- Email: [email protected]
Role of complement in immunosuppression
174
Recent References
Thomson P. D., Till G. O., Woolliscroft J. 0. et al. (1990) Superoxide dismutase prevents lipid peroxidation in burned patients. Bums 16,(6), 406-408. Tompkins R. G. and Burke J. F. (1990) Progress in burn treatment and the use of artificial skin. Wortil. Sttrg. 14,(6), 819-824. Upfal M. and Doyle C. (1990) Medical management of hydrofluoric acid exposure. 1 &up. Med. 32, (8) 726-731. Vikhriev B. S., Kichemasov S. K. and Kochish A. I. (1990) Free transplantation of skin flaps with axial blood supply in IV 69-73. degree burns. Khirurgiya (Mask.) (6), Vila-Carbo J. J., Gutierrez-SanRoman C., Garcia-Sala-Viguer C. et al. (1990) Caustic bums of the stomach secondary to ingestion of acid in infants: importance of fibroendoscopy. An. Esp. P&ah: 32, (5), 451-454. Washio M., Onoyama K., Hirakata H. et al. (1990) A case of cardiac injury and acute renal failure induced by electrical burn. lap. 1. Med. 29, (3), 320-323. Wu W. A. (1990) Bums complicated by multiple organ failure report of 41 cases. Chung Hua Cheng Hsing Shao Shang Wai fi Tsa Chih 6, (2), 111-112, 157-158.
Yang J. Y. (1990) Clinical application of collagen sheet, YCWM, as 457-461. a bum wound dressing. Bums 16,(6),
Yarbrough D. R. (1990) Improving survival in the burned patient. 1. Sth. Carol. Med. Assoc. 86, (6), 347-349. Zellner P. R. (1990) The 1990 Everett Idris Evans Memorial Lecture. The inhalation injury. ]. Bum Care R.&a&i/. II, (6), 487-495. Zer M. and Freud E. (1990) T-tube intubation in the management of oesphageal fistula. Br. 1. Surg. 77,(9), 1074. Zha Y. K. (1990) Complications of soft tissue expander dilatation and its prevention. Chung Hua Cheng tiing Shao ShangWai Ko Tsa Chih 6, (2), 113-114.
Recent References and Abstracts are compiled by the Editor using Current Contents Clinical Medicine and Datastar Medex Medline supplied by Wakefield Postgraduate Medical Centre, West Yorkshire, UK.
Abstracts CLINICAL STUDIES
Role of complement in immunosuppression The role of complement fragments in inducing immunosuppress-
Benefits of human growth hormone
ion was assessed in patients with major and massive bums. Serum from these patients, which was shown to be immunosuppressive, was analysed for its ability to suppress mitogen-induced lymphocyte blastogenesis before and after exposure of the burn serum to temperatures which inactivate complement. Heat inactivation partially restored immune competence in the serum of all patients, although more so in the patients with only major burns (less than 60 per cent TBSA) than in the massive burns (greater than 60 per cent TBSA). In the latter patients additional suppressive factors of a different type are also found in the serum. Ferrara J. J., Dyess D. L., Luterman A. et al. (1990) In vitro effects of complement inactivation upon bum-associated cell mediated 571-574. immunosuppression. Am. Surg. 56,(9),
Forty patients between 2 and 18 years of age and with deep bums covering more than 39 per cent of the body surface area received, daily, either placebo or recombinant human growth hormone (rHGH) throughout their stay in hospital. Compared with the findings in the control patients the patients receiving rHGH showed a significant decrease in donor site healing times and a reduced length of hospital stay. This latter amounted to a reduction of 14 days (from 46 to 32 days) if the patient initially had a burn covering about 60 per cent of the body surface area. Hemdon D. N., Barrow R. E., Kunkel K. R. et al. (1990) Effects of recombinant human growth hormone on donor site healing in severely burned children. Ann. Surg. 212,(4), 424-431. Harmful serum aluminium levels
Human albumin solutions available for fluid resuscitation are contaminated with significant amounts of aluminium, the latter being associated with bone disease and encephalopathy. The serum of 12 patients with extensive bums who had received generous volumes of albumin solution showed elevated aluminium levels in eight of the 12 and toxic levels in three of the 12. Aluminium and creatinine levels in serum were directly and significantly correlated. No relationship was found between the volume of albumin solution given and the serum aluminium levels. The patients with the highest serum aluminium levels had the most severe burns and none of them survived. Klein G. L., Hemdon D. N., Rutan T. C. et al. (1990) Elevated serum aluminium levels in severely burned patients who are receiving large quantities of albumin. J. Bum Care Rehabi~. 11,(6), 526-530. 0 1991Butterworth-Heinemann 0305-4179/91/0201i&O2
Ltd
ANIMAL STUDIES
Early bum excision and endotoxin eHect
Sheep with burns covering 15 per cent of the body surface area had their wounds excised early to determine if this pattern ol treatment modified the marked accentuation of the lung and systemic response induced by the administration of endotoxin. Compared with the findings in non-excised burned sheep and nonburned sheep, the early excision prevented the continuing post bum lipid peroxidation and lung inflammation and decreased ths pulmonary hypertension and hypoxia. Demling R. H. and Lalonde C. (1990)Early burn excisior attenuates the postbum lung and systemic response to endotoxin Surgery 108,(l), 28-35.
Recent References
Thomson P. D., Till G. O., Woolliscroft J. 0. et al. (1990) Superoxide dismutase prevents lipid peroxidation in burned patients. Bums 16,(6), 406-408. Tompkins R. G. and Burke J. F. (1990) Progress in burn treatment and the use of artificial skin. Wortil. Sttrg. 14,(6), 819-824. Upfal M. and Doyle C. (1990) Medical management of hydrofluoric acid exposure. 1 &up. Med. 32, (8) 726-731. Vikhriev B. S., Kichemasov S. K. and Kochish A. I. (1990) Free transplantation of skin flaps with axial blood supply in IV 69-73. degree burns. Khirurgiya (Mask.) (6), Vila-Carbo J. J., Gutierrez-SanRoman C., Garcia-Sala-Viguer C. et al. (1990) Caustic bums of the stomach secondary to ingestion of acid in infants: importance of fibroendoscopy. An. Esp. P&ah: 32, (5), 451-454. Washio M., Onoyama K., Hirakata H. et al. (1990) A case of cardiac injury and acute renal failure induced by electrical burn. lap. 1. Med. 29, (3), 320-323. Wu W. A. (1990) Bums complicated by multiple organ failure report of 41 cases. Chung Hua Cheng Hsing Shao Shang Wai fi Tsa Chih 6, (2), 111-112, 157-158.
Yang J. Y. (1990) Clinical application of collagen sheet, YCWM, as 457-461. a bum wound dressing. Bums 16,(6),
Yarbrough D. R. (1990) Improving survival in the burned patient. 1. Sth. Carol. Med. Assoc. 86, (6), 347-349. Zellner P. R. (1990) The 1990 Everett Idris Evans Memorial Lecture. The inhalation injury. ]. Bum Care R.&a&i/. II, (6), 487-495. Zer M. and Freud E. (1990) T-tube intubation in the management of oesphageal fistula. Br. 1. Surg. 77,(9), 1074. Zha Y. K. (1990) Complications of soft tissue expander dilatation and its prevention. Chung Hua Cheng tiing Shao ShangWai Ko Tsa Chih 6, (2), 113-114.
Recent References and Abstracts are compiled by the Editor using Current Contents Clinical Medicine and Datastar Medex Medline supplied by Wakefield Postgraduate Medical Centre, West Yorkshire, UK.
Abstracts CLINICAL STUDIES
Role of complement in immunosuppression The role of complement fragments in inducing immunosuppress-
Benefits of human growth hormone
ion was assessed in patients with major and massive bums. Serum from these patients, which was shown to be immunosuppressive, was analysed for its ability to suppress mitogen-induced lymphocyte blastogenesis before and after exposure of the burn serum to temperatures which inactivate complement. Heat inactivation partially restored immune competence in the serum of all patients, although more so in the patients with only major burns (less than 60 per cent TBSA) than in the massive burns (greater than 60 per cent TBSA). In the latter patients additional suppressive factors of a different type are also found in the serum. Ferrara J. J., Dyess D. L., Luterman A. et al. (1990) In vitro effects of complement inactivation upon bum-associated cell mediated 571-574. immunosuppression. Am. Surg. 56,(9),
Forty patients between 2 and 18 years of age and with deep bums covering more than 39 per cent of the body surface area received, daily, either placebo or recombinant human growth hormone (rHGH) throughout their stay in hospital. Compared with the findings in the control patients the patients receiving rHGH showed a significant decrease in donor site healing times and a reduced length of hospital stay. This latter amounted to a reduction of 14 days (from 46 to 32 days) if the patient initially had a burn covering about 60 per cent of the body surface area. Hemdon D. N., Barrow R. E., Kunkel K. R. et al. (1990) Effects of recombinant human growth hormone on donor site healing in severely burned children. Ann. Surg. 212,(4), 424-431. Harmful serum aluminium levels
Human albumin solutions available for fluid resuscitation are contaminated with significant amounts of aluminium, the latter being associated with bone disease and encephalopathy. The serum of 12 patients with extensive bums who had received generous volumes of albumin solution showed elevated aluminium levels in eight of the 12 and toxic levels in three of the 12. Aluminium and creatinine levels in serum were directly and significantly correlated. No relationship was found between the volume of albumin solution given and the serum aluminium levels. The patients with the highest serum aluminium levels had the most severe burns and none of them survived. Klein G. L., Hemdon D. N., Rutan T. C. et al. (1990) Elevated serum aluminium levels in severely burned patients who are receiving large quantities of albumin. J. Bum Care Rehabi~. 11,(6), 526-530. 0 1991Butterworth-Heinemann 0305-4179/91/0201i&O2
Ltd
ANIMAL STUDIES
Early bum excision and endotoxin eHect
Sheep with burns covering 15 per cent of the body surface area had their wounds excised early to determine if this pattern ol treatment modified the marked accentuation of the lung and systemic response induced by the administration of endotoxin. Compared with the findings in non-excised burned sheep and nonburned sheep, the early excision prevented the continuing post bum lipid peroxidation and lung inflammation and decreased ths pulmonary hypertension and hypoxia. Demling R. H. and Lalonde C. (1990)Early burn excisior attenuates the postbum lung and systemic response to endotoxin Surgery 108,(l), 28-35.