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Risk Factors and Outcomes of Pneumonia in Lung Cancer Patients
October 2014, Vol 146, No. 4_MeetingAbstracts
Lung Cancer | October 2014
Risk Factors and Outcomes of Pneumonia in Lung Cancer Patients Ye ryung Jung; Won Yeon Lee; Sang-Ha Kim; Myoung Kyu Lee; KyeChul Shin; Suk Joong Yong Yonsei University Wonju College of Medicine, Wonju, Republic of Korea
Chest. 2014;146(4_MeetingAbstracts):595A. doi:10.1378/chest.1994172
Abstract SESSION TITLE: Lung Cancer Posters II SESSION TYPE: Original Investigation Poster PRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PM PURPOSE: Development of pneumonia in patients with lung cancer is common and results in increasing the mortality of patients. The aim of this study was to describe the clinical features and outcomes of patients with pneumonia and assess the risk factors for the development of pneumonia in patients with lung cancer.
METHODS: Following a retrospective review of clinical data from 2009 to 2012, total 348 patients with lung cancer admitted to a local tertiary hospital were enrolled in this study.
RESULTS: The mean age of enrolled patients was 60 ± 0.3 year(0.3) and 71% (n=247) were male. Risk factor for development of pneumonia was structural lung disease.(P = .021). Among the patients with pneumonia (60.8%, n=211), squamous cell carcinoma (37.4%, n=130) was the most common histologic type and the most frequently revealed pathogen was Klebsiella pneumoniae (19.4%, n=67). In 50.8% of the pneumonia patients, microbiologic causes were ESBL- producing K. pneumoniae, MRSA, Acinetobacter, Pseudomonas. In the multivariate analysis, predictors for the mortality in patients with pneumonia was delayed time of diagnosis, white blood cell count, and structural lung disease (P = .032, P = .013, P = .019 ). Patients with pneumonia showed hazard ratio of 3.913 (95% confidence interval, 1.653-9.265) compared to those without pneumonia in the Cox's regression analysis.
CONCLUSIONS: Structural lung disease was risk factor for the development of pneumonia and also mortality. In laboratory findings, white blood cell count was independent determinants of mortality but inflammation markers such as CRP and PCT was not. CLINICAL IMPLICATIONS: Factors described above may assist with diagnosis of pneumonia and predict prognosis of it. And this could lead to prompt initiation of therapy and proper choice of antibiotics.
DISCLOSURE: The following authors have nothing to disclose: Ye ryung Jung, Won Yeon Lee, Sang-Ha Kim, Myoung Kyu Lee, KyeChul Shin, Suk Joong Yong No Product/Research Disclosure Information
Lung Cancer | October 2014
Risk Factors and Outcomes of Pneumonia in Lung Cancer Patients Ye ryung Jung; Won Yeon Lee; Sang-Ha Kim; Myoung Kyu Lee; KyeChul Shin; Suk Joong Yong Yonsei University Wonju College of Medicine, Wonju, Republic of Korea
Chest. 2014;146(4_MeetingAbstracts):595A. doi:10.1378/chest.1994172
Abstract SESSION TITLE: Lung Cancer Posters II SESSION TYPE: Original Investigation Poster PRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PM PURPOSE: Development of pneumonia in patients with lung cancer is common and results in increasing the mortality of patients. The aim of this study was to describe the clinical features and outcomes of patients with pneumonia and assess the risk factors for the development of pneumonia in patients with lung cancer.
METHODS: Following a retrospective review of clinical data from 2009 to 2012, total 348 patients with lung cancer admitted to a local tertiary hospital were enrolled in this study.
RESULTS: The mean age of enrolled patients was 60 ± 0.3 year(0.3) and 71% (n=247) were male. Risk factor for development of pneumonia was structural lung disease.(P = .021). Among the patients with pneumonia (60.8%, n=211), squamous cell carcinoma (37.4%, n=130) was the most common histologic type and the most frequently revealed pathogen was Klebsiella pneumoniae (19.4%, n=67). In 50.8% of the pneumonia patients, microbiologic causes were ESBL- producing K. pneumoniae, MRSA, Acinetobacter, Pseudomonas. In the multivariate analysis, predictors for the mortality in patients with pneumonia was delayed time of diagnosis, white blood cell count, and structural lung disease (P = .032, P = .013, P = .019 ). Patients with pneumonia showed hazard ratio of 3.913 (95% confidence interval, 1.653-9.265) compared to those without pneumonia in the Cox's regression analysis.
CONCLUSIONS: Structural lung disease was risk factor for the development of pneumonia and also mortality. In laboratory findings, white blood cell count was independent determinants of mortality but inflammation markers such as CRP and PCT was not. CLINICAL IMPLICATIONS: Factors described above may assist with diagnosis of pneumonia and predict prognosis of it. And this could lead to prompt initiation of therapy and proper choice of antibiotics.
DISCLOSURE: The following authors have nothing to disclose: Ye ryung Jung, Won Yeon Lee, Sang-Ha Kim, Myoung Kyu Lee, KyeChul Shin, Suk Joong Yong No Product/Research Disclosure Information