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Short-Term Observation on the Change of Lower Airway Inflammation and Airway Hyperresponsiveness in Non Asthmatic Patients With Allergic Rhinitis
Allergy and Airway SESSION TITLE: Asthma I SESSION TYPE: Original Investigation Poster PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
Short-Term Observation on the Change of Lower Airway Inflammation and Airway Hyperresponsiveness in Non Asthmatic Patients With Allergic Rhinitis Baojuan Liu PhD* Yanqing Xie PhD KeFang Lai MD; and Wei Luo Guangzhou Institute of Respiratory Disease, Guangzhou, China PURPOSE: To determine the change of airway inflammation and brochial responsiveness in patients with allergic rhinitis. METHODS: Sixty non-asthmatic patients with allergic rhinitis and twenty healthy adults who participated our study between 1st Jan,2011 and 12nd Dec,2011 were recruited between July,2012 and May,2013. All patients underwent peripheral blood routine test, Fractional exhaled nitric oxide (FeNO), nasal lavage, spirometry, methacholine bronchial provocation tests and induced sputum test. VAS scale was adopted to measure the severity of nasal symptoms. The newly onset respiraroty symptoms were carefully documented. RESULTS: In allergic rhinitis group, the severity of rhinitis in 5 (12%) subjects were mid and in 55 (88%) subjects were moderate to severe;Rhinitis in 45 (75%) subjects in were intermittent, in 15 (25%) subjects were perennial;51 subjects were symptom-free at least one week prior to the study;14 subjects were reporting improvement in nasal symptoms; VAS score decreased at the second visit (V2) compared with the first visit (V1) (P<0.05). Significant difference in sputum eosinophils count (V1 vs V2: 4 (0.00w65.5)%vs1.00 (0.00w27.25)%) and nasal lavage eosinophils (V1: 10.55 (0.00w131.8) 个/200 (HE) vs V2: 0.05 (0.00w69.6) 个/200 (HE)) between two visits was observed in AR (P¼0.018). Lung function and FeNO were stable between two visits (All P>0.05). AR patients with newly onset of BHR at V2 had a lower FEF25-75/pred% than that at V1 (P<0.05).
ALLERGY AND AIRWAY
CONCLUSIONS: AR patient with absence of lower airway related symptoms would not develop into asthma in a short-term. Bronchial hyperresponsiveness and lower airway eosinophilic inflammation gradually appears in nonasthmatic patients with allergic rhinitis. CLINICAL IMPLICATIONS: This study has revealed that change of lower airway inflammtion and airway hyperresponsiveness in AR before the onset of asthma. DISCLOSURE: The following authors have nothing to disclose: Baojuan Liu, Yanqing Xie, KeFang Lai, Wei Luo No Product/Research Disclosure Information DOI:
http://dx.doi.org/10.1016/j.chest.2016.02.010
Copyright ª 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
8A
[
149#4S CHEST APRIL 2016
]
Short-Term Observation on the Change of Lower Airway Inflammation and Airway Hyperresponsiveness in Non Asthmatic Patients With Allergic Rhinitis Baojuan Liu PhD* Yanqing Xie PhD KeFang Lai MD; and Wei Luo Guangzhou Institute of Respiratory Disease, Guangzhou, China PURPOSE: To determine the change of airway inflammation and brochial responsiveness in patients with allergic rhinitis. METHODS: Sixty non-asthmatic patients with allergic rhinitis and twenty healthy adults who participated our study between 1st Jan,2011 and 12nd Dec,2011 were recruited between July,2012 and May,2013. All patients underwent peripheral blood routine test, Fractional exhaled nitric oxide (FeNO), nasal lavage, spirometry, methacholine bronchial provocation tests and induced sputum test. VAS scale was adopted to measure the severity of nasal symptoms. The newly onset respiraroty symptoms were carefully documented. RESULTS: In allergic rhinitis group, the severity of rhinitis in 5 (12%) subjects were mid and in 55 (88%) subjects were moderate to severe;Rhinitis in 45 (75%) subjects in were intermittent, in 15 (25%) subjects were perennial;51 subjects were symptom-free at least one week prior to the study;14 subjects were reporting improvement in nasal symptoms; VAS score decreased at the second visit (V2) compared with the first visit (V1) (P<0.05). Significant difference in sputum eosinophils count (V1 vs V2: 4 (0.00w65.5)%vs1.00 (0.00w27.25)%) and nasal lavage eosinophils (V1: 10.55 (0.00w131.8) 个/200 (HE) vs V2: 0.05 (0.00w69.6) 个/200 (HE)) between two visits was observed in AR (P¼0.018). Lung function and FeNO were stable between two visits (All P>0.05). AR patients with newly onset of BHR at V2 had a lower FEF25-75/pred% than that at V1 (P<0.05).
ALLERGY AND AIRWAY
CONCLUSIONS: AR patient with absence of lower airway related symptoms would not develop into asthma in a short-term. Bronchial hyperresponsiveness and lower airway eosinophilic inflammation gradually appears in nonasthmatic patients with allergic rhinitis. CLINICAL IMPLICATIONS: This study has revealed that change of lower airway inflammtion and airway hyperresponsiveness in AR before the onset of asthma. DISCLOSURE: The following authors have nothing to disclose: Baojuan Liu, Yanqing Xie, KeFang Lai, Wei Luo No Product/Research Disclosure Information DOI:
http://dx.doi.org/10.1016/j.chest.2016.02.010
Copyright ª 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
8A
[
149#4S CHEST APRIL 2016
]