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Re: Is Risk of Artificial Urethral Sphincter Cuff Erosion Higher in Patients with Penile Prosthesis?
492
MALE AND FEMALE SEXUAL FUNCTION AND DYSFUNCTION; ANDROLOGY
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/27611652 Editorial Comment: These data emphasize the role that nonphysician providers can have in handling sexual concerns following stroke. Often patients and practitioners need to rely on these important resources to assist in this effort. It is noteworthy that the partners are involved, as reported in this study, and have a significant role in the rehabilitation program. The PLISSIT (Permission, Limited Information, Specific Suggestion, Intensive Therapy) model, also known as the PLISSIT model of sex therapy, is a modeling system used in the field of sexology to determine the different levels of intervention for individual clients.1 Allen D. Seftel, MD 1. Taylor B and Davis S: The extended PLISSIT model for addressing the sexual wellbeing of individuals with an acquired disability or chronic illness. Sex Disabil 2007; 25: 135.
Re: Lifestyle Factors and Premature Ejaculation: Are Physical Exercise, Alcohol Consumption, and Body Mass Index Associated with Premature Ejaculation and Comorbid Erectile Problems? D. Ventus and P. Jern Departments of Psychology, A˚bo Akademi University and University of Turku, Turku, Finland J Sex Med 2016; 13: 1482e1487. doi: 10.1016/j.jsxm.2016.08.007
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/27590186 Editorial Comment: These researchers explored associations among physical exercise, alcohol use, body mass index, premature ejaculation (PE) and erectile dysfunction. A population based sample of Finnish men and a sample of Finnish men diagnosed with PE were surveyed for statistical comparisons. Participants using selective serotonin reuptake inhibitors or other medications known to affect symptoms of PE were excluded from analyses. The clinical sample (69 patients) reported lower levels of physical exercise (mean SD 27.53 21.01) than the population based sample (863 patients, 34.68 22.82, overall 2.52 for 930 patients, p ¼ 0.012), and the effect size was large (d ¼ 0.85). The association between physical exercise and PE remained significant after controlling for effects of age, erectile dysfunction, alcohol use and body mass index. This is an interesting observation that deserves further attention. Allen D. Seftel, MD
Suggested Reading Montague DK, Jarow J, Broderick GA et al: Guideline on the pharmacologic management of premature ejaculation. Available at https://www.auanet.org/ education/guidelines/premature-ejaculation.cfm. Accessed July 19, 2016.
Re: Is Risk of Artificial Urethral Sphincter Cuff Erosion Higher in Patients with Penile Prosthesis? V. Sundaram, B. H. Cordon, M. D. Hofer and A. F. Morey Department of Urology, University of Texas Southwestern, Dallas, Texas J Sex Med 2016; 13: 1432e1437. doi: 10.1016/j.jsxm.2016.06.013
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/27555513 Editorial Comment: The aim of this study was to compare the rate of artificial urethral sphincter (AUS) cuff erosion in patients with and without a penile prosthesis (PP). The authors reviewed 366 AUS operations at a tertiary center between 2007 and 2015 with a mean followup of 41 months.
MALE AND FEMALE SEXUAL FUNCTION AND DYSFUNCTION; ANDROLOGY
There were 248 AUS cases (67.8%), compared to 118 AUS plus PP cases (32.2%). Among 304 evaluable patients the authors found a significantly higher rate of erosion in the AUS/PP group (11 of 95 patients, 11.6%), compared to the AUS alone group (9 of 209, 4.3%, p ¼ 0.037). This is an interesting finding that has immediate clinical implications. Allen D. Seftel, MD
Suggested Reading Linder BJ, Piotrowski JT, Ziegelmann MJ et al: Perioperative complications following artificial urinary sphincter placement. J Urol 2015; 194: 716.
Re: Preserved Erectile Function in the Aged Transgenic Rat Harboring Human Tissue Kallikrein 1 Y. Luan, Y. Ruan, T. Wang, L. Zhuan, Z. Wen, R. Chen, Y. Zhang, K. Cui, J. Yang, S. Wang, J. Liu, Z. Ye and D. Wang Department of Urology, Institute of Urology and Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China J Sex Med 2016; 13: 1311e1322. doi: 10.1016/j.jsxm.2016.07.005
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/27555503 Editorial Comment: Kallikreins are a subgroup of serine proteases with diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is 1 of the 15 kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.1 Human tissue kallikrein 1 (hKLK1) has enormous potential for the protection of vasodilation and endothelial function in the cardiovascular system. Male wild-type Sprague DawleyÒ rats (WTR) and transgenic rats harboring the hKLK1 gene (TGR) were fed to 4 and 27 months of age, respectively, and divided into 4 groups of young WTR as the control, young TGR, aged WTR and aged TGR. Erectile function was evaluated by the cavernous nerve electrostimulation method. Then, corpora cavernosa were collected for verification of hKLK1 followed by measurement of nitric oxide-cyclic guanosine monophosphate (NO-cGMP) and RhoA-Rho-kinase (ROCK) signaling activities. hKLK1 alleviated the decrease of erectile function in the aged WTR group. hKLK1 prevented the sharp decrease of the ratio of smooth muscle-to-collagen and the increase of the apoptosis index in the corpora cavernosa of the aged WTR group. These results suggest that hKLK1 could play a preventive role in age related erectile dysfunction by activation of the NO-cGMP pathway and inhibition of the RhoA-ROCK pathway, and by antitissue fibrotic and apoptotic effects. Allen D. Seftel, MD 1. KLK1 kallikrein 1 [Homo sapiens (human)]. Available at http://www.ncbi.nlm.nih.gov/gene/3816. Accessed July 19, 2016.
Suggested Reading Luan Y, Ruan Y, Wang T et al: Human tissue kallikrein 1 restores erectile function of streptozotocin-induced diabetic rats by activating PI3K/eNOS pathway, inhibiting oxidative stress and apoptosis in the corpus cavernosum. J Urol, suppl., 2016; 195: e1110, abstract MP86-12.
493
MALE AND FEMALE SEXUAL FUNCTION AND DYSFUNCTION; ANDROLOGY
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/27611652 Editorial Comment: These data emphasize the role that nonphysician providers can have in handling sexual concerns following stroke. Often patients and practitioners need to rely on these important resources to assist in this effort. It is noteworthy that the partners are involved, as reported in this study, and have a significant role in the rehabilitation program. The PLISSIT (Permission, Limited Information, Specific Suggestion, Intensive Therapy) model, also known as the PLISSIT model of sex therapy, is a modeling system used in the field of sexology to determine the different levels of intervention for individual clients.1 Allen D. Seftel, MD 1. Taylor B and Davis S: The extended PLISSIT model for addressing the sexual wellbeing of individuals with an acquired disability or chronic illness. Sex Disabil 2007; 25: 135.
Re: Lifestyle Factors and Premature Ejaculation: Are Physical Exercise, Alcohol Consumption, and Body Mass Index Associated with Premature Ejaculation and Comorbid Erectile Problems? D. Ventus and P. Jern Departments of Psychology, A˚bo Akademi University and University of Turku, Turku, Finland J Sex Med 2016; 13: 1482e1487. doi: 10.1016/j.jsxm.2016.08.007
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/27590186 Editorial Comment: These researchers explored associations among physical exercise, alcohol use, body mass index, premature ejaculation (PE) and erectile dysfunction. A population based sample of Finnish men and a sample of Finnish men diagnosed with PE were surveyed for statistical comparisons. Participants using selective serotonin reuptake inhibitors or other medications known to affect symptoms of PE were excluded from analyses. The clinical sample (69 patients) reported lower levels of physical exercise (mean SD 27.53 21.01) than the population based sample (863 patients, 34.68 22.82, overall 2.52 for 930 patients, p ¼ 0.012), and the effect size was large (d ¼ 0.85). The association between physical exercise and PE remained significant after controlling for effects of age, erectile dysfunction, alcohol use and body mass index. This is an interesting observation that deserves further attention. Allen D. Seftel, MD
Suggested Reading Montague DK, Jarow J, Broderick GA et al: Guideline on the pharmacologic management of premature ejaculation. Available at https://www.auanet.org/ education/guidelines/premature-ejaculation.cfm. Accessed July 19, 2016.
Re: Is Risk of Artificial Urethral Sphincter Cuff Erosion Higher in Patients with Penile Prosthesis? V. Sundaram, B. H. Cordon, M. D. Hofer and A. F. Morey Department of Urology, University of Texas Southwestern, Dallas, Texas J Sex Med 2016; 13: 1432e1437. doi: 10.1016/j.jsxm.2016.06.013
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/27555513 Editorial Comment: The aim of this study was to compare the rate of artificial urethral sphincter (AUS) cuff erosion in patients with and without a penile prosthesis (PP). The authors reviewed 366 AUS operations at a tertiary center between 2007 and 2015 with a mean followup of 41 months.
MALE AND FEMALE SEXUAL FUNCTION AND DYSFUNCTION; ANDROLOGY
There were 248 AUS cases (67.8%), compared to 118 AUS plus PP cases (32.2%). Among 304 evaluable patients the authors found a significantly higher rate of erosion in the AUS/PP group (11 of 95 patients, 11.6%), compared to the AUS alone group (9 of 209, 4.3%, p ¼ 0.037). This is an interesting finding that has immediate clinical implications. Allen D. Seftel, MD
Suggested Reading Linder BJ, Piotrowski JT, Ziegelmann MJ et al: Perioperative complications following artificial urinary sphincter placement. J Urol 2015; 194: 716.
Re: Preserved Erectile Function in the Aged Transgenic Rat Harboring Human Tissue Kallikrein 1 Y. Luan, Y. Ruan, T. Wang, L. Zhuan, Z. Wen, R. Chen, Y. Zhang, K. Cui, J. Yang, S. Wang, J. Liu, Z. Ye and D. Wang Department of Urology, Institute of Urology and Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China J Sex Med 2016; 13: 1311e1322. doi: 10.1016/j.jsxm.2016.07.005
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/27555503 Editorial Comment: Kallikreins are a subgroup of serine proteases with diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is 1 of the 15 kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.1 Human tissue kallikrein 1 (hKLK1) has enormous potential for the protection of vasodilation and endothelial function in the cardiovascular system. Male wild-type Sprague DawleyÒ rats (WTR) and transgenic rats harboring the hKLK1 gene (TGR) were fed to 4 and 27 months of age, respectively, and divided into 4 groups of young WTR as the control, young TGR, aged WTR and aged TGR. Erectile function was evaluated by the cavernous nerve electrostimulation method. Then, corpora cavernosa were collected for verification of hKLK1 followed by measurement of nitric oxide-cyclic guanosine monophosphate (NO-cGMP) and RhoA-Rho-kinase (ROCK) signaling activities. hKLK1 alleviated the decrease of erectile function in the aged WTR group. hKLK1 prevented the sharp decrease of the ratio of smooth muscle-to-collagen and the increase of the apoptosis index in the corpora cavernosa of the aged WTR group. These results suggest that hKLK1 could play a preventive role in age related erectile dysfunction by activation of the NO-cGMP pathway and inhibition of the RhoA-ROCK pathway, and by antitissue fibrotic and apoptotic effects. Allen D. Seftel, MD 1. KLK1 kallikrein 1 [Homo sapiens (human)]. Available at http://www.ncbi.nlm.nih.gov/gene/3816. Accessed July 19, 2016.
Suggested Reading Luan Y, Ruan Y, Wang T et al: Human tissue kallikrein 1 restores erectile function of streptozotocin-induced diabetic rats by activating PI3K/eNOS pathway, inhibiting oxidative stress and apoptosis in the corpus cavernosum. J Urol, suppl., 2016; 195: e1110, abstract MP86-12.
493