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Recommended Articles
J Acupunct Meridian Stud 2015;8(2):108e111
Available online at www.sciencedirect.com
Journal of Acupuncture and Meridian Studies journal homepage: www.jams-kpi.com
- RECOMMENDED
ARTICLES
-
In this issue of the journal, recommended articles are selected from the Korean Journal of Acupuncture (ISSN: 1229-7933) published in Korean and from the Journal of Pharmacopuncture (ISSN: 1226-4849) published in English.
(1) Korean Journal of Acupuncture, Vol. 30, No. 4, pp. 201-211, 2013
Comparison Study of Acupuncture Point Selection between the Classics of Traditional Medicine and Clinical Trials in Dental Disorders
Song-Yi Kim, Jihyeon Oh, Jaehwa Hong, Sang Kyun Park, Hi-Joon Park) Corresponding Author’s Affiliation: Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul, Korea. [email protected]
)
Abstract Objectives: The aim of this study is to summarize and compare acupuncture points used for dental disorders in the classics with those used in recent clinical trials. Methods: We searched for data on acupuncture points used and on the rationale for the use of acupuncture in dentistry. We searched the seven Classics of traditional medicine and clinical trials in the database Pubmed from January 2000 to March 2013 with no language restrictions. Results: Dental pain was the most common disorder in the dentistry section of the Classics of traditional medicine. We found many similarities of the acupuncture points used between the literature and clinical trials. From the meridian perspective, the large intestine meridian (LI), the stomach meridian (ST), the triple energizer meridian (TE), and the gallbladder meridian (GB) were frequently used in both the Classics of traditional medicine and clinical trials. From the acupuncture point of view, acupuncture points were selected according to the syndrome. Specific points, such as the five transport points, source points, and connecting points, were also used. In clinical trials, combinations of acupuncture points usually consisted adjacent points and distant points. Among them, LI4 was used in all of the studies included in this review. Conclusions: For a well-designed clinical trial, appropriate intervention is essential. To establish appropriate acupuncture treatment, we have to suggest a reason for the treatment based on literature and/or expert consensus. Our review only focused on pain relief in dentistry and had many limitations. Further studies based on literature such as the Classics of traditional medicine are required to ensure that a rationale exists for the use of acupuncture to treat various dental disorders. Keywords: acupuncture point, acupuncture rationale, dental disorder, dental pain
(2) Korean Journal of Acupuncture, Vol. 30, No. 4, pp. 212-219, 2013
Anti-migratory Effect of Cirsium japonicum Pharmacopuncture in C6 Glioma Cells
Juyeon Park, Kangpa Lee, Haeryong Chang, Jinyoung Moon) ) Corresponding Author’s Affiliation: Department of Acupoint, College of Korean Medicine, Dongguk University, Goyang, Korea. [email protected] Abstract Objectives: Cirsium japonicum is a traditional Korean medicine that has been used in the treatment of inflammatory diseases such as appendicitis, hepatitis, pulmonary abscesses and tumors. The aim of study was to elucidate the anti-
pISSN 2005-2901 eISSN 2093-8152
Recommended Article
109
migratory activity of CJP (Cirsium japonicum pharmacopuncture) through the regulation of inflammatory mediators in C6 glioma cells. Methods: Nitric oxide (NO) production was determined by using a nitrite assay. The cell migration was analyzed by using a wound-healing assay and a Boyden chamber assay. The expression levels of iNOS, and protein kinase C (PKC)-a were measured by using Western blotting assays. Results: CJP showed a significant decrease in NO production. Moreover, glioma cell migration was effectively suppressed by CJP. Furthermore, CJP inhibited the expressions of iNOS and PKC-a in C6 glioma cells. Conclusions: These results suggest that CJP inhibits glioma cell migration and iNOS expression through regulation of PKC-a. Therefore, CJP should be an effective agent for blocking malignant progression of a glioma. Keywords: C6 glioma cells, Circium japonicum, iNOS, Migration, PKC-alpha
(3) Korean Journal of Acupuncture, Vol. 30, No. 4, pp. 220-229, 2013
Mechanism for the Analgesic Effects of Electroacupuncture on a Surgical Anklesprain Model Classified as Grade 3 in Rats
Seung-Bum Yang, Suck-Jun Choi, Sung-Ho Lee, Min-Su Kim, In-Chul Sohn, Jae-Hyo Kim) ) Corresponding Author’s Affiliation: Department of Meridian & Acupoint, College of Korean Medicine, Wonkwang University, Iksan, Korea. [email protected] Abstract Objectives: Electroacupuncture (EA) has been used effectively in producing analgesia for ankle sprain pain in humans and animals. To examine the underlying mechanisms of EA-induced analgesia, we examined the effects of EA on weight-bearing forces (WBFs) for ankle sprains classified as grade 3 in rats. Methods: Severe ankle sprains classified as grade 3 were induced surgically by ankle ligament injury in Sprague-Dawley rats. The WBRs of the affected foot were examined to evaluate the effects and the mechanism of EA (2 Hz, 1-ms pulse width, 2-mA intensity, for 15 min) applied to the SI6, GB34, or GB39 acupoint. At 30 min before EA, the rats were pretreated with naltrexone (10 mg/kg, i.p.) as an opioid receptor antagonist or phentolamine (5 mg/kg, i.p) as an a-adrenoceptor antagonist. Results: EA repeated daily at SI6, GB34, or GB39 showed significant analgesic effects on the severe ankle sprain. Particularly, daily EA at GB34 showed a more potent analgesic effect than EA at the other acupoints. In addition, the naltrexone pretreatment completely blocked the analgesic effect of EA at GB34, indicating the involvement of the endogenous opioid system in mediating the effect of EA at GB34. However, the phentolamine pretreatment blocked the analgesic effect of EA at SI6 or GB39, indicating the involvement of a-adrenoceptors in mediating the effect of EA at SI6 or GB39. Conclusions: These data suggest that EA-induced analgesia for ankle sprain pain is mediated through either endogenous opioids or a-adrenoceptors, depending on specific pattern of acupoints. Keywords: alpha-adrenoceptors, analgesia, ankle sprain, electroacupuncture, endogenous opioids, point specificity http://dx.doi.org/10.1016/j.jams.2015.01.003
(4) Journal of Pharmacopuncture, Vol. 16, No. 4, pp. 14-21, 2013
Role of Glyco-PersicaÒ in Targeting Diabetes Type 2: an Integrative Approach
Mehrab Dashtdar), Mohammad Reza Dashtdar, Babak Dashtdar, Saeed Ahmad Khan ) Corresponding Author’s Affiliation: Department of Integrative Medicine, Dubai Pharmacy College, United Arab Emirates, Bur Dubai, United Arab Emirates. [email protected] Abstract Objectives: The objective of this study was to examine how an integrated approach to type 2 diabetes mellitus treatment could improve glycemic control and immune-potentiating activities adherent to oral hypoglycemic agents along with a botanical compound, among primary care patients. Methods: In this study, we used the self-control and the group-control methods. Candidates meeting the trial conditions were selected from among volunteers who had taken the test substance for 45 days. During the trial, all groups were on a controlled diet; neither were the original medications nor their dosages changed. Results: The results showed that the botanical compound (Glyco-PersicaÒ) significantly reduced the main clinical symptoms in diabetes type 2. In the treatment group, 36 of 52 patients (69.23%) and in the control group 10 of 52 patients (19.23%) showed reduced symptoms, and this difference was statistically significant (P < 0.05). The fasting blood sugar in the
Available online at www.sciencedirect.com
Journal of Acupuncture and Meridian Studies journal homepage: www.jams-kpi.com
- RECOMMENDED
ARTICLES
-
In this issue of the journal, recommended articles are selected from the Korean Journal of Acupuncture (ISSN: 1229-7933) published in Korean and from the Journal of Pharmacopuncture (ISSN: 1226-4849) published in English.
(1) Korean Journal of Acupuncture, Vol. 30, No. 4, pp. 201-211, 2013
Comparison Study of Acupuncture Point Selection between the Classics of Traditional Medicine and Clinical Trials in Dental Disorders
Song-Yi Kim, Jihyeon Oh, Jaehwa Hong, Sang Kyun Park, Hi-Joon Park) Corresponding Author’s Affiliation: Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul, Korea. [email protected]
)
Abstract Objectives: The aim of this study is to summarize and compare acupuncture points used for dental disorders in the classics with those used in recent clinical trials. Methods: We searched for data on acupuncture points used and on the rationale for the use of acupuncture in dentistry. We searched the seven Classics of traditional medicine and clinical trials in the database Pubmed from January 2000 to March 2013 with no language restrictions. Results: Dental pain was the most common disorder in the dentistry section of the Classics of traditional medicine. We found many similarities of the acupuncture points used between the literature and clinical trials. From the meridian perspective, the large intestine meridian (LI), the stomach meridian (ST), the triple energizer meridian (TE), and the gallbladder meridian (GB) were frequently used in both the Classics of traditional medicine and clinical trials. From the acupuncture point of view, acupuncture points were selected according to the syndrome. Specific points, such as the five transport points, source points, and connecting points, were also used. In clinical trials, combinations of acupuncture points usually consisted adjacent points and distant points. Among them, LI4 was used in all of the studies included in this review. Conclusions: For a well-designed clinical trial, appropriate intervention is essential. To establish appropriate acupuncture treatment, we have to suggest a reason for the treatment based on literature and/or expert consensus. Our review only focused on pain relief in dentistry and had many limitations. Further studies based on literature such as the Classics of traditional medicine are required to ensure that a rationale exists for the use of acupuncture to treat various dental disorders. Keywords: acupuncture point, acupuncture rationale, dental disorder, dental pain
(2) Korean Journal of Acupuncture, Vol. 30, No. 4, pp. 212-219, 2013
Anti-migratory Effect of Cirsium japonicum Pharmacopuncture in C6 Glioma Cells
Juyeon Park, Kangpa Lee, Haeryong Chang, Jinyoung Moon) ) Corresponding Author’s Affiliation: Department of Acupoint, College of Korean Medicine, Dongguk University, Goyang, Korea. [email protected] Abstract Objectives: Cirsium japonicum is a traditional Korean medicine that has been used in the treatment of inflammatory diseases such as appendicitis, hepatitis, pulmonary abscesses and tumors. The aim of study was to elucidate the anti-
pISSN 2005-2901 eISSN 2093-8152
Recommended Article
109
migratory activity of CJP (Cirsium japonicum pharmacopuncture) through the regulation of inflammatory mediators in C6 glioma cells. Methods: Nitric oxide (NO) production was determined by using a nitrite assay. The cell migration was analyzed by using a wound-healing assay and a Boyden chamber assay. The expression levels of iNOS, and protein kinase C (PKC)-a were measured by using Western blotting assays. Results: CJP showed a significant decrease in NO production. Moreover, glioma cell migration was effectively suppressed by CJP. Furthermore, CJP inhibited the expressions of iNOS and PKC-a in C6 glioma cells. Conclusions: These results suggest that CJP inhibits glioma cell migration and iNOS expression through regulation of PKC-a. Therefore, CJP should be an effective agent for blocking malignant progression of a glioma. Keywords: C6 glioma cells, Circium japonicum, iNOS, Migration, PKC-alpha
(3) Korean Journal of Acupuncture, Vol. 30, No. 4, pp. 220-229, 2013
Mechanism for the Analgesic Effects of Electroacupuncture on a Surgical Anklesprain Model Classified as Grade 3 in Rats
Seung-Bum Yang, Suck-Jun Choi, Sung-Ho Lee, Min-Su Kim, In-Chul Sohn, Jae-Hyo Kim) ) Corresponding Author’s Affiliation: Department of Meridian & Acupoint, College of Korean Medicine, Wonkwang University, Iksan, Korea. [email protected] Abstract Objectives: Electroacupuncture (EA) has been used effectively in producing analgesia for ankle sprain pain in humans and animals. To examine the underlying mechanisms of EA-induced analgesia, we examined the effects of EA on weight-bearing forces (WBFs) for ankle sprains classified as grade 3 in rats. Methods: Severe ankle sprains classified as grade 3 were induced surgically by ankle ligament injury in Sprague-Dawley rats. The WBRs of the affected foot were examined to evaluate the effects and the mechanism of EA (2 Hz, 1-ms pulse width, 2-mA intensity, for 15 min) applied to the SI6, GB34, or GB39 acupoint. At 30 min before EA, the rats were pretreated with naltrexone (10 mg/kg, i.p.) as an opioid receptor antagonist or phentolamine (5 mg/kg, i.p) as an a-adrenoceptor antagonist. Results: EA repeated daily at SI6, GB34, or GB39 showed significant analgesic effects on the severe ankle sprain. Particularly, daily EA at GB34 showed a more potent analgesic effect than EA at the other acupoints. In addition, the naltrexone pretreatment completely blocked the analgesic effect of EA at GB34, indicating the involvement of the endogenous opioid system in mediating the effect of EA at GB34. However, the phentolamine pretreatment blocked the analgesic effect of EA at SI6 or GB39, indicating the involvement of a-adrenoceptors in mediating the effect of EA at SI6 or GB39. Conclusions: These data suggest that EA-induced analgesia for ankle sprain pain is mediated through either endogenous opioids or a-adrenoceptors, depending on specific pattern of acupoints. Keywords: alpha-adrenoceptors, analgesia, ankle sprain, electroacupuncture, endogenous opioids, point specificity http://dx.doi.org/10.1016/j.jams.2015.01.003
(4) Journal of Pharmacopuncture, Vol. 16, No. 4, pp. 14-21, 2013
Role of Glyco-PersicaÒ in Targeting Diabetes Type 2: an Integrative Approach
Mehrab Dashtdar), Mohammad Reza Dashtdar, Babak Dashtdar, Saeed Ahmad Khan ) Corresponding Author’s Affiliation: Department of Integrative Medicine, Dubai Pharmacy College, United Arab Emirates, Bur Dubai, United Arab Emirates. [email protected] Abstract Objectives: The objective of this study was to examine how an integrated approach to type 2 diabetes mellitus treatment could improve glycemic control and immune-potentiating activities adherent to oral hypoglycemic agents along with a botanical compound, among primary care patients. Methods: In this study, we used the self-control and the group-control methods. Candidates meeting the trial conditions were selected from among volunteers who had taken the test substance for 45 days. During the trial, all groups were on a controlled diet; neither were the original medications nor their dosages changed. Results: The results showed that the botanical compound (Glyco-PersicaÒ) significantly reduced the main clinical symptoms in diabetes type 2. In the treatment group, 36 of 52 patients (69.23%) and in the control group 10 of 52 patients (19.23%) showed reduced symptoms, and this difference was statistically significant (P < 0.05). The fasting blood sugar in the