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Routine laboratory variables may be used to predict imminent hospitalization in Congestive Heart Failure (CHF) patients
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ABSTRACTS / Journal of Molecular and Cellular Cardiology 42 (2007) S145–S161
Acknowledgments The study was supported by the research projects of the Charles University Prague No.MSM0021620817 and MZO 00179906. Keywords: Heart failure; Ventricular function doi:10.1016/j.yjmcc.2007.03.504
Low-intensity exercise training delays onset of heart failure and improves survival in female SHHF rats Adam J. Chicco, Sylvia A. McCune, Meredith L. Rees, Genevieve C. Sparagna, Kurt D. Marshall, Russell L. Moore. University of Colorado, Boulder, CO Exercise training improves functional capacity and quality of life in patients with heart failure (HF); however, its effect on the progression of the disease and associated mortality remains unclear. The present study was conducted to determine if chronic low-intensity exercise training (LIET) would delay the onset of decompensated HF and improve survival in female spontaneously hypertensive heart failure (SHHF) rats, a well-characterized genetic animal model of idiopathic dilated cardiomyopathy. Female SHHF rats with compensated LV hypertrophy (16 months old) were trained on a motorized treadmill at 14.5 m/min, 45 min/day, 3 days/week until rats developed signs of overt HF or needed to be sacrificed due to other age-related complications. LIET significantly delayed mortality resulting from HF (P < 0.004) with the LIET rats living an average of 4 months longer than sedentary rats. All-cause mortality was also significantly delayed by LIET compared to sedentary rats (P < 0.05). However, LIET had no effect on cardiac morphology, contractile function, cardiac antioxidant enzyme protein expression or calcium handling proteins compared to sedentary animals at the time of sacrifice. LIET did significantly improve the enzymatic activity of cytochrome oxidase (complex IV of the respiratory chain) in cardiac mitochondria and levels of tetralinoleoyl cardiolipin (L4CL), a mitochondrial phospholipid that is required for optimal mitochondrial energy metabolism. The present study indicates that LIET improves survival in the SHHF model of HF, which may be due in part to a preservation of L4CL and mitochondrial energy metabolism. Keywords: Heart failure; Prevention; Mitochondria doi:10.1016/j.yjmcc.2007.03.505
Routine laboratory variables may be used to predict imminent hospitalization in congestive heart failure (CHF) patients M.S. Munir, D. Lai, A.H. Ahmed, K.J. Shankar, A.M. Brewer, I.V. Stupin, S.W. Casscells, R.M. Delgado. THI, Houston, TX
Introduction: We sought to determine the use of routine laboratory variables measured during out-patient visits in predicting de-compensation in CHF patients through mid-term follow-up. Methods: Ambulatory CHF patients visiting the Texas Heart Institute from July 2004 to October 2005 were included in the study. Data on BNP, BUN and creatinine from the first clinic visit falling within the study period were collected. Elevated BNP, BUN and creatinine were defined as > 73 μg/dl, > 35 mg/dl and > 1.5 mg/dl, respectively. Patients were followed for hospitalization from de-compensated CHF through the study period. Logistic regression statistics was used to determine the association of elevated BNP, BUN and creatinine during outpatient setting with de-compensation. The study was approved by the Texas Heart Institute, IRB. Results: Out of 226 patients included in the study, 40 were hospitalized with de-compensation. According to logistic regression, patients with BNP > 73 μg/dl were at a significantly greater risk of hospitalization due to de-compensated CHF during mid term follow-up [OR = 13.06; CI 95% 3.04–56.15]. Plasma creatinine > 1.5 mg/dl and BUN > 35 mg/dl were also associated with greater risk of de-compensation. The odds ratios were 2.59 (CI95% 1.23–5.42) and 3.36 (CI95% 1.54–7.33), respectively. Conclusion: Elevated BNP, BUN and creatinine at outpatient clinic visits may be predictive of future CHF de-compensation. These variables may be used to assess the risk of hospitalization in CHF patients. Keywords: Cardiology; Heart failure doi:10.1016/j.yjmcc.2007.03.506
Correlation of temperature with common prognostic markers of heart failure (HF) M.S. Munir, A.H. Ahmed, K.J. Shankar, I.V. Stupin, A.M. Brewer, G. Poulin, S.W. Casscells, R.M. Delgado. THI, Houston TX Background: Worsening heart failure (HF) may affect thermo-genesis due to tissue hypo-perfusion thus lowering body temperature (T). We sought to determine the association of T with other markers of HF. Methods: Records of 226 patients visiting the Texas Heart Institute (THI) were reviewed from 07/04 to 09/05. Data on T, other vital signs, body mass index (BMI) and salient HF prognostic factors were collected. T, BMI, Na, BNP, BUN, creatinine and BUN/creatinine ratio were available for over 95% of patients. Spearman's coefficient (r) was calculated to determine correlation of T with mentioned factors. The patients were assigned to “normal body temperature” (NBT) and “low body temperature” (LBT) sub-populations based on an arbitrary chosen cut-off of 97 °F. Differences in values of each variable were determined by t. test. Variables with scant data were excluded. The study complied with standard IRB regulations.
ABSTRACTS / Journal of Molecular and Cellular Cardiology 42 (2007) S145–S161
Acknowledgments The study was supported by the research projects of the Charles University Prague No.MSM0021620817 and MZO 00179906. Keywords: Heart failure; Ventricular function doi:10.1016/j.yjmcc.2007.03.504
Low-intensity exercise training delays onset of heart failure and improves survival in female SHHF rats Adam J. Chicco, Sylvia A. McCune, Meredith L. Rees, Genevieve C. Sparagna, Kurt D. Marshall, Russell L. Moore. University of Colorado, Boulder, CO Exercise training improves functional capacity and quality of life in patients with heart failure (HF); however, its effect on the progression of the disease and associated mortality remains unclear. The present study was conducted to determine if chronic low-intensity exercise training (LIET) would delay the onset of decompensated HF and improve survival in female spontaneously hypertensive heart failure (SHHF) rats, a well-characterized genetic animal model of idiopathic dilated cardiomyopathy. Female SHHF rats with compensated LV hypertrophy (16 months old) were trained on a motorized treadmill at 14.5 m/min, 45 min/day, 3 days/week until rats developed signs of overt HF or needed to be sacrificed due to other age-related complications. LIET significantly delayed mortality resulting from HF (P < 0.004) with the LIET rats living an average of 4 months longer than sedentary rats. All-cause mortality was also significantly delayed by LIET compared to sedentary rats (P < 0.05). However, LIET had no effect on cardiac morphology, contractile function, cardiac antioxidant enzyme protein expression or calcium handling proteins compared to sedentary animals at the time of sacrifice. LIET did significantly improve the enzymatic activity of cytochrome oxidase (complex IV of the respiratory chain) in cardiac mitochondria and levels of tetralinoleoyl cardiolipin (L4CL), a mitochondrial phospholipid that is required for optimal mitochondrial energy metabolism. The present study indicates that LIET improves survival in the SHHF model of HF, which may be due in part to a preservation of L4CL and mitochondrial energy metabolism. Keywords: Heart failure; Prevention; Mitochondria doi:10.1016/j.yjmcc.2007.03.505
Routine laboratory variables may be used to predict imminent hospitalization in congestive heart failure (CHF) patients M.S. Munir, D. Lai, A.H. Ahmed, K.J. Shankar, A.M. Brewer, I.V. Stupin, S.W. Casscells, R.M. Delgado. THI, Houston, TX
Introduction: We sought to determine the use of routine laboratory variables measured during out-patient visits in predicting de-compensation in CHF patients through mid-term follow-up. Methods: Ambulatory CHF patients visiting the Texas Heart Institute from July 2004 to October 2005 were included in the study. Data on BNP, BUN and creatinine from the first clinic visit falling within the study period were collected. Elevated BNP, BUN and creatinine were defined as > 73 μg/dl, > 35 mg/dl and > 1.5 mg/dl, respectively. Patients were followed for hospitalization from de-compensated CHF through the study period. Logistic regression statistics was used to determine the association of elevated BNP, BUN and creatinine during outpatient setting with de-compensation. The study was approved by the Texas Heart Institute, IRB. Results: Out of 226 patients included in the study, 40 were hospitalized with de-compensation. According to logistic regression, patients with BNP > 73 μg/dl were at a significantly greater risk of hospitalization due to de-compensated CHF during mid term follow-up [OR = 13.06; CI 95% 3.04–56.15]. Plasma creatinine > 1.5 mg/dl and BUN > 35 mg/dl were also associated with greater risk of de-compensation. The odds ratios were 2.59 (CI95% 1.23–5.42) and 3.36 (CI95% 1.54–7.33), respectively. Conclusion: Elevated BNP, BUN and creatinine at outpatient clinic visits may be predictive of future CHF de-compensation. These variables may be used to assess the risk of hospitalization in CHF patients. Keywords: Cardiology; Heart failure doi:10.1016/j.yjmcc.2007.03.506
Correlation of temperature with common prognostic markers of heart failure (HF) M.S. Munir, A.H. Ahmed, K.J. Shankar, I.V. Stupin, A.M. Brewer, G. Poulin, S.W. Casscells, R.M. Delgado. THI, Houston TX Background: Worsening heart failure (HF) may affect thermo-genesis due to tissue hypo-perfusion thus lowering body temperature (T). We sought to determine the association of T with other markers of HF. Methods: Records of 226 patients visiting the Texas Heart Institute (THI) were reviewed from 07/04 to 09/05. Data on T, other vital signs, body mass index (BMI) and salient HF prognostic factors were collected. T, BMI, Na, BNP, BUN, creatinine and BUN/creatinine ratio were available for over 95% of patients. Spearman's coefficient (r) was calculated to determine correlation of T with mentioned factors. The patients were assigned to “normal body temperature” (NBT) and “low body temperature” (LBT) sub-populations based on an arbitrary chosen cut-off of 97 °F. Differences in values of each variable were determined by t. test. Variables with scant data were excluded. The study complied with standard IRB regulations.