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Relationship between fatty acid and dementia in Japanese centenarians
Abstracts / Experimental Gerontology 42 (2007) 139–149
ty to IGF-1 in comparison to normally aging mice. (Supported by NIH AG19145-05 and BioTime, Inc.) doi:10.1016/j.exger.2006.06.043
Relationship between fatty acid and dementia in Japanese centenarians K. Yamamura a, M. Hashimoto b, Y. Arai a, K. Shimizu a, O. Shido b, N. Hirose a a
Division of Geriatric Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan b Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Japan The average human life span in most developed countries including Japan has increased steadily, with a great number of demented elderly people. Although no special medicine for Alzheimer’s disease (AD) still remains unknown, the nutrition is a possible effective factor in AD. Several studies have reported that x-3 polyunsaturated fatty acids (PUFA), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), can be contributive to prevention for dementia via their anti-atherogenic, anti-inflammatory, anti-oxidant, anti-amyloid and neuroprotective properties. We therefore
149
examined the relationship between EPA, DHA and cognitive function in Japanese centenarians. Two hundred centenarians (mean age 101.1 ± 0.1 years old, 42 males and 158 females) and 150 sex-matched healthy young subjects (mean age 26.5 ± 0.7 years old, 32 males and 118 females) were enrolled in this study. Cognitive function was evaluated using Mini Mental State Examination (MMSE) and Clinical Dementia Rating (CDR). Serum concentrations of EPA and DHA in centenarian group were significant greater than those in the control group (EPA 1.32 ± 0.08 vs. 1.83 ± 0.07*; DHA 3.17 ± 0.07 vs. 4.53 ± 0.08*; Arachidonic acid 5.80 ± 0.08 vs. 5.18 ± 0.08 mol%*, respectively, control vs. centenarians, *p < 0.05 vs. control). In addition, EPA concentrations in centenarians were associated with cognitive function (2.18 ± 0.16#, 1.89 ± 0.10 and 1.63 ± 0.10 mol% for normal to subdementia, mild to moderate dementia severe dementia in MMSE respectively, #p < 0.05 vs. severe dementia; 2.05 ± 0.12 for centenarians without dementia and 1.70 ± 0.08 mol%* for centenarians with dementia in CDR, *p < 0.05 vs. centenarians without dementia). These results suggest that in centenarians, EPA might be important for prevention of dementia. doi:10.1016/j.exger.2006.06.044
ty to IGF-1 in comparison to normally aging mice. (Supported by NIH AG19145-05 and BioTime, Inc.) doi:10.1016/j.exger.2006.06.043
Relationship between fatty acid and dementia in Japanese centenarians K. Yamamura a, M. Hashimoto b, Y. Arai a, K. Shimizu a, O. Shido b, N. Hirose a a
Division of Geriatric Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan b Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Japan The average human life span in most developed countries including Japan has increased steadily, with a great number of demented elderly people. Although no special medicine for Alzheimer’s disease (AD) still remains unknown, the nutrition is a possible effective factor in AD. Several studies have reported that x-3 polyunsaturated fatty acids (PUFA), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), can be contributive to prevention for dementia via their anti-atherogenic, anti-inflammatory, anti-oxidant, anti-amyloid and neuroprotective properties. We therefore
149
examined the relationship between EPA, DHA and cognitive function in Japanese centenarians. Two hundred centenarians (mean age 101.1 ± 0.1 years old, 42 males and 158 females) and 150 sex-matched healthy young subjects (mean age 26.5 ± 0.7 years old, 32 males and 118 females) were enrolled in this study. Cognitive function was evaluated using Mini Mental State Examination (MMSE) and Clinical Dementia Rating (CDR). Serum concentrations of EPA and DHA in centenarian group were significant greater than those in the control group (EPA 1.32 ± 0.08 vs. 1.83 ± 0.07*; DHA 3.17 ± 0.07 vs. 4.53 ± 0.08*; Arachidonic acid 5.80 ± 0.08 vs. 5.18 ± 0.08 mol%*, respectively, control vs. centenarians, *p < 0.05 vs. control). In addition, EPA concentrations in centenarians were associated with cognitive function (2.18 ± 0.16#, 1.89 ± 0.10 and 1.63 ± 0.10 mol% for normal to subdementia, mild to moderate dementia severe dementia in MMSE respectively, #p < 0.05 vs. severe dementia; 2.05 ± 0.12 for centenarians without dementia and 1.70 ± 0.08 mol%* for centenarians with dementia in CDR, *p < 0.05 vs. centenarians without dementia). These results suggest that in centenarians, EPA might be important for prevention of dementia. doi:10.1016/j.exger.2006.06.044