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Second Interim Revision Announcement PHARMACOPEIA OF THE UNITED STATES
JOURNAL OF THE AMERICAN PHARMACEUTICAL ASSOCIATION
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Second Interim Revision Announcement
~ PHARMACOPEIA OF THE UNITED STATES ~
I" , , , , , ., , , , , , , , , , , , , , , , , , , ,"~:,~:,: ,:,~, , ,~,: :~:"~",.,~" "," , , , , , ., , "~J
The following U.S.P. XV interim revisions have been approved, to become effective as of June I, 1956. In view of the fact that the First U.S.P. XV Supplement is scheduled for release in the near future, the U .S.P. headquarters does not contemplate distributing reprints of the Second Interim Revision Announcement. The interim revisions announced herein and in the previous announcement (see THIS JOURNAL. 17, 40, Jan. 1956) will be included in the First U.S.P. XV Supplement, which is scheduled to appear this year, and which will be mailed to all registered holders of U.S.P. XV who have returned the Supplements postcard supplied with each copy. Aluminum, page 30-Change the section Heavy metals to read: Heavy metals, page 898-Dilute 25 m!. of Solution A with water to 50 ml.: the heavy metals limit for Aluminum, determined in 25 mI. of the solution, is 100 parts per million. Calamine Lotion, page nO-Insert after the first paragraph of the directions for preparation, the following: If a more viscous consistency in the Lotion is desired, the quantity of bentonite magma may be increased to not more than 400 m!. Dibasic Calcium Phosphate, page 123-1n the rubric de1~t~, the words "calculated on the anhydrous basIs. . Erythromycin Tablets, page 269-Change the rubric to read:
Erythromycin Tablets contain not less than 85 per cent of the labeled amount of erythromycin, present in the form of erythromycin or a suitable salt of erythromycin. Heparin Sodium Injection page 318-Change the section Pyrogen to read: Pyrogen-Heparin Sodium Injection, diluted if necessary with pyrogen-free saline T .S. to a concentration of 1000 U.S.P. Heparin Units in each mI., meets the requirements of the Pyrogen Test, page 883, the test dose being 2 m!. per Kg. of body weight. Methenamine Mandelate, page 427-1n the rubric change "not more than 50 per cent of mandelic acid (CSH S03)" to: not less than 50 per cent of mandelic acid (CsHsOa). Polymyxin B Sulfate, page 564-1n the section Loss on drying change "4 per cent" to: 7 per cent. Sulfoxone Sodium Tablets, page 703-1n the Assay, delete "X 100" from the formula in the second sentence of the paragraph Procedure. Calcium Pantothenate Assay, page 861-1n the section Para-aminobenzoic Acid-Nicotinic AcidPyridoxine Hydrochloride Solution, page 862, change "20 mcg. of nicotinic acid" to: 50 mcg. of nicotinic acid. Reagents, page 948-Under Papaic Digest of Soybean Meal, page 1026, delete the second sentence and substitute therefore the following: It meets the specifications under Pancreatic Digest of Casein, page 1024, except that it shows substantial amounts of reducing sugars. It contains fermentable carbohydrates and gives positive tests for indole, acetylmethylcarbinol and sulfide upon inoculation and incubation with the specified organisms. Released May 22, 1956; Official June 1, 1956. By authority of the U.S.P. Board of Trustees and of the Executive Committee of Revision. C. MILLER, Director of P harmacopeial Revision
ROU~S.~~B~:"dI~ ¥~:;!e':san
LLOYD
Drs. Fischelis and Hughes Honored Seated (I. to r.)-Drs. Robert P. Fischelf,s and Edward J. Hughes. Standing (1. to r.)-Dr. Ivor Griffith, Dr. John N. McDonnell, and Mr. James B. Merrick. The Alumni Association of the Philadelphia College of Pharmacy and Science at the Drake Hotel in Philadelphia, May 12, presented the Annual Alumni Associat.ion A wards to Dr. Robert P. Fischelis, Secretary and General Manager of the AMERICAN PHARMACEUTICAL ASSOCIATION,
and to Dr. Edward J. Hughes, recently retired from the post of Director of the analytical laboratories of Eli Lilly and Co. Dr. Fischelis graduated in 1911 from the School of Pharmacy of Medico-Chirurgical College, now merged with the Philadelphia College, and Dr. Hughes was a member of the P.C.P. class of 1916. The presentations were made by Alumni President James B. Merrick and Dr. John N. McDonnell, Chairman of the awards committee. Dr. Tvor Griffith, President of the College, extellded greetings to more than 300 returning graduates.
408
Vol. XVII, No.6
I
I
=1111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111I1I1I11111II111I111I1I111111II11I1I111I1I11l1111I11l!
Second Interim Revision Announcement
~ PHARMACOPEIA OF THE UNITED STATES ~
I" , , , , , ., , , , , , , , , , , , , , , , , , , ,"~:,~:,: ,:,~, , ,~,: :~:"~",.,~" "," , , , , , ., , "~J
The following U.S.P. XV interim revisions have been approved, to become effective as of June I, 1956. In view of the fact that the First U.S.P. XV Supplement is scheduled for release in the near future, the U .S.P. headquarters does not contemplate distributing reprints of the Second Interim Revision Announcement. The interim revisions announced herein and in the previous announcement (see THIS JOURNAL. 17, 40, Jan. 1956) will be included in the First U.S.P. XV Supplement, which is scheduled to appear this year, and which will be mailed to all registered holders of U.S.P. XV who have returned the Supplements postcard supplied with each copy. Aluminum, page 30-Change the section Heavy metals to read: Heavy metals, page 898-Dilute 25 m!. of Solution A with water to 50 ml.: the heavy metals limit for Aluminum, determined in 25 mI. of the solution, is 100 parts per million. Calamine Lotion, page nO-Insert after the first paragraph of the directions for preparation, the following: If a more viscous consistency in the Lotion is desired, the quantity of bentonite magma may be increased to not more than 400 m!. Dibasic Calcium Phosphate, page 123-1n the rubric de1~t~, the words "calculated on the anhydrous basIs. . Erythromycin Tablets, page 269-Change the rubric to read:
Erythromycin Tablets contain not less than 85 per cent of the labeled amount of erythromycin, present in the form of erythromycin or a suitable salt of erythromycin. Heparin Sodium Injection page 318-Change the section Pyrogen to read: Pyrogen-Heparin Sodium Injection, diluted if necessary with pyrogen-free saline T .S. to a concentration of 1000 U.S.P. Heparin Units in each mI., meets the requirements of the Pyrogen Test, page 883, the test dose being 2 m!. per Kg. of body weight. Methenamine Mandelate, page 427-1n the rubric change "not more than 50 per cent of mandelic acid (CSH S03)" to: not less than 50 per cent of mandelic acid (CsHsOa). Polymyxin B Sulfate, page 564-1n the section Loss on drying change "4 per cent" to: 7 per cent. Sulfoxone Sodium Tablets, page 703-1n the Assay, delete "X 100" from the formula in the second sentence of the paragraph Procedure. Calcium Pantothenate Assay, page 861-1n the section Para-aminobenzoic Acid-Nicotinic AcidPyridoxine Hydrochloride Solution, page 862, change "20 mcg. of nicotinic acid" to: 50 mcg. of nicotinic acid. Reagents, page 948-Under Papaic Digest of Soybean Meal, page 1026, delete the second sentence and substitute therefore the following: It meets the specifications under Pancreatic Digest of Casein, page 1024, except that it shows substantial amounts of reducing sugars. It contains fermentable carbohydrates and gives positive tests for indole, acetylmethylcarbinol and sulfide upon inoculation and incubation with the specified organisms. Released May 22, 1956; Official June 1, 1956. By authority of the U.S.P. Board of Trustees and of the Executive Committee of Revision. C. MILLER, Director of P harmacopeial Revision
ROU~S.~~B~:"dI~ ¥~:;!e':san
LLOYD
Drs. Fischelis and Hughes Honored Seated (I. to r.)-Drs. Robert P. Fischelf,s and Edward J. Hughes. Standing (1. to r.)-Dr. Ivor Griffith, Dr. John N. McDonnell, and Mr. James B. Merrick. The Alumni Association of the Philadelphia College of Pharmacy and Science at the Drake Hotel in Philadelphia, May 12, presented the Annual Alumni Associat.ion A wards to Dr. Robert P. Fischelis, Secretary and General Manager of the AMERICAN PHARMACEUTICAL ASSOCIATION,
and to Dr. Edward J. Hughes, recently retired from the post of Director of the analytical laboratories of Eli Lilly and Co. Dr. Fischelis graduated in 1911 from the School of Pharmacy of Medico-Chirurgical College, now merged with the Philadelphia College, and Dr. Hughes was a member of the P.C.P. class of 1916. The presentations were made by Alumni President James B. Merrick and Dr. John N. McDonnell, Chairman of the awards committee. Dr. Tvor Griffith, President of the College, extellded greetings to more than 300 returning graduates.
408
Vol. XVII, No.6