- Email: [email protected]
Saccadic error rates predict the psychomotor poverty syndrome in schizophrenia
poster session ill
BIOL. PSYCHIATRY 1997;42:tS-297S
In pyramidal cell orientation between the two groups. These findings are In agreement with the hypothesis that schizophrenia Is a neurodevelopmental diIOf'der. Further studies on the hippocampus in schizophrenic brains by tlll;1OChemical and Immunohistochemical methods are necessary.
165-151]
Exploratory eye movements for late onset schizophrenia
E. Tanabe I, S. Takahashi 1 • K. Yara 1, E. Matsushima 2, T. Kojima 1.
of Neuropsychiatry. Nlhon University. School of Medicine. Japan, 2 Department of Neuropsychiatry. Tokyo Medical and Dental I)niversity. Tokyo, Japan In our prevlous studies, it has been suggested that exploratory eye movement (EEM) was specific maker of schizophrenia. The aim of this study Is to Investigate the property of late onset schizophrenia (LOS) whose onset was OI/er the age of 40 years. This LOS group was compared w~h nonnal controls and non late onset schizophrenia (NLOS) whose onset was under the age 0140 years. Twenty LOS patients (mean age 54.3 years; 5 men; 15 women; mean age at onset 47.8 years), 18 NLOS patients (mean age 49.6 years; 11 men: 7 women; mean age at onset: 27.8 years) and 18 nonnal controls (mean age 50.7 years; 9 men; 9 women) were Included In the SUbjects. The E£M was measured while subjects viewing a geometrical S-shaped figure. The EEM test was perlonned to all patients and nonnal controls and we measured 4 parameters from this test; 1) numbers of eye fixations (NEF), 2) total eye scanning length (TESL), 3) cognitive search score (eSS), and 4) e search score (RSS). Compare with nonnal controls, 1) LOS and ~p had significantly shorter TESL, 2) NLOS group had significantly lower CSS and 3) LOS and NLOS group had significantly lower RSS. NLOS PIP had significantly lower RSS compared with LOS group. These results IUggest that there may be heterogeneity of schizophrenia.
error rates In the antlsaccade paradigm In schizophrenic patients, but not In bipolar patients. There was no correlation with Raven's 10 or Mini Mental State Scores. Conclusions: These results further support the view that the Psychomotor Poverty and Negative Syndromes are associated with frontal lobe dysfunc• tion In schizophrenia.
165-1541
1 Depar11TI6nt
o
@5-152]
Working memory dysfunction In schizophrenia
S:NeufOPSYCIllatry. f.1aM'\8N H. Ando K. Ando T. Kojima Department of Nlhon University. School of Medicine. Japan. Department S Takahashi I, E. Tanabe t, K. Yara I , E. Matsushima 2, Y. Tomaru 3, 3.
3,
3,
I. 1
1915
Relations between consciously controlled memory and positive symptoms in schizophrenia
LC. Berthet 1 , M. Kazes 2, I. Amado 3, I. Medecln-Chalx I , D. Willard 3, P.H. Robert I , M.F. Poirier 3, J.-M. Danlon 2. 1 Department of Psychiatry. Hopltal Pasteur, Nice. France. 2/NSERM U405. Strasbourg, France. 3 Department of Psychiatry. Hopital St. Anne. Paris. France In explicit memory tasks such as recall or recognition, subjects are instructed to Voluntarily retrieve Infonnation. This lead to hypothesize that this type of memory Is Influenced by consciousness and volition. Jacoby (1991) has developed and experimental procedure called "the process dissociation procedure" In order to allow differentiation between consciously controlled versus automatic Influences of memory. This procedure was used In the present study in order to evaluate 35 patients (mean age 31.9) who satisfied the DSM IV criteria for chronic schizophrenia and 35 healthy subjects matched for age, sex and education level. Clinical symptomatology was evaluated using scales for the assessment of negative (SANS) and positive (SAPS). In comparison to the control group, the schizophrenic patients had a significantly reduced consciously controlled Influence of memory but no difference on automatic Influence. For the schizophrenic group, there Is an Inverse correlation between conscious Influence memory and the SAPS total score (P .. 0.01) but no correlation with the SANS total score (P .. 0.15). This relation between the presence of positive symptoms, such as hallu• clnation or delusion and an Impaimlent of memory controlled by conscious• ness,lead to different questions which have to be Investigated: (1) the place 01 memory Impalnnent; contemporary or secondary to positive symptoma• tology, (2) the importance of the temporal regions for memory and positive symptomatology.
2
d NeuroPSychiatry. Faculty of Medicine, Tokyo Medical and Dental I)niversity. Japan, 3 Yamada Hospital. Japan ThiI studY was designed to Investigate whether exploratory eye movement EM) abflOrlTl8lities in schizophrenia are associated with worKing memory ~1Cit. Twenty five schizophrenic patients and sixteen nonnal controls were tested on oculomotor delayed-response (ODR) task, which Is used to assess fle W()I1dng memory function, and EEM task. The schizophrenic patients shoWed deficits relative to nonnal controls In both the ODR task and E£M task. Responsive search score (RSS), which Is one of the EEM test Bl: was associated with perfonnance on ODR task In schizophrenia. =j~ demonstrate that abnonnality of RSS Is associated with working rrerr«Y deficit In schizophrenia.
[!S-15~ saccadic error rates predict the psychomotor poverty syndrome in schizophrenia M.A. Reveley. T. Crawford, B. Haegar, C. Kennard, L Henderson.
~t of psychiatry. University of Leicester School of Medicine. LMc8S1er, UK. Academic Unit of Neurosclenc~•. ~harlng Cross & westminster Medical School. London, UK, DIVISion of Psychology, UniversitY of Hertfordshire, Hatfield, UK
ObjeCtIve: Saccadic error rates have been associated with dyslunction fn)ntO-COrtico-striataJ network. Correlations of scores on the three ~.!:'_s of schizophrenia as derived from factor analysis of SANS and -·~es with eye movements In the remembered saccade and ~ paradigms were carried out in 40 neuroleptic (NL)-treated tcHzOPhrenic (DSM-III-R) patients and In 18 NL-treated bipolar affectlve
·J·.. .
~. Eye movements were detennined
by an infrared limbus tech-
~diC error rates In the antlsaccade paradigm, those saccades ~ away from the stimulus to the mirror Image location, and the re• ~ed paradigm, those directed towards the remembered location of a now extinguished, were detennined. target ItS. There was a significant correlation between the Psychomotor ,...u R·.O 45, p. 0.009) and Negative (R .. 0.47, p .. 0.006) Syndromes, ~ov::: Re~lIty Distortion (Psychotic) or Disorganization Syndromes, end o
J.e
165-1551
Early diagnosis in the schizophrenic psychoses with the aid of the computerized BSABS test
J.C. Morlnigo Escalante. Dept. of Psychiatry Faculty of Medical Sciences. Nat! Unlv. of Asuncl6n, Paraguay The concept of psychosis Is valid only for the productive psychotic stages but It does not consider the global evolution of the great majorities of schizophrenic diseases specifically, at the eal1y stages of the disease. Results of a longitudinal follow up study of one hundred cases from the Outpatient Dept of the Psychlatryc Hospital are throughoutly discussed. A novel diagnostic computerized methodology Known as the Bonn Scale for the Assessment of Basic Symptoms (BSABS) was utilized which was translated Into Spanish by the first author ot the paper and standardized In the Department. The system allow to critically spot psychopathological predictors as well as first and second range symptoms of the K. Schneider Scale. The BSABS test also allows correlation with other ancillary diagnostic methods and was employed In patients with idiopathic psycho-syndromes.
165-1561
Neurological soft signs and deficit SUbtype in schizophrenia: A preliminary study
F. Moity. S. langlois-Thery, S. Doillus. M. Petit. Groupe de recherche et Programme Hospltaller de Recherche Clinlque (P.H.R.C.), S. Doillus, CHU. C6te de Nacre 14033 Caen. France. Groupe de recherche et Programme Hospltalier de Recherche Clinlque (P.H.R.C.). M. Petit Unlversit~ de Rouen, France The aim of this study was to test a relationship between neurological soft signs (NSS) and deficit SUbtype In schizophrenic patients. Methods: 13 schizophrenic women and 19 men (OSM 11\ R and DSM IV), aged from 21 to 71 (mean .. 39.4) were categorized with the Schedule for the Deficit Syndrome (SOS; Kirkpatrick et at 1989) into 2 groups: 18 deficit ~tients (SDS score > 2) and 14 non deficit patients (SDS < 2). Each pallent was evaluated with a French version of neurological evaluation scale (NES; Buchanan et ai, 1969). Antipsychotic doses were converted into equlvalent-ehlorpromazine (CPZ).
BIOL. PSYCHIATRY 1997;42:tS-297S
In pyramidal cell orientation between the two groups. These findings are In agreement with the hypothesis that schizophrenia Is a neurodevelopmental diIOf'der. Further studies on the hippocampus in schizophrenic brains by tlll;1OChemical and Immunohistochemical methods are necessary.
165-151]
Exploratory eye movements for late onset schizophrenia
E. Tanabe I, S. Takahashi 1 • K. Yara 1, E. Matsushima 2, T. Kojima 1.
of Neuropsychiatry. Nlhon University. School of Medicine. Japan, 2 Department of Neuropsychiatry. Tokyo Medical and Dental I)niversity. Tokyo, Japan In our prevlous studies, it has been suggested that exploratory eye movement (EEM) was specific maker of schizophrenia. The aim of this study Is to Investigate the property of late onset schizophrenia (LOS) whose onset was OI/er the age of 40 years. This LOS group was compared w~h nonnal controls and non late onset schizophrenia (NLOS) whose onset was under the age 0140 years. Twenty LOS patients (mean age 54.3 years; 5 men; 15 women; mean age at onset 47.8 years), 18 NLOS patients (mean age 49.6 years; 11 men: 7 women; mean age at onset: 27.8 years) and 18 nonnal controls (mean age 50.7 years; 9 men; 9 women) were Included In the SUbjects. The E£M was measured while subjects viewing a geometrical S-shaped figure. The EEM test was perlonned to all patients and nonnal controls and we measured 4 parameters from this test; 1) numbers of eye fixations (NEF), 2) total eye scanning length (TESL), 3) cognitive search score (eSS), and 4) e search score (RSS). Compare with nonnal controls, 1) LOS and ~p had significantly shorter TESL, 2) NLOS group had significantly lower CSS and 3) LOS and NLOS group had significantly lower RSS. NLOS PIP had significantly lower RSS compared with LOS group. These results IUggest that there may be heterogeneity of schizophrenia.
error rates In the antlsaccade paradigm In schizophrenic patients, but not In bipolar patients. There was no correlation with Raven's 10 or Mini Mental State Scores. Conclusions: These results further support the view that the Psychomotor Poverty and Negative Syndromes are associated with frontal lobe dysfunc• tion In schizophrenia.
165-1541
1 Depar11TI6nt
o
@5-152]
Working memory dysfunction In schizophrenia
S:NeufOPSYCIllatry. f.1aM'\8N H. Ando K. Ando T. Kojima Department of Nlhon University. School of Medicine. Japan. Department S Takahashi I, E. Tanabe t, K. Yara I , E. Matsushima 2, Y. Tomaru 3, 3.
3,
3,
I. 1
1915
Relations between consciously controlled memory and positive symptoms in schizophrenia
LC. Berthet 1 , M. Kazes 2, I. Amado 3, I. Medecln-Chalx I , D. Willard 3, P.H. Robert I , M.F. Poirier 3, J.-M. Danlon 2. 1 Department of Psychiatry. Hopltal Pasteur, Nice. France. 2/NSERM U405. Strasbourg, France. 3 Department of Psychiatry. Hopital St. Anne. Paris. France In explicit memory tasks such as recall or recognition, subjects are instructed to Voluntarily retrieve Infonnation. This lead to hypothesize that this type of memory Is Influenced by consciousness and volition. Jacoby (1991) has developed and experimental procedure called "the process dissociation procedure" In order to allow differentiation between consciously controlled versus automatic Influences of memory. This procedure was used In the present study in order to evaluate 35 patients (mean age 31.9) who satisfied the DSM IV criteria for chronic schizophrenia and 35 healthy subjects matched for age, sex and education level. Clinical symptomatology was evaluated using scales for the assessment of negative (SANS) and positive (SAPS). In comparison to the control group, the schizophrenic patients had a significantly reduced consciously controlled Influence of memory but no difference on automatic Influence. For the schizophrenic group, there Is an Inverse correlation between conscious Influence memory and the SAPS total score (P .. 0.01) but no correlation with the SANS total score (P .. 0.15). This relation between the presence of positive symptoms, such as hallu• clnation or delusion and an Impaimlent of memory controlled by conscious• ness,lead to different questions which have to be Investigated: (1) the place 01 memory Impalnnent; contemporary or secondary to positive symptoma• tology, (2) the importance of the temporal regions for memory and positive symptomatology.
2
d NeuroPSychiatry. Faculty of Medicine, Tokyo Medical and Dental I)niversity. Japan, 3 Yamada Hospital. Japan ThiI studY was designed to Investigate whether exploratory eye movement EM) abflOrlTl8lities in schizophrenia are associated with worKing memory ~1Cit. Twenty five schizophrenic patients and sixteen nonnal controls were tested on oculomotor delayed-response (ODR) task, which Is used to assess fle W()I1dng memory function, and EEM task. The schizophrenic patients shoWed deficits relative to nonnal controls In both the ODR task and E£M task. Responsive search score (RSS), which Is one of the EEM test Bl: was associated with perfonnance on ODR task In schizophrenia. =j~ demonstrate that abnonnality of RSS Is associated with working rrerr«Y deficit In schizophrenia.
[!S-15~ saccadic error rates predict the psychomotor poverty syndrome in schizophrenia M.A. Reveley. T. Crawford, B. Haegar, C. Kennard, L Henderson.
~t of psychiatry. University of Leicester School of Medicine. LMc8S1er, UK. Academic Unit of Neurosclenc~•. ~harlng Cross & westminster Medical School. London, UK, DIVISion of Psychology, UniversitY of Hertfordshire, Hatfield, UK
ObjeCtIve: Saccadic error rates have been associated with dyslunction fn)ntO-COrtico-striataJ network. Correlations of scores on the three ~.!:'_s of schizophrenia as derived from factor analysis of SANS and -·~es with eye movements In the remembered saccade and ~ paradigms were carried out in 40 neuroleptic (NL)-treated tcHzOPhrenic (DSM-III-R) patients and In 18 NL-treated bipolar affectlve
·J·.. .
~. Eye movements were detennined
by an infrared limbus tech-
~diC error rates In the antlsaccade paradigm, those saccades ~ away from the stimulus to the mirror Image location, and the re• ~ed paradigm, those directed towards the remembered location of a now extinguished, were detennined. target ItS. There was a significant correlation between the Psychomotor ,...u R·.O 45, p. 0.009) and Negative (R .. 0.47, p .. 0.006) Syndromes, ~ov::: Re~lIty Distortion (Psychotic) or Disorganization Syndromes, end o
J.e
165-1551
Early diagnosis in the schizophrenic psychoses with the aid of the computerized BSABS test
J.C. Morlnigo Escalante. Dept. of Psychiatry Faculty of Medical Sciences. Nat! Unlv. of Asuncl6n, Paraguay The concept of psychosis Is valid only for the productive psychotic stages but It does not consider the global evolution of the great majorities of schizophrenic diseases specifically, at the eal1y stages of the disease. Results of a longitudinal follow up study of one hundred cases from the Outpatient Dept of the Psychlatryc Hospital are throughoutly discussed. A novel diagnostic computerized methodology Known as the Bonn Scale for the Assessment of Basic Symptoms (BSABS) was utilized which was translated Into Spanish by the first author ot the paper and standardized In the Department. The system allow to critically spot psychopathological predictors as well as first and second range symptoms of the K. Schneider Scale. The BSABS test also allows correlation with other ancillary diagnostic methods and was employed In patients with idiopathic psycho-syndromes.
165-1561
Neurological soft signs and deficit SUbtype in schizophrenia: A preliminary study
F. Moity. S. langlois-Thery, S. Doillus. M. Petit. Groupe de recherche et Programme Hospltaller de Recherche Clinlque (P.H.R.C.), S. Doillus, CHU. C6te de Nacre 14033 Caen. France. Groupe de recherche et Programme Hospltalier de Recherche Clinlque (P.H.R.C.). M. Petit Unlversit~ de Rouen, France The aim of this study was to test a relationship between neurological soft signs (NSS) and deficit SUbtype In schizophrenic patients. Methods: 13 schizophrenic women and 19 men (OSM 11\ R and DSM IV), aged from 21 to 71 (mean .. 39.4) were categorized with the Schedule for the Deficit Syndrome (SOS; Kirkpatrick et at 1989) into 2 groups: 18 deficit ~tients (SDS score > 2) and 14 non deficit patients (SDS < 2). Each pallent was evaluated with a French version of neurological evaluation scale (NES; Buchanan et ai, 1969). Antipsychotic doses were converted into equlvalent-ehlorpromazine (CPZ).