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Schizophrenic inpatients with suicidal thoughts: I. social and clinical parameters
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Poster A. Clinical
25 females of 22-42 ears with anxious-depressive syndrome were examined. The examined were subdivided into two groups: patients with generalized anxiety disorder (1st group) and patients with periodically emerging anxiety attacks (panic disorder, 2nd group). Serotonin level in blood platelets and in plasma was measured with methods based on HPLC with electrochemical detection. Results showed that serotonin amount in platelets of patients with panic manifestations (950?89 ng/109) significantly exceeded values of the first: (4432103, p
A-15 El
Schizophrenic inpatients with suicidal thoughts: I. social and clinical parameters
V. Kontaxakis, B. Havaki-Kontaxaki, M. Margariti, K. Kollias, S. Department of Psychiatry, University of Stamouli, G.N. Christodoulou. Athens. Eginition Hospital. 74 Vas. Sophias Av., 11528 Athens, Greece There is a high prevalence of suicidal behaviour among individuals with schizophrenia. Although suicide attempters and suicide completers have been extensively studied, less is known on suicidal ideators. The aim of this study is to obtain knowledge on the differential social and clinical characteristics of schizophrenic inpatients with suicidal thoughts. A total of 93 schizophrenic inpatients (male 69%, female 31%) defined according to DSM-IV criteria, representing consecutive admissions to the Eginition Hospital, Psychiatric Department, Athens, from October 1996 to October 1997, were included in the study. All patients were assessed using the Positive and Negative Syndrome Scale (PANSS, Kay 1991). and the Calgary Depression Scale for Schizophrenics (CDS, Addington 1994) on admission (during the first week). Schizophrenic patients rating 1 or more on the CDS item 8 “suicidality” (subjects with suicidal thoughts, N= 19, mean age 31.3 years, Group A) were compared with schizophrenics matched for age and sex and scoring zero on the same item (subjects without suicidal thoughts, N= 19, mean age 31.2 years, Group B) in many social, clinical and psychopathological parameters. Patients with suicidal thoughts (Group A) were differentiated from controls (Group B) in that they scored higher on the CDS (10.52 vs 3.52, p
References 1. Hawley, Cl., James, DV., Birkett, P.L., M.J., Priest, R.G., Suicidal ideation as a Psychiatry 1991, 159:232-238. 2. Landmark, J., Cemovsky, Z.Z., Mersky, attempts and ideation in schizophrenia. Br 20
A-16 El
Baldwin, D.S., De Ruiter, presenting complain. Br J H., Correlates of suicide J Psychiatry 1987, 15 1: 18-
Schizophrenic inpatients with suicidal thoughts: II. pharmacological parameters
Department, Athens, from October 1996 to October 1997, were included in the study. All patients were assessed using the Positive and Negative Syndrome Scale (PANSS, Kay 1991). the Calgary Depression Scale for Schizophrenics (CDS, Addington 1994), the Rating Scale for Extrapyramidal Side Effects (RSESE, Simpson 1970), the Rating Scale for Drug-Induced Akathisia (RSDIA, Barnes 1989), and the Abnormal Involuntary Movement Scale (AIMS, Guy 1976) on admission (during the frst week). Schizophrenic patients rating 1 or more on the CDS item 8 “suicidality” (subjects with suicidal thoughts, N= 19, mean age 31.3 years, Group A) were compared with schizophrenics matched for age and sex and scoring zero on the same item (subjects without suicidal thoughts, N= 19, mean age 31.2 years, Group B) in many pharmacological parameters. There were no significant differences between the two matched groups in all the pharmacological parameters studied, i.e. use of conventional neuroleptics (58% vs 68%). use of atypical neuroleptics (21% vs 16%), use of antidepressants (5% vs 16%), use of anxiolytics (74% vs 42%), use of antiparkinsonian agents (53% vs 53%). mean daily dose of neuroleptic (CPZ eqv, 747 mg vs 610 mg). and mean scores on the RSESE (9.36 vs 8.15) on the RSDIA (0.36 vs 0.21) or on the AIMS (4.36 vs 2.15).
Reference Azhar, M.Z., Varma, S.L., Akathisia-induced Psychiatry, 1992,7,5:239-241.
A-17 El
suicidal
behaviour.
Eur
Therapeutic possibilities of Cassadan by borderline disorders
V Semke, M. Aksyonov, I. Kupriyanova, L.Yakutyonok. Mental Health Research Institute, Sosnovy bor, Tomsk, 6340146, Russia Application of benzodiazepines is traditional in the therapy of psychosomatic disorders. We have conducted clinical trial of the preparation of this class cassadan (alprazolam) - firm Asta Medica (Germany). Preparation was administered depending on clinical indications at doses from 75 to 150 mg per day, duration of treatment course has constituted from 3 till 25 days. In our case indication to the therapy with cassadan was presence of anxious-depressive disorders of different degree of severity within two diagnostic headings on ICD-10: affective disorders and neurotic associated with stress, anxious-phobic states. In both subgroups application of the preparation led to valuable reduction of psychopathological phenomena of the first and the second spectrum, what became apparent in disappearance of tension feeling, concern about one’s somatic and mental state, weakening of watchfulness and hypochondria&. This testified to width of therapeutic effect of cassadan by borderline (neurotic, personality) states. All the components of cardiophobic syndrome (sensory, ideatory, vegetative) in parallel underwent reverse development: cardialgic sensations, feeling of “hindemiss in the chest”. difficult breathing, sweating, insomniac manifestations weakened and then disappeared completely; actions and thoughts of patients became more purposeful and fears - disactual. Results of investigations have shown that therapeutic range of preparation cassadan consist in normothymoleptic, anxiolytic, sedative and vegetostabilizing effects. Neurovegetative and cardiovascular disorders possess severe sensitivity to impact of the preparation. Among affective disturbances asthenodepressive and anxious-phobic disorders are notable for disposition to the preparation’s action,
A-16 El
P 300 in the families of schizophrenics
V. Kontaxakis, B. Havaki-Kontaxaki, M. Margariti, S. Stamouli, K. Kollias, G.N. Christodoulou. Department of Psychiatry, University of Athens, Eginition Hospital, 74 Vas. Sophias Av., 11528 Athens, Greece
Lebedeva, IS., Orlova, V.A., Savina, T.D. Preventive Genetics Laboratory, National Mental Health Research Cmtre, 2, Zagorodnoe shosse. Moscow, Russia.
The increased risk of suicide among schizophrenic patients is well documented. There is evidence on a possible relationship between suicidal behaviour and pharmacological parameters. The aim of this study is to describe the differential pharmacological characteristics of schizophrenic inpatients with suicidal thoughts. A total of 93 schizophrenic inpatients (male 69%, female 31%) defined according to DSM-IV criteria, representing consecutive admissions to the Eginition Hospital, Psychiatric
The study was done in the boundaries of the complex multidisciplinary examination of families of schizophrenics. EEG was recorded in 12 derivations (frontal, central, parietal and temporal zones). P 300 was obtained in auditory oddball paradigm (probability of target tone-0.2.). Tested group included 20 probands (on medication), 32 parents and 15 sibs. Obtained data were subjected to statistical analysis (Student tcriterion).
Poster A. Clinical
25 females of 22-42 ears with anxious-depressive syndrome were examined. The examined were subdivided into two groups: patients with generalized anxiety disorder (1st group) and patients with periodically emerging anxiety attacks (panic disorder, 2nd group). Serotonin level in blood platelets and in plasma was measured with methods based on HPLC with electrochemical detection. Results showed that serotonin amount in platelets of patients with panic manifestations (950?89 ng/109) significantly exceeded values of the first: (4432103, p
A-15 El
Schizophrenic inpatients with suicidal thoughts: I. social and clinical parameters
V. Kontaxakis, B. Havaki-Kontaxaki, M. Margariti, K. Kollias, S. Department of Psychiatry, University of Stamouli, G.N. Christodoulou. Athens. Eginition Hospital. 74 Vas. Sophias Av., 11528 Athens, Greece There is a high prevalence of suicidal behaviour among individuals with schizophrenia. Although suicide attempters and suicide completers have been extensively studied, less is known on suicidal ideators. The aim of this study is to obtain knowledge on the differential social and clinical characteristics of schizophrenic inpatients with suicidal thoughts. A total of 93 schizophrenic inpatients (male 69%, female 31%) defined according to DSM-IV criteria, representing consecutive admissions to the Eginition Hospital, Psychiatric Department, Athens, from October 1996 to October 1997, were included in the study. All patients were assessed using the Positive and Negative Syndrome Scale (PANSS, Kay 1991). and the Calgary Depression Scale for Schizophrenics (CDS, Addington 1994) on admission (during the first week). Schizophrenic patients rating 1 or more on the CDS item 8 “suicidality” (subjects with suicidal thoughts, N= 19, mean age 31.3 years, Group A) were compared with schizophrenics matched for age and sex and scoring zero on the same item (subjects without suicidal thoughts, N= 19, mean age 31.2 years, Group B) in many social, clinical and psychopathological parameters. Patients with suicidal thoughts (Group A) were differentiated from controls (Group B) in that they scored higher on the CDS (10.52 vs 3.52, p
References 1. Hawley, Cl., James, DV., Birkett, P.L., M.J., Priest, R.G., Suicidal ideation as a Psychiatry 1991, 159:232-238. 2. Landmark, J., Cemovsky, Z.Z., Mersky, attempts and ideation in schizophrenia. Br 20
A-16 El
Baldwin, D.S., De Ruiter, presenting complain. Br J H., Correlates of suicide J Psychiatry 1987, 15 1: 18-
Schizophrenic inpatients with suicidal thoughts: II. pharmacological parameters
Department, Athens, from October 1996 to October 1997, were included in the study. All patients were assessed using the Positive and Negative Syndrome Scale (PANSS, Kay 1991). the Calgary Depression Scale for Schizophrenics (CDS, Addington 1994), the Rating Scale for Extrapyramidal Side Effects (RSESE, Simpson 1970), the Rating Scale for Drug-Induced Akathisia (RSDIA, Barnes 1989), and the Abnormal Involuntary Movement Scale (AIMS, Guy 1976) on admission (during the frst week). Schizophrenic patients rating 1 or more on the CDS item 8 “suicidality” (subjects with suicidal thoughts, N= 19, mean age 31.3 years, Group A) were compared with schizophrenics matched for age and sex and scoring zero on the same item (subjects without suicidal thoughts, N= 19, mean age 31.2 years, Group B) in many pharmacological parameters. There were no significant differences between the two matched groups in all the pharmacological parameters studied, i.e. use of conventional neuroleptics (58% vs 68%). use of atypical neuroleptics (21% vs 16%), use of antidepressants (5% vs 16%), use of anxiolytics (74% vs 42%), use of antiparkinsonian agents (53% vs 53%). mean daily dose of neuroleptic (CPZ eqv, 747 mg vs 610 mg). and mean scores on the RSESE (9.36 vs 8.15) on the RSDIA (0.36 vs 0.21) or on the AIMS (4.36 vs 2.15).
Reference Azhar, M.Z., Varma, S.L., Akathisia-induced Psychiatry, 1992,7,5:239-241.
A-17 El
suicidal
behaviour.
Eur
Therapeutic possibilities of Cassadan by borderline disorders
V Semke, M. Aksyonov, I. Kupriyanova, L.Yakutyonok. Mental Health Research Institute, Sosnovy bor, Tomsk, 6340146, Russia Application of benzodiazepines is traditional in the therapy of psychosomatic disorders. We have conducted clinical trial of the preparation of this class cassadan (alprazolam) - firm Asta Medica (Germany). Preparation was administered depending on clinical indications at doses from 75 to 150 mg per day, duration of treatment course has constituted from 3 till 25 days. In our case indication to the therapy with cassadan was presence of anxious-depressive disorders of different degree of severity within two diagnostic headings on ICD-10: affective disorders and neurotic associated with stress, anxious-phobic states. In both subgroups application of the preparation led to valuable reduction of psychopathological phenomena of the first and the second spectrum, what became apparent in disappearance of tension feeling, concern about one’s somatic and mental state, weakening of watchfulness and hypochondria&. This testified to width of therapeutic effect of cassadan by borderline (neurotic, personality) states. All the components of cardiophobic syndrome (sensory, ideatory, vegetative) in parallel underwent reverse development: cardialgic sensations, feeling of “hindemiss in the chest”. difficult breathing, sweating, insomniac manifestations weakened and then disappeared completely; actions and thoughts of patients became more purposeful and fears - disactual. Results of investigations have shown that therapeutic range of preparation cassadan consist in normothymoleptic, anxiolytic, sedative and vegetostabilizing effects. Neurovegetative and cardiovascular disorders possess severe sensitivity to impact of the preparation. Among affective disturbances asthenodepressive and anxious-phobic disorders are notable for disposition to the preparation’s action,
A-16 El
P 300 in the families of schizophrenics
V. Kontaxakis, B. Havaki-Kontaxaki, M. Margariti, S. Stamouli, K. Kollias, G.N. Christodoulou. Department of Psychiatry, University of Athens, Eginition Hospital, 74 Vas. Sophias Av., 11528 Athens, Greece
Lebedeva, IS., Orlova, V.A., Savina, T.D. Preventive Genetics Laboratory, National Mental Health Research Cmtre, 2, Zagorodnoe shosse. Moscow, Russia.
The increased risk of suicide among schizophrenic patients is well documented. There is evidence on a possible relationship between suicidal behaviour and pharmacological parameters. The aim of this study is to describe the differential pharmacological characteristics of schizophrenic inpatients with suicidal thoughts. A total of 93 schizophrenic inpatients (male 69%, female 31%) defined according to DSM-IV criteria, representing consecutive admissions to the Eginition Hospital, Psychiatric
The study was done in the boundaries of the complex multidisciplinary examination of families of schizophrenics. EEG was recorded in 12 derivations (frontal, central, parietal and temporal zones). P 300 was obtained in auditory oddball paradigm (probability of target tone-0.2.). Tested group included 20 probands (on medication), 32 parents and 15 sibs. Obtained data were subjected to statistical analysis (Student tcriterion).