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Renal amino acid transport in immature and adult rats during thallium-induced nephrotoxicity
prediiion is conlirmed 9, refuted. In the fourth and f&l tid,. the ii duction 01 these genas will be ,nvestyldtedin human biopsy mawi,,,
decrease bf their quality The i&&e 01 &tickle background It1t,a~1n8.acenile) on the a&ii of three pmleaso inhibiton (trypqm.
in high VieIdscultivated urdw modal BXce”mQnts
The affect 01 Tl$iOn ITL 2 mg/lOO g b.w ) on ,enal antww acid axcretion and plasma amino acid composition was investigated in I& and 55dwold rats. Tl decreased glamerularliftratronrate onlyin adult rats (0.91 + 0.04 ys. 0 78 f 0.05 mWminx 100 g b WC.) On the other hand. the renal fractional excrecicw~ (FE) of amko actis was diitinetlv enhanced in adun ,a15 as a sian of reduced amino acti reabsamimn ca~scltv after Tt. In immatureanimals FE was lncnasad ontv lo, few &a bcids. However. in both aga groups Tl administration sign6 cantlydecreasedplasmeaminoaeid c~ncent,athnx.morp,cwwcad inimmatu,~,a~.~einwstigat,onol,e~laminaac~handling(l~conhens that Tl was mwe nephrotoxicin 55&y& animals as could be demonstrated before usino other parameters lw nechmtoxicitvtesting and *awed 12) that &termi&kn of ,enal a&o acid handling IS a suitabla maker for nephrotoxkii. This 1%a funher evidencethat sensitivityof functional parameten is pear to that of morphological invertigatmna.
The human dint. which is a compx mixll,s of chemical entities.contains a anlicarcmngens. Dietary wake of natunl amioxidana may be
decrease bf their quality The i&&e 01 &tickle background It1t,a~1n8.acenile) on the a&ii of three pmleaso inhibiton (trypqm.
in high VieIdscultivated urdw modal BXce”mQnts
The affect 01 Tl$iOn ITL 2 mg/lOO g b.w ) on ,enal antww acid axcretion and plasma amino acid composition was investigated in I& and 55dwold rats. Tl decreased glamerularliftratronrate onlyin adult rats (0.91 + 0.04 ys. 0 78 f 0.05 mWminx 100 g b WC.) On the other hand. the renal fractional excrecicw~ (FE) of amko actis was diitinetlv enhanced in adun ,a15 as a sian of reduced amino acti reabsamimn ca~scltv after Tt. In immatureanimals FE was lncnasad ontv lo, few &a bcids. However. in both aga groups Tl administration sign6 cantlydecreasedplasmeaminoaeid c~ncent,athnx.morp,cwwcad inimmatu,~,a~.~einwstigat,onol,e~laminaac~handling(l~conhens that Tl was mwe nephrotoxicin 55&y& animals as could be demonstrated before usino other parameters lw nechmtoxicitvtesting and *awed 12) that &termi&kn of ,enal a&o acid handling IS a suitabla maker for nephrotoxkii. This 1%a funher evidencethat sensitivityof functional parameten is pear to that of morphological invertigatmna.
The human dint. which is a compx mixll,s of chemical entities.contains a anlicarcmngens. Dietary wake of natunl amioxidana may be