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Sacrococcygeal teratomas in infants and children
1014
INTERNATIONAL ABSTRACTS
were small and clinically inconsequential. There were no significant differences in degree of physical handicap. Any differences that were found tended to reflect research findings from the nonhandicapped population. Likewise, the males and females with meningoceles, lipomas, and encephaloceles were remarkably similar in their intellectual and physical handicap characteristics. Sex differences in patients with neural tube malformations are of minimal significance and only likely to affect clinical decisions in the area of genitourinary problems.--Thomas A. Angerpointer Does the Spina Bifida Clinic Need an Ophthalmologist? H. Gaston.
Z Kinderchir 40:46-50, (December), 1985 (suppl 1). Three hundred twenty-two children who were suffering from either spina bifida or hydrocephalus were examined over a 6-year period. Regular examinations were made of visual acuity and field, ocular motility, and fundus starting at the time of birth or diagnosis and repeated, whenever possible, at each clinical visit or hospital admission. A particular effort was made to see children about to have exploratory surgery for suspected shunt dysfunction or raised intracranial pressure to determine the frequency of positive eye findings in such cases. Ophthalmic complications were found to be very common in the children studied. One hundred thirty-six (42%) had a manifest squint, 93 (29%) had a lateral rectus palsy or musculoparetic nystagmus, 44 (14%) had papilledema, and 55 (17%) had optic atrophy. Only 86 (27%) definitely had normal visual function. Seventy percent of proven episodes of shunt dysfunction had positive ophthalmologic evidence of raised intracranial pressure. The presence of an ophthalmologist in the spina bifida and hydrocephalus clinic was increasingly valued as the study progressed.-- Thomas A. Angerpointer NEOPLASMS The Current Management of Bilateral Wilms' Tumor. R. Kay and
E. Tank. J Urol 135:983-985, (May), 1986. The good prognosis of synchronous bilateral Wilms' tumor seems inappropriate for the magnitude of the disease process. Experience with 11 cases demonstrates the unusual tumor response to chemotherapy and limited preservative surgery. Although two patients died, two with metastatic disease have responded to chemotherapy and are alive at 5 and 8 years after treatment. In addition, one patient ttas survived with biopsy only and no definitive surgery. Although all surgical options have been used, ranging from biopsy alone to bench surgery with autotransplantation to bilateral nephrectomy, this experience demonstrates the effectiveness of a conservative approach with initial biopsy, chemotherapy, and subsequent partial nephrectomy, if needed. These survival data and the histologic examination of the tumors after chemotherapy suggest a strong relationship of bilateral Wilms' tumor to the nodular renal blastemanephroblastomatosis complex and a mechanism to explain
the excellent tumor response to chemotherapy--George Holcomb, Jr Uroradiographie Manifestations of Burkitt's Lymphoma in Children. S.K. Fernbach and R.B.J. Glass. J Urol 135:986-988, (May),
1986. The radiologic studies of 18 children with biopsy-proved Burkitt's lymphoma were analyzed retrospectively. Before therapy, the genitourinary tract was evaluated in 15 children by excretory urography, sonography, computerized tomography, and/or citrate scintigraphy. Genitourinary abnormalities were detected in nine children. Changes due to tumor included renal or ureteral displacement in 4 children, hydronephrosis in 3, and intraparenchymal masses in 4. Extrinsic compression of the bladder causing no compromise of function was seen in only two children. Gonadal involvement occurred in two boys and one girl. The modality of choice for evaluating the genitourinary tract in patients with Burkitt's lymphoma has been excretory urography. Since ultrasound and computerized tomography provide more direct information about tumor deposits within the kidney and retroperitoneum, either should be performed in this population before initiation of chemotherapy.George Holcomb, Jr Lipoblastomastosis in Childhood. S. Tsingoglou and C. Pappis. Ann
Pediatr Surg 1: 194-196, (July), 1984. Lipoblastomatosis is a congenital benign lipomatous tumor with specific histologic characteristics. Eleven children with this tumor were operated upon during the last 10 years. Only four were females. The age at the time of operation ranged from 2 months to 5 years (mean 21 months). The tumors were located in the back (3), the groin (2), the neck (1), the anterior abdominal wall (1), and in the extremities (4). In nine children the tumor had a nonencapsulated diffuse form. In two children, the tumor recurred twice.--Prem Puri Sacrococcygeal Teratomas in Infants and Children. T.V. Whalen,
G.H. Mahous, B.H. Landing, et al. Am J Surg 150:373-375, (September), 1985. A retrospective review of 66 patients with the diagnosis of sacrococcygeal teratoma seen over 43 years was undertaken. Nineteen had a malignant tumor, with 32 classified benign and 15 as intermediate embryonic tissue without a malignant component. As expected, the patients with benign tumors all fared well, and the patients with true malignancy did poorly, with only one long-term survivor recorded. In the embryonal group, one patient developed pulmonary and hepatic metastases and succumbed 1 year after primary excision. No advantage with chemotherapy or radiotherapy was demonstrable.--Thomas V. Whalen
INTERNATIONAL ABSTRACTS
were small and clinically inconsequential. There were no significant differences in degree of physical handicap. Any differences that were found tended to reflect research findings from the nonhandicapped population. Likewise, the males and females with meningoceles, lipomas, and encephaloceles were remarkably similar in their intellectual and physical handicap characteristics. Sex differences in patients with neural tube malformations are of minimal significance and only likely to affect clinical decisions in the area of genitourinary problems.--Thomas A. Angerpointer Does the Spina Bifida Clinic Need an Ophthalmologist? H. Gaston.
Z Kinderchir 40:46-50, (December), 1985 (suppl 1). Three hundred twenty-two children who were suffering from either spina bifida or hydrocephalus were examined over a 6-year period. Regular examinations were made of visual acuity and field, ocular motility, and fundus starting at the time of birth or diagnosis and repeated, whenever possible, at each clinical visit or hospital admission. A particular effort was made to see children about to have exploratory surgery for suspected shunt dysfunction or raised intracranial pressure to determine the frequency of positive eye findings in such cases. Ophthalmic complications were found to be very common in the children studied. One hundred thirty-six (42%) had a manifest squint, 93 (29%) had a lateral rectus palsy or musculoparetic nystagmus, 44 (14%) had papilledema, and 55 (17%) had optic atrophy. Only 86 (27%) definitely had normal visual function. Seventy percent of proven episodes of shunt dysfunction had positive ophthalmologic evidence of raised intracranial pressure. The presence of an ophthalmologist in the spina bifida and hydrocephalus clinic was increasingly valued as the study progressed.-- Thomas A. Angerpointer NEOPLASMS The Current Management of Bilateral Wilms' Tumor. R. Kay and
E. Tank. J Urol 135:983-985, (May), 1986. The good prognosis of synchronous bilateral Wilms' tumor seems inappropriate for the magnitude of the disease process. Experience with 11 cases demonstrates the unusual tumor response to chemotherapy and limited preservative surgery. Although two patients died, two with metastatic disease have responded to chemotherapy and are alive at 5 and 8 years after treatment. In addition, one patient ttas survived with biopsy only and no definitive surgery. Although all surgical options have been used, ranging from biopsy alone to bench surgery with autotransplantation to bilateral nephrectomy, this experience demonstrates the effectiveness of a conservative approach with initial biopsy, chemotherapy, and subsequent partial nephrectomy, if needed. These survival data and the histologic examination of the tumors after chemotherapy suggest a strong relationship of bilateral Wilms' tumor to the nodular renal blastemanephroblastomatosis complex and a mechanism to explain
the excellent tumor response to chemotherapy--George Holcomb, Jr Uroradiographie Manifestations of Burkitt's Lymphoma in Children. S.K. Fernbach and R.B.J. Glass. J Urol 135:986-988, (May),
1986. The radiologic studies of 18 children with biopsy-proved Burkitt's lymphoma were analyzed retrospectively. Before therapy, the genitourinary tract was evaluated in 15 children by excretory urography, sonography, computerized tomography, and/or citrate scintigraphy. Genitourinary abnormalities were detected in nine children. Changes due to tumor included renal or ureteral displacement in 4 children, hydronephrosis in 3, and intraparenchymal masses in 4. Extrinsic compression of the bladder causing no compromise of function was seen in only two children. Gonadal involvement occurred in two boys and one girl. The modality of choice for evaluating the genitourinary tract in patients with Burkitt's lymphoma has been excretory urography. Since ultrasound and computerized tomography provide more direct information about tumor deposits within the kidney and retroperitoneum, either should be performed in this population before initiation of chemotherapy.George Holcomb, Jr Lipoblastomastosis in Childhood. S. Tsingoglou and C. Pappis. Ann
Pediatr Surg 1: 194-196, (July), 1984. Lipoblastomatosis is a congenital benign lipomatous tumor with specific histologic characteristics. Eleven children with this tumor were operated upon during the last 10 years. Only four were females. The age at the time of operation ranged from 2 months to 5 years (mean 21 months). The tumors were located in the back (3), the groin (2), the neck (1), the anterior abdominal wall (1), and in the extremities (4). In nine children the tumor had a nonencapsulated diffuse form. In two children, the tumor recurred twice.--Prem Puri Sacrococcygeal Teratomas in Infants and Children. T.V. Whalen,
G.H. Mahous, B.H. Landing, et al. Am J Surg 150:373-375, (September), 1985. A retrospective review of 66 patients with the diagnosis of sacrococcygeal teratoma seen over 43 years was undertaken. Nineteen had a malignant tumor, with 32 classified benign and 15 as intermediate embryonic tissue without a malignant component. As expected, the patients with benign tumors all fared well, and the patients with true malignancy did poorly, with only one long-term survivor recorded. In the embryonal group, one patient developed pulmonary and hepatic metastases and succumbed 1 year after primary excision. No advantage with chemotherapy or radiotherapy was demonstrable.--Thomas V. Whalen