- Email: [email protected]
Signal transducer and activator of transcription signals in allergic disease
Reviews and feature articles
Continuing Medical Education examination
Signal transducer and activator of transcription signals in allergic disease Instructions for category 1 Continuing Medical Education credit The American Academy of Allergy, Asthma & Immunology is accredited as a provider of Continuing Medical Education (CME) by the Accreditation Council for Continuing Medical Education. Test ID no.: mai00111 Contact hours: 1.5 Expiration date: February 28, 2009 Category 1 credit can be earned by reading the text material and taking this CME examination online. For complete instructions, visit the Journal’s Web site at www.jacionline.org.
The Editors thank the State University of New York at Buffalo (SUNY), School of Medicine and Biomedical Sciences Allergy/Immunology training program for developing this CME examination. The individuals who contributed to its preparation were Heather Lehman, MD, Jessica Blume, MD, Siwat Kiratiseavee, MD, Purvi Shah, MD, and Nalini Packianathan, MD, MPH, MS.
Learning objectives: ‘‘Signal transducer and activator of transcription signals in allergic disease’’ 1. 2. 3. 4. 5.
To review the role of signal transducer and activator of transcription (STAT) proteins in allergic disease. To understand the STAT signaling pathway in cells. To outline the control mechanisms that influence STAT activation and deactivation. To understand the interaction of STAT proteins and regulatory T-cell development. To explain how pharmaceutical agents can be useful in targeting the STAT signaling pathway.
CME items Question 1. What structural part of the STAT protein must be modified for STATs to dimerize? A. N-terminal domain B. DNA-binding domain C. linker domain D. conserved single tyrosine residue Question 2. Where do the phosphorylated STAT proteins form a dimer, and where do they initiate new gene transcription? A. cytoplasm, nucleus B. cell membrane, cytoplasm C. cytoplasm, cell membrane D. cell membrane, nucleus Question 3. Which of the following cofactors is involved in the activation of STAT 3? A. Janus kinase (Jak) B. minichromosome maintenance 5 C. CREB-binding protein D. IFN-regulatory factor 9
542
March 2007
Question 4. Which STAT protein does not form phosphorylated homodimers but depends on heterodimerization with STAT1 for nuclear import? A. STAT2 B. STAT3 C. STAT4 D. STAT6 Question 5. Which of the following is a tyrosine phosphatase, involved in the dephosphorylation and deactivation of STAT proteins? A. CD45 B. Fyn C. Lck D. Jak2 Question 6. Mutations in forkhead box P3 (FOXP3) principally affect which cell type? A. CD4+CD252 B. CD4+CD251 C. CD8+CD252 D. CD8+CD251
J ALLERGY CLIN IMMUNOL
Question 7. Which of the following cytokines inhibits STAT6-dependent signaling? A. IL-4 B. IFN-g C. IL-13 D. IL-25 Question 8. Which STAT protein has been shown to be crucial for the survival of mast cells? A. STAT1 B. STAT3 C. STAT4 D. STAT5
Chen and Khurana Hershey 543
Question 9. CP-690550, an orally available Jak3 inhibitor, is associated with which of the following biologic effects? A. It promotes graft rejection. B. It blocks IL-2 signaling. C. It blocks T-cell receptor signaling. D. It stimulates delayed-type hypersensitivity. Question 10. Which of the following STAT proteins is involved in promoting TH2 responses in allergic diseases? A. STAT1 B. STAT3 C. STAT4 D. STAT6
Reviews and feature articles
J ALLERGY CLIN IMMUNOL VOLUME 119, NUMBER 3
Continuing Medical Education examination
Signal transducer and activator of transcription signals in allergic disease Instructions for category 1 Continuing Medical Education credit The American Academy of Allergy, Asthma & Immunology is accredited as a provider of Continuing Medical Education (CME) by the Accreditation Council for Continuing Medical Education. Test ID no.: mai00111 Contact hours: 1.5 Expiration date: February 28, 2009 Category 1 credit can be earned by reading the text material and taking this CME examination online. For complete instructions, visit the Journal’s Web site at www.jacionline.org.
The Editors thank the State University of New York at Buffalo (SUNY), School of Medicine and Biomedical Sciences Allergy/Immunology training program for developing this CME examination. The individuals who contributed to its preparation were Heather Lehman, MD, Jessica Blume, MD, Siwat Kiratiseavee, MD, Purvi Shah, MD, and Nalini Packianathan, MD, MPH, MS.
Learning objectives: ‘‘Signal transducer and activator of transcription signals in allergic disease’’ 1. 2. 3. 4. 5.
To review the role of signal transducer and activator of transcription (STAT) proteins in allergic disease. To understand the STAT signaling pathway in cells. To outline the control mechanisms that influence STAT activation and deactivation. To understand the interaction of STAT proteins and regulatory T-cell development. To explain how pharmaceutical agents can be useful in targeting the STAT signaling pathway.
CME items Question 1. What structural part of the STAT protein must be modified for STATs to dimerize? A. N-terminal domain B. DNA-binding domain C. linker domain D. conserved single tyrosine residue Question 2. Where do the phosphorylated STAT proteins form a dimer, and where do they initiate new gene transcription? A. cytoplasm, nucleus B. cell membrane, cytoplasm C. cytoplasm, cell membrane D. cell membrane, nucleus Question 3. Which of the following cofactors is involved in the activation of STAT 3? A. Janus kinase (Jak) B. minichromosome maintenance 5 C. CREB-binding protein D. IFN-regulatory factor 9
542
March 2007
Question 4. Which STAT protein does not form phosphorylated homodimers but depends on heterodimerization with STAT1 for nuclear import? A. STAT2 B. STAT3 C. STAT4 D. STAT6 Question 5. Which of the following is a tyrosine phosphatase, involved in the dephosphorylation and deactivation of STAT proteins? A. CD45 B. Fyn C. Lck D. Jak2 Question 6. Mutations in forkhead box P3 (FOXP3) principally affect which cell type? A. CD4+CD252 B. CD4+CD251 C. CD8+CD252 D. CD8+CD251
J ALLERGY CLIN IMMUNOL
Question 7. Which of the following cytokines inhibits STAT6-dependent signaling? A. IL-4 B. IFN-g C. IL-13 D. IL-25 Question 8. Which STAT protein has been shown to be crucial for the survival of mast cells? A. STAT1 B. STAT3 C. STAT4 D. STAT5
Chen and Khurana Hershey 543
Question 9. CP-690550, an orally available Jak3 inhibitor, is associated with which of the following biologic effects? A. It promotes graft rejection. B. It blocks IL-2 signaling. C. It blocks T-cell receptor signaling. D. It stimulates delayed-type hypersensitivity. Question 10. Which of the following STAT proteins is involved in promoting TH2 responses in allergic diseases? A. STAT1 B. STAT3 C. STAT4 D. STAT6
Reviews and feature articles
J ALLERGY CLIN IMMUNOL VOLUME 119, NUMBER 3