Ruminant cluster WC15

Veterinary immunology and immunopathology

Veterinary Immunology and lmmunopathology 52 (1996) 263

ELSEVIER

Ruminant cluster WC 15 C.J. Howard Institute jiv

Animal

Heulth.

Compton Laboratory.

Compton,

Newhury,

RG20 7NN, UK

Abstract

A new cluster is described, WC15, comprised an antigen an antigen expressed on erythrocytes

of five monoclonal

antibodies

which recognise

1. Introduction Four monoclonal antibodies (mAbs) belong to this cluster: IL-Al37 (3W-2481, ANA8 (3W-3621, IL-Al35 (3W-405) and IL-Al38 (3W-448). Inhibition of binding studies with these mAbs and another, IL-A160, not included in the workshop indicated that all five recognised the same antigen (Naessens et al., 1996; Naessens, J., Nthale, J.M. and Muiya, P., 1996. Biochemical analysis of preliminary clusters in the non-lineage panel. Vet. Immunol. Immunopathol., 52: . . ._. . . 1.

2. Immunochemistry No data were generated

within the workshop.

3. Cellular expression These monoclonal

antibodies

bind specifically

to erythrocytes

from Bos tuurus and

Bos indicus.

4. Function

and human homologue

No biological

function

or human homologue

has been identified.

Reference Naessens,

J.,

Nthale,

J.M. and Muiya, P., 1996. Biochemical analysis

panel. Vet. Immunol. Immunopathol.,

0165.2427/96/$15.00

Published by

PII SO1 65.2427(96)05575-4

52: 347-356.

Elsevier Science

B.V

of preliminary clusters in the non-lineage