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Rosette-forming glioneuronal tumor—reply
Human Pathology (2009) 40, 1510–1515
www.elsevier.com/locate/humpath
Correspondence
Rosette-forming glioneuronal tumor To the Editor: I recently read with interest the case report published in the June issue of HUMAN PATHOLOGY entitled “A rosette-forming glioneuronal tumor of the spinal cord: the first case of a rosetteforming glioneuronal tumor originating from the spinal cord,” by Anan and colleagues [1]. We have published a very similar case report in 2000 describing an aggressive glioneuronal neoplasm with “rosette” formation occurring in the spinal cord in a 44-year-old woman [2]. Subsequently, several additional cases have been reported in pediatric patients [3,4]. These CNS tumors are rare, especially in the spinal cord, but are now recognized in the WHO classification of CNS neoplasms [5]. Given that only a handful of cases have been reported in the spinal cord, the article by Anan and colleagues is a very important contribution to the literature. It is unfortunate, though, that the authors and reviewers of this case report did not recognize and discuss some of the other prior cases that exist in the literature. With so few cases reported, it is difficult to predict the biologic behavior of these neoplasms, but a couple of the reported cases have shown meningeal dissemination and recurrence [2,4] indicating that careful follow-up of patients is necessary. Sincerely, Brent T. Harris MD, PhD Department of Pathology Dartmouth Medical School Lebanon, NH 03756, USA
[4] Syed S, Rajaram V, Leonard JR, Perry A, Raghavan R. Mixed glioneuronal tumors of the spinal cord in two children. Acta Neuropathol 2006;111:53-5. [5] Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114:97-109.
Rosette-forming glioneuronal tumor—reply To the Editor: We received the letter from Dr Harris and acknowledge his report and the additional references. According to his opinion, their cases are very similar to our RGNT originating from the spinal cord. However, we emphasize that our “rosette” is entirely different from theirs. We think the cases he described are “glioneuronal tumor with neurophil-like islands” from the spinal cord. We must distinguish our benign RGNT from their glioneuronal tumor with neurophil-like islands. The differential point is a feature of the “rosette.” Sincerely, Mitsuhiro Anan MD Department of Neurosurgery, Oita University Oita 8795593, Japan doi:10.1016/j.humpath.2009.06.005
Tubular invasion and the morphogenesis of tumor budding in colorectal carcinoma
doi:10.1016/j.humpath.2009.06.004
References [1] Anan M, Inoue R, Ishii K, et al. A rosette-forming glioneuronal tumor of the spinal cord: the first case of a rosette-forming glioneuronal tumor originating from the spinal cord. HUM PATHOL 2009;40:757-908. [2] Harris BT, Horoupian DS. Spinal cord glioneuronal tumor with “rosetted” neuropil islands and meningeal dissemination: a case report. Acta Neuropathol 2000;100:575-9. [3] Rickert CH, Jasper M, Sepehrnia A, Jeibmann A. Rosetted glioneuronal tumour of the spine: clinical, histological and cytogenetic data. Acta Neuropathol 2006;112:231-3. 0046-8177/$ – see front matter © 2009 Elsevier Inc. All rights reserved.
To the Editor: The epithelial-mesenchymal transition (EMT) is a hot topic in tumor biology that, with the recognition of tumor budding as a prognostic factor, has found its way into the surgical pathology of colorectal cancer. As a morphogenetic program of embryonic gastrulation governed by WNT/βcatenin signaling, in executing the EMT, epithelia dissociate and migrate as fibroblast-like cells. Phenotypic similarities, particularly when highlighting tumor budding by pancytokeratin immunohistochemistry, are so striking that researchers and pathologists seem to fall prey to the temptation of
www.elsevier.com/locate/humpath
Correspondence
Rosette-forming glioneuronal tumor To the Editor: I recently read with interest the case report published in the June issue of HUMAN PATHOLOGY entitled “A rosette-forming glioneuronal tumor of the spinal cord: the first case of a rosetteforming glioneuronal tumor originating from the spinal cord,” by Anan and colleagues [1]. We have published a very similar case report in 2000 describing an aggressive glioneuronal neoplasm with “rosette” formation occurring in the spinal cord in a 44-year-old woman [2]. Subsequently, several additional cases have been reported in pediatric patients [3,4]. These CNS tumors are rare, especially in the spinal cord, but are now recognized in the WHO classification of CNS neoplasms [5]. Given that only a handful of cases have been reported in the spinal cord, the article by Anan and colleagues is a very important contribution to the literature. It is unfortunate, though, that the authors and reviewers of this case report did not recognize and discuss some of the other prior cases that exist in the literature. With so few cases reported, it is difficult to predict the biologic behavior of these neoplasms, but a couple of the reported cases have shown meningeal dissemination and recurrence [2,4] indicating that careful follow-up of patients is necessary. Sincerely, Brent T. Harris MD, PhD Department of Pathology Dartmouth Medical School Lebanon, NH 03756, USA
[4] Syed S, Rajaram V, Leonard JR, Perry A, Raghavan R. Mixed glioneuronal tumors of the spinal cord in two children. Acta Neuropathol 2006;111:53-5. [5] Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114:97-109.
Rosette-forming glioneuronal tumor—reply To the Editor: We received the letter from Dr Harris and acknowledge his report and the additional references. According to his opinion, their cases are very similar to our RGNT originating from the spinal cord. However, we emphasize that our “rosette” is entirely different from theirs. We think the cases he described are “glioneuronal tumor with neurophil-like islands” from the spinal cord. We must distinguish our benign RGNT from their glioneuronal tumor with neurophil-like islands. The differential point is a feature of the “rosette.” Sincerely, Mitsuhiro Anan MD Department of Neurosurgery, Oita University Oita 8795593, Japan doi:10.1016/j.humpath.2009.06.005
Tubular invasion and the morphogenesis of tumor budding in colorectal carcinoma
doi:10.1016/j.humpath.2009.06.004
References [1] Anan M, Inoue R, Ishii K, et al. A rosette-forming glioneuronal tumor of the spinal cord: the first case of a rosette-forming glioneuronal tumor originating from the spinal cord. HUM PATHOL 2009;40:757-908. [2] Harris BT, Horoupian DS. Spinal cord glioneuronal tumor with “rosetted” neuropil islands and meningeal dissemination: a case report. Acta Neuropathol 2000;100:575-9. [3] Rickert CH, Jasper M, Sepehrnia A, Jeibmann A. Rosetted glioneuronal tumour of the spine: clinical, histological and cytogenetic data. Acta Neuropathol 2006;112:231-3. 0046-8177/$ – see front matter © 2009 Elsevier Inc. All rights reserved.
To the Editor: The epithelial-mesenchymal transition (EMT) is a hot topic in tumor biology that, with the recognition of tumor budding as a prognostic factor, has found its way into the surgical pathology of colorectal cancer. As a morphogenetic program of embryonic gastrulation governed by WNT/βcatenin signaling, in executing the EMT, epithelia dissociate and migrate as fibroblast-like cells. Phenotypic similarities, particularly when highlighting tumor budding by pancytokeratin immunohistochemistry, are so striking that researchers and pathologists seem to fall prey to the temptation of