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SEPTUM PELLUCIDUM CAVITIES AND SCHIZOPHRENIA 25 YEARS ON: A REVIEW AND META-ANALYSIS
Abstracts
345
Poster 106
Poster 107
CONTRIBUTION OF GENETIC VARIABILITY IN INTERLEUKIN-1 CLUSTER (2Q13) TO THE RISK OF FUNCTIONAL PSYCHOSIS AND ITS ASSOCIATED BRAIN ABNORMALITIES
EFFECT OF OLIG2 IN WHITE MATTER INTEGRITY IN HEALTHY SUBJECTS AND PATIENTS WITH SCHIZOPHRENIA
Sergi Papiol1,4, Vicente Molina2,4, Mar Fatjó-Vilas1,4, Ana Monfort1, Araceli Rosa1,4, Bárbara Arias1,4, Javier Sanz3,4, J. Calama2, A.I. Hernández2, C. Martín2, Lourdes Fañanás1,4 1 Unitat d'Antropologia (Dep de Biologia Animal) Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain; 2Department of Psychiatry, Hospital Clínico de Salamanca, Salamanca, Spain; 3Department of Psychiatry, Hospital Doce de Octubre, Edificio de Medicina Comunitaria, Madrid, Spain; 4 CIBER Salud Mental, Instituto de Salud Carlos III (CIBERSAM), Spain Background: Current knowledge indicates an important degree of overlap between schizophrenia and bipolar disorder in terms of epidemiology, psychopathology, symptoms, treatment and risk factors (Murray et al., 2004). This overlap strongly suggests the existence of a common genetic risk Background that may account for some of these similarities (Murray et al., 2004, Lichtenstein et al., 2009, Potash & Bienvenu 2009). Among these shared features, altered levels of cytokines have been classically described in both diagnoses (Maes et al., 1995, 1997; Strous & Shoenfeld 2006; Drzyzga et al., 2006; Nawa & Takei 2006; O'Brien et al., 2006). The Interleukin-1β (IL-1β) and the Interleukin-1 Receptor Antagonist (IL-1Ra) are two cytokines which compete for the occupancy of IL-1 receptor type I. These cytokines are involved in the regulation of dopaminergic differentiation of mesencephalic precursors (Potter et al., 1999; Rodriguez-Pallares et al., 2005) and modulating the dendritic development and complexity in cortical neurons (Gilmore et al., 2004). Genes encoding IL-1β and IL-1Ra are located in the IL-1 cluster, encompassing 400Kb on chromosome 2q13. Linkage studies in schizophrenia (Ng et al., 2009) and in bipolar disorder (Goes et al., 2007), have robustly implicated 2q13 as a candidate region for both disorders. Previous association studies based on functional genetic variants affecting expression of IL-1B and IL-1RN genes have shown that certain haplotypic combination in the IL-1 cluster was associated with an increased risk to develop schizophrenia and bipolar disorder (Katila et al.,1999; Papiol et al., 2004). Interestingly, neuroimaging data in schizophrenia have shown that a IL-1RN gene is associated with lateral ventricles enlargement in schizophrenia (Papiol et al., 2005) and IL1B gene is associated with grey and white matter deficits (Meisenzahl et al., 2001; Maitra et al., 2009). Methods: Genetic variability at IL-1B and IL-1RN genes was analyzed in a new sample of schizophrenic patients (n = 40) and healthy controls (n = 20) with available MRI data, aiming to understand whether the genetic effects of IL-1 cluster on brain morphology are disease-specific or independent of disease status. Results: We present further evidence regarding the effect of IL-1 cluster genetic variability on brain morphology, including the estimation of the haplotypic effect of this genetic variability on these structural variables. Discussion: The relevance and implications of a cytokine unbalance with regard to the increased risk for psychosis are still unknown. However our data suggest that this risk might perhaps be mediated by brain morphological changes, likely to originate from an altered neurodevelopment. In this context the cytokine relative levels might play a key role i) in front of exposures to infection, ii) the development of cortical neurons and/or iii) the differentiation of dopaminergic precursors (Weinberger 1987; Rapoport et al., 2005). Acknowledgements: Supported by Fundació "La Caixa" (99-111-00; 99-042-00), Instituto de Salud Carlos III, CIBER-Salud Mental (CIBERSAM) and Spanish Ministry of Science and Innovation (SAF2008-05674-C03-01). doi:10.1016/j.schres.2010.02.601
Diana P. Prata1, Richard Kanaan1, Gareth Barker1, Sukhwinder Shergill1, James Woolley1, Lyudmila Georgieva2, Marco Picchioni1, Fergus Kane1, Muriel Walsh1, Matt Allin1, Timothea Toulopoulou1, Elvira Bramon1, Colm McDonald3, Vincent Giampietro1, Michael O'Donovan2, Philip McGuire1 1 Institute of Psychiatry, King's College London, London, England, United Kingdom; 2MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University Cardiff, Wales, United Kingdom; 3Clinical Science Institute, National University of Ireland, Galway, Ireland, Ireland Background: Altered brain connectivity is a feature of schizophrenia, and genetic, functional and neuroimaging studies have suggested white matter deficits may contribute to it. Factors that affect the myelination of white matter, such as the function of oligodendroglia, may thus contribute substantially to the aetiology of the disorder. The oligodendrocyte lineage transcription factor 2 (OLIG2) regulates the genesis of oligodendrocytes and has been previously associated with schizophrenia. We examined the effect of a polymorphism in OLIG2, rs1059004, on cerebral white matter integrity in healthy volunteers and in subjects with schizophrenia. We predicted that the allele previously found to be more frequent in the schizophrenic population would be associated with lower white matter integrity in the healthy and in the schizophrenic population. Methods: We used Diffusion tensor imaging (DTI) to measure voxelwise fractional anisotropy (FA), a neuroimaging proxy of white matter integrity, in 78 healthy volunteers and 36 patients with schizophrenia, all caucasian. The effects of genotype and diagnostic group on activation and their interaction were estimated using a factorial ANOVA. Results: The A allele, previously found to be significantly more common in schizophrenia patients, was significantly associated with lower FA in the L and R posterior limb of the internal capsule, L and R superior and posterior corona radiata, L corpus callosum, and R superior longitudinal fasciculus, irrespective of diagnostic group. This was mainly driven by an allele-load effect in healthy subjects. In healthy subjects, but not the schizophrenic group, lower FA was also significantly associated with the A allele in the L and R superior and posterior corona radiata. Discussion: The putative schizophrenia susceptibility gene OLIG2 is associated with differences in FA which is indicative of differences in white matter integrity. This lends further support to the idea that deficits in white matter organization, plausibly related to myelination abnormalities, lie at the origin of the anatomical and functional disconnectivity evident in schizophrenia. doi:10.1016/j.schres.2010.02.602
Poster 108 SEPTUM PELLUCIDUM CAVITIES AND SCHIZOPHRENIA 25 YEARS ON: A REVIEW AND META-ANALYSIS S. Arkoma, B. Kennedy, S.W. Lewis The University of Manchester, Manchester, Greater Manchester, United Kingdom Background: Septum pellucidum cavities are a neurodevelopmental anomaly. Since a claimed association with psychosis in 1985, many case-control studies using MR and post-mortem have been done, with mixed results. Our aim was to find out if there is an association between presence of cavities in the septum pellucidum and psychosis and whether there is an association with large cavities.
346
Abstracts
Methods: Medline, Embase, Psychinfo, Cochrane, Scopus and Web of knowledge were searched to find the relevant articles published before August 2009. Because of the fast advanced MR imaging techniques meta-analysis was performed only on seven studies that used high quality MR imaging and were constructed similarly. Data was pooled using Mantel–Haenzel Odds Ratio (fixed effect model). With the rest of the included studies a narrative synthesis was used. Results: 610 studies were found in the searches and 37 studies were extractred.18 studies with 2849 participants were included. Studies were screened by one reviewer. All the selected studies were case controlled studies. There were 16 MRI studies and 2 post mortem studies. Technical quality varied widely among the studies. Because of this meta-analysis was performed on only seven studies. This showed no overall increased rate of cavities in psychotic patients (n = 555/722) versus healthy controls (n = 397/517), but a significantly increased rate of large (6 mm or more) cavities (OR 95% CI p = 0.04). Men seemed to have a CSP more often than women. Discussion: The review concluded that presence of a CSP does not constitute a pathological phenomena but is more a normal anatomical variant. However, when the size of the CSP is defined quantitatively using appropriate high resolution techniques, a significant association with psychosis is seen when the CSP is 6 mm or more in it's anterior to posterior length. doi:10.1016/j.schres.2010.02.603
Poster 109 VOXEL-BASED MORPHOMETRY AND DEFAULT MODE NETWORK IN SCHIZOPHRENIA: RELATION TO COGNITION, SYMPTOMS AND SOCIAL FUNCTIONING Nuria Pujol1,2, Rafael Penadés1,2, Rosa Catalan1, Clemente García1 Hospital Clinic i Provincial de Barcelona Barcelona, Barcelona, Spain; 2 Universitat de Barcelona Barcelona, Barcelona, Spain
1
Background: The purpose of the present study was to characterize the association between cognition, clinical symptoms and social functioning and anatomical cerebral deficits in a sample of schizophrenia outpatients using voxel-based morphometry (VBM). Methods: Participants were 6 schizophrenia outpatients and 8 matched (sex ,age) healthy comparison subjects. Both patients and healthy controls were assessed using VBM. Cognitive status was assessed by standardised neuropsychological test battery. Psychopathology was evaluated using the Positive and Negative Syndrome Scale (PANSS). Social functioning was assessed using Life Skills Profile (LSP). Results: (preliminar results) Decreased gray matter volume was observed in schizophrenia patients in left medial temporal gyrus, left insula and bilateral superior temporal gyri (uncorrected data). Discussion: These preliminar findings revealed volume loss in the the left medial temporal gyrus, left insula and bilateral superior temporal gyri in schizophrenia outpatients. doi:10.1016/j.schres.2010.02.604
Poster 110 EARLY ONSET PSYCHOSIS: LONGITUDINAL BRAIN CHANGES AT TWO YEARS FOLLOW-UP Marta Rapado-Castro1, Santiago Reig2, Mara Parellada1, Dolores Moreno1, Josefina Castro-Fornieles3, Ana González-Pinto4, Soraya Otero5, Inmaculada Baeza3, Montserrat Graell6, Joost Janssen2, Manuel Desco2, Celso Arango1
1 Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Madrid, Spain; 2Experimental Medicine Department, Hospital General Universitario Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Madrid, Spain; 3Servicio de Psiquiatría y Psicología Infanto-Juvenil, Hospital Clinic de Barcelona, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM Barcelona, Cataluña, Spain; 4Stanley Institute International Mood-Disorders Research Center, 03-RC-003, Hospital Santiago Apóstol de Vitoria, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM. Vitoria, Pais Vasco, Spain; 5Unidad de Psiquiatría Infantil, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain; 6 Sección de Psiquiatría y Psicología, Hospital Infantil Universitario Niño Jesús Madrid, Madrid, Spain
Background: Progressive loss of cortical grey matter and increase of ventricular volumes have been reported, not only in patients with childhood-onset schizophrenia but also in early-onset psychoses. This study examines progressive brain changes in first-episode early-onset psychosis. Methods: A sample of 110 patients and 98 healthy controls was recruited. Of those, 61 (20 females) patients (mean age at baseline 15.5 ± 1.8) and a matched control sample of 70 (23 females) had anatomical brain MRI valid data both at baseline and at 2 years follow-up (mean = 25 months). Total volumes of gray matter and cerebrospinal fluid of the frontal, parietal, temporal and occipital lobes were obtained using automated method based in Talairach´ atlas. Results: Frontal lobe rate of GM volume loss within the 2 yr follow-up was larger in patients -2.9% males; -3.3% females) than in controls (-0.3% males; -0.0% females). Male patients showed a significant increase of CSF volume in the left frontal lobe within the follow up (26.6% males; 24.6% females) than in controls (10.4% males; 11.0% females). Discussion: Patients showed deficits of GM volume and excess of CSF in the frontal lobe and smaller volume of CSF in the temporal lobes. Differences between groups increased along the two year follow-up. Volume deficits in this population are not static suggesting that patients experience progressive changes larger than expected after the appearance of psychotic symptoms. doi:10.1016/j.schres.2010.02.605
Poster 111 GREY MATTER REDUCTION IN FIRST-EPISODE PSYCHOSIS: RELATIONSHIP TO DIAGNOSIS Diana Tordesillas-Gutierrez1, Nikolaos Koutsouleris2, Roberto Roiz-Santiañez1, Rocío Pérez-Iglesias1, Eva Meisenzahl2, Enrique Marco de Lucas3, Elsa Gómez-Ruiz1, Rosa Ayesa-Arriola1, Benedicto Crespo-Facorro1 1 University Hospital Marqués de Valdecilla, CIBERSAM, Department of Psychiatry, School of Medicine, University of Cantabria Santander, Cantabria, Spain; 2Klinik und Poliklinik für Psychiatrie und Psychotherapie, Ludwig-Maximilians-Universität München Muenchen, Bavaria, Germany; 3University Hospital Marqués de Valdecilla, Department of Neuroradiology Santander, Cantabria, Spain Background: Previous VBM studies in the literature reveal grey mater abnormalities in psychotic patients when compared with healthy controls. But those studies are usually carried out in heterogeneous samples were the patients have different diagnostics and the subjects are not further classified. Here we have investigated a large sample (118) of first episode psychosis patients that are then separated in
345
Poster 106
Poster 107
CONTRIBUTION OF GENETIC VARIABILITY IN INTERLEUKIN-1 CLUSTER (2Q13) TO THE RISK OF FUNCTIONAL PSYCHOSIS AND ITS ASSOCIATED BRAIN ABNORMALITIES
EFFECT OF OLIG2 IN WHITE MATTER INTEGRITY IN HEALTHY SUBJECTS AND PATIENTS WITH SCHIZOPHRENIA
Sergi Papiol1,4, Vicente Molina2,4, Mar Fatjó-Vilas1,4, Ana Monfort1, Araceli Rosa1,4, Bárbara Arias1,4, Javier Sanz3,4, J. Calama2, A.I. Hernández2, C. Martín2, Lourdes Fañanás1,4 1 Unitat d'Antropologia (Dep de Biologia Animal) Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain; 2Department of Psychiatry, Hospital Clínico de Salamanca, Salamanca, Spain; 3Department of Psychiatry, Hospital Doce de Octubre, Edificio de Medicina Comunitaria, Madrid, Spain; 4 CIBER Salud Mental, Instituto de Salud Carlos III (CIBERSAM), Spain Background: Current knowledge indicates an important degree of overlap between schizophrenia and bipolar disorder in terms of epidemiology, psychopathology, symptoms, treatment and risk factors (Murray et al., 2004). This overlap strongly suggests the existence of a common genetic risk Background that may account for some of these similarities (Murray et al., 2004, Lichtenstein et al., 2009, Potash & Bienvenu 2009). Among these shared features, altered levels of cytokines have been classically described in both diagnoses (Maes et al., 1995, 1997; Strous & Shoenfeld 2006; Drzyzga et al., 2006; Nawa & Takei 2006; O'Brien et al., 2006). The Interleukin-1β (IL-1β) and the Interleukin-1 Receptor Antagonist (IL-1Ra) are two cytokines which compete for the occupancy of IL-1 receptor type I. These cytokines are involved in the regulation of dopaminergic differentiation of mesencephalic precursors (Potter et al., 1999; Rodriguez-Pallares et al., 2005) and modulating the dendritic development and complexity in cortical neurons (Gilmore et al., 2004). Genes encoding IL-1β and IL-1Ra are located in the IL-1 cluster, encompassing 400Kb on chromosome 2q13. Linkage studies in schizophrenia (Ng et al., 2009) and in bipolar disorder (Goes et al., 2007), have robustly implicated 2q13 as a candidate region for both disorders. Previous association studies based on functional genetic variants affecting expression of IL-1B and IL-1RN genes have shown that certain haplotypic combination in the IL-1 cluster was associated with an increased risk to develop schizophrenia and bipolar disorder (Katila et al.,1999; Papiol et al., 2004). Interestingly, neuroimaging data in schizophrenia have shown that a IL-1RN gene is associated with lateral ventricles enlargement in schizophrenia (Papiol et al., 2005) and IL1B gene is associated with grey and white matter deficits (Meisenzahl et al., 2001; Maitra et al., 2009). Methods: Genetic variability at IL-1B and IL-1RN genes was analyzed in a new sample of schizophrenic patients (n = 40) and healthy controls (n = 20) with available MRI data, aiming to understand whether the genetic effects of IL-1 cluster on brain morphology are disease-specific or independent of disease status. Results: We present further evidence regarding the effect of IL-1 cluster genetic variability on brain morphology, including the estimation of the haplotypic effect of this genetic variability on these structural variables. Discussion: The relevance and implications of a cytokine unbalance with regard to the increased risk for psychosis are still unknown. However our data suggest that this risk might perhaps be mediated by brain morphological changes, likely to originate from an altered neurodevelopment. In this context the cytokine relative levels might play a key role i) in front of exposures to infection, ii) the development of cortical neurons and/or iii) the differentiation of dopaminergic precursors (Weinberger 1987; Rapoport et al., 2005). Acknowledgements: Supported by Fundació "La Caixa" (99-111-00; 99-042-00), Instituto de Salud Carlos III, CIBER-Salud Mental (CIBERSAM) and Spanish Ministry of Science and Innovation (SAF2008-05674-C03-01). doi:10.1016/j.schres.2010.02.601
Diana P. Prata1, Richard Kanaan1, Gareth Barker1, Sukhwinder Shergill1, James Woolley1, Lyudmila Georgieva2, Marco Picchioni1, Fergus Kane1, Muriel Walsh1, Matt Allin1, Timothea Toulopoulou1, Elvira Bramon1, Colm McDonald3, Vincent Giampietro1, Michael O'Donovan2, Philip McGuire1 1 Institute of Psychiatry, King's College London, London, England, United Kingdom; 2MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University Cardiff, Wales, United Kingdom; 3Clinical Science Institute, National University of Ireland, Galway, Ireland, Ireland Background: Altered brain connectivity is a feature of schizophrenia, and genetic, functional and neuroimaging studies have suggested white matter deficits may contribute to it. Factors that affect the myelination of white matter, such as the function of oligodendroglia, may thus contribute substantially to the aetiology of the disorder. The oligodendrocyte lineage transcription factor 2 (OLIG2) regulates the genesis of oligodendrocytes and has been previously associated with schizophrenia. We examined the effect of a polymorphism in OLIG2, rs1059004, on cerebral white matter integrity in healthy volunteers and in subjects with schizophrenia. We predicted that the allele previously found to be more frequent in the schizophrenic population would be associated with lower white matter integrity in the healthy and in the schizophrenic population. Methods: We used Diffusion tensor imaging (DTI) to measure voxelwise fractional anisotropy (FA), a neuroimaging proxy of white matter integrity, in 78 healthy volunteers and 36 patients with schizophrenia, all caucasian. The effects of genotype and diagnostic group on activation and their interaction were estimated using a factorial ANOVA. Results: The A allele, previously found to be significantly more common in schizophrenia patients, was significantly associated with lower FA in the L and R posterior limb of the internal capsule, L and R superior and posterior corona radiata, L corpus callosum, and R superior longitudinal fasciculus, irrespective of diagnostic group. This was mainly driven by an allele-load effect in healthy subjects. In healthy subjects, but not the schizophrenic group, lower FA was also significantly associated with the A allele in the L and R superior and posterior corona radiata. Discussion: The putative schizophrenia susceptibility gene OLIG2 is associated with differences in FA which is indicative of differences in white matter integrity. This lends further support to the idea that deficits in white matter organization, plausibly related to myelination abnormalities, lie at the origin of the anatomical and functional disconnectivity evident in schizophrenia. doi:10.1016/j.schres.2010.02.602
Poster 108 SEPTUM PELLUCIDUM CAVITIES AND SCHIZOPHRENIA 25 YEARS ON: A REVIEW AND META-ANALYSIS S. Arkoma, B. Kennedy, S.W. Lewis The University of Manchester, Manchester, Greater Manchester, United Kingdom Background: Septum pellucidum cavities are a neurodevelopmental anomaly. Since a claimed association with psychosis in 1985, many case-control studies using MR and post-mortem have been done, with mixed results. Our aim was to find out if there is an association between presence of cavities in the septum pellucidum and psychosis and whether there is an association with large cavities.
346
Abstracts
Methods: Medline, Embase, Psychinfo, Cochrane, Scopus and Web of knowledge were searched to find the relevant articles published before August 2009. Because of the fast advanced MR imaging techniques meta-analysis was performed only on seven studies that used high quality MR imaging and were constructed similarly. Data was pooled using Mantel–Haenzel Odds Ratio (fixed effect model). With the rest of the included studies a narrative synthesis was used. Results: 610 studies were found in the searches and 37 studies were extractred.18 studies with 2849 participants were included. Studies were screened by one reviewer. All the selected studies were case controlled studies. There were 16 MRI studies and 2 post mortem studies. Technical quality varied widely among the studies. Because of this meta-analysis was performed on only seven studies. This showed no overall increased rate of cavities in psychotic patients (n = 555/722) versus healthy controls (n = 397/517), but a significantly increased rate of large (6 mm or more) cavities (OR 95% CI p = 0.04). Men seemed to have a CSP more often than women. Discussion: The review concluded that presence of a CSP does not constitute a pathological phenomena but is more a normal anatomical variant. However, when the size of the CSP is defined quantitatively using appropriate high resolution techniques, a significant association with psychosis is seen when the CSP is 6 mm or more in it's anterior to posterior length. doi:10.1016/j.schres.2010.02.603
Poster 109 VOXEL-BASED MORPHOMETRY AND DEFAULT MODE NETWORK IN SCHIZOPHRENIA: RELATION TO COGNITION, SYMPTOMS AND SOCIAL FUNCTIONING Nuria Pujol1,2, Rafael Penadés1,2, Rosa Catalan1, Clemente García1 Hospital Clinic i Provincial de Barcelona Barcelona, Barcelona, Spain; 2 Universitat de Barcelona Barcelona, Barcelona, Spain
1
Background: The purpose of the present study was to characterize the association between cognition, clinical symptoms and social functioning and anatomical cerebral deficits in a sample of schizophrenia outpatients using voxel-based morphometry (VBM). Methods: Participants were 6 schizophrenia outpatients and 8 matched (sex ,age) healthy comparison subjects. Both patients and healthy controls were assessed using VBM. Cognitive status was assessed by standardised neuropsychological test battery. Psychopathology was evaluated using the Positive and Negative Syndrome Scale (PANSS). Social functioning was assessed using Life Skills Profile (LSP). Results: (preliminar results) Decreased gray matter volume was observed in schizophrenia patients in left medial temporal gyrus, left insula and bilateral superior temporal gyri (uncorrected data). Discussion: These preliminar findings revealed volume loss in the the left medial temporal gyrus, left insula and bilateral superior temporal gyri in schizophrenia outpatients. doi:10.1016/j.schres.2010.02.604
Poster 110 EARLY ONSET PSYCHOSIS: LONGITUDINAL BRAIN CHANGES AT TWO YEARS FOLLOW-UP Marta Rapado-Castro1, Santiago Reig2, Mara Parellada1, Dolores Moreno1, Josefina Castro-Fornieles3, Ana González-Pinto4, Soraya Otero5, Inmaculada Baeza3, Montserrat Graell6, Joost Janssen2, Manuel Desco2, Celso Arango1
1 Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Madrid, Spain; 2Experimental Medicine Department, Hospital General Universitario Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Madrid, Spain; 3Servicio de Psiquiatría y Psicología Infanto-Juvenil, Hospital Clinic de Barcelona, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM Barcelona, Cataluña, Spain; 4Stanley Institute International Mood-Disorders Research Center, 03-RC-003, Hospital Santiago Apóstol de Vitoria, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM. Vitoria, Pais Vasco, Spain; 5Unidad de Psiquiatría Infantil, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain; 6 Sección de Psiquiatría y Psicología, Hospital Infantil Universitario Niño Jesús Madrid, Madrid, Spain
Background: Progressive loss of cortical grey matter and increase of ventricular volumes have been reported, not only in patients with childhood-onset schizophrenia but also in early-onset psychoses. This study examines progressive brain changes in first-episode early-onset psychosis. Methods: A sample of 110 patients and 98 healthy controls was recruited. Of those, 61 (20 females) patients (mean age at baseline 15.5 ± 1.8) and a matched control sample of 70 (23 females) had anatomical brain MRI valid data both at baseline and at 2 years follow-up (mean = 25 months). Total volumes of gray matter and cerebrospinal fluid of the frontal, parietal, temporal and occipital lobes were obtained using automated method based in Talairach´ atlas. Results: Frontal lobe rate of GM volume loss within the 2 yr follow-up was larger in patients -2.9% males; -3.3% females) than in controls (-0.3% males; -0.0% females). Male patients showed a significant increase of CSF volume in the left frontal lobe within the follow up (26.6% males; 24.6% females) than in controls (10.4% males; 11.0% females). Discussion: Patients showed deficits of GM volume and excess of CSF in the frontal lobe and smaller volume of CSF in the temporal lobes. Differences between groups increased along the two year follow-up. Volume deficits in this population are not static suggesting that patients experience progressive changes larger than expected after the appearance of psychotic symptoms. doi:10.1016/j.schres.2010.02.605
Poster 111 GREY MATTER REDUCTION IN FIRST-EPISODE PSYCHOSIS: RELATIONSHIP TO DIAGNOSIS Diana Tordesillas-Gutierrez1, Nikolaos Koutsouleris2, Roberto Roiz-Santiañez1, Rocío Pérez-Iglesias1, Eva Meisenzahl2, Enrique Marco de Lucas3, Elsa Gómez-Ruiz1, Rosa Ayesa-Arriola1, Benedicto Crespo-Facorro1 1 University Hospital Marqués de Valdecilla, CIBERSAM, Department of Psychiatry, School of Medicine, University of Cantabria Santander, Cantabria, Spain; 2Klinik und Poliklinik für Psychiatrie und Psychotherapie, Ludwig-Maximilians-Universität München Muenchen, Bavaria, Germany; 3University Hospital Marqués de Valdecilla, Department of Neuroradiology Santander, Cantabria, Spain Background: Previous VBM studies in the literature reveal grey mater abnormalities in psychotic patients when compared with healthy controls. But those studies are usually carried out in heterogeneous samples were the patients have different diagnostics and the subjects are not further classified. Here we have investigated a large sample (118) of first episode psychosis patients that are then separated in