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Relationship between fetal growth and maternal fructosamine in diabetic pregnancy
Citations from the Literature Relationship between fetal growth and matemal fmctosamine in diabetic pregnancy Roberts AB; Baker JR Department of Clinical Biochemistty, Green Lane Hospital, Auckland, New Zealand OBSTET. GYNECOL.; 70/2 (242-246)/1987/ We studied 30 diabetic pregnant women to compare serum fructosamine concentrations at different stages of gestation with fetal growth (as determined by ultrasonography) and with birth weight. Serum fructosamine levels in mothers of macrosomic infants were significantly higher (P < .05) during the first trimester of pregnancy as compared with mothers of normal birth weight infants. Moreover, first-trimester fructosamine concentrations correlated significantly with birth weight ratio (r = 0.68, P < .OOl) and with ultrasound measurements of fetal abdominal circumference and femur length. The fetus destined to be macrosomic had an enlarged abdomen in the second trimester, often before 20 weeks’ gestation. We conclude that maternal diabetic control during early gestation has an important influence on fetal growth and contributes to the development of fetal marcrosomia.
Morpbologkal findings in placentae of insulin-dependent dkbetk patknts treated with continuous subcutaneous insulin infusion (CSII) Laurini RN; Visser GHA; Van Ballegooie E; Schoots CJF Department of Pathology, University Hospit@, Groningen. Netherlank PLACENTA; 812 (153-165)/1987/ Twenty-one placentae from type I (insulin-dependent) pregnant diabetic patients, treated with continuous subcutaneous insulin infusion (CSII), were studied morphologically. Despite a near-optimal blood glucose control the placental changes were identical to those previously reported in diabetic pregnancy. The most frequency observed lesion was that of relative placental immaturity; thus, when extensive, was related to antenatal fetal asphyxia. These data indicate that near normoglycaemia, achieved with CSII, does not modify the morphological expression of the disease in the placenta. Furthermore, it highlights the importance of placental development in the context of diabetic pregnancy.
Defective haemochorial pkcentation as a cause of miscarriage: A preliminary study Khong TY; Liddell HS; Robertson WB Department of Histopathology, St. George’s Hospital Medical School, London, UK BR. J. OBSTET. GYNAECOL.; 94/7 (649-655)/1987/ The morphology of the placental bed in idiopathic sporadic and recurrent miscarriages was studied and the findings correlated with the fetal chromosomal pattern where possible. Defective development of haemochorial placentation, which was not necessarily linked with fetal chromosomal abnormality, was seen in association with some miscarriages. These preliminary results, not previously demonstrated, strongly
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support the concept that miscarriages and pregnancies complicated by prceclampsia and/or small-for-gestational-age infants may be a continuum of disorders with a similar pathology in the placental bed. Outcome of pregnandee pnofnsaal beyond 24 weeks gestation in womea with 8 history of recurrent mkarrkge Reginald PW; Beard RW; Chapple J; et al Department of Obstetrics and Gynecology, St. Maty’s Hospital Medica! School, London W2 INY, UK BR. J. OBSTET. GYNAECOL.; 94/7 (643-648)/1987/ Ninety-seven women who had had three or more miscarriages had also had at least one pregnancy with a singleton birth that had reached 28 weeks gestation. Information was available on these 118 babies: 30% were small-for-gestational age (bhthweight < 10th centile using figures from Scotland 1973-1979). 28% were born preterm, and the perinatal mortality rate (excluding babies of < 28 weeks gestation) was 161/ 1000 births, all of which are significantly increased above the prevalence for a normal obstetric population. These observations may serve to alert the clinician to the increased risk of these complications when dealing with women who have a history of recurrent miscarriage. Presedptlon dmg use before aod during pregtuucy in a medicaid population Piper JM; Baum C; Kennedy DL EpidemioloflBranch, Division of Epidemiology and Surveillance, Center for Drugs and Biologics. Food and Drug Administration, Rockville, MD 20857, USA AM. J. OBSTET. GYNECOL.; 157/l (l&-156)/1987/ This study describes prescription drug use before and during pregnancy and is based on data obtained from the paid Medicaid claims of 18,886 Michigan women aged 15 to 44 years who were delivered of a live infant. Rates of exposure to drugs within 15 therapeutic categories are presented for each of five 9O-day periods preceding delivery. Overall dispense-d drug use (excluding vitamins) decreased during pregnancy; however, there was still substantial exposure to drugs including drugs that are contraindicated during pregnancy. During the gestational period, study mothers received an average of 3.1 prescriptions for nonvitamin drugs. Black mothers received more exposure to drugs other than vitamins than did white mothers. Black mothers had higher rates of exposure to analgesics, ampicillin, codeine, and vaginal preparations. Similarities between black and white mothers in the use of vitamins with and without other drugs suggest there is no racial difference in attaining prenatal care within the Medicaid system, but that black mothers may have more medical problems that warrant the use of other medications in addition to vitamins during pregnancy. Delivery after caesarean se&ion: Revkw of 2176 coasecutive cases Molloy BG; Sheil 0; Duignan NM Coon& Lying-In Hospital, Dublin 8, Ireland BR. MED. J.; 294/6588 (1645-1647)/1987/ Int J Gynecol Obstet 26
Morpbologkal findings in placentae of insulin-dependent dkbetk patknts treated with continuous subcutaneous insulin infusion (CSII) Laurini RN; Visser GHA; Van Ballegooie E; Schoots CJF Department of Pathology, University Hospit@, Groningen. Netherlank PLACENTA; 812 (153-165)/1987/ Twenty-one placentae from type I (insulin-dependent) pregnant diabetic patients, treated with continuous subcutaneous insulin infusion (CSII), were studied morphologically. Despite a near-optimal blood glucose control the placental changes were identical to those previously reported in diabetic pregnancy. The most frequency observed lesion was that of relative placental immaturity; thus, when extensive, was related to antenatal fetal asphyxia. These data indicate that near normoglycaemia, achieved with CSII, does not modify the morphological expression of the disease in the placenta. Furthermore, it highlights the importance of placental development in the context of diabetic pregnancy.
Defective haemochorial pkcentation as a cause of miscarriage: A preliminary study Khong TY; Liddell HS; Robertson WB Department of Histopathology, St. George’s Hospital Medical School, London, UK BR. J. OBSTET. GYNAECOL.; 94/7 (649-655)/1987/ The morphology of the placental bed in idiopathic sporadic and recurrent miscarriages was studied and the findings correlated with the fetal chromosomal pattern where possible. Defective development of haemochorial placentation, which was not necessarily linked with fetal chromosomal abnormality, was seen in association with some miscarriages. These preliminary results, not previously demonstrated, strongly
411
support the concept that miscarriages and pregnancies complicated by prceclampsia and/or small-for-gestational-age infants may be a continuum of disorders with a similar pathology in the placental bed. Outcome of pregnandee pnofnsaal beyond 24 weeks gestation in womea with 8 history of recurrent mkarrkge Reginald PW; Beard RW; Chapple J; et al Department of Obstetrics and Gynecology, St. Maty’s Hospital Medica! School, London W2 INY, UK BR. J. OBSTET. GYNAECOL.; 94/7 (643-648)/1987/ Ninety-seven women who had had three or more miscarriages had also had at least one pregnancy with a singleton birth that had reached 28 weeks gestation. Information was available on these 118 babies: 30% were small-for-gestational age (bhthweight < 10th centile using figures from Scotland 1973-1979). 28% were born preterm, and the perinatal mortality rate (excluding babies of < 28 weeks gestation) was 161/ 1000 births, all of which are significantly increased above the prevalence for a normal obstetric population. These observations may serve to alert the clinician to the increased risk of these complications when dealing with women who have a history of recurrent miscarriage. Presedptlon dmg use before aod during pregtuucy in a medicaid population Piper JM; Baum C; Kennedy DL EpidemioloflBranch, Division of Epidemiology and Surveillance, Center for Drugs and Biologics. Food and Drug Administration, Rockville, MD 20857, USA AM. J. OBSTET. GYNECOL.; 157/l (l&-156)/1987/ This study describes prescription drug use before and during pregnancy and is based on data obtained from the paid Medicaid claims of 18,886 Michigan women aged 15 to 44 years who were delivered of a live infant. Rates of exposure to drugs within 15 therapeutic categories are presented for each of five 9O-day periods preceding delivery. Overall dispense-d drug use (excluding vitamins) decreased during pregnancy; however, there was still substantial exposure to drugs including drugs that are contraindicated during pregnancy. During the gestational period, study mothers received an average of 3.1 prescriptions for nonvitamin drugs. Black mothers received more exposure to drugs other than vitamins than did white mothers. Black mothers had higher rates of exposure to analgesics, ampicillin, codeine, and vaginal preparations. Similarities between black and white mothers in the use of vitamins with and without other drugs suggest there is no racial difference in attaining prenatal care within the Medicaid system, but that black mothers may have more medical problems that warrant the use of other medications in addition to vitamins during pregnancy. Delivery after caesarean se&ion: Revkw of 2176 coasecutive cases Molloy BG; Sheil 0; Duignan NM Coon& Lying-In Hospital, Dublin 8, Ireland BR. MED. J.; 294/6588 (1645-1647)/1987/ Int J Gynecol Obstet 26