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Retrovial insertion and oncogene activation. Current topics in microbiology and immunology, vol. 171
268
VIRUS
00842
Retrovial Insertion and Oncogene Activation. Current Topics in Microbiology and Immunology, Vol. 171. Edited by H.J. Kung and P.K. Vogt. ISBN: O-387-53857-7.
US $98.00. This is a timely review on a topic that has been somewhat overshadowed by the race to identify new oncogenes. It provides important insight into the ‘biology’ of host-retroviral relationships at the molecular level. What is of particular interest in this volume are the many subtleties and facets of how retroviral insertions affect activation and/or expression of ‘virus-host genes’. Specifically, this volume focuses on how the integration of proviruses into cellular genes either activates their expression or disrupts and inactivates their function. Additionally, insertions are used to map genes important at different stages of embryonic development. The five chapters in this monograph provide a wide spectrum of information on retroviral insertion mutagenesis ranging from the initial overview provided by Kung et al. on describing multiple (40) common insertion sites in retrovirally induced tumors to acquisition of germline proviruses in mice (Locke et al.). Also, there is a description of insertional mutagenesis with mouse mammary tumor virus focusing on the function of host genes such as Wnt-1 and int-2 (Nusse), a discussion of studies on oncogenesis and pathogenesis with feline leukemia virus (Neil et al.) and finally, an extensive review by Tsichilis et al. on the role of murine viral LTR and env genes, as well as the effects of provirus insertion and host genes on oncogenesis. Several useful tables are provided in this last chapter, such as one on the effects of provirus insertion on the expression and/or structure of neighboring genes and another on chromosomal location of common regions of provirus integration. All in all this volume should be of interest to retrovirologists investigating embryonic development, pathogenesis and tumor development. I recommend it as a state-of-the-art treatment by leaders in the field of retroviral insertional mutagenesis. Ronald B. Luftig
VIRUS
00845
Biotechnology and Veterinary US$26; FF155.
Science.
Volume
9, Number
3. ISSN
0253-1933;
Although a struggle for my personal scientific interests, this review of biotechnology and its applications for agriculture and veterinary sciences provides a useful
VIRUS
00842
Retrovial Insertion and Oncogene Activation. Current Topics in Microbiology and Immunology, Vol. 171. Edited by H.J. Kung and P.K. Vogt. ISBN: O-387-53857-7.
US $98.00. This is a timely review on a topic that has been somewhat overshadowed by the race to identify new oncogenes. It provides important insight into the ‘biology’ of host-retroviral relationships at the molecular level. What is of particular interest in this volume are the many subtleties and facets of how retroviral insertions affect activation and/or expression of ‘virus-host genes’. Specifically, this volume focuses on how the integration of proviruses into cellular genes either activates their expression or disrupts and inactivates their function. Additionally, insertions are used to map genes important at different stages of embryonic development. The five chapters in this monograph provide a wide spectrum of information on retroviral insertion mutagenesis ranging from the initial overview provided by Kung et al. on describing multiple (40) common insertion sites in retrovirally induced tumors to acquisition of germline proviruses in mice (Locke et al.). Also, there is a description of insertional mutagenesis with mouse mammary tumor virus focusing on the function of host genes such as Wnt-1 and int-2 (Nusse), a discussion of studies on oncogenesis and pathogenesis with feline leukemia virus (Neil et al.) and finally, an extensive review by Tsichilis et al. on the role of murine viral LTR and env genes, as well as the effects of provirus insertion and host genes on oncogenesis. Several useful tables are provided in this last chapter, such as one on the effects of provirus insertion on the expression and/or structure of neighboring genes and another on chromosomal location of common regions of provirus integration. All in all this volume should be of interest to retrovirologists investigating embryonic development, pathogenesis and tumor development. I recommend it as a state-of-the-art treatment by leaders in the field of retroviral insertional mutagenesis. Ronald B. Luftig
VIRUS
00845
Biotechnology and Veterinary US$26; FF155.
Science.
Volume
9, Number
3. ISSN
0253-1933;
Although a struggle for my personal scientific interests, this review of biotechnology and its applications for agriculture and veterinary sciences provides a useful