S77. Non-invasive closed-circuit brain stimulation for gait rehabilitation of patients with Parkinsonian syndrome

S77. Non-invasive closed-circuit brain stimulation for gait rehabilitation of patients with Parkinsonian syndrome

e170 Abstracts / Clinical Neurophysiology 129 (2018) e142–e212 S75. Polysomnographic parameters and their computed tomography brain morphology corre...

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e170

Abstracts / Clinical Neurophysiology 129 (2018) e142–e212

S75. Polysomnographic parameters and their computed tomography brain morphology correlates in depression—Madhu Nayak *, Amil Hayat Khan, Mridul Sharma (India) ⇑

Presenting author.

Introduction: Sleep in depression is characterized by a reduction of slow wave sleep (SWS) and shortening of the interval between sleep onset and the occurrence of the first REM period (i.e. REM latency). In this study, the authors sought to study and compare the polysomnographic patterns in patients with major depressive disorder and their first degree relatives and also to establish any correlation between sleep parameters and brain ventricular system measurements in patients with depression. Methods: In this study, patients (N = 15) with ICD-10 clinical diagnosis of unipolar depression (N = 7) or recurrent depressive disorder (N = 8) along with their first degree male relatives (N = 15) and normal controls (N = 15) were enrolled. All the participants underwent two nights of polysomnography. The polysomnographic data was collected and analyzed using the Sandman Elite Polysomnography System. Computed Tomography was used for neuroimaging of brain. Results: Significant difference was observed between the three groups in terms of total sleep period, sleep onset latency, stage 1 latency, REM duration, REM percentage of total sleep time and REM latency. Ventricular brain ratio (VBR) was found to be significantly more in the patient group (7.26 ± 1.55) and Bicaudate ratio (BCR) showed significantly more in patients group (0.140 ± 0.047). Bifrontal ratio was also observed to be significantly more in the patient group. Conclusion: This study failed to find any correlation between polysomnographic parameters and ventricular dysmorphology. doi:10.1016/j.clinph.2018.04.435

S76. Effectiveness of Kinesio tape on wrist extensor muscles in children with obstetric brachial plexus injuries—Hiba A. Awooda 1,*, Rufida Kamal-Eldeen 1, Gehan Abd El-Maksoud 2 (1 Sudan, 2 Egypt) ⇑

Presenting author.

Introduction: Obstetric brachial plexus injury (OBPI) is partial or total paralysis of the upper limb due to trauma of brachial plexus during delivery, wrist flexion is a common deformity that develops in children with Erb’s Palsy. Kinesio tape (KT) is thin and elastic tape that can be extended up to 120–140% of its original length, this elasticity result in less constraints. KT allows a partial to full range of motion for the applied muscles and joints with different pulling forces to skin, it can be used for both muscle relaxation and to facilitate muscle contraction depending on its. The purpose of the study was to assess the effect of Kinesio tape in stimulation of the extensor muscle wrist contraction in children with Erb’s palsy. Methods: This is a hospital-based controlled study conducted in Al-taher marzouq clinic at Khartoum, Sudan in 2015. Thirty children with Erb’s palsy were involved, their age ranged from one month to three years. They were divided into two matched groups (control and study) 15 children each. They evaluated by Active movement scale and Gilbert-Raimondi classification before and after fifteen successive sessions of the treatment program. Control group received selected physical therapy program included the following: Neuromuscular stimulation, for wrist extension for 20 min. Facilitation of muscle contraction for all weak muscle of upper limb.

Exceoreceptor such as brushing, brief ice scratch. Proproceptor such as taping, approximation, quick stretch (Strengthen Exercise). Very gentle stretch for subscapularis, prontator and wrist flexor. Graduated active exercise (active assist, active free, active resist). Facilitate of basic hand skill (reaching, grasping, released, bilateral hand use). Weight bearing exercise from prone on hand, side sitting and quadruped positions. While and study group received Kinesio tape in addition to the program given to control group. Results: The results of this study revealed statistically significant improvement in both group while the favor improvement in wrist extensor muscles in children with Erb’s palsy in study group (Active movement scale p = 0.006) (Gilbert Raimondi classification p = 0.02). Conclusion: Using the Kinesio tape in addition to selected physical therapy program is beneficial therapeutic technique to improve active wrist extension and functional activities in children with Erb’s palsy. doi:10.1016/j.clinph.2018.04.436

S77. Non-invasive closed-circuit brain stimulation for gait rehabilitation of patients with Parkinsonian syndrome—Mitsuya Horiba *, Yoshino Ueki, Tatsuya Mima, Yasuyuki Takamatsu, Kento Sahashi, Shogo Itamoto, Yoko Shimizu, Masao Matsuhashi, Jun Mizutani, Noriyuki Matsukawa, Ikuo Wada (Japan) ⇑

Presenting author.

Introduction: Gait disturbance of Parkinsonian syndrome is characterized by dysrhythmic gait cycle including freezing, small steps and slowness. These symptoms are often not sufficiently responsive to dopaminergic therapy. Recently, we developed new rehabilitation system using non-invasive closed–circuit brain stimulation targeting on dysrhythmic gait dysfunction. Methods: The objective of this study is to investigate whether the oscillatory closed-circuit brain stimulation mimicking the appropriate gait cycle can modulate the gait speed and cycle in patients with parkinsonian syndrome. Six patients with Parkinsonian syndrome participated in this study. Three were diagnosed as Parkinson’s disease, two as corticobasal syndrome and one as vascular parkinsonism. Before gait rehabilitation, we decided optimal brain stimulation frequency to each subject as 1/averaged gait cycle when they were best on condition. All participants performed gait rehabilitation for total ten days which contained 4 sessions (4 min. walk and 3 min. rest) per each day. During gait rehabilitation, slow oscillatory DC stimulation (current intensity 0–2 mA) was applied over ipsilateral cerebellum as symptom dominant side, which was triggered by their flat foot switch attached to the ipsilateral heels. Closed-circuit system enabled the implementation of the oscillatory brain stimulation with a fixed pre-set phase lag with respect to the intrinsic gait cycle. Ten m gait speed, cadence, laterality of gait cycle and frozen of gait questionnaire (FOGQ) were evaluated before and after gait rehabilitation. Results: Gait speed and cadence were significantly increased after gait rehabilitation (speed: 98 ± 39 cm/s before and 116 ± 38 cm/s after, cadence: 114 ± 18 steps/min before and 124 ± 20 steps/min after). Laterality of gait cycle and FOGQ were significantly decreased after the rehabilitation (laterality: 0.07 ± 0.05 before and 0.0021 ± 0.004 after, FOGQ: 10 ± 7 before and 7 ± 5 after). Conclusion: Closed-circuit brain stimulation during walking is useful method to parkinsonian gait disturbance possibly by normalizing dysrhythmic and lateralized gait control system in patients with

Abstracts / Clinical Neurophysiology 129 (2018) e142–e212

Parkinsonian syndrome. This new system may provide the personalized rehabilitation in patients with Parkinson related disorders. doi:10.1016/j.clinph.2018.04.437

S78. MRI assessment of neck muscles in patients with unilateral cervical radiculopathy patients—Joon Shik Yoon *, Seok Kang, Hanboram Choi, Kwang-Jae Lee, Jang-Yeol Kim, Seong-Ho Son (Republic of Korea) ⇑

Presenting author.

Introduction: Several recent studies have investigated the changes of multifidus muscles in patients with chronic neck pain. Also, the longus coli muscle, one of the deep cervical flexor muscles, showed smaller cross sectional area (CSA) in patients with chronic neck pain in comparison with healthy people. To our knowledge, there is no study investigating the association between morphological features of cervical paravertebral muscles in electrodiagnosed cervical radiculopathy patients. In this study, we investigate the change in CSA and composition of the cervical flexor and multifidus muscles using the digital data from MRIs of patients with electrodiagnosed cervical radiculopathy. Methods: Twenty-four patients with unilateral cervical radicular pain who had cervical MRI and EMG examinations between 1 January 2015 and 2016 were retrospectively analysed. The inclusion criteria were as follows: (1) patients with the symptoms of unilateral cervical pain or referral to one upper limb, (2) diagnosis of cervical radiculopathy in EMG. Exclusion criteria included: (1) a history of cervical surgery; (2) a history of spinal fracture or injuries; (3) primary or metastatic spinal tumor. Axial slice at the level of C4-5 mid disc level image was selected to calculate the muscle CSA, with their maximal CSAs. Total CSA and functional CSA measurements of the bilateral longus colli, sternocleidomastoid and multifidus muscles were measured by using Image J (version 1.43, National Institutes of Health, Bethesda, Maryland). All muscle measurements were acquired by one investigators. Functional CSA measurement was obtained by using threshold method (including only pixels within lean muscle tissue range). Statistical analysis was performed using SPSSÒ v. 15. Results: The baseline characteristics of the study participants are shown in Table 1. There was no significant difference in total CSA in longus colli, sternocleidomastoid and multifidus muscles between involved and uninvolved groups. Data analysis showed significant difference between the functional CSA of the lognus colli muscle the involved/uninvolved sides (Table 2). Also, there is significant difference in the ratio of longus colli musle (functional longus colli muscle CSA/total longus colli muscle CSA) between the involved and uninvolved sides (P < 0.001). Conclusion: This is the study to show via MRI assessment that patients with cervical radiculopathy have smaller ipsilateral functional CSA of the longus colli muscle LCM in comparison with uninvolved side. Consideration of these muscles in MRI could be helpful in the diagnosis and prognosis of cervical radiculopathy. doi:10.1016/j.clinph.2018.04.438

S79. The utility of tibial nerve SEPs in diagnosing lumbar spinal stenosis, comparison with NCS and F-Waves—Chizuko Oishi *, Yoshikazu Mizoi, Chiba Atsuro, Masahiro Sonoo (Japan) ⇑

Presenting author.

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Introduction: Lumbar spinal stenosis (LSS) is a popular cause of lower limb motor and sensory impairments and gait disturbance. SEPs can be a tool to evaluate LSS, and there have been considerable number of studies investigating the utility of dermatomal SEP in evaluating LSS or lumbar radiculopathy. However, few studies investigated the utility of tibial nerve SEPs. Tibial nerve SEPs have an advantage that they can evaluate plural points along the whole course of the peripheral nerve and can localize the lesion site. Three segments of ankle-knee, knee-pelvis, and pelvis-spinal entry can be evaluated by N8o latency, N8o-P15 interval, and P15-N21 interval. In this study, we compared the utility of tibial nerve SEPs with nerve conduction studies (NCS) and F-waves. Methods: We searched our EMG database from 2012 to 2017 with the keyword of ‘‘LSS” or ‘‘lumbar” and SEP examinations. For extracted cases, we retrospectively reviewed clinical and EMG records and MRI images. The entry criteria were as follows: (1) presence of sensory, motor, or gait (typically, intermittent claucication) complaints, (2) unequivocal LSS in lumbar MRI, (3) final diagnosis that the chief complaint was caused by the MRI-documented LSS, (4) Tibial nerve SEPs, motor conduction study (MCS) and F waves of the tibial nerve, and sensory conduction study (SCS) of the sural nerve were conducted for the same lower-limb that was the more affected, (5) no other causes that can explain his or her symptoms, especially neuropathies and diabetes, (6) no prior lumbar surgery. Results: Among 39 patients initially extracted, many have been excluded by the strict inclusion criteria. Finally enrolled were 8 patients (53–82 years, all men). The clinical features of these patients were as follows. Weakness was present in 7 (absent in 1). Sensory symptoms or signs were present in 4 (absent in 4). Intermittent claucication was present in 3 patients. Tibial nerve SEPs were abnormal in 7, and could localize the lesion at the lumbar segment (P15-N21) in 6. Notably, in 3 out of 4 patients without sensory symptoms or signs, tibial nerve SEPs localized the lesion at lumbar segment. The amplitude of the compound muscle action potential (CMAP) of the tibial MCS was reduced in 2 cases, and Fwave latency was prolonged in the same 2 cases. In no cases, Fwaves were abnormal despite normal SEPs. Sural SCS was normal for all cases. In two patients in which tibial nerve SEPs could not localize the lesion, needle EMG confirmed the diagnosis of LSS. Conclusion: Tibial nerve SEPs are useful in diagnosing LSS by localizing the lesion at the lumbar segments. Especially the fact that they documented lumbar lesions in patients lacking sensory symptoms or signs would contribute to the differentiation from amyotrophic lateral sclerosis. The sensitivity of F-waves was much lower than tibial nerve SEPs and added no value to the amplitude of the tibial CMAP. doi:10.1016/j.clinph.2018.04.439

S80. Utility of reduced montage EEG in detecting seizures or seizure-like activity—Kapil Gururangan *, Babak Razavi, Josef Parvizi (USA) ⇑

Presenting author.

Introduction: Standard scalp EEG is used to detect a wide range of cerebral pathologies. However, its utility in emergency and resourcelimited settings may be impeded by delays in setup and interpretation. Past studies have investigated reduced channel arrays as screening tools, but inferred a lower utility in detecting epileptiform abnormalities. The current study tested the utility of reduced (8channel) montage (rm-EEG) covering the lateral hemispheres compared to full (18-channel) montage (fm-EEG) for detection of generalized and hemispheric seizures and seizure-like patterns by