Role of macrophages in atherosclerosis

J Mol

Cell

Cardiol

20 (Supplement

V) (1988)

BS- -3ROLE

OF MACROPRAGES IN ATHEROSCLEROSIS. M.J. Mitchinson, Department of Pathology, Cambridge University. There is now good evidence that the foam cells of human atherosclerosis are Many of the known properties of macrophages might contribute to macrophages. plaque development in viva, and these will be reviewed briefly. Particular emphasis will be placed on the hypothesis that macrophages in the lesion are oxidising low density lipoprotein with the production of oxidised lipids, some of which are cytotoxic, and others affecting cell behaviour in the lesion. Mitchinson 1134-1140.

& Ball, Carew

Lancet et al.

1987; ii:146-149. Ball PNAS 1987; 84:7725-7729.

S.87

et

al.

Arch

Path

1987;

111: