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Re: Is Routine Excision of Testicular Remnants in Testicular Regression Syndrome Indicated?
PEDIATRIC UROLOGY
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Re: The Effect of Parenteral Testosterone Administration prior to Hypospadias Surgery: A Prospective, Randomized and Controlled Study S. A. Asgari, M. R. Safarinejad, F. Poorreza, A. S. Asl, M. M. Ghanaie and E. Shahab Urology Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht and Clinical Center for Urological Disease Diagnosis, and Private Clinic Specializing in Urological and Andrological Genetics, Tehran, Iran J Pediatr Urol 2015; 11: 143.e1ee6. doi: 10.1016/j.jpurol.2014.12.014
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/25837705 Editorial Comment: The authors randomized 182 boys with hypospadias to receive 2 mg/kg testosterone enanthate injected parenterally at 2 months and 1 month preoperatively. Controls received no drug. There was an increase in stretched penile length from tip of glans to pubis, from an average of 28.1 to 38.5 mm, and penile circumference measured at the penopubic junction increased from from 35.1 to 45.5 mm in the group receiving testosterone. There was no corresponding change in penile length in the control group. These changes were evident in the first month. Urethrocutaneous fistula and meatal stenosis were significantly less frequent in those who underwent testosterone therapy. Although the control group was slightly younger and there was relatively short followup, use of preoperative testosterone seems to convey an advantage to boys undergoing tubularized incised plate hypospadias repair. Douglas A. Canning, MD
Re: Is Routine Excision of Testicular Remnants in Testicular Regression Syndrome Indicated? R. M. Nataraja, C. M. Asher, R. Nash and F. L. Murphy Department of Paediatric Surgery and Urology, Monash Children’s Hospital, Monash Medical Center, Clayton, Melbourne, Victoria, Australia, and Department of Paediatric Surgery and Urology, and Department of Histopathology, St. George’s Healthcare NHS Trust, London, United Kingdom J Pediatr Urol 2015; 11: 151.e1ee5. doi: 10.1016/j.jpurol.2015.01.018
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/25913475 Editorial Comment: The authors reviewed 140 boys who had an absent testis that was excised during the time of exploration. Of these testes 14 had evidence of germ cells. Abdominal testes were no more likely to have germ cells than inguinal testes. However, intra-abdominal remnants were much more likely to contain seminiferous tubules compared to inguinal remnants. If 10% of remnant testes contain germ cells, perhaps these remnants should be removed regardless of whether additional excision is required. Douglas A. Canning, MD
Dochead: Urological Survey
LIT 5.4.0 DTD JURO14063_proof 4 October 2016 1:19 pm EO:
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115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163
Re: The Effect of Parenteral Testosterone Administration prior to Hypospadias Surgery: A Prospective, Randomized and Controlled Study S. A. Asgari, M. R. Safarinejad, F. Poorreza, A. S. Asl, M. M. Ghanaie and E. Shahab Urology Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht and Clinical Center for Urological Disease Diagnosis, and Private Clinic Specializing in Urological and Andrological Genetics, Tehran, Iran J Pediatr Urol 2015; 11: 143.e1ee6. doi: 10.1016/j.jpurol.2014.12.014
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/25837705 Editorial Comment: The authors randomized 182 boys with hypospadias to receive 2 mg/kg testosterone enanthate injected parenterally at 2 months and 1 month preoperatively. Controls received no drug. There was an increase in stretched penile length from tip of glans to pubis, from an average of 28.1 to 38.5 mm, and penile circumference measured at the penopubic junction increased from from 35.1 to 45.5 mm in the group receiving testosterone. There was no corresponding change in penile length in the control group. These changes were evident in the first month. Urethrocutaneous fistula and meatal stenosis were significantly less frequent in those who underwent testosterone therapy. Although the control group was slightly younger and there was relatively short followup, use of preoperative testosterone seems to convey an advantage to boys undergoing tubularized incised plate hypospadias repair. Douglas A. Canning, MD
Re: Is Routine Excision of Testicular Remnants in Testicular Regression Syndrome Indicated? R. M. Nataraja, C. M. Asher, R. Nash and F. L. Murphy Department of Paediatric Surgery and Urology, Monash Children’s Hospital, Monash Medical Center, Clayton, Melbourne, Victoria, Australia, and Department of Paediatric Surgery and Urology, and Department of Histopathology, St. George’s Healthcare NHS Trust, London, United Kingdom J Pediatr Urol 2015; 11: 151.e1ee5. doi: 10.1016/j.jpurol.2015.01.018
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/25913475 Editorial Comment: The authors reviewed 140 boys who had an absent testis that was excised during the time of exploration. Of these testes 14 had evidence of germ cells. Abdominal testes were no more likely to have germ cells than inguinal testes. However, intra-abdominal remnants were much more likely to contain seminiferous tubules compared to inguinal remnants. If 10% of remnant testes contain germ cells, perhaps these remnants should be removed regardless of whether additional excision is required. Douglas A. Canning, MD
Dochead: Urological Survey
LIT 5.4.0 DTD JURO14063_proof 4 October 2016 1:19 pm EO:
164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212