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Response to: Letter to the editor on: Optimisation of post-mortem cardiac computed tomography compared to optical coherence tomography and histopathology – Technical note
Journal of Forensic Radiology and Imaging ∎ (∎∎∎∎) ∎∎∎–∎∎∎
Contents lists available at ScienceDirect
Journal of Forensic Radiology and Imaging journal homepage: www.elsevier.com/locate/jofri
Letter to the editor
Response to: Letter to the editor on: Optimisation of post-mortem cardiac computed tomography compared to optical coherence tomography and histopathology – Technical note To the Editor, The authors appreciate the opportunity to respond to the letter by David Adlam et al. [1] and would like to thank the author group for the contribution and their interest in our work [2]. We fully agree on their comments. The primary goal of our research is to improve the plaque characterization of Cardiac CT as a noninvasive imaging modality. It is not the primary goal to replace invasive high resolution imaging modalities like OCT and histology. OCT indeed can show thin cap fibroatheroma. Cardiac CT will only show the indirect proof by showing low attenuation areas close to the lumen area which might be an indication for the presence of vulnerable plaque. Our main task is therefore to exploit weather new developed CT technique as model based iterative reconstructions or dual energy could optimize the Cardiac CT possibility to detect vulnerable plaque even with relatively low resolution validated through OCT and histology. References [1] D. Adlam, B. Morgan, C Robinson, M. Biggs, A. Adnan, G.N. Rutty, Letter to the editor on: optimisation of post-mortem cardiac computed tomography compared to optical coherence tomography and histopathology – technical note, J. Forensic Radiol. Imaging (2014) (accepted for publication). [2] H. Precht, PM. Leth, J. Thygesen, M. Hardt-Madsen, B. Nielsen, E. Falk, K. Egstrup, O. Gerke, A. Broersen, PH. Kitslaar, J. Dijkstra, J. Lambrechtsen, Optimisation of postmortem cardiac computed tomography compared to optical coherence tomography and histopathology – technical note, J. Forensic Radiol. Imaging 2 (2) (2014) 85–90.
Helle Prechtn Odense University Hospital Svendborg, Medical Research Department, Valdemarsgade 53, 5700 Svendborg, Denmark Conrad Research Center, University College Lillebelt, Blangstedgaardsvej 4, 5220 Odense SØ, Denmark E-mail addresses: [email protected], [email protected]
n Corresponding author at: Conrad Research Center, University College Lillebelt, Blangstedgaardsvej 4, 5220 Odense SØ, Denmark. Tel.: þ 45 23 27 19 31; fax: þ45 63 18 32 26.
http://dx.doi.org/10.1016/j.jofri.2014.04.001 2212-4780/& 2014 Elsevier Ltd. All rights reserved.
Peter Mygind Leth University of Southern Denmark, Institute of Forensic Medicine, J.B. Winsløws Vej 17B, 5000 Odense C, Denmark Jesper Thygesen Aarhus University Hospital Skejby, Department of Medico Engineering, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark Michael Hardt-Madsen Odense University Hospital Svendborg, Department of Clinical Pathology, Valdemarsgade 53, 5700 Svendborg, Denmark Bjarne Nielsen Hospital of Southern Jutland, Department of Pathology, Sydvang 1, 6400 Sønderborg, Denmark Erling Falk Aarhus University Hospital Skejby, Department of Cardiology, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark Kenneth Egstrup, Jess Lambrechtsen Odense University Hospital Svendborg, Medical Research Department, Valdemarsgade 53, 5700 Svendborg, Denmark Oke Gerke Odense University Hospital, Department of Nuclear Medicine, Sdr. Boulevard 29, 5000 Odense C, Denmark University of Southern Denmark, Center of Health Economics Research, J.B. Winsløws Vej 9, 1. Sal, 5000 Odense C, Denmark Alexander Broersen, Pieter H. Kitslaar, Jouke Dijkstra Leiden University Medical Center, Department of Radiology, Division of Image Processing, Albinusdreef 2, 2300 RC Leiden, the Netherlands
Contents lists available at ScienceDirect
Journal of Forensic Radiology and Imaging journal homepage: www.elsevier.com/locate/jofri
Letter to the editor
Response to: Letter to the editor on: Optimisation of post-mortem cardiac computed tomography compared to optical coherence tomography and histopathology – Technical note To the Editor, The authors appreciate the opportunity to respond to the letter by David Adlam et al. [1] and would like to thank the author group for the contribution and their interest in our work [2]. We fully agree on their comments. The primary goal of our research is to improve the plaque characterization of Cardiac CT as a noninvasive imaging modality. It is not the primary goal to replace invasive high resolution imaging modalities like OCT and histology. OCT indeed can show thin cap fibroatheroma. Cardiac CT will only show the indirect proof by showing low attenuation areas close to the lumen area which might be an indication for the presence of vulnerable plaque. Our main task is therefore to exploit weather new developed CT technique as model based iterative reconstructions or dual energy could optimize the Cardiac CT possibility to detect vulnerable plaque even with relatively low resolution validated through OCT and histology. References [1] D. Adlam, B. Morgan, C Robinson, M. Biggs, A. Adnan, G.N. Rutty, Letter to the editor on: optimisation of post-mortem cardiac computed tomography compared to optical coherence tomography and histopathology – technical note, J. Forensic Radiol. Imaging (2014) (accepted for publication). [2] H. Precht, PM. Leth, J. Thygesen, M. Hardt-Madsen, B. Nielsen, E. Falk, K. Egstrup, O. Gerke, A. Broersen, PH. Kitslaar, J. Dijkstra, J. Lambrechtsen, Optimisation of postmortem cardiac computed tomography compared to optical coherence tomography and histopathology – technical note, J. Forensic Radiol. Imaging 2 (2) (2014) 85–90.
Helle Prechtn Odense University Hospital Svendborg, Medical Research Department, Valdemarsgade 53, 5700 Svendborg, Denmark Conrad Research Center, University College Lillebelt, Blangstedgaardsvej 4, 5220 Odense SØ, Denmark E-mail addresses: [email protected], [email protected]
n Corresponding author at: Conrad Research Center, University College Lillebelt, Blangstedgaardsvej 4, 5220 Odense SØ, Denmark. Tel.: þ 45 23 27 19 31; fax: þ45 63 18 32 26.
http://dx.doi.org/10.1016/j.jofri.2014.04.001 2212-4780/& 2014 Elsevier Ltd. All rights reserved.
Peter Mygind Leth University of Southern Denmark, Institute of Forensic Medicine, J.B. Winsløws Vej 17B, 5000 Odense C, Denmark Jesper Thygesen Aarhus University Hospital Skejby, Department of Medico Engineering, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark Michael Hardt-Madsen Odense University Hospital Svendborg, Department of Clinical Pathology, Valdemarsgade 53, 5700 Svendborg, Denmark Bjarne Nielsen Hospital of Southern Jutland, Department of Pathology, Sydvang 1, 6400 Sønderborg, Denmark Erling Falk Aarhus University Hospital Skejby, Department of Cardiology, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark Kenneth Egstrup, Jess Lambrechtsen Odense University Hospital Svendborg, Medical Research Department, Valdemarsgade 53, 5700 Svendborg, Denmark Oke Gerke Odense University Hospital, Department of Nuclear Medicine, Sdr. Boulevard 29, 5000 Odense C, Denmark University of Southern Denmark, Center of Health Economics Research, J.B. Winsløws Vej 9, 1. Sal, 5000 Odense C, Denmark Alexander Broersen, Pieter H. Kitslaar, Jouke Dijkstra Leiden University Medical Center, Department of Radiology, Division of Image Processing, Albinusdreef 2, 2300 RC Leiden, the Netherlands