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Roentgen picture of the lungs in bronchial asthma
213
ABSTRACTS Hiatamir,le
in Allergic
Conditions.
Dzsinich,
A.:
Klin.
Wchnsehr.
14:
1612,
1935.
The author reviews various experimental studies tending to prove that anThe latest theory assumes aphylactic shock and histamine shock are identical. that histamine is liberated by the cells of a sensitized organism and tlY;tt it plays In asthma histamine is liberated from a decisive role in the allergic reaction. the vascular cells of the bronchi and then produces the local and general symnBy introducing exogenously small doses of histamine in atams of the disease. lergic individuals they may be desensitized against the histamine formed within This idea led to the author’s attempts to treat allergic conditions the organism. with small doses of histamine. His experiments included 15 cases with bronchial asthma. The choice of the proper dose for the initial injection presented great difficulties. In the first patient an overdose produced grave asthmatic attacks, worse than before treatment. To avoid these disagreeable symptoms, the author began to use very small doses for the first, injection. He differentiated between the grave and the mild cases. In all cases injections were made every other day, and the first injection was intracutaneous. If no untoward reartion resulted, the same dose was injected subcutaneously after a one-day interval. The author used “Histamine set Richter” of which 1 C.C. ampule contains 1 mg. active substance. In the grave cases the beginning dose was 0.00001 mg. increasing by 50 to 100 per cent increments until 0.01 mg. was reached about the thirteenth treatment. In the mild cases the initial dose was 0.0001 mg., reaching the 0.01 mg. dose ahout the tenth treatment. In either type the 0.01 mg. dose was the maximum dose used thereafter. In 12 cases out, of 15, complete cure was achieved. During treatment the asthmatic attacks and the dyspnea disappeared. Then followed an improvement in the subjective condition. After treatment the patients gained weight and had During fifteen months since the beginning of their working capacity restored. treatment they hzave been entirely free of symptoms. Three cases proved refractory to histamine treatment. Possibly t,hey might, have yielded to repeated attempts, hot when 29 or more injections brought no results treatments were stopped. Individual differences coalled for variations in technic. In some cases a rapid increase in the dose was possible, in others a slower procedure was necessary. Larger doses than 0.01 mg. are never advisable. The treatments were arranged in series, and often 10 to 12 injections w-ere sufficient to stop all symptoms, while in other cases 18 to 20 injections were needed.
Roentgen J. B.:
Picture
of the Lungs in Bronchial
Fortschr.
a. d. Gel).
d. Rfintgenstrahlen
Asthma. 53:
Dillon, J. CT., and 66, 1936.
Gureurtsch,
A study of 14i patients with bronchial asthma showed no roentgen findings characteristic of the condition. l’uberculous changes were found to he no more common than in any other groups. Pulmonary emphysema was found to be present in a large number of the cases and was more common the greater the duration of the asthma. Other pathologic conditions, such as bronchial glandular swellings, pleural and bronchial changes, were not more common in bronchial asthma than in other diseases.
The Effect of Intranasal by a New Intranasal scope
46:
717,
Phenol Application in Hay Fever. Quantitatively Swab Test With Pollen Extracts. Vistreich, F.:
Studied Laryngo-
1936.
In 24 consecutive phenol intranasally. another 20 per cent
cases of early and late hay fever the author applied pure In 75 per cent practically complete relief was obtained. In the results were fair or good; only one patient failed to
ABSTRACTS Hiatamir,le
in Allergic
Conditions.
Dzsinich,
A.:
Klin.
Wchnsehr.
14:
1612,
1935.
The author reviews various experimental studies tending to prove that anThe latest theory assumes aphylactic shock and histamine shock are identical. that histamine is liberated by the cells of a sensitized organism and tlY;tt it plays In asthma histamine is liberated from a decisive role in the allergic reaction. the vascular cells of the bronchi and then produces the local and general symnBy introducing exogenously small doses of histamine in atams of the disease. lergic individuals they may be desensitized against the histamine formed within This idea led to the author’s attempts to treat allergic conditions the organism. with small doses of histamine. His experiments included 15 cases with bronchial asthma. The choice of the proper dose for the initial injection presented great difficulties. In the first patient an overdose produced grave asthmatic attacks, worse than before treatment. To avoid these disagreeable symptoms, the author began to use very small doses for the first, injection. He differentiated between the grave and the mild cases. In all cases injections were made every other day, and the first injection was intracutaneous. If no untoward reartion resulted, the same dose was injected subcutaneously after a one-day interval. The author used “Histamine set Richter” of which 1 C.C. ampule contains 1 mg. active substance. In the grave cases the beginning dose was 0.00001 mg. increasing by 50 to 100 per cent increments until 0.01 mg. was reached about the thirteenth treatment. In the mild cases the initial dose was 0.0001 mg., reaching the 0.01 mg. dose ahout the tenth treatment. In either type the 0.01 mg. dose was the maximum dose used thereafter. In 12 cases out, of 15, complete cure was achieved. During treatment the asthmatic attacks and the dyspnea disappeared. Then followed an improvement in the subjective condition. After treatment the patients gained weight and had During fifteen months since the beginning of their working capacity restored. treatment they hzave been entirely free of symptoms. Three cases proved refractory to histamine treatment. Possibly t,hey might, have yielded to repeated attempts, hot when 29 or more injections brought no results treatments were stopped. Individual differences coalled for variations in technic. In some cases a rapid increase in the dose was possible, in others a slower procedure was necessary. Larger doses than 0.01 mg. are never advisable. The treatments were arranged in series, and often 10 to 12 injections w-ere sufficient to stop all symptoms, while in other cases 18 to 20 injections were needed.
Roentgen J. B.:
Picture
of the Lungs in Bronchial
Fortschr.
a. d. Gel).
d. Rfintgenstrahlen
Asthma. 53:
Dillon, J. CT., and 66, 1936.
Gureurtsch,
A study of 14i patients with bronchial asthma showed no roentgen findings characteristic of the condition. l’uberculous changes were found to he no more common than in any other groups. Pulmonary emphysema was found to be present in a large number of the cases and was more common the greater the duration of the asthma. Other pathologic conditions, such as bronchial glandular swellings, pleural and bronchial changes, were not more common in bronchial asthma than in other diseases.
The Effect of Intranasal by a New Intranasal scope
46:
717,
Phenol Application in Hay Fever. Quantitatively Swab Test With Pollen Extracts. Vistreich, F.:
Studied Laryngo-
1936.
In 24 consecutive phenol intranasally. another 20 per cent
cases of early and late hay fever the author applied pure In 75 per cent practically complete relief was obtained. In the results were fair or good; only one patient failed to