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S&T-29 EIGHT YEAR MEDIAN FOLLOW UP OF MIDURETHRAL SLINGS, SINGLE CENTER EXPERIENCE
THE JOURNAL OF UROLOGYâ
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functioning and the general health of transsexual women with a similiar group of biological women. In these patients we considered the current age and the age at surgery, socio-demographic factors, comorbidities, lifestyle, habits and sexual orientation. All analysis was performed using SAS 9.3 software. RESULTS: Of the 40 patients who agreed to take part in the study, 22 completed the questionnaire FSFI: 11 patients underwent (NCP) and 11 operated with the pubic neoclitoris technique. There were no significant differences between the two groups except for age at the time of surgery (PNT 43.5 vs NCP 33.5; p ¼ 0.02). The results showed a mean FSFI Total Score of 25.81 NCP group vs 18.62 PNT group. Average value of FSFI Total Score: BCP group single 9.16, 22.15 in a relationship; PNT group single 26.03, 25.56 in a relationship. CONCLUSIONS: Patients underwent NCP have reached FSFI Total Score greater than those operated with the previous technique (p <0.05). The stable relationship with a partner influences more sexual satisfaction of the BCP group than patients in the other group. The FSFI did not get statistically significant results in the evaluation of lubrication and dyspareunia. This study showed that, even in patients undergoing GRS, neoclitoris localization could be considered a parameter for evaluating sexual function and that a reduction of the distance between neovagina and neoclitoris is associated with greater sexual satisfaction. We think could be useful to draft a specific questionnaire to assess sexual function of patients undergoing GRS. Source of Funding: none
S&T-29 EIGHT YEAR MEDIAN FOLLOW UP OF MIDURETHRAL SLINGS, SINGLE CENTER EXPERIENCE Mohamed Elkhamesy, Tamer Helmy, Ahmed El Hefnawy, Mohamed Gaballah, Bassem Wadie*, Mansoura, Egypt INTRODUCTION AND OBJECTIVES: Midurethral slings (MUS) are the mainstay of treatment for stress incontinent women. We looked into long term outcome of the different procedures well after 5 years, so as to examine the durability of success as well as adverse events that might be seen long after surgery METHODS: Data were retrospectively collected for patients who underwent MUS with minimum follow up of 5 years. A total of 68 female patients were assessed. All patients underwent physical examination including stress test and pad test, PVR as well as urodynamic testing; in those who had treatment failure. Failure was defined as +ve stress test, +ve pad test, both or re-treatment of SUI. RESULTS: The study included a total of 68 female patients having mean age 45.82 7.09 SD were followed to a minimum of 5 years. Mean follow up was 8.59 years (range. 5-15). All had MUS as treatment of their incontinence. Thirty-six patients underwent PVS, while 18 patients underwent TVT and 14 underwent TOT. 10 patients had history of surgical correction of pelvic organ prolapse, 14 had history of other pelvic surgeries and 24 patients had other surgeries not related to the pelvis. Concomitant surgery for POP was carried out in less than 40% of our patients (42) underwent sling, 20 underwent anterior colporrhaphy, 4 underwent posterior colporrhaphy while 2 patients underwent anterior and posterior colporrhaphy for their complaint. CONCLUSIONS: MUS are attended with 85% objective cure rate at median follow up of 8 years. The type of sling did not seem to affect this outcome.
Vol. 195, No. 4S, Supplement, May 7-10, 2016
S&T-30 COMPARISON OF QUALITY OF LIFE IN PATIENTS WITH LOCALLY ADVANCED PROSTATE CANCER TREATED WITH NEOADJUVANT ENDOCRINE, EXTERNAL BEAM RADIATION AND ADJUVANT CONTINUOUS/INTERMITTENT ENDOCRINE THERAPY IN RANDOMIZED PHASE III TRIAL Akira Yokomizo*, Hirofumi Koga, Fukuoka, Japan; Kazuto Ito, Kazuhiro Suzuki, Maebashi, Japan; Hidetoshi Yamanaka, Takasaki, Japan; Seiji Naito, Fukuoka, Japan INTRODUCTION AND OBJECTIVES: To evaluate the quality of life (QOL) of locally advanced prostate cancer (Pca) patients who were treated by neoadjuvant androgen deprivation therapy (ADT), external beam radiation (EBRT) and adjuvant continuous/intermittent ADT in prospective randomized phase III trial. METHODS: Between 2001 and 2003, 280 intention-to-treat (ITT) patients with locally advanced Pca patients (cT3 or T4(bladder neck invasion only) N0M0) were treated 6 months of ADT, followed by 72 Gy of external beam radiation therapy. After 14 months, patients were randomly assigned to be treated with continuous ADT (arm 1) or intermittent ADT (arm 2) as shown in Figure 1. The QOL questionnaires were assesses in six points as shown in Fig.1. The QOL was evaluated by the FACT-G, P plus urinary, bowel and sexual subscales of EPIC. The 228 patients out of 280 ITT patients completed the protocol treatment. The number of patients who fit the FACT scoring manual in each QOL points were 270 (baseline), 258 (6 months, (M)), 254 (8M), 226 (14M), 201(20M) and 192 (28M). RESULTS: FACT-P total scores significantly decreased after the EBRT (8M) but recovered to baseline at 14M. Physical subscale was similar change as FACT-P total score. The emotional subscale continuously increased but social/family subscale continuously decreased sequentially, suggesting that the patients’ anxiety improved but supports from their family and friends decreased as the treatment progressed. The urinary subscale were significantly improved after the neoadjuvant ADT (6M), decreased after EBRT(8M) and improved at 14M. The bowel subscale decreased after EBRT (8M) but recovered soon at 14M. The sexual subscales were continuously decreased after ADT. Comparing the arm1 and 2, functional and FACT-P Trial Outcome Index (TOI) were significant better in intermittent ADT group (Figure 1). CONCLUSIONS: Fact-P total score and urinary and bowel subscale were rapidly decline after EBRT but recover soon after 6 month of EBRT (14M). The functional and FACT-P (TOI) score were significant better in intermittent ADT group.
Source of Funding: None Source of Funding: The Ministry of Health, Labor and Welfare in Japan, Grant number 12-14
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functioning and the general health of transsexual women with a similiar group of biological women. In these patients we considered the current age and the age at surgery, socio-demographic factors, comorbidities, lifestyle, habits and sexual orientation. All analysis was performed using SAS 9.3 software. RESULTS: Of the 40 patients who agreed to take part in the study, 22 completed the questionnaire FSFI: 11 patients underwent (NCP) and 11 operated with the pubic neoclitoris technique. There were no significant differences between the two groups except for age at the time of surgery (PNT 43.5 vs NCP 33.5; p ¼ 0.02). The results showed a mean FSFI Total Score of 25.81 NCP group vs 18.62 PNT group. Average value of FSFI Total Score: BCP group single 9.16, 22.15 in a relationship; PNT group single 26.03, 25.56 in a relationship. CONCLUSIONS: Patients underwent NCP have reached FSFI Total Score greater than those operated with the previous technique (p <0.05). The stable relationship with a partner influences more sexual satisfaction of the BCP group than patients in the other group. The FSFI did not get statistically significant results in the evaluation of lubrication and dyspareunia. This study showed that, even in patients undergoing GRS, neoclitoris localization could be considered a parameter for evaluating sexual function and that a reduction of the distance between neovagina and neoclitoris is associated with greater sexual satisfaction. We think could be useful to draft a specific questionnaire to assess sexual function of patients undergoing GRS. Source of Funding: none
S&T-29 EIGHT YEAR MEDIAN FOLLOW UP OF MIDURETHRAL SLINGS, SINGLE CENTER EXPERIENCE Mohamed Elkhamesy, Tamer Helmy, Ahmed El Hefnawy, Mohamed Gaballah, Bassem Wadie*, Mansoura, Egypt INTRODUCTION AND OBJECTIVES: Midurethral slings (MUS) are the mainstay of treatment for stress incontinent women. We looked into long term outcome of the different procedures well after 5 years, so as to examine the durability of success as well as adverse events that might be seen long after surgery METHODS: Data were retrospectively collected for patients who underwent MUS with minimum follow up of 5 years. A total of 68 female patients were assessed. All patients underwent physical examination including stress test and pad test, PVR as well as urodynamic testing; in those who had treatment failure. Failure was defined as +ve stress test, +ve pad test, both or re-treatment of SUI. RESULTS: The study included a total of 68 female patients having mean age 45.82 7.09 SD were followed to a minimum of 5 years. Mean follow up was 8.59 years (range. 5-15). All had MUS as treatment of their incontinence. Thirty-six patients underwent PVS, while 18 patients underwent TVT and 14 underwent TOT. 10 patients had history of surgical correction of pelvic organ prolapse, 14 had history of other pelvic surgeries and 24 patients had other surgeries not related to the pelvis. Concomitant surgery for POP was carried out in less than 40% of our patients (42) underwent sling, 20 underwent anterior colporrhaphy, 4 underwent posterior colporrhaphy while 2 patients underwent anterior and posterior colporrhaphy for their complaint. CONCLUSIONS: MUS are attended with 85% objective cure rate at median follow up of 8 years. The type of sling did not seem to affect this outcome.
Vol. 195, No. 4S, Supplement, May 7-10, 2016
S&T-30 COMPARISON OF QUALITY OF LIFE IN PATIENTS WITH LOCALLY ADVANCED PROSTATE CANCER TREATED WITH NEOADJUVANT ENDOCRINE, EXTERNAL BEAM RADIATION AND ADJUVANT CONTINUOUS/INTERMITTENT ENDOCRINE THERAPY IN RANDOMIZED PHASE III TRIAL Akira Yokomizo*, Hirofumi Koga, Fukuoka, Japan; Kazuto Ito, Kazuhiro Suzuki, Maebashi, Japan; Hidetoshi Yamanaka, Takasaki, Japan; Seiji Naito, Fukuoka, Japan INTRODUCTION AND OBJECTIVES: To evaluate the quality of life (QOL) of locally advanced prostate cancer (Pca) patients who were treated by neoadjuvant androgen deprivation therapy (ADT), external beam radiation (EBRT) and adjuvant continuous/intermittent ADT in prospective randomized phase III trial. METHODS: Between 2001 and 2003, 280 intention-to-treat (ITT) patients with locally advanced Pca patients (cT3 or T4(bladder neck invasion only) N0M0) were treated 6 months of ADT, followed by 72 Gy of external beam radiation therapy. After 14 months, patients were randomly assigned to be treated with continuous ADT (arm 1) or intermittent ADT (arm 2) as shown in Figure 1. The QOL questionnaires were assesses in six points as shown in Fig.1. The QOL was evaluated by the FACT-G, P plus urinary, bowel and sexual subscales of EPIC. The 228 patients out of 280 ITT patients completed the protocol treatment. The number of patients who fit the FACT scoring manual in each QOL points were 270 (baseline), 258 (6 months, (M)), 254 (8M), 226 (14M), 201(20M) and 192 (28M). RESULTS: FACT-P total scores significantly decreased after the EBRT (8M) but recovered to baseline at 14M. Physical subscale was similar change as FACT-P total score. The emotional subscale continuously increased but social/family subscale continuously decreased sequentially, suggesting that the patients’ anxiety improved but supports from their family and friends decreased as the treatment progressed. The urinary subscale were significantly improved after the neoadjuvant ADT (6M), decreased after EBRT(8M) and improved at 14M. The bowel subscale decreased after EBRT (8M) but recovered soon at 14M. The sexual subscales were continuously decreased after ADT. Comparing the arm1 and 2, functional and FACT-P Trial Outcome Index (TOI) were significant better in intermittent ADT group (Figure 1). CONCLUSIONS: Fact-P total score and urinary and bowel subscale were rapidly decline after EBRT but recover soon after 6 month of EBRT (14M). The functional and FACT-P (TOI) score were significant better in intermittent ADT group.
Source of Funding: None Source of Funding: The Ministry of Health, Labor and Welfare in Japan, Grant number 12-14