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Sarcoma of the Fallopian tube. Clinical case report
Selected Abstracts Caacer, lbklignancies Stokes,
E. Melcolm: The Association of Eetrogenic ArlmMatration of the Endometxium, West. J. Surg., page 494, Sept., 1948.
and Adenocarclnoma
A carcinogen is a chemical or physical substance which applied under certain conditions induces a malignant tumor. Estrogen, chemically related to polyeyclic hydrocarbons, is a carcinogen. Neoplastic cells arise from foci where rapid cell division is occurring in response to a repair or regeneration stimulus. When some external factor is introduced which interferes with the maturation of the normal cell enzyme pattern, the cells revert to the embryonic type. There is evidence to suggest that the estrogens accelerate such a reversion, possibly through their effects upon cell protoplasmic enzyme maturation. There was a Negro woman, aged 65 years, 19 years postmenopausal, who received 470 doses of 0.1 mg. of stilbestrol over a period of 21 months. The uterus enlarged progressively and at operation an endometrial polyp with adenoesrcinoma was found. It is the long, continuous administration of amall estrogen doses that is more apt to cause carcinoma WILLIAM BICKERS. than the larger doses administered over shorter periods.
Cabrera, G., and clutman, F.: Sot.
chilena
de obst.
Sarcoma of the Fallopian
y ginec.
13:
64-67,
May,
Tube.
Clinical Uaee Report,
Bol.
1948.
The authors describe a rare case of primary sarcoma of the Fallopian tube in a 59year-old patient with history of 8 deliveries and two spontaneous abortions. Her menoPain and six days of vagina1 bleeding were the first pause occurred at age of 56 years. She gained 13 kilograms in eight months. The tumor on the right tube symptoms. measured 8.0 cm. in diameter and the microscopic diagnosis was sarcoma of the tube. Because of peritoneal implantations the patient received radiotherapy subsequent to surCLAIR E. Fo~~oanx. gery.
Vergaxa,
C. Caeazin:
3: 115-128,
April,
Uterine
Fibroids
and Fundal
Carcinoma,
Ginec.
y obst.
de Mexico
1948.
Vergara reviews 4,012 operative cases seen in Pavillion 25 of the Qeaeral Hospital in Mexico City between October, 1938, and August, 1947. Among these were 410 C&S%S of Ten of these cases, 2.5 per cent, presented coexisting uterine fibroids treated surgically. adenocareinomas of the fundus uteri. The hysterography curettage. The thirteen uterine
author
concludes that any woman who bleeds in menopause and endometrial biopsy although preferably a diagnostic His treatment recommendation includes total hysterectomy.
article includes three tables and fourteen illustrations. hysterograms are striking in their bizarre shadows and patterns of coexistent fibroids and corporal carcinoma. 190
should submit dilatation
to and
The photographs of illustrate well the intraGLAXR E. FuL~#~ME.
E. Melcolm: The Association of Eetrogenic ArlmMatration of the Endometxium, West. J. Surg., page 494, Sept., 1948.
and Adenocarclnoma
A carcinogen is a chemical or physical substance which applied under certain conditions induces a malignant tumor. Estrogen, chemically related to polyeyclic hydrocarbons, is a carcinogen. Neoplastic cells arise from foci where rapid cell division is occurring in response to a repair or regeneration stimulus. When some external factor is introduced which interferes with the maturation of the normal cell enzyme pattern, the cells revert to the embryonic type. There is evidence to suggest that the estrogens accelerate such a reversion, possibly through their effects upon cell protoplasmic enzyme maturation. There was a Negro woman, aged 65 years, 19 years postmenopausal, who received 470 doses of 0.1 mg. of stilbestrol over a period of 21 months. The uterus enlarged progressively and at operation an endometrial polyp with adenoesrcinoma was found. It is the long, continuous administration of amall estrogen doses that is more apt to cause carcinoma WILLIAM BICKERS. than the larger doses administered over shorter periods.
Cabrera, G., and clutman, F.: Sot.
chilena
de obst.
Sarcoma of the Fallopian
y ginec.
13:
64-67,
May,
Tube.
Clinical Uaee Report,
Bol.
1948.
The authors describe a rare case of primary sarcoma of the Fallopian tube in a 59year-old patient with history of 8 deliveries and two spontaneous abortions. Her menoPain and six days of vagina1 bleeding were the first pause occurred at age of 56 years. She gained 13 kilograms in eight months. The tumor on the right tube symptoms. measured 8.0 cm. in diameter and the microscopic diagnosis was sarcoma of the tube. Because of peritoneal implantations the patient received radiotherapy subsequent to surCLAIR E. Fo~~oanx. gery.
Vergaxa,
C. Caeazin:
3: 115-128,
April,
Uterine
Fibroids
and Fundal
Carcinoma,
Ginec.
y obst.
de Mexico
1948.
Vergara reviews 4,012 operative cases seen in Pavillion 25 of the Qeaeral Hospital in Mexico City between October, 1938, and August, 1947. Among these were 410 C&S%S of Ten of these cases, 2.5 per cent, presented coexisting uterine fibroids treated surgically. adenocareinomas of the fundus uteri. The hysterography curettage. The thirteen uterine
author
concludes that any woman who bleeds in menopause and endometrial biopsy although preferably a diagnostic His treatment recommendation includes total hysterectomy.
article includes three tables and fourteen illustrations. hysterograms are striking in their bizarre shadows and patterns of coexistent fibroids and corporal carcinoma. 190
should submit dilatation
to and
The photographs of illustrate well the intraGLAXR E. FuL~#~ME.