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Receptor-ligand interactions; a practical approach
Gen. Pharmac. Vol. 24, No. 2, pp. 517-518, 1993 Pergamon Press Ltd. Printed in Great Britain
BOOK REVIEWS
Urinary Enzymes In Clinical and Experimental Medicine-Edited by K. Jung, H. Mattenheimer and U. Burchardt 326pp. 1992. Springer Verlag, Berlin. DM 148.
principles and practice; how groups of proteins titrate. The reviews are well written and provide an excellent and interesting up-to-date account of their subjects.
Urine contains more than 40 enzymes (hydrolases, oxidoreductases, transferases and lyases) about I0 of which are used as diagnostic indicators. This book deals with: the origin of the enzymes in urine; distribution of diagnostically relevant enzymes along the nephron; mechanisms of enzyme release and altered enzyme excretion; enzyme-ureia; factors affecting enzyme excretion; pre-analytical treatment of urine; quality assurance; methods for measuring enzyme activity; use in clinical medicine; clinical interpretation; renal disorders; kidney transplantation; nephrotoxicity; extrarenal diseases (hypertension; hepato-biliary; pancreas; hyperthryroidism, diabetes mellitus, rheumatoid diseases); animal models; effect of drugs and chemicals; nephrotoxicity. It is probable that better use of the biochemical information obtainable from urine will provide greater insight into the nature and cure of disease.
Protein Targeting; a Practical AI)proacb--Edited by A. 1. Magec and T. Wileman. 267pp. 1992. IRL/Oxford University Press, Oxford. Paperback £22.50.
Biological Significance of Snperantigens--Edited by B. Fleischer. 200pp. 1992. Karger, Basel. S.Fr 196; DM 235. Superantigens have an extremely potent activating effect on T lymphocytes. Toxic shock syndrome toxin 1 is the prototype superantigen and other are produced by S. aureus, Streptococcus pyrogenes, Mycoplasma arthriditis and by mouse mammillary tumor retrovirus. This book deals with the topics of the Staphylococcal enterotoxins; S. pyrogenes exotoxins; T lymphocyte stimulation; retroviral superantigens; Mls antigens; T cells dependent shock; germ line encoded recognition of certain short peptides. Receptor-Ligand intentctions; a Practical Approach---Edited by E. C. Hulme. 258pp. 1992. IRL/Oxford University Press, Oxford. Paperback $50. Cell surface receptors are well defined molecules that will specifically bind drugs, hormones, or neurotransmitters in a stochiometric manner. This book deals with: selection and synthesis of receptor specific radioligands; anti-receptor antibodies as ligands; polypeptide neurotoxins as probes for certain voltage dependent K channels; strategy and tactics in receptor-binding studies; receptor preparations for binding studies; filtration technique in in-vitro radioligand binding assays for membrane bound and solubilized receptors; centrifugation binding assays; charcoal adsorption for separating bound and free radioligand; gel-filtration assays for solubilized receptors; receptor-binding kinetics; analysis and interpretation of binding equilibrium. Essays in Biochemistry, Vol. 27--Edited by K. Tipton. 183pp. Portland Press, London. Paperback £15.
Substrates and products have to be transported within the cell and between cells in a specific targeted manner. This book deals with: receptor mediated endocytosis and lysosomal transport; membrane traffic pathways in polarized epithelial cells; sorting between exocytic pathways in PCI2 cells; intracellular trafficking in fission yeast; network antibodies as tools for studying intracellular protein traffic; protein targeting to mitochondria; techniques in nuclear protein transport;/n vitro reconstitution of endocytic vesical fusion; in vitro reconstitution of vesicular transport from ER to the cis Golgi in semi-intact cells; lipid modifications involved in protein targeting. Lipid Modifications of Proteins; a Practical Approacl~-Edited by N. M. Hooper and A. J. Turner. 290pp. 1992. IRL/Oxford University Press, Oxford. Paperback £22.50. Many cellular and virus proteins can be modified by fatty acids, glycolipids or poly-isoprenoid moieties. Such modifications play an important role in protein structure and function. This book deals with: the diversity of lipid modification of proteins; labelling cell proteins with radioactive fatty acids and methods for studying palmitoyl-acyl transferase; methods for studying myristoyl-CoA protein Nmyristoyl transferase; structure determination of acylated proteins; identification of glycosyl-phosphatidylinositol (GPI) anchor on membrane proteins; phospholipases that degrade G-PI; biosynthesis of G-PI, analysis of G-PI; analysis of prenylated proteins; identification and characterization of lipid modified bacterial proteins. Biochemical Nomenclature and related documents, 2nd edn-Edited by C. Liebecq. 345pp. 1992. Portland Press, London. Paperback £ 18. This volume is published on behalf of the International Union of Biochemistry and Molecular Biology and is a necessary reference volume for all those wishing to know the correct recommended nomenclature of amino acids, peptides, proteins, enzymes, nucleotides, nucleic acids, proteins, carbohydrates, lipids, stereoisomers, natural products, isotopically labelled compounds, terms in thermodynamics, and the citation of bibliographic references. In many cases the articles are reprints from the recommendations published in the European Journal of Biochemistry. Most laboratories will find it useful to have them collected here in an easily referable volume and know what it is to be "correct" even if writers go on sinning.
The topics reviewed in this volume are: proteolysis is a key process in virus replication; the biochemistry of blood clotting, the digestion of a liquid to form a solid; ubiquitin; the collagen superfamily; the repair of DNA alkylation damage by methyltransferases and glycosylases; endothelins; role for protein phosphorylation in synaptic transmission; cell death in Parkinson's disease; whither PQQ; towards understanding C3-C4 photosynthesis; biosensors,
Practical Curve Fitting and Data Analysis; Software Sdf~tion for Scientists and F _ a l g i ~ J . H. Noggle. 192pp. 1992. Ellis Horwood/Prentice Hall, New Jersey, U.S.A. At last! A book plus an EZFIT floppy disc to allow curve fitting on an IBM PC. You need a graphics board (CGA, 517
BOOK REVIEWS
Urinary Enzymes In Clinical and Experimental Medicine-Edited by K. Jung, H. Mattenheimer and U. Burchardt 326pp. 1992. Springer Verlag, Berlin. DM 148.
principles and practice; how groups of proteins titrate. The reviews are well written and provide an excellent and interesting up-to-date account of their subjects.
Urine contains more than 40 enzymes (hydrolases, oxidoreductases, transferases and lyases) about I0 of which are used as diagnostic indicators. This book deals with: the origin of the enzymes in urine; distribution of diagnostically relevant enzymes along the nephron; mechanisms of enzyme release and altered enzyme excretion; enzyme-ureia; factors affecting enzyme excretion; pre-analytical treatment of urine; quality assurance; methods for measuring enzyme activity; use in clinical medicine; clinical interpretation; renal disorders; kidney transplantation; nephrotoxicity; extrarenal diseases (hypertension; hepato-biliary; pancreas; hyperthryroidism, diabetes mellitus, rheumatoid diseases); animal models; effect of drugs and chemicals; nephrotoxicity. It is probable that better use of the biochemical information obtainable from urine will provide greater insight into the nature and cure of disease.
Protein Targeting; a Practical AI)proacb--Edited by A. 1. Magec and T. Wileman. 267pp. 1992. IRL/Oxford University Press, Oxford. Paperback £22.50.
Biological Significance of Snperantigens--Edited by B. Fleischer. 200pp. 1992. Karger, Basel. S.Fr 196; DM 235. Superantigens have an extremely potent activating effect on T lymphocytes. Toxic shock syndrome toxin 1 is the prototype superantigen and other are produced by S. aureus, Streptococcus pyrogenes, Mycoplasma arthriditis and by mouse mammillary tumor retrovirus. This book deals with the topics of the Staphylococcal enterotoxins; S. pyrogenes exotoxins; T lymphocyte stimulation; retroviral superantigens; Mls antigens; T cells dependent shock; germ line encoded recognition of certain short peptides. Receptor-Ligand intentctions; a Practical Approach---Edited by E. C. Hulme. 258pp. 1992. IRL/Oxford University Press, Oxford. Paperback $50. Cell surface receptors are well defined molecules that will specifically bind drugs, hormones, or neurotransmitters in a stochiometric manner. This book deals with: selection and synthesis of receptor specific radioligands; anti-receptor antibodies as ligands; polypeptide neurotoxins as probes for certain voltage dependent K channels; strategy and tactics in receptor-binding studies; receptor preparations for binding studies; filtration technique in in-vitro radioligand binding assays for membrane bound and solubilized receptors; centrifugation binding assays; charcoal adsorption for separating bound and free radioligand; gel-filtration assays for solubilized receptors; receptor-binding kinetics; analysis and interpretation of binding equilibrium. Essays in Biochemistry, Vol. 27--Edited by K. Tipton. 183pp. Portland Press, London. Paperback £15.
Substrates and products have to be transported within the cell and between cells in a specific targeted manner. This book deals with: receptor mediated endocytosis and lysosomal transport; membrane traffic pathways in polarized epithelial cells; sorting between exocytic pathways in PCI2 cells; intracellular trafficking in fission yeast; network antibodies as tools for studying intracellular protein traffic; protein targeting to mitochondria; techniques in nuclear protein transport;/n vitro reconstitution of endocytic vesical fusion; in vitro reconstitution of vesicular transport from ER to the cis Golgi in semi-intact cells; lipid modifications involved in protein targeting. Lipid Modifications of Proteins; a Practical Approacl~-Edited by N. M. Hooper and A. J. Turner. 290pp. 1992. IRL/Oxford University Press, Oxford. Paperback £22.50. Many cellular and virus proteins can be modified by fatty acids, glycolipids or poly-isoprenoid moieties. Such modifications play an important role in protein structure and function. This book deals with: the diversity of lipid modification of proteins; labelling cell proteins with radioactive fatty acids and methods for studying palmitoyl-acyl transferase; methods for studying myristoyl-CoA protein Nmyristoyl transferase; structure determination of acylated proteins; identification of glycosyl-phosphatidylinositol (GPI) anchor on membrane proteins; phospholipases that degrade G-PI; biosynthesis of G-PI, analysis of G-PI; analysis of prenylated proteins; identification and characterization of lipid modified bacterial proteins. Biochemical Nomenclature and related documents, 2nd edn-Edited by C. Liebecq. 345pp. 1992. Portland Press, London. Paperback £ 18. This volume is published on behalf of the International Union of Biochemistry and Molecular Biology and is a necessary reference volume for all those wishing to know the correct recommended nomenclature of amino acids, peptides, proteins, enzymes, nucleotides, nucleic acids, proteins, carbohydrates, lipids, stereoisomers, natural products, isotopically labelled compounds, terms in thermodynamics, and the citation of bibliographic references. In many cases the articles are reprints from the recommendations published in the European Journal of Biochemistry. Most laboratories will find it useful to have them collected here in an easily referable volume and know what it is to be "correct" even if writers go on sinning.
The topics reviewed in this volume are: proteolysis is a key process in virus replication; the biochemistry of blood clotting, the digestion of a liquid to form a solid; ubiquitin; the collagen superfamily; the repair of DNA alkylation damage by methyltransferases and glycosylases; endothelins; role for protein phosphorylation in synaptic transmission; cell death in Parkinson's disease; whither PQQ; towards understanding C3-C4 photosynthesis; biosensors,
Practical Curve Fitting and Data Analysis; Software Sdf~tion for Scientists and F _ a l g i ~ J . H. Noggle. 192pp. 1992. Ellis Horwood/Prentice Hall, New Jersey, U.S.A. At last! A book plus an EZFIT floppy disc to allow curve fitting on an IBM PC. You need a graphics board (CGA, 517