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Role of herbal medicine in geriatrics
1 * S.rno.09.2
1
lie Orimo, I-I. Department of Geriatrics, Fmdty of Medicine, University of Tokyo. Tokyo, Japan
Recently- herbal medicine is widely used in the field of geriatrics and the purpose of my talk is to consider t sig~~~an~ of herbal medicine in the t~tment of the disease in the elderly. Firstly, big differences exisit among individuals in the elderly and usually herbal medicine is prescribed according to the “she” of the patients. Therefore, the herbal medicine enable us to conduct more individual&d mediie, so called “‘case by case” treatment of the patient. !%condly, immune functions of the organisms declines with aging and this is the main cause which makes achy people more susceptible to infections or malignant diseases. There are many agents among herbal medicine which activate immune functions, while few drugs with simular potency are avairable in the Western medicine. Therefore, as for the host defence purposes, herbat medicine is more advantageous than western medicine. Thirdly, chronic diseases is very common in the elderly and the long-term treatment is usually required in the management of the diseases in the elderly. Compared with the Western medicine, herbal medicine acts more slowly and is free from severe side effects. Therefore, it is safely used in the elderly. Fouthly, multiple pathology is the major characteritic of the diseases in the elderly and the average number of the diseases increases linealy with age. Due to the multiple pathology of the elderly, quite a number of medicines are usually given, which causes more adverse effects to occur in the elderly. Since herbal medicine have many pharmacological effect, number of drugs to be given to the patients can be kept at minimum. In view of these fact, it is concluded that herbal medicine is quite useful and fitted in the treatment of the diseases in the elderly.
Zhengang, W. and Zhenmin, N. Institute of Basic Medical Science, Peking Union Medical College Bejjing. 100730, People’s Republic of China
Recent years, many smart Chinese pharmacologists pay their attentions on the research of active components of traditional Chinese drugs or folklore herbal drugs. Plenty of the extracts from the herbers in anti-hypertension, anti-a~yt~c and other cardiovascular diseases for thousand years have been analysed and studied in details on the machinisms of their actions. It was proved that quite a few of them were potential celluar Caf+ channel blockers like verapamil and other kinds of Ca ++ blocker when they used in treatment. In this paper we focus on several compounds which widespread interests and advances are in evidence today. Tetrandrine (tet), an alkaloid isolated from Stephania tetrandra has been reported to posses a wide cardiac-v~~lar and anti-allergic activities both in vivo and in vitro, such as relaxing lots of smooth muscles in rabbit and pig, reducing the force of contraction of heart and cardiac rate in cat and mouth, antagonizing tracheal contraction induced by the anaphylactic mediators and inhibiting the release of mast cell induced by Calcium inophore A23187, compound 48/80 and radix trichosanthis in guinea-pig. All of the action above is proved to be produced by Ca+ influx blockade. On the research of effects of tet on ‘%a influx in tracheal smooth muscles, it was found that the rate of inhibition of histamine-stimulated and high K+-stimulated Ca+ influx were 11.1% and 38.3% (p < 0.05) respectively in dog and 48.7% (p < 0.05) and 33.3% (p -z 0.05) in guinea-pig by 60 ug/mg tet. The results suggested that tet block the potential-operated channel superior to the receptor-operated channel. Dau~cin~dau), extracts from ~e~spermum dauricum root, also a promising alkaloid serves as Caf channel
1
lie Orimo, I-I. Department of Geriatrics, Fmdty of Medicine, University of Tokyo. Tokyo, Japan
Recently- herbal medicine is widely used in the field of geriatrics and the purpose of my talk is to consider t sig~~~an~ of herbal medicine in the t~tment of the disease in the elderly. Firstly, big differences exisit among individuals in the elderly and usually herbal medicine is prescribed according to the “she” of the patients. Therefore, the herbal medicine enable us to conduct more individual&d mediie, so called “‘case by case” treatment of the patient. !%condly, immune functions of the organisms declines with aging and this is the main cause which makes achy people more susceptible to infections or malignant diseases. There are many agents among herbal medicine which activate immune functions, while few drugs with simular potency are avairable in the Western medicine. Therefore, as for the host defence purposes, herbat medicine is more advantageous than western medicine. Thirdly, chronic diseases is very common in the elderly and the long-term treatment is usually required in the management of the diseases in the elderly. Compared with the Western medicine, herbal medicine acts more slowly and is free from severe side effects. Therefore, it is safely used in the elderly. Fouthly, multiple pathology is the major characteritic of the diseases in the elderly and the average number of the diseases increases linealy with age. Due to the multiple pathology of the elderly, quite a number of medicines are usually given, which causes more adverse effects to occur in the elderly. Since herbal medicine have many pharmacological effect, number of drugs to be given to the patients can be kept at minimum. In view of these fact, it is concluded that herbal medicine is quite useful and fitted in the treatment of the diseases in the elderly.
Zhengang, W. and Zhenmin, N. Institute of Basic Medical Science, Peking Union Medical College Bejjing. 100730, People’s Republic of China
Recent years, many smart Chinese pharmacologists pay their attentions on the research of active components of traditional Chinese drugs or folklore herbal drugs. Plenty of the extracts from the herbers in anti-hypertension, anti-a~yt~c and other cardiovascular diseases for thousand years have been analysed and studied in details on the machinisms of their actions. It was proved that quite a few of them were potential celluar Caf+ channel blockers like verapamil and other kinds of Ca ++ blocker when they used in treatment. In this paper we focus on several compounds which widespread interests and advances are in evidence today. Tetrandrine (tet), an alkaloid isolated from Stephania tetrandra has been reported to posses a wide cardiac-v~~lar and anti-allergic activities both in vivo and in vitro, such as relaxing lots of smooth muscles in rabbit and pig, reducing the force of contraction of heart and cardiac rate in cat and mouth, antagonizing tracheal contraction induced by the anaphylactic mediators and inhibiting the release of mast cell induced by Calcium inophore A23187, compound 48/80 and radix trichosanthis in guinea-pig. All of the action above is proved to be produced by Ca+ influx blockade. On the research of effects of tet on ‘%a influx in tracheal smooth muscles, it was found that the rate of inhibition of histamine-stimulated and high K+-stimulated Ca+ influx were 11.1% and 38.3% (p < 0.05) respectively in dog and 48.7% (p < 0.05) and 33.3% (p -z 0.05) in guinea-pig by 60 ug/mg tet. The results suggested that tet block the potential-operated channel superior to the receptor-operated channel. Dau~cin~dau), extracts from ~e~spermum dauricum root, also a promising alkaloid serves as Caf channel