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Relationship between adrenal function and pulmonary disease in preterm infants
S96
Abstracts
measured in the morning. Peak serum cortisol values were measured after 30 min low-dose ACTH stimulation test.
Materials and methods
The mean basal serum and peak serum cortisol values of ventilated preterm infants (n=21; 11.46±7.61 and 23.25±7.46 μg/dl) were significantly lower than that of preterm infants not ventilated (n=12; 18.21±8.68 and 31.21±9.38 μg/dl) in respire disease group and similar to controls (n=10; 10.91±5.50 and 26.27±7.12). Response to ACTH stimulation was not significantly different in the three groups.
Retrospective review of 40 PPHN infants from 2001 to 2007 admitted to our NICU. The diagnosis of PPHN was made by clinical manifestation and/or echocardiography. All of them received tolazoline and nonhyperventilation mechanical ventilation. Initial dosage of tolazoline was 1 mg/kg IV in 10 min, maintaining dosage was 1 mg/kg h. They were divided by two groups: effected group (group A) and invalid group (group B). Compare with OI of two groups before and after using tolazoline 6 h, 12 h, and 24 h. To investigate the therapeutic efficacy and complications of tolazoline.
Conclusions
Results
Adrenal function of preterm infants with and without respiratory disease, whether ventilated or not ventilated has a similar response to ACTH test. We did not find any relationship between adrenal function, and respiratory disease and/or mechanical ventilation.
The main gestational weeks were 38.97 ± 2.86";; main birth weight were 3038 ± 662 g, main age were 7.45 h (1.5–24 h). 77.5% (31/40) of infants was effective, 22.5% was ineffective. There were statistically significant difference (F 45.37, p < 0.01) compare with OI before and after using tolazoline 6 h, 12 h, and 24 h in A group. Although OI decreased after using tolazoline, there was no statistically significant difference (F 0.83, p > 0.05) in B group. The main tolazoline using times was 24.15 + 5.57 h and the main mechanical ventilation time was 5.18 ± 2.43d in A group.
Results
doi:10.1016/j.earlhumdev.2008.09.245
Abstract UENPS.230 Relationship between adrenal function and pulmonary disease in preterm infants Yunlin Shen⁎ Shanghai, China Background and aim To assess the adrenal function in preterm infants with various degrees of pulmonary diseases and respiratory support in order to elucidate relationship between adrenal function and pulmonary disease. Materials and methods 43 preterm infants (33 preterm with respire disease and 10 control) treated at Shanghai Children's Hospital. Serum cortisol values were measured in the morning. Peak serum cortisol values were measured after 30 min low-dose ACTH stimulation test.
Conclusions The effective rate of administration of tolazoline in PPHN was 77.5%. Tolazoline was a nonexpensive and easy to use drug. We recommended if the OI was not significantly decrease after 6 h administration of tolazoline, other therapeutic method should be considered.
doi:10.1016/j.earlhumdev.2008.09.247
Abstract UENPS.232 Cystic fibrosis presenting with hypoproteinemia, anemia, and failure to thrive in two neonates Cristina Maria Mihai⁎,a, Larisia Mihaia, Elena Leub, Adriana Luminita Balasaa, Viviana Cuzica, Corina Elena Frecusa, Ramona Mihaela Stoicescua “Ovidius” University, Faculty of Medicine, Constanta, Romania Constanta County Hospital, Constanta, Romania
Results Background and aim The mean basal serum and peak serum cortisol values of ventilated preterm infants (n=21; 11.46±7.61 and 23.25±7.46 μg/dl) were significantly lower than that of preterm infants not ventilated (n=12; 18.21±8.68 and 31.21±9.38 μg/dl) in respire disease group and similar to controls (n=10; 10.91±5.50 and 26.27±7.12). Response to ACTH stimulation was not significantly different in the three groups.
Adrenal function of preterm infants with and without respiratory disease, whether ventilated or not ventilated have a similar response to ACTH test. We did not find any relationship between adrenal function, and respiratory disease and/or mechanical ventilation.
Cystic fibrosis (CF) is a hereditary disease that has primary effects on the lungs, pancreas, intestine, liver, sweat glands, and male reproductive tract as well as important secondary effects on growth and nutrition. The clinical course is variable, but most patients succumb to lung disease in early adulthood. CF usually presents in infancy. Meconium ileus, a neonatal intestinal obstruction, occurs in approximately 17% of infants with CF. Beyond the perinatal period, CF presents as failure to thrive secondary to exocrine pancreatic insufficiency, chronic respiratory symptoms, or both. Nutritional deficits can be severe at presentation and may lead to edema and hypoproteinemia from protein–calorie malnutrition.
doi:10.1016/j.earlhumdev.2008.09.246
Materials and methods
Conclusions
The authors present two patients with hypoproteinemia in neonatal period of different clinical severities. Both of them had anemia and failure to thrive. Abstract UENPS.231 Tolazoline treating persistent pulmonary hypertension of the newborn Qunfang Rong⁎ Shanghai, China
Results The diagnosis of cystic fibrosis was confirmed by a positive sweat test. No one of the patients had prenatal diagnosis. Conclusions
Background and aim To evaluate the effectiveness of tolazoline treating persistent pulmonary hypertension of the newborn.
Despite its relative frequency among autosomal recessive diseases and the availability of the sweat test, cystic fibrosis (CF) has been difficult to diagnose in early childhood, and delays can lead to severe malnutrition, lung
Abstracts
measured in the morning. Peak serum cortisol values were measured after 30 min low-dose ACTH stimulation test.
Materials and methods
The mean basal serum and peak serum cortisol values of ventilated preterm infants (n=21; 11.46±7.61 and 23.25±7.46 μg/dl) were significantly lower than that of preterm infants not ventilated (n=12; 18.21±8.68 and 31.21±9.38 μg/dl) in respire disease group and similar to controls (n=10; 10.91±5.50 and 26.27±7.12). Response to ACTH stimulation was not significantly different in the three groups.
Retrospective review of 40 PPHN infants from 2001 to 2007 admitted to our NICU. The diagnosis of PPHN was made by clinical manifestation and/or echocardiography. All of them received tolazoline and nonhyperventilation mechanical ventilation. Initial dosage of tolazoline was 1 mg/kg IV in 10 min, maintaining dosage was 1 mg/kg h. They were divided by two groups: effected group (group A) and invalid group (group B). Compare with OI of two groups before and after using tolazoline 6 h, 12 h, and 24 h. To investigate the therapeutic efficacy and complications of tolazoline.
Conclusions
Results
Adrenal function of preterm infants with and without respiratory disease, whether ventilated or not ventilated has a similar response to ACTH test. We did not find any relationship between adrenal function, and respiratory disease and/or mechanical ventilation.
The main gestational weeks were 38.97 ± 2.86";; main birth weight were 3038 ± 662 g, main age were 7.45 h (1.5–24 h). 77.5% (31/40) of infants was effective, 22.5% was ineffective. There were statistically significant difference (F 45.37, p < 0.01) compare with OI before and after using tolazoline 6 h, 12 h, and 24 h in A group. Although OI decreased after using tolazoline, there was no statistically significant difference (F 0.83, p > 0.05) in B group. The main tolazoline using times was 24.15 + 5.57 h and the main mechanical ventilation time was 5.18 ± 2.43d in A group.
Results
doi:10.1016/j.earlhumdev.2008.09.245
Abstract UENPS.230 Relationship between adrenal function and pulmonary disease in preterm infants Yunlin Shen⁎ Shanghai, China Background and aim To assess the adrenal function in preterm infants with various degrees of pulmonary diseases and respiratory support in order to elucidate relationship between adrenal function and pulmonary disease. Materials and methods 43 preterm infants (33 preterm with respire disease and 10 control) treated at Shanghai Children's Hospital. Serum cortisol values were measured in the morning. Peak serum cortisol values were measured after 30 min low-dose ACTH stimulation test.
Conclusions The effective rate of administration of tolazoline in PPHN was 77.5%. Tolazoline was a nonexpensive and easy to use drug. We recommended if the OI was not significantly decrease after 6 h administration of tolazoline, other therapeutic method should be considered.
doi:10.1016/j.earlhumdev.2008.09.247
Abstract UENPS.232 Cystic fibrosis presenting with hypoproteinemia, anemia, and failure to thrive in two neonates Cristina Maria Mihai⁎,a, Larisia Mihaia, Elena Leub, Adriana Luminita Balasaa, Viviana Cuzica, Corina Elena Frecusa, Ramona Mihaela Stoicescua “Ovidius” University, Faculty of Medicine, Constanta, Romania Constanta County Hospital, Constanta, Romania
Results Background and aim The mean basal serum and peak serum cortisol values of ventilated preterm infants (n=21; 11.46±7.61 and 23.25±7.46 μg/dl) were significantly lower than that of preterm infants not ventilated (n=12; 18.21±8.68 and 31.21±9.38 μg/dl) in respire disease group and similar to controls (n=10; 10.91±5.50 and 26.27±7.12). Response to ACTH stimulation was not significantly different in the three groups.
Adrenal function of preterm infants with and without respiratory disease, whether ventilated or not ventilated have a similar response to ACTH test. We did not find any relationship between adrenal function, and respiratory disease and/or mechanical ventilation.
Cystic fibrosis (CF) is a hereditary disease that has primary effects on the lungs, pancreas, intestine, liver, sweat glands, and male reproductive tract as well as important secondary effects on growth and nutrition. The clinical course is variable, but most patients succumb to lung disease in early adulthood. CF usually presents in infancy. Meconium ileus, a neonatal intestinal obstruction, occurs in approximately 17% of infants with CF. Beyond the perinatal period, CF presents as failure to thrive secondary to exocrine pancreatic insufficiency, chronic respiratory symptoms, or both. Nutritional deficits can be severe at presentation and may lead to edema and hypoproteinemia from protein–calorie malnutrition.
doi:10.1016/j.earlhumdev.2008.09.246
Materials and methods
Conclusions
The authors present two patients with hypoproteinemia in neonatal period of different clinical severities. Both of them had anemia and failure to thrive. Abstract UENPS.231 Tolazoline treating persistent pulmonary hypertension of the newborn Qunfang Rong⁎ Shanghai, China
Results The diagnosis of cystic fibrosis was confirmed by a positive sweat test. No one of the patients had prenatal diagnosis. Conclusions
Background and aim To evaluate the effectiveness of tolazoline treating persistent pulmonary hypertension of the newborn.
Despite its relative frequency among autosomal recessive diseases and the availability of the sweat test, cystic fibrosis (CF) has been difficult to diagnose in early childhood, and delays can lead to severe malnutrition, lung