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Reproductive factors and Breast cancer subtypes among Japanese women
15th St.Gallen International Breast Cancer Conference / The Breast 32S1 (2017) S22–S77
age of first diagnosis with breast cancer was 41.6 years (range 22.2– 81.0 years) and in prophylactic group was 38.9 (range 30.8–55.5 years). All of CPM patients had married. Significantly more professions than non-professions (25.0% vs 4.1%; p = 0.049) underwent CPM. Most of patients who underwent CPM graduated university (87.5% vs 32.5%; p = 0.101). Six of 8 CPM patients underwent ipsilateral total mastectomy for resection of primary breast cancer. Conclusions: CPM rates were significantly different among different socioeconomic status of patients. It tends to actively underwent CPM in highly educated, profession, married women. Risk-reducing salpingo-oophorectomy (RRSO) was also actively received. Disclosure of Interest: No significant relationships. P103 Cultural practices and breast cancer in rural Cameroon J.N. Menang1 *, S. Njimogu2. 1CALMEF Practice, Mutengene, Tiko, SWR, Cameroon, 2St. Louis Medical University, Nkwen/Bamenda, Cameroon Background: Ask a woman about the most valued part of her body and about 83% would point at their breasts while a few will point the hair or so. The breast in a woman is not only as any other because its use it not limited to breast feeding, but complements a woman’s beauty, pleasure and pride and catastrophic consequences like deformity, pain, surgery especially mastectomy, depression etc set in when breast cancer is diagnosed. My community mothers of female teenagers between ages 9–16 carry dangerous cultural practices of using heated hard objects like stones, iron, leaves or even barks of trees to use in ironing the teens’ breasts. Methods: A newly launched pilot study of cross-sectional breast needle aspirates for biopsies and cultures of all girls presently with breast abscesses between ages 9–16 which is the common age range for breast ironing. Samples are preserved for delivery for cytology, sample questionnaires relation to knowledge of causes to breast abscesses and cancer, any breast ironing and if yes, dates and age as well as frequency and short oral questionnaires are applied in the study. Physical examination for grading, if the presenting teen has visible signs of breast injury such as burns. Results: The study is still at its very initial stages and the study outcome will be made available at subsequent meetings. Conclusions: Our goal is to analyze monthly samples – about 30 over 12 months, then embark on a final analysis and conclusions; then devising appropriate intervention approach. Even though cancer therapy is currently unavailable at CALMEF Practice, the aim of this study is understanding if the cultural practices of breast ironing precipitate breast cancer in teenagers so that we can devise intervention approach. Disclosure of Interest: No significant relationships. P104 Reproductive factors and Breast cancer subtypes among Japanese women
S57
Results: Parity (≧1) was positively associated with H2E type (odds ratio: 1.379, 95% confidence interval: 1.072–1.834 p = 0.018). Earlier age at menarche (≦12) was associated with increased odds of TN type (odds ratio: 1.139, 95% confidential interval: 1.003–1.293 p = 0.042). Breast feeding had no significantly association with breast cancer subtypes. Conclusions: These results suggested that reproductive factors might affect breast cancer subtypes among Japanese women. Disclosure of Interest: No significant relationships. P105 Evaluation of intraoperative touch imprint cytology on sentinel nodes in invasive breast carcinomas, a retrospective study of 1,225 patients comparing sensitivity between different tumor subtypes H. Petursson*, R. Olofsson Bagge, J. Mattsson, A. Kovacs. Sahlgrenska University Hospital, Gothenburg, Sweden Background: The sensitivity of intraoperative touch imprint cytology (TIC) examination on sentinel nodes is not consistent between different studies. It varies according to different tumor types, tumor size and the age of the patient. The aim was to evaluate the sensitivity of TIC according to tumor size, tumor type and the age of the patient. Methods: A retrospective review was performed for 1,225 clinically node negative patients treated with SLNB with intraoperative TIC. The SLN was bisected and stained with May-Grünwald-Giemsa method and immunocytochemically with antibody MNF 116. Results: The sensitivity was 68.9% and the specificity was 99.7%. There was no statistically significant difference between the detection of metastases from ductal cancer versus lobular cancer. The sensitivity has improved since 2003. Table 3. Characteristics of false negative and true positive TIC Characteristic
Tumor type ductal lobular tubular T stage T1 T2 T3 NPH = high grade ER positive PR positive HER2 positive SLN metastas size ITC micrometastases macrometastases
False negative (n = 88) n(%)
True positive (n = 195) n(%)
67 (76.1) 10 (11.4) 11 (12.5)
154 (79.0) 28 (14.4) 12 (6.2)
44 (50.0) 40 (45.5) 4 (4.5) 22 (25.0) 81 (92.0) 62 (70.5) 6 (6.8)
55 (28.2) 110 (56.4) 30 (15.4) 59 (30.3) 174 (89.2) 126 (64.6) 35 (17.9)
5 (5.7) 34 (38.6) 49 (55.7)
7 (3.6) 14 (7.2) 174 (89.2)
Y. Miyoshi*, E. Suzuki, S. Kiyoto, M. Takahashi, S. Takashima, F. Hara, K. Aogi, O. Shozo. Department of Breast Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan
Conclusions: The overall sensitivity of TIC was acceptable. Further analysis is needed to determine in which patient groups the test will be more useful.
Aims: Etiological difference of reproductive factors in influencing their subtypes remains unclear. Methods: A total of 3,215 breast cancer patients, who were diagnosed between 2003 and 2016 at NHO Shikoku Cancer Center, were utilized. Their cases were categorized into three subtypes (Luminal A type: ER+/HER2−, Luminal B type: ER+/HER2+, HER2 enriched (H2E) type: ER−/HER2+, Triple negative (TN) type: ER−/HER2−). We investigated the significance of association between reproductive factors and breast cancer subtypes. Odds ratio was calculated by multiple logistic regression adjusted for potential confounders (menopausal status, BMI, family history of breast cancer, age at menarche, and parity), comparing respective subtypes vs Luminal A type as reference group.
Disclosure of Interest: No significant relationships. P106 Impact of social support as a determinant of Health Related Quality of Life (HRQOL) in breast cancer survivors from low socio economic status in California F. Rab*, A. Thind. Western University, London, Canada Aim: Women diagnosed with breast cancer suffer from a debilitating illness, often undergoing protracted treatments and are subjected to economic burdens of treatment and rehabilitation. These economic burdens are starker for women belonging to lower economic strata (SES), who face additional challenges when diagnosed with breast
age of first diagnosis with breast cancer was 41.6 years (range 22.2– 81.0 years) and in prophylactic group was 38.9 (range 30.8–55.5 years). All of CPM patients had married. Significantly more professions than non-professions (25.0% vs 4.1%; p = 0.049) underwent CPM. Most of patients who underwent CPM graduated university (87.5% vs 32.5%; p = 0.101). Six of 8 CPM patients underwent ipsilateral total mastectomy for resection of primary breast cancer. Conclusions: CPM rates were significantly different among different socioeconomic status of patients. It tends to actively underwent CPM in highly educated, profession, married women. Risk-reducing salpingo-oophorectomy (RRSO) was also actively received. Disclosure of Interest: No significant relationships. P103 Cultural practices and breast cancer in rural Cameroon J.N. Menang1 *, S. Njimogu2. 1CALMEF Practice, Mutengene, Tiko, SWR, Cameroon, 2St. Louis Medical University, Nkwen/Bamenda, Cameroon Background: Ask a woman about the most valued part of her body and about 83% would point at their breasts while a few will point the hair or so. The breast in a woman is not only as any other because its use it not limited to breast feeding, but complements a woman’s beauty, pleasure and pride and catastrophic consequences like deformity, pain, surgery especially mastectomy, depression etc set in when breast cancer is diagnosed. My community mothers of female teenagers between ages 9–16 carry dangerous cultural practices of using heated hard objects like stones, iron, leaves or even barks of trees to use in ironing the teens’ breasts. Methods: A newly launched pilot study of cross-sectional breast needle aspirates for biopsies and cultures of all girls presently with breast abscesses between ages 9–16 which is the common age range for breast ironing. Samples are preserved for delivery for cytology, sample questionnaires relation to knowledge of causes to breast abscesses and cancer, any breast ironing and if yes, dates and age as well as frequency and short oral questionnaires are applied in the study. Physical examination for grading, if the presenting teen has visible signs of breast injury such as burns. Results: The study is still at its very initial stages and the study outcome will be made available at subsequent meetings. Conclusions: Our goal is to analyze monthly samples – about 30 over 12 months, then embark on a final analysis and conclusions; then devising appropriate intervention approach. Even though cancer therapy is currently unavailable at CALMEF Practice, the aim of this study is understanding if the cultural practices of breast ironing precipitate breast cancer in teenagers so that we can devise intervention approach. Disclosure of Interest: No significant relationships. P104 Reproductive factors and Breast cancer subtypes among Japanese women
S57
Results: Parity (≧1) was positively associated with H2E type (odds ratio: 1.379, 95% confidence interval: 1.072–1.834 p = 0.018). Earlier age at menarche (≦12) was associated with increased odds of TN type (odds ratio: 1.139, 95% confidential interval: 1.003–1.293 p = 0.042). Breast feeding had no significantly association with breast cancer subtypes. Conclusions: These results suggested that reproductive factors might affect breast cancer subtypes among Japanese women. Disclosure of Interest: No significant relationships. P105 Evaluation of intraoperative touch imprint cytology on sentinel nodes in invasive breast carcinomas, a retrospective study of 1,225 patients comparing sensitivity between different tumor subtypes H. Petursson*, R. Olofsson Bagge, J. Mattsson, A. Kovacs. Sahlgrenska University Hospital, Gothenburg, Sweden Background: The sensitivity of intraoperative touch imprint cytology (TIC) examination on sentinel nodes is not consistent between different studies. It varies according to different tumor types, tumor size and the age of the patient. The aim was to evaluate the sensitivity of TIC according to tumor size, tumor type and the age of the patient. Methods: A retrospective review was performed for 1,225 clinically node negative patients treated with SLNB with intraoperative TIC. The SLN was bisected and stained with May-Grünwald-Giemsa method and immunocytochemically with antibody MNF 116. Results: The sensitivity was 68.9% and the specificity was 99.7%. There was no statistically significant difference between the detection of metastases from ductal cancer versus lobular cancer. The sensitivity has improved since 2003. Table 3. Characteristics of false negative and true positive TIC Characteristic
Tumor type ductal lobular tubular T stage T1 T2 T3 NPH = high grade ER positive PR positive HER2 positive SLN metastas size ITC micrometastases macrometastases
False negative (n = 88) n(%)
True positive (n = 195) n(%)
67 (76.1) 10 (11.4) 11 (12.5)
154 (79.0) 28 (14.4) 12 (6.2)
44 (50.0) 40 (45.5) 4 (4.5) 22 (25.0) 81 (92.0) 62 (70.5) 6 (6.8)
55 (28.2) 110 (56.4) 30 (15.4) 59 (30.3) 174 (89.2) 126 (64.6) 35 (17.9)
5 (5.7) 34 (38.6) 49 (55.7)
7 (3.6) 14 (7.2) 174 (89.2)
Y. Miyoshi*, E. Suzuki, S. Kiyoto, M. Takahashi, S. Takashima, F. Hara, K. Aogi, O. Shozo. Department of Breast Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan
Conclusions: The overall sensitivity of TIC was acceptable. Further analysis is needed to determine in which patient groups the test will be more useful.
Aims: Etiological difference of reproductive factors in influencing their subtypes remains unclear. Methods: A total of 3,215 breast cancer patients, who were diagnosed between 2003 and 2016 at NHO Shikoku Cancer Center, were utilized. Their cases were categorized into three subtypes (Luminal A type: ER+/HER2−, Luminal B type: ER+/HER2+, HER2 enriched (H2E) type: ER−/HER2+, Triple negative (TN) type: ER−/HER2−). We investigated the significance of association between reproductive factors and breast cancer subtypes. Odds ratio was calculated by multiple logistic regression adjusted for potential confounders (menopausal status, BMI, family history of breast cancer, age at menarche, and parity), comparing respective subtypes vs Luminal A type as reference group.
Disclosure of Interest: No significant relationships. P106 Impact of social support as a determinant of Health Related Quality of Life (HRQOL) in breast cancer survivors from low socio economic status in California F. Rab*, A. Thind. Western University, London, Canada Aim: Women diagnosed with breast cancer suffer from a debilitating illness, often undergoing protracted treatments and are subjected to economic burdens of treatment and rehabilitation. These economic burdens are starker for women belonging to lower economic strata (SES), who face additional challenges when diagnosed with breast