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Regression of oestrogen induced mammary tumours in female rats following removal of the stimulus
362
AMERICAN
.JOURNAI>
OF
nut the ovaries are present. At least. tation and has the power of stimulating
OBSTETRICS
ASI)
GYNECOI~OGI
one androgen, testosterone, mammary growt,h.
also
inhii)itw
lac-
Estrogens are also capaltle, under suitable conditious, of enhancing milk start’tion hy increasing the concentration of both fatty and nonfatty solids. !I’he thrcsllold for the enrichment effect is lower than for inhibition. These two effects :(l’e more readily separable with nnt,ural estrogens than with diethvlstilbestrol.
Noble, R. L., and Collip, J. B.: Regression of Oestrogen Induced Mammary Tumours in Female Rats Following Removal of the Stimulus, Canad. M. :I. J. 44: 1, 1911. Mammary tumors produced in rats by the subcutaneous implantation of estrone pellets showed marked cellular hyperplasia but were all localized and showecl little tendency to invade the stroma or adjacent tissue. Continuous growth occurs until the animal’s death, provided the pellets remain intact. Attempts to transplant the tumors into other rats have failed but in two cases homotransplants grew succor+fully. Lung metastases were found in one rat with advanced tumor formation of nine months’ duration. Cellular infiltration of a typically malignant :tppearaIlcr was encountered in a few cases. Four rats treated with progesterone showed cessation of tumor growth. In 4 rats from whom the estrone pellets were remo\-rd. the tumors completely regressed. One of these animals had an ulcerated primar? mammary tumor with a histologic picture of malignancy and a successful homotransplant. After long periods nearly all animals were found to have large pitui. tary adenomas, and in :! rats large hemorrhagic adenomas developed during t 111~ first year of treatment. CARL
Wirth, Karl, and Peters, Max: Puerperal Mastitis, Miinchen.
Report on the Roentgen med.
Wchnschr.
P.
Ray Treatment
TtUHEII.
of Early
86: 59, 1939.
Wirth and Peters present their results and experiences in treating patients with an early infiltrative mastitis by using soft roentgen rays, giving 19 to 30 per cent skin erythema doses. Treatment, they believe, must begin within forty-eight hours of the onset of symptoms. In patients in whom infiltrations have occurred and nodules have formed, and in cases of interstitial mastitis the roentgen ray treatment promises hut little success; in fact, it may even lead to more necrosis of the tissues thus causing retardation of recovery because of the chronic, inflammatory edema resulting. The value of using roentgen therapy in the early cases must not be ovcrestimated, however, since these inflammations also recede quickly under ordinary treatment. The advantages of the roentgen therapy lie in the fact that, pain tlisappears quickly and the patient is able to continue nursing her baby.
Antoine,
T.: Endocrine
Influences
on Lactation,
Zentralbl.
f. Gyn%k. 65: 465, 19-1-l.
The author emphasizes that the problem of regulating lactation therapeutically is a complex one depending upon the multiple influences initiating lactation in the first place. With some of the endocrines now available the problem is mainly one of dosage, while with others the mechanism of inhibition or increase of lactation is obscure. The vitamin status of the gravid and post-partum woman is of more than minor significance.
AMERICAN
.JOURNAI>
OF
nut the ovaries are present. At least. tation and has the power of stimulating
OBSTETRICS
ASI)
GYNECOI~OGI
one androgen, testosterone, mammary growt,h.
also
inhii)itw
lac-
Estrogens are also capaltle, under suitable conditious, of enhancing milk start’tion hy increasing the concentration of both fatty and nonfatty solids. !I’he thrcsllold for the enrichment effect is lower than for inhibition. These two effects :(l’e more readily separable with nnt,ural estrogens than with diethvlstilbestrol.
Noble, R. L., and Collip, J. B.: Regression of Oestrogen Induced Mammary Tumours in Female Rats Following Removal of the Stimulus, Canad. M. :I. J. 44: 1, 1911. Mammary tumors produced in rats by the subcutaneous implantation of estrone pellets showed marked cellular hyperplasia but were all localized and showecl little tendency to invade the stroma or adjacent tissue. Continuous growth occurs until the animal’s death, provided the pellets remain intact. Attempts to transplant the tumors into other rats have failed but in two cases homotransplants grew succor+fully. Lung metastases were found in one rat with advanced tumor formation of nine months’ duration. Cellular infiltration of a typically malignant :tppearaIlcr was encountered in a few cases. Four rats treated with progesterone showed cessation of tumor growth. In 4 rats from whom the estrone pellets were remo\-rd. the tumors completely regressed. One of these animals had an ulcerated primar? mammary tumor with a histologic picture of malignancy and a successful homotransplant. After long periods nearly all animals were found to have large pitui. tary adenomas, and in :! rats large hemorrhagic adenomas developed during t 111~ first year of treatment. CARL
Wirth, Karl, and Peters, Max: Puerperal Mastitis, Miinchen.
Report on the Roentgen med.
Wchnschr.
P.
Ray Treatment
TtUHEII.
of Early
86: 59, 1939.
Wirth and Peters present their results and experiences in treating patients with an early infiltrative mastitis by using soft roentgen rays, giving 19 to 30 per cent skin erythema doses. Treatment, they believe, must begin within forty-eight hours of the onset of symptoms. In patients in whom infiltrations have occurred and nodules have formed, and in cases of interstitial mastitis the roentgen ray treatment promises hut little success; in fact, it may even lead to more necrosis of the tissues thus causing retardation of recovery because of the chronic, inflammatory edema resulting. The value of using roentgen therapy in the early cases must not be ovcrestimated, however, since these inflammations also recede quickly under ordinary treatment. The advantages of the roentgen therapy lie in the fact that, pain tlisappears quickly and the patient is able to continue nursing her baby.
Antoine,
T.: Endocrine
Influences
on Lactation,
Zentralbl.
f. Gyn%k. 65: 465, 19-1-l.
The author emphasizes that the problem of regulating lactation therapeutically is a complex one depending upon the multiple influences initiating lactation in the first place. With some of the endocrines now available the problem is mainly one of dosage, while with others the mechanism of inhibition or increase of lactation is obscure. The vitamin status of the gravid and post-partum woman is of more than minor significance.