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Serum-sickness in rabbits: VII. A method for removing or destroying the factor causing serum-sickness
103
ABSTRACTS
volume” of ragweed in 0.2 C.C. of a 3 per cent solution was injected subcutaneously in the opposite arm. Forty-eight, hours later the opposite forearm was sensitized, and the procedure was repeated, using an equivalent amount of antigen hut in “large volume,” i.e., 2 c.c. of a 0.3 per cent solution. The time of appearance of the earliest and latest reactions at the sensitized sites and the highest dilution of reagin which reacted were measures of the rate and degree of al)sorption of the antigen. Control experiments were run in which the order of xtlministration of the “large” and “small volumes” was reversctl. In other CRSPS the two administrations were separated hy an interval of
of ragweed extract, than with subcutaneous
ahsorption was administration.
shown
to Ije more
Serum-Sickness in Rabbits: VII. A Method for Removing or Destroying the Fleisher, Al. S., and Jones, T,. H.: J. Tmrnunol. Factor Causing Serum-Sickness. 36:
311,
3039.
The treatment of horse antisera of various types with heat and alkali oveI specified periods of time resulted in a destruction of the factor causing serum sickness in rabbits. Destruction of the serum-sickness factor, however, was not By varying the concentration obtained in every serum with the same technique. of alkali, the temperature, the time of exposure to heat, and the dilution of the serum-alkali mixture, it was possible to destroy the factor causing salurn-sickness The effect of the without scriouslv impairing the antibody potency of the serum. treatment upon the antibody potency varied in different sera containing the same type of antibody and in different types of antisera. The samples human
results reported relate only to serum-sickness the use of treated serum proved toxic, beings is definitely contraindicated.
of
in the similarly
rabbit. treated
Since some serums in
Vaccine.
(‘lu~ilp, J.:
Pediatrics Asthma in Children Am.
J. Dis.
Chiltl.
Treated 58:
With
768,
Autogenous
Bronchoscopic
1939.
TITO huntlretl and twenty-three consecutive children M-it]1 :Istll,lla %v
ABSTRACTS
volume” of ragweed in 0.2 C.C. of a 3 per cent solution was injected subcutaneously in the opposite arm. Forty-eight, hours later the opposite forearm was sensitized, and the procedure was repeated, using an equivalent amount of antigen hut in “large volume,” i.e., 2 c.c. of a 0.3 per cent solution. The time of appearance of the earliest and latest reactions at the sensitized sites and the highest dilution of reagin which reacted were measures of the rate and degree of al)sorption of the antigen. Control experiments were run in which the order of xtlministration of the “large” and “small volumes” was reversctl. In other CRSPS the two administrations were separated hy an interval of
of ragweed extract, than with subcutaneous
ahsorption was administration.
shown
to Ije more
Serum-Sickness in Rabbits: VII. A Method for Removing or Destroying the Fleisher, Al. S., and Jones, T,. H.: J. Tmrnunol. Factor Causing Serum-Sickness. 36:
311,
3039.
The treatment of horse antisera of various types with heat and alkali oveI specified periods of time resulted in a destruction of the factor causing serum sickness in rabbits. Destruction of the serum-sickness factor, however, was not By varying the concentration obtained in every serum with the same technique. of alkali, the temperature, the time of exposure to heat, and the dilution of the serum-alkali mixture, it was possible to destroy the factor causing salurn-sickness The effect of the without scriouslv impairing the antibody potency of the serum. treatment upon the antibody potency varied in different sera containing the same type of antibody and in different types of antisera. The samples human
results reported relate only to serum-sickness the use of treated serum proved toxic, beings is definitely contraindicated.
of
in the similarly
rabbit. treated
Since some serums in
Vaccine.
(‘lu~ilp, J.:
Pediatrics Asthma in Children Am.
J. Dis.
Chiltl.
Treated 58:
With
768,
Autogenous
Bronchoscopic
1939.
TITO huntlretl and twenty-three consecutive children M-it]1 :Istll,lla %v