- Email: [email protected]
S178 Detection of prostate cancer at low volume prostate and low PSA range
S178
Detection of prostate cancer at low volume prostate and low PSA range Eur Urol Suppl 2013;12;e1286
Bajramovic S., Junuzovic D. Clinical centre University of Sarajevo, Urology Clinic, Sarajevo, Bosnia and Herzegovina INTRODUCTION & OBJECTIVES: In daily practice one of the main issue in prostate cancer diagnosis is to identify men with cancers who can benefit from early diagnosis. Sometimes, it is difficult to decide who need to go for prostate biopsy at low PSA range. MATERIALS & METHODS: From January 2006 to January 2012, a total of 1570 patients were included in the study. The Abbot PSA assay was used, and pretreatment prostate specific antigen level (PSA) was measured prior digital rectal examination (DRE) and transrectal ultrasound (TRUS) guided biopsies. The individual ANN predictions were generated with the use of ANN application for the Abbot PSA and free PSA assays, which relies on age, PSA, percent free prostate specific antigen (%fPSA), prostate volume, and DRE. Diagnostic validity of total prostate specific antigen (tPSA), (%fPSA) and the ANN was evaluated by ROC curve analysis. RESULTS: PCa revealed at 251 pts (28,33%) with PSA below 10 ng/ml. PCa revealed at 20 pts with PSA below 3 ng/ml (8,2%), while most of the patients were identified in the PSA range from 4-10 ng/ml (84,5%), while PCa revealed at 45 pts (17,9%) with prostate volume below 40 ml. For the PSA range below 3ng/ml ANN predicition was 0,758, p=0,043 while it was 0,651 and 0,717 for PSA range below 2ng/ml and PSA range 2-2,5ng/ml respectively. For all PSA range ROC curve analysis for ANN was superior than individual ROC curve analysis for each parameter. CONCLUSIONS: Even in low PSA range and low prostate volume it is easy to identify who need to go for prostate biopsy using ANN combining several parameters.
Detection of prostate cancer at low volume prostate and low PSA range Eur Urol Suppl 2013;12;e1286
Bajramovic S., Junuzovic D. Clinical centre University of Sarajevo, Urology Clinic, Sarajevo, Bosnia and Herzegovina INTRODUCTION & OBJECTIVES: In daily practice one of the main issue in prostate cancer diagnosis is to identify men with cancers who can benefit from early diagnosis. Sometimes, it is difficult to decide who need to go for prostate biopsy at low PSA range. MATERIALS & METHODS: From January 2006 to January 2012, a total of 1570 patients were included in the study. The Abbot PSA assay was used, and pretreatment prostate specific antigen level (PSA) was measured prior digital rectal examination (DRE) and transrectal ultrasound (TRUS) guided biopsies. The individual ANN predictions were generated with the use of ANN application for the Abbot PSA and free PSA assays, which relies on age, PSA, percent free prostate specific antigen (%fPSA), prostate volume, and DRE. Diagnostic validity of total prostate specific antigen (tPSA), (%fPSA) and the ANN was evaluated by ROC curve analysis. RESULTS: PCa revealed at 251 pts (28,33%) with PSA below 10 ng/ml. PCa revealed at 20 pts with PSA below 3 ng/ml (8,2%), while most of the patients were identified in the PSA range from 4-10 ng/ml (84,5%), while PCa revealed at 45 pts (17,9%) with prostate volume below 40 ml. For the PSA range below 3ng/ml ANN predicition was 0,758, p=0,043 while it was 0,651 and 0,717 for PSA range below 2ng/ml and PSA range 2-2,5ng/ml respectively. For all PSA range ROC curve analysis for ANN was superior than individual ROC curve analysis for each parameter. CONCLUSIONS: Even in low PSA range and low prostate volume it is easy to identify who need to go for prostate biopsy using ANN combining several parameters.