- Email: [email protected]
Relationship between oxidative stress and neurodevelopmental abnormalities in schizophrenia
IACAPAP 2012 – 20th World congress / Neuropsychiatrie de l’enfance et de l’adolescence 60S (2012) S197–S253 Background.– To describe a sample 47 patients treated with clozapine between 1985/2010, indicating: age, gender, diagnoses, hospitalization, electroconvulsive therapy, dosing, adverse effects specially hematological. Methods.– Patients between ages 10 and 18 treated with clozapine. Review of clinical charts, protocol investigation and Excel statistics analysis. Results.– Sample consisted in: male 40%, female 60%, youngest 10 and oldest 18 years old; most frequent age 15 years. Mean number of hospitalization was 1.5. Diagnosis.– Axis-I, DSM-IV: affective disorders 64%, schizophreniform disorder 23%. Treatment indications.– Irreducible psychosis 23%. Suicidability 33%. Severe impulsive out control behaviour and aggressiveness 9%. Combined treatment.– Patients who received electroconvulsive therapy 57%. Average dosing.– 200 mg. Adverse effects.– Sedation: 76%, hypersalivation: 68%, increase in weight: 66%, Neutropenia: not severe (more than 2000/mm3): 17%; severe II: 2%, severe III: 2%. Conclusions.– Clozapine appears as an effective drug, with moderate but frequent adverse effects. Hematologic adverse effects were transient; only one in 47 patients presented a severe neutropenia and required cancellation of treatment, which was reinstalled after three month without mayor side effects. http://dx.doi.org/10.1016/j.neurenf.2012.04.590 Tu-P-2214
Relationship between oxidative stress and neurodevelopmental abnormalities in schizophrenia H. Slama a,∗ , A. Mechri b , A. Kerkeni b , M. Nasr a , C. Fendri b , L. Gaha b Hôpital Taher Sfar, Mahdia, Tunisia b Hôpital Fattouma Bourguiba, Monastir, Tunisia ∗ Corresponding author.
a
Objective.– To examine the relationship between antioxidant stress markers and neurodevelopmental abnormalities in schizophrenic patients sample. Methods.– Sixty schizophrenic patients and 30 control subjects were recruited. Neurological and physical abnormalities were assessed in two groups by a standardised neurological examination of Neurological Soft Sign (NSS), and Minor Physical Anomalies Scale (MPAS) .It consisted in dosage by spectrophotometer of the erythrocyte antioxidant enzymes activity: Superoxide Dismutase (SOD), Glutathione Peroxidase and Catalase, and dosage by of plasmatic level of Thiobarbituric Acid Reactive Substances. Results.– Activities of all enzymes studied were lower in the schizophrenic group compared to control group .Also the group of schizophrenic patients showed a higher NSS total score especially for motor coordination, motor and sensory integration sub scores (P < 0.001). Conclusion.– Correlation between low SOD activity as a marker of oxidative stress and NSS in schizophrenic patients suggest a common pathophysiological process of these anomalies. http://dx.doi.org/10.1016/j.neurenf.2012.04.591 Tu-P-2215
A therapeutic group as an affirmative intervention for parents of gender-variant children H.R. Hernandez a,∗ , E. Perrin b Department Of Child And Adolescent Psychiatry, Tufts Medical Center, Boston, USA b Developmental-behavioral Pediatrics, Tufts Medical Center, Boston, USA ∗ Corresponding author.
a
Gender variance is complex and involves psychological, biological, family, and social issues. A multidisciplinary approach to care and treatment is advocated. There is currently a dearth of mental health professionals and pediatricians who evaluate, advocate, and treat gender-variant children. Increasingly, younger gender-variant patients up to ten years old present to doctorsTM clinics; this trend raises the need to help parents to accept, support, and advocate for their children. Concerns include a lack of safe environments, poor access to physical health services, inadequate resources, and a lack of continuity of caregiving
S241
by the community. The staff at Tufts Floating HospitalTM Center for Children with Special Needs (CCSN) provides bimonthly group support/discussion groups for parents in a respectful and trusting setting in which confidentiality is paramount. http://dx.doi.org/10.1016/j.neurenf.2012.04.592 Tu-P-2216
Sleep problems of elementary school children W.S. Seo a,∗ , H. Sea b , Y.C. Jeong c Psychiatry, Yeungnam University, Daegu, Korea b Psychiatry, Sungdong mental hospital, Daegu, Korea c Psychiatry, J’s Mind Clinic, Pohang, Korea ∗ Corresponding author.
a
Objectives.– The first aim of this study is to evaluate the prevalence of sleep problems in Korean elementary school children. The second aim is to compare the difference of sleep problems among age, gender and sleep duration. Methods.– Four elementary schools were randomly selected and whole children were enrolled. Demographic data, sleep diary were applied. Thirteen sleep problems were evaluated using the Korean version of modified Tucson Children’s Assessment of Sleep Apnea screening questionnaire. Results.– Three thousand seven hundred and six children were enrolled and their data were analyzed. 75.1% of the children had at least one sleep problem, 50% had two sleep problems and 29% of them had three sleep problems respectively. Most common sleep problem was “falling asleep in a vehicle” and 36.3% of children had the problem. The prevalence was different significantly by age (P < 0.001). Younger children had more in sleep bruxism, snoring, and nocturnal enuresis than older children. But, older children had more in daytime fatigue than younger children (P < 0.05). Girls had more in falling asleep in a vehicle, daytime fatigue than boys. But, boys had more in snoring, oral breathing, nocturnal enuresis, and sleep bruxism than girls (P < 0.05). In comparison of sleep problems among groups by sleep duration, falling asleep while watching TV before 8 P.M., doing homework, daytime fatigue, falling asleep in a vehicle, snoring were more in short sleep group (P < 0.05). Conclusion.– This study shows that quite many children had at least one sleep problems. The most common sleep problems are related to sleepiness or fatigue. We postulate that it might be related to pediatric developmental and medical problems, sleep duration and environment. We also assume that younger children have development-related sleep problems and older children have sleep problems, which related to sleep deprivation and non-restorative sleep per se. For the same reason, short sleep group of children have more sleepiness-related sleep problems. In comparison of sleep problems by gender, girls might be more vulnerable to stress-related sleep problems. http://dx.doi.org/10.1016/j.neurenf.2012.04.593 Tu-P-2217
The reasons for and consequences of cosleeping in early childhood: The results of longitudinal study
R. Jusiene ∗ , D. Cekuoliene , R. Breidokiene General Psychology, Vilnius University Faculty of Philosophy, 01513, Lithuania ∗ Corresponding author.
The findings on benefits and potential hazards of co-sleeping in early childhood are rather controversial. Again, who initiates the cosleeping and who benefits from it remain the relevant questions both for mental health professionals and parents. The aim of this study is to analyze the associations among sleeping arrangements, sleep problems and familial variables from early infancy through early childhood. The participants of the longitudinal birth cohort study are 200 full term infants and their mothers. The inquiries about sleeping, maternal distress, and relationships with the partner were made at infants’ age 3, 6, 12 and 18 months. The number of cosleepers almost doubles from infancy to early childhood. Also the associations among cosleeping and maternal distress, poor relationships with partner and non-married status become more salient with the child’s age. Both “migrating” cosleepers (sleeping part-time
Relationship between oxidative stress and neurodevelopmental abnormalities in schizophrenia H. Slama a,∗ , A. Mechri b , A. Kerkeni b , M. Nasr a , C. Fendri b , L. Gaha b Hôpital Taher Sfar, Mahdia, Tunisia b Hôpital Fattouma Bourguiba, Monastir, Tunisia ∗ Corresponding author.
a
Objective.– To examine the relationship between antioxidant stress markers and neurodevelopmental abnormalities in schizophrenic patients sample. Methods.– Sixty schizophrenic patients and 30 control subjects were recruited. Neurological and physical abnormalities were assessed in two groups by a standardised neurological examination of Neurological Soft Sign (NSS), and Minor Physical Anomalies Scale (MPAS) .It consisted in dosage by spectrophotometer of the erythrocyte antioxidant enzymes activity: Superoxide Dismutase (SOD), Glutathione Peroxidase and Catalase, and dosage by of plasmatic level of Thiobarbituric Acid Reactive Substances. Results.– Activities of all enzymes studied were lower in the schizophrenic group compared to control group .Also the group of schizophrenic patients showed a higher NSS total score especially for motor coordination, motor and sensory integration sub scores (P < 0.001). Conclusion.– Correlation between low SOD activity as a marker of oxidative stress and NSS in schizophrenic patients suggest a common pathophysiological process of these anomalies. http://dx.doi.org/10.1016/j.neurenf.2012.04.591 Tu-P-2215
A therapeutic group as an affirmative intervention for parents of gender-variant children H.R. Hernandez a,∗ , E. Perrin b Department Of Child And Adolescent Psychiatry, Tufts Medical Center, Boston, USA b Developmental-behavioral Pediatrics, Tufts Medical Center, Boston, USA ∗ Corresponding author.
a
Gender variance is complex and involves psychological, biological, family, and social issues. A multidisciplinary approach to care and treatment is advocated. There is currently a dearth of mental health professionals and pediatricians who evaluate, advocate, and treat gender-variant children. Increasingly, younger gender-variant patients up to ten years old present to doctorsTM clinics; this trend raises the need to help parents to accept, support, and advocate for their children. Concerns include a lack of safe environments, poor access to physical health services, inadequate resources, and a lack of continuity of caregiving
S241
by the community. The staff at Tufts Floating HospitalTM Center for Children with Special Needs (CCSN) provides bimonthly group support/discussion groups for parents in a respectful and trusting setting in which confidentiality is paramount. http://dx.doi.org/10.1016/j.neurenf.2012.04.592 Tu-P-2216
Sleep problems of elementary school children W.S. Seo a,∗ , H. Sea b , Y.C. Jeong c Psychiatry, Yeungnam University, Daegu, Korea b Psychiatry, Sungdong mental hospital, Daegu, Korea c Psychiatry, J’s Mind Clinic, Pohang, Korea ∗ Corresponding author.
a
Objectives.– The first aim of this study is to evaluate the prevalence of sleep problems in Korean elementary school children. The second aim is to compare the difference of sleep problems among age, gender and sleep duration. Methods.– Four elementary schools were randomly selected and whole children were enrolled. Demographic data, sleep diary were applied. Thirteen sleep problems were evaluated using the Korean version of modified Tucson Children’s Assessment of Sleep Apnea screening questionnaire. Results.– Three thousand seven hundred and six children were enrolled and their data were analyzed. 75.1% of the children had at least one sleep problem, 50% had two sleep problems and 29% of them had three sleep problems respectively. Most common sleep problem was “falling asleep in a vehicle” and 36.3% of children had the problem. The prevalence was different significantly by age (P < 0.001). Younger children had more in sleep bruxism, snoring, and nocturnal enuresis than older children. But, older children had more in daytime fatigue than younger children (P < 0.05). Girls had more in falling asleep in a vehicle, daytime fatigue than boys. But, boys had more in snoring, oral breathing, nocturnal enuresis, and sleep bruxism than girls (P < 0.05). In comparison of sleep problems among groups by sleep duration, falling asleep while watching TV before 8 P.M., doing homework, daytime fatigue, falling asleep in a vehicle, snoring were more in short sleep group (P < 0.05). Conclusion.– This study shows that quite many children had at least one sleep problems. The most common sleep problems are related to sleepiness or fatigue. We postulate that it might be related to pediatric developmental and medical problems, sleep duration and environment. We also assume that younger children have development-related sleep problems and older children have sleep problems, which related to sleep deprivation and non-restorative sleep per se. For the same reason, short sleep group of children have more sleepiness-related sleep problems. In comparison of sleep problems by gender, girls might be more vulnerable to stress-related sleep problems. http://dx.doi.org/10.1016/j.neurenf.2012.04.593 Tu-P-2217
The reasons for and consequences of cosleeping in early childhood: The results of longitudinal study
R. Jusiene ∗ , D. Cekuoliene , R. Breidokiene General Psychology, Vilnius University Faculty of Philosophy, 01513, Lithuania ∗ Corresponding author.
The findings on benefits and potential hazards of co-sleeping in early childhood are rather controversial. Again, who initiates the cosleeping and who benefits from it remain the relevant questions both for mental health professionals and parents. The aim of this study is to analyze the associations among sleeping arrangements, sleep problems and familial variables from early infancy through early childhood. The participants of the longitudinal birth cohort study are 200 full term infants and their mothers. The inquiries about sleeping, maternal distress, and relationships with the partner were made at infants’ age 3, 6, 12 and 18 months. The number of cosleepers almost doubles from infancy to early childhood. Also the associations among cosleeping and maternal distress, poor relationships with partner and non-married status become more salient with the child’s age. Both “migrating” cosleepers (sleeping part-time