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Re: Role of the Brain Stem in Tibial Inhibition of the Micturition Reflex in Cats
VOIDING FUNCTION, BLADDER PHYSIOLOGY AND PHARMACOLOGY, AND FEMALE UROLOGY
Jiang J, Knight J, Easter LH et al: Impact of dietary calcium and oxalate, and Oxalobacter formigenes colonization on urinary oxalate excretion. J Urol 2011; 186: 135. Barnett C, Nazzal L, Goldfarb DS et al: The presence of Oxalobacter formigenes in the microbiome of healthy young adults. J Urol 2016; 195: 499.
Voiding Function and Dysfunction, Bladder Physiology and Pharmacology, and Female Urology Re: Role of the Brain Stem in Tibial Inhibition of the Micturition Reflex in Cats M. C. Ferroni, R. C. Slater, B. Shen, Z. Xiao, J. Wang, A. Lee, J. R. Roppolo, W. C. de Groat and C. Tai Departments of Urology, and Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, and Department of Urology, Second Hospital, Shandong University, Jinan, P.R. China Am J Physiol Renal Physiol 2015; 309: F242eF250. doi: 10.1152/ajprenal.00135.2015
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/26017973 Editorial Comment: The Pittsburgh group has once again made a significant contribution to the study of the micturition reflex in cats by examining the role of the brain stem in inhibition of bladder reflexes induced by tibial nerve stimulation in a decerebrate alpha-chloralose anesthetized animal. They conclude that the micturition switching circuitry in the periaqueductal gray-pontine micturition center in the cat is tonically inhibited by an opioid receptor mechanism and that it is probable that the acute nerve stimulation inhibition of bladder overactivity is mediated by activation of supraspinal opioid receptors that suppress excitatory transmission in this circuitry. They admit there is a possibility that a supraspinal opioid mechanism may activate a descending inhibitory input to the sacral spinal cord. The ultimate goal of understanding the sites of action of neurotransmitters involved in the inhibition of bladder reflexes by tibial nerve and other peripheral neural or root stimulation could lead to a combination of an agent with a similar pharmacological profile with electrical stimulation induced neuromodulation to achieve better efficacy with fewer side effects. Alan J. Wein, MD, PhD (hon)
Suggested Reading Chen G, Larson JA, Ogagan PD et al: Post-stimulation inhibitory effect on reflex bladder activity induced by activation of somatic afferent nerves in the foot. J Urol 2012; 187: 338. Mally AD, Matsuta Y, Zhang F et al: Role of opioid and metabotropic glutamate 5 receptors in pudendal inhibition of bladder overactivity in cats. J Urol 2013; 189: 1574.
Male and Female Sexual Function and Dysfunction; Andrology Re: The Effects of Adipose-Derived Stem Cells in a Rat Model of TobaccoAssociated Erectile Dysfunction Y. C. Huang, Y. H. Kuo, Y. H. Huang, C. S. Chen, D. R. Ho and C. S. Shi Divisions of Urology, and Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi and Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan, and Department of Occupational Therapy, School of Health and Human Services, College of Professional Studies, California State University, Dominguez Hills, Carson, California PLoS One 2016; 11: e0156725. doi: 10.1371/journal.pone.0156725
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/27257818
1587
Jiang J, Knight J, Easter LH et al: Impact of dietary calcium and oxalate, and Oxalobacter formigenes colonization on urinary oxalate excretion. J Urol 2011; 186: 135. Barnett C, Nazzal L, Goldfarb DS et al: The presence of Oxalobacter formigenes in the microbiome of healthy young adults. J Urol 2016; 195: 499.
Voiding Function and Dysfunction, Bladder Physiology and Pharmacology, and Female Urology Re: Role of the Brain Stem in Tibial Inhibition of the Micturition Reflex in Cats M. C. Ferroni, R. C. Slater, B. Shen, Z. Xiao, J. Wang, A. Lee, J. R. Roppolo, W. C. de Groat and C. Tai Departments of Urology, and Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, and Department of Urology, Second Hospital, Shandong University, Jinan, P.R. China Am J Physiol Renal Physiol 2015; 309: F242eF250. doi: 10.1152/ajprenal.00135.2015
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/26017973 Editorial Comment: The Pittsburgh group has once again made a significant contribution to the study of the micturition reflex in cats by examining the role of the brain stem in inhibition of bladder reflexes induced by tibial nerve stimulation in a decerebrate alpha-chloralose anesthetized animal. They conclude that the micturition switching circuitry in the periaqueductal gray-pontine micturition center in the cat is tonically inhibited by an opioid receptor mechanism and that it is probable that the acute nerve stimulation inhibition of bladder overactivity is mediated by activation of supraspinal opioid receptors that suppress excitatory transmission in this circuitry. They admit there is a possibility that a supraspinal opioid mechanism may activate a descending inhibitory input to the sacral spinal cord. The ultimate goal of understanding the sites of action of neurotransmitters involved in the inhibition of bladder reflexes by tibial nerve and other peripheral neural or root stimulation could lead to a combination of an agent with a similar pharmacological profile with electrical stimulation induced neuromodulation to achieve better efficacy with fewer side effects. Alan J. Wein, MD, PhD (hon)
Suggested Reading Chen G, Larson JA, Ogagan PD et al: Post-stimulation inhibitory effect on reflex bladder activity induced by activation of somatic afferent nerves in the foot. J Urol 2012; 187: 338. Mally AD, Matsuta Y, Zhang F et al: Role of opioid and metabotropic glutamate 5 receptors in pudendal inhibition of bladder overactivity in cats. J Urol 2013; 189: 1574.
Male and Female Sexual Function and Dysfunction; Andrology Re: The Effects of Adipose-Derived Stem Cells in a Rat Model of TobaccoAssociated Erectile Dysfunction Y. C. Huang, Y. H. Kuo, Y. H. Huang, C. S. Chen, D. R. Ho and C. S. Shi Divisions of Urology, and Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi and Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan, and Department of Occupational Therapy, School of Health and Human Services, College of Professional Studies, California State University, Dominguez Hills, Carson, California PLoS One 2016; 11: e0156725. doi: 10.1371/journal.pone.0156725
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/27257818
1587