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SIALOLITHIASIS IN BUCCAL MUCOSA: A CASE REPORT
OOOO Volume 129, Number 1 hypotheses were radicular cyst, odontogenic keratocyst, ameloblastoma, and simple bone cyst. The treatment consisted of enucleation and curettage of the lesion. The histopathologic analysis of the surgical specimen was suggestive of a glandular odontogenic cyst. The patient is still being followed up.
SIALOLITHIASIS IN BUCCAL MUCOSA: A CASE REPORT. LEONARDO DE SOUZA LOUZARDO, VANESSA SANTOS RODRIGUES CANUTO, PRISCILLA FLORES SILVA GONCALVES, ¸ DIOGO DOS SANTOS DA MATA REZENDE, WALDNER RICARDO SOUZA DE CARVALHO, HELDER ANTONIO REBELO PONTES and, FLAVIA SIROTHEAU CORREA PONTES Sialoliths are calcified structures developed into the salivary duct system. They occur in approximately 1.2% of the population and are more common in men, although they may appear in young people, elderly people, and, more rarely, children. Here, we report a case of a 12-year-old female patient, who was attended by the oral pathology service in December 2015, with asymptomatic lesion in buccal mucosa with 3 years of evolution. Incisional biopsy was performed with histopathologic diagnosis of juvenile xanthogranuloma, subsequent removal of the lesion, and anatomopathologic examination evidencing the nodule size. After 5 months of follow-up, there was no sign of recurrence and oral cavity was normal.
METABOLIC-RELATED AND STEM CELL MARKERS IN A SERIES OF PRIMARY ORAL MUCOSAL MELANOMAS AND ORAL NEVI. JUAN CARLOS HERNANDEZ GUERRERO, CIRO DANTAS SOARES, THAYNA MELO DE LIMA MORAIS, ADALBERTO MOSQUEDA TAYLOR, MARIA DOLORES JIMENEZ FARFAN and, OSLEI PAES DE ALMEIDA Primary oral mucosal melanomas (POMM) are rare and aggressive neoplasms arising in the melanocytes from the epithelial lining of the oral cavity, and currently few prognostic markers are described. Objective: In this study, we investigated the expression of glucose transporter 1 (GLUT1), antimitochondrial antibody (AMT), and stem cell markers (CD44) in a series of 3 POMM and 3 oral nevi. Methods: Immunostainings of GLUT1, CD44, and AMT were quantitatively assessed by digital analyses. Results: POMM showed a proliferation of epithelioid or fusiform variable-pigmented melanocytes. GLUT1, CD44, and AMT were negative in all nevi and strongly expressed in the melanomas. Conclusion: Our results suggest that overexpression of mitochondrial and stem cells markers can help confirm the diagnosis of melanomas and they can be associated with the aggressive behavior of these rare tumors.
OCCURRENCE OF ORAL CANDIDIASIS IN PATIENTS WITH HEAD AND NECK CANCER SUBMITTED TO ANTINEOPLASTIC TREAT MENTS. FLAVIA GODINHO COSTA WANDERLEY ROCHA, JULIANA BORGES DE LIMA DANTAS, GABRIELA BOTELHO MARTINS, HAYANA RAMOS LIMA, MANOELA CARRERA, ROBERTO PAULO
ABSTRACTS
e129
CORREIA DE ARAUJO and, ALENA RIBEIRO ALVES PEIXOTO MEDRADO Objective: To assess the frequency of candidiasis in patients with head and neck cancer submitted to radiotherapy and/or chemotherapy. Study Design: This is a cross-sectional study consisting of a nonprobabilistic sample of patients with oral candidiasis diagnosed in a convenience group. Data were collected on people with oral candidiasis, such as sex, age, and type of treatment (chemotherapy, radiotherapy, or both), as well as the location and clinical diagnosis of the type of candidiasis. Results: Of the total 36 patients that met the inclusion criteria, 16 presented candidiasis (44.4%). Eleven individuals (68.75%) were of male sex, and 7 (43.75%) were between the fifth and sixth decades of life. The most prevalent type of candidiasis was pseudomembranous (87.5%), and the most affected site was the hard palate (50%). Of the 16 patients with oral candidiasis, 14 (87.5%) underwent radiotherapy associated with chemotherapy, while 2 (12.5%) only underwent radiotherapy. Conclusion: Oral candidiasis is a very common clinical condition in patients with neoplasia submitted to antineoplastic treatments. The presence of the dental surgeon in the multidisciplinary team that follows up oncologic patients is relevant, as it may help in the prevention and treatment of candidiasis and other clinical conditions.
PHOTODYNAMIC THERAPY USING CHLOROALUMINUM PHTHALOCYANINE IN AN EXPERIMENTAL RAT PERIODONTAL DISEASE MODEL. MAIARA DE MORAES, ROSEANE e PAULO FIGUEIRO CARVALHO VASCONCELOS, JOAO LONGO, LUIS ALEXANDRE MUEHLMANN, RICARDO BENTES DE AZEVEDO, AURIGENA ANTUNES ARAUJO and, ANTONIO DE LISBOA LOPES COSTA Objective: The purpose of the present study was to analyze cytokine profiles after application of photodynamic therapy (PDT) in gingival tissues of rats with ligature-induced periodontal disease (PD). Study Design: Periodontal disease was induced through the introduction of a cotton thread around the first left mandibular molar, while the right side molars did not receive ligatures. After 7 days of PD evolution, ligatures were removed, and animals were randomly divided into the following treatment groups: I, rats without treatment; II, rats received chloroaluminum phthalocyanine (AlClPc); III, rats received low-level laser alone; and IV, rats received AlClPc associated with low-level laser. The animals were killed 7 days after the treatments, and the mandibles were histologically processed to assess morphologic and immunohistochemical profile, while gingival tissues were removed for quantification of tumor necrosis factor a (TNF-a), interleukin (IL) 1 b and IL-10 expression (by enzyme-linked immunosorbent assay). Results: Histomorphologic analysis of periodontal tissues demonstrated that PDT-treated animals show tissue necrosis as well as lower TNF-a expression compared with ligatured animals treated with AlClPc alone. Conclusions: It was concluded that PDT using AlClPc entrapped in a lipid nanoemulsion may be useful in therapies because of immunomodulatory effects that decreased the inflammatory response and caused tissue destruction.
SIALOLITHIASIS IN BUCCAL MUCOSA: A CASE REPORT. LEONARDO DE SOUZA LOUZARDO, VANESSA SANTOS RODRIGUES CANUTO, PRISCILLA FLORES SILVA GONCALVES, ¸ DIOGO DOS SANTOS DA MATA REZENDE, WALDNER RICARDO SOUZA DE CARVALHO, HELDER ANTONIO REBELO PONTES and, FLAVIA SIROTHEAU CORREA PONTES Sialoliths are calcified structures developed into the salivary duct system. They occur in approximately 1.2% of the population and are more common in men, although they may appear in young people, elderly people, and, more rarely, children. Here, we report a case of a 12-year-old female patient, who was attended by the oral pathology service in December 2015, with asymptomatic lesion in buccal mucosa with 3 years of evolution. Incisional biopsy was performed with histopathologic diagnosis of juvenile xanthogranuloma, subsequent removal of the lesion, and anatomopathologic examination evidencing the nodule size. After 5 months of follow-up, there was no sign of recurrence and oral cavity was normal.
METABOLIC-RELATED AND STEM CELL MARKERS IN A SERIES OF PRIMARY ORAL MUCOSAL MELANOMAS AND ORAL NEVI. JUAN CARLOS HERNANDEZ GUERRERO, CIRO DANTAS SOARES, THAYNA MELO DE LIMA MORAIS, ADALBERTO MOSQUEDA TAYLOR, MARIA DOLORES JIMENEZ FARFAN and, OSLEI PAES DE ALMEIDA Primary oral mucosal melanomas (POMM) are rare and aggressive neoplasms arising in the melanocytes from the epithelial lining of the oral cavity, and currently few prognostic markers are described. Objective: In this study, we investigated the expression of glucose transporter 1 (GLUT1), antimitochondrial antibody (AMT), and stem cell markers (CD44) in a series of 3 POMM and 3 oral nevi. Methods: Immunostainings of GLUT1, CD44, and AMT were quantitatively assessed by digital analyses. Results: POMM showed a proliferation of epithelioid or fusiform variable-pigmented melanocytes. GLUT1, CD44, and AMT were negative in all nevi and strongly expressed in the melanomas. Conclusion: Our results suggest that overexpression of mitochondrial and stem cells markers can help confirm the diagnosis of melanomas and they can be associated with the aggressive behavior of these rare tumors.
OCCURRENCE OF ORAL CANDIDIASIS IN PATIENTS WITH HEAD AND NECK CANCER SUBMITTED TO ANTINEOPLASTIC TREAT MENTS. FLAVIA GODINHO COSTA WANDERLEY ROCHA, JULIANA BORGES DE LIMA DANTAS, GABRIELA BOTELHO MARTINS, HAYANA RAMOS LIMA, MANOELA CARRERA, ROBERTO PAULO
ABSTRACTS
e129
CORREIA DE ARAUJO and, ALENA RIBEIRO ALVES PEIXOTO MEDRADO Objective: To assess the frequency of candidiasis in patients with head and neck cancer submitted to radiotherapy and/or chemotherapy. Study Design: This is a cross-sectional study consisting of a nonprobabilistic sample of patients with oral candidiasis diagnosed in a convenience group. Data were collected on people with oral candidiasis, such as sex, age, and type of treatment (chemotherapy, radiotherapy, or both), as well as the location and clinical diagnosis of the type of candidiasis. Results: Of the total 36 patients that met the inclusion criteria, 16 presented candidiasis (44.4%). Eleven individuals (68.75%) were of male sex, and 7 (43.75%) were between the fifth and sixth decades of life. The most prevalent type of candidiasis was pseudomembranous (87.5%), and the most affected site was the hard palate (50%). Of the 16 patients with oral candidiasis, 14 (87.5%) underwent radiotherapy associated with chemotherapy, while 2 (12.5%) only underwent radiotherapy. Conclusion: Oral candidiasis is a very common clinical condition in patients with neoplasia submitted to antineoplastic treatments. The presence of the dental surgeon in the multidisciplinary team that follows up oncologic patients is relevant, as it may help in the prevention and treatment of candidiasis and other clinical conditions.
PHOTODYNAMIC THERAPY USING CHLOROALUMINUM PHTHALOCYANINE IN AN EXPERIMENTAL RAT PERIODONTAL DISEASE MODEL. MAIARA DE MORAES, ROSEANE e PAULO FIGUEIRO CARVALHO VASCONCELOS, JOAO LONGO, LUIS ALEXANDRE MUEHLMANN, RICARDO BENTES DE AZEVEDO, AURIGENA ANTUNES ARAUJO and, ANTONIO DE LISBOA LOPES COSTA Objective: The purpose of the present study was to analyze cytokine profiles after application of photodynamic therapy (PDT) in gingival tissues of rats with ligature-induced periodontal disease (PD). Study Design: Periodontal disease was induced through the introduction of a cotton thread around the first left mandibular molar, while the right side molars did not receive ligatures. After 7 days of PD evolution, ligatures were removed, and animals were randomly divided into the following treatment groups: I, rats without treatment; II, rats received chloroaluminum phthalocyanine (AlClPc); III, rats received low-level laser alone; and IV, rats received AlClPc associated with low-level laser. The animals were killed 7 days after the treatments, and the mandibles were histologically processed to assess morphologic and immunohistochemical profile, while gingival tissues were removed for quantification of tumor necrosis factor a (TNF-a), interleukin (IL) 1 b and IL-10 expression (by enzyme-linked immunosorbent assay). Results: Histomorphologic analysis of periodontal tissues demonstrated that PDT-treated animals show tissue necrosis as well as lower TNF-a expression compared with ligatured animals treated with AlClPc alone. Conclusions: It was concluded that PDT using AlClPc entrapped in a lipid nanoemulsion may be useful in therapies because of immunomodulatory effects that decreased the inflammatory response and caused tissue destruction.