Gmups I, II, and III. Acute ~~~manT~,EORTCuiru*.mrywrJldurhg~~~~~pm*n.Vdmn.ofme~udo( volumsswemdfgltiifmmahwhthn~ Asaaph-offfran oahuhtedushgacomputerprogram;sbove luMxked~eirrsdimedmn wewusahoablotolooksttieracfaf,tisoaiyshof prMtateWklmsa annpa&le h all tbreo groups (41.4%. 34.W. and 35.O%f: Ll toxicftku YY~R lowsr In tba BEV gmup ~AouteGutoldd&wera ~1.6%~compPredbo41.6Yend60~XinGmupI~Ures~~y.~~pmrtatsvolu~~~maM~~~d jncr~~l~forGrouprIIndIII~7~5cc~98.5a:L~Vdll~)Udl103 olqnotbsmspoosWtorabovrdWemncu ccandt256cc(ths1~vok~11~s~mspecthmly. T~m~PSAlwdr~~inblockrthaninwhitsr@=O~~,smsfor~~8ngta stage and grads in s multivadata analysb fp-0.0081. Meen prostate voksner h blacks (96.0 ccl and whites (80.3 ccl wara aunpar&c ~~1~~UtDddty~tobeleuwimBNbassdtachniqwUISin~thisisnot~l~Eo~wl~in~ttsd. custwnfzatkm with BEV may be msponsiMs (31 The racial diinces h PSA levela probably are related to facttier than differences in prostate volumes. Since survival is poorer in bhcka than in whiter, even after adjusbnent fur stage (1.21, furlher studies em needed to explain these diemoces.
References ::
Natarajan N, Murphy GP, Mettlin C: J. Surg. Onmi. 1989;40:232 Mebane C, Gibbs Y, Horrn J: Nat. Med. Assoc. 1990;82:782
1076 Title: RADIOSURGERY
TARGET POINT ALIGNMENT ERRORS DETECTED WITH PORTAL FILM VERIFICATION
Authors: Serago, C;F.l'*, Lewin, A.A.l", Gonzalez-Arias, S.l, Houdek, P.V.', Schwade, J.G.', Abitbo1,A.A. ’ , and Martial-Vega, V1". Affiliation: Baptist Hospital of MiamiI, University of Miami, Dept. Radiation Oncology', Miami, Florida Purpose: Precise alignment of the intended therapeutic radiation distribution to the localized target volume is a prerequisite for radiosurgery. A verification technique for linear accelerators which uses portal x ray films is described. The portal films are used to verify that the stereotactic coordinates of the center of the intended radiation distribution are in agreement with the localized target point coordinates. Alignment errors are analyzed and reported for 26 cases. Materials and Methods: Intracranial target points were localized with either CT scan or angiograms. Verification of the stereotactic coordinates of the center of the intended radiation distribution was done for 26 cases using port films from a linear accelerator with a x ray localizer. AP and lateral port films of the patient permit in vivo verification with an accuracy of 0.3 mm. A comparison of the localized target point coordinates in stereotactic space with the above was done. Results: Alignment errors of the position of the intended radiation distribution in excess of 1 mm were commonly detected using the portal film verification procedure. The patients position was adjusted prior to treatment so that the maximum error of the therapeutic radiation dose distribution was less than 1 mm. Conclusion: Alignment errors of the patient position may be easily detected and corrected using portal films to verify the in vivo location of the intended radiation distribution in stereotactic space.