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Rubella embryopathy
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D,cembcr 15. 1963 Am . .J, Obst. & Gynec.
Selected abstracts
mode of administration to the progestin studied, was used. Because of continuation of the study, the identity of the compound under study is not as yet disclosed. Of those receiving solution A, 18.5 per cent had abortions, and solution B, 21.7 per cent had abortions. Thus far the evidence does not support the claims for progesterone treatment in first trimester abortions. It is suggested that declining progesterone secretion, as reflected by falling urinary pregnanediol levels, may not represent the cause of the abortive process, but may represent instead the result. Edward E. Wallach
Taylor: Nuclear Sex of Embryonic Tumors, p. 377. Eight teratomas of 50 and 4 other embryonic tumors out of 49 were examined and showed sex chromatin discrepancies. The authors suggest that these discrepancies express abnormal sex chromosome complements produced by errors of mitosis, such as nondisjunction or anaphase lagging of the sex chromosomes at the inception of the tumor or shortly thereafter.
weeks of pregnancy, and single defects ( 4) all occurred between 11 and 15 weeks. Of the 32 pregnancies in which the rash appeared during the first trimester, embryopathy occurred in 11 (34 per cent). Edward E. Wallach
Pierson and Lockhart: Effect of Menstruation on Simple Reaction and Movement Time, p. 794. Twenty-five nulliparas aged 20 to 25 were studied for quantitative simple reaction time and speed of arm movement. Measurements were carried out 4 times during the menstrual ~ycle, on days 2, 8, and 18, and 2 days prior to menstruation. There were no significant change$ in reaction time, speed of movement, or relationship of the two during the cycle. The authors suggest that the accident proneness and diminished efficiency which have previously been described during the premenstrual period, and at the time of menstruation, are due to inattentiveness secondary to di~comfort and distractions. Edward E. IVallach
Edward E. W a/lack March, 1963. *Liggins, G. C., and Phillips, L. I.: Rubella Embryopathy, p. 711. *Pierson, W. R., and Lockhart, A.: Effect of Menstruation on Simple Reaction and Movement Time, p. 794.
Liggins and Phillips: Rubella Embryopathy, p. 711. The outcome of 89 pregnancies complicated by rubella, during the 1959 epidemic in New Zealand, was studied. Each case of rubella was well documented and each pregnancy at the time of the infection had been progressing normally. Fifteen pregnancies were terminated by therapeutic abortion; seven others terminated in spontaneous abortion. Three infants died, each with major malformations, and 2 were attributed to rubella. In each of the 12 cases which had embryopathies ascribed to rubella, maternal rubella had occurred in the first 15 weeks of pregnancy. The incidence of babies with malformations was 100 per cent with maternal rubella during the first 4 weeks of pregnancy, 50 per cent in the fifth to eighth weeks, 13 per cent in the ninth to twelfth weeks, and 12 per cent in the thirteenth to sixteenth weeks. Multiple defects ( 8) all occurred in the first 8
Bulletin of the Sloane Hospital for Women Vol. IX, No.1, 1963. Lesneski, A. C., and James, L. S.: Heart Rate Changes in the Newborn During the First Hour of Life, p. 3. O'Leary, James A., and Tovell, Harold M. M .. Thrombotic Thrombocytopenic Purpura Complicating Pregnancy, p. 6.
Canadian Medical Association Journal Vol. 88, No. 15, April13, 1963. Hannah, W. J.: Prevention of Urinary Tract Infections After Vaginal Surgery, p. 803.
Clinical Obstetrics and Gynecology Vol. 6, No. 1, March, 1963. Krantz, Kermit E., editor: Symposium on the Physiology of the Placenta. Corner, George W., Jr.: The Fetal and Maternal Circulation of the Placenta, p. 17. Krantz, Kermit E., and Parker, Joe C.: Contractile Properties of the Smooth Muscle in the Human Placenta, p. 26. McGaughey, Harry S., Jr., Johnson, Wayne L., and Scoggin, W. A.: Fetomaternal Exchange at Term in Normal Human Gestation, p. 39.
D,cembcr 15. 1963 Am . .J, Obst. & Gynec.
Selected abstracts
mode of administration to the progestin studied, was used. Because of continuation of the study, the identity of the compound under study is not as yet disclosed. Of those receiving solution A, 18.5 per cent had abortions, and solution B, 21.7 per cent had abortions. Thus far the evidence does not support the claims for progesterone treatment in first trimester abortions. It is suggested that declining progesterone secretion, as reflected by falling urinary pregnanediol levels, may not represent the cause of the abortive process, but may represent instead the result. Edward E. Wallach
Taylor: Nuclear Sex of Embryonic Tumors, p. 377. Eight teratomas of 50 and 4 other embryonic tumors out of 49 were examined and showed sex chromatin discrepancies. The authors suggest that these discrepancies express abnormal sex chromosome complements produced by errors of mitosis, such as nondisjunction or anaphase lagging of the sex chromosomes at the inception of the tumor or shortly thereafter.
weeks of pregnancy, and single defects ( 4) all occurred between 11 and 15 weeks. Of the 32 pregnancies in which the rash appeared during the first trimester, embryopathy occurred in 11 (34 per cent). Edward E. Wallach
Pierson and Lockhart: Effect of Menstruation on Simple Reaction and Movement Time, p. 794. Twenty-five nulliparas aged 20 to 25 were studied for quantitative simple reaction time and speed of arm movement. Measurements were carried out 4 times during the menstrual ~ycle, on days 2, 8, and 18, and 2 days prior to menstruation. There were no significant change$ in reaction time, speed of movement, or relationship of the two during the cycle. The authors suggest that the accident proneness and diminished efficiency which have previously been described during the premenstrual period, and at the time of menstruation, are due to inattentiveness secondary to di~comfort and distractions. Edward E. IVallach
Edward E. W a/lack March, 1963. *Liggins, G. C., and Phillips, L. I.: Rubella Embryopathy, p. 711. *Pierson, W. R., and Lockhart, A.: Effect of Menstruation on Simple Reaction and Movement Time, p. 794.
Liggins and Phillips: Rubella Embryopathy, p. 711. The outcome of 89 pregnancies complicated by rubella, during the 1959 epidemic in New Zealand, was studied. Each case of rubella was well documented and each pregnancy at the time of the infection had been progressing normally. Fifteen pregnancies were terminated by therapeutic abortion; seven others terminated in spontaneous abortion. Three infants died, each with major malformations, and 2 were attributed to rubella. In each of the 12 cases which had embryopathies ascribed to rubella, maternal rubella had occurred in the first 15 weeks of pregnancy. The incidence of babies with malformations was 100 per cent with maternal rubella during the first 4 weeks of pregnancy, 50 per cent in the fifth to eighth weeks, 13 per cent in the ninth to twelfth weeks, and 12 per cent in the thirteenth to sixteenth weeks. Multiple defects ( 8) all occurred in the first 8
Bulletin of the Sloane Hospital for Women Vol. IX, No.1, 1963. Lesneski, A. C., and James, L. S.: Heart Rate Changes in the Newborn During the First Hour of Life, p. 3. O'Leary, James A., and Tovell, Harold M. M .. Thrombotic Thrombocytopenic Purpura Complicating Pregnancy, p. 6.
Canadian Medical Association Journal Vol. 88, No. 15, April13, 1963. Hannah, W. J.: Prevention of Urinary Tract Infections After Vaginal Surgery, p. 803.
Clinical Obstetrics and Gynecology Vol. 6, No. 1, March, 1963. Krantz, Kermit E., editor: Symposium on the Physiology of the Placenta. Corner, George W., Jr.: The Fetal and Maternal Circulation of the Placenta, p. 17. Krantz, Kermit E., and Parker, Joe C.: Contractile Properties of the Smooth Muscle in the Human Placenta, p. 26. McGaughey, Harry S., Jr., Johnson, Wayne L., and Scoggin, W. A.: Fetomaternal Exchange at Term in Normal Human Gestation, p. 39.