- Email: [email protected]
Selective radiotherapy of unresectable hepatocellular carcinoma
216 SELE”WE RADIOTHERAPY OF UNRESECTABLE HEPATGCELLULAR CARClNGM.4 J R Novell. A HiIron’. G Dusheik”. A Green’. K Hobbs_ Hepatobiliary and Liver Tmnsplantati”n Unit, of Nuclear Medicine. + Clinical 0ncol”gy Department, Royal Free Hospital London, UK
’ Department
The therapeutic role of 131-I Lipicdal was evaluated in a pilot group of patients with primary ““resectable hepatocellular carcinoma (HCC). Ten patients, mean age 63 (SD 10) years, received a mean total actitity of IOBO (SD 521) MBq via the hepatic artery as one or wo treatments. All showed scleedve loealisadon afthe isatape with t”mo”r:liver rados of up to 3O:l. The mean cumulative radiation dose was 3340 (SD 3390) cGy t” t”m”“r, 370 (SD 169) ffiy to liver and 390 (SD 190) cGy t” lung. The mean dme per administered activity was 3.8 (SD 4.3) cGy/MBq. Nine patients are evaluable between 1 and 21 months from treatment. Partial turnour response (reduction in t”m”“r size ~-50% + reduction in semm APP levels) was seen in six. One patient has undergone excision of two l”mo”r nodules which proved to be completely necrotic. The mean suwival to date is 9.0 (SD 6.8) mmdhr. 131-l Lipiodol is capable of delivetig highly selective internsl irrsdiadon to inoperable foci of HCC with objective response in two-lhirds of cases, and may be the treatment of choice fm small t”mo”rs in patients with cirrhosis.
’ Department
The therapeutic role of 131-I Lipicdal was evaluated in a pilot group of patients with primary ““resectable hepatocellular carcinoma (HCC). Ten patients, mean age 63 (SD 10) years, received a mean total actitity of IOBO (SD 521) MBq via the hepatic artery as one or wo treatments. All showed scleedve loealisadon afthe isatape with t”mo”r:liver rados of up to 3O:l. The mean cumulative radiation dose was 3340 (SD 3390) cGy t” t”m”“r, 370 (SD 169) ffiy to liver and 390 (SD 190) cGy t” lung. The mean dme per administered activity was 3.8 (SD 4.3) cGy/MBq. Nine patients are evaluable between 1 and 21 months from treatment. Partial turnour response (reduction in t”m”“r size ~-50% + reduction in semm APP levels) was seen in six. One patient has undergone excision of two l”mo”r nodules which proved to be completely necrotic. The mean suwival to date is 9.0 (SD 6.8) mmdhr. 131-l Lipiodol is capable of delivetig highly selective internsl irrsdiadon to inoperable foci of HCC with objective response in two-lhirds of cases, and may be the treatment of choice fm small t”mo”rs in patients with cirrhosis.