- Email: [email protected]
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Signalling mechanisms Web alert Martin G Todman* and Philip J Benson† A selection of World Wide Web sites relevant to the reviews published in this issue of Current Opinion in Neurobiology. Addresses *Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Falmer, Brighton, East Sussex BN1 9QG, UK; e-mail: [email protected] † University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK; e-mail: [email protected]; URL: http://www.physiol.ox.ac.uk/~pjb/ Current Opinion in Neurobiology 2000, 10:287
Signalling mechanisms Signalling and gene control resources http://193.175.244.148/intro/overview/sigmech.html This is an example of the network modelling pages available as part of the parent TRANSPATH signal transduction browser, which is in turn a member of the TRANSFAC family of databases (http://transfac.gbf.de/index.html). Together these sites, compiled by the GBF group in Germany, represent a large and searchable resource in signalling and gene control. Much of the information is concentrated on human, mouse and rat, although many molecules and pathways from other organisms are also included. Ion Channel Network http://www.le.ac.uk/csn/ and a mirror-site at http://www.pain.med.umn.edu/csn/ The aim of the Ion Channel Network is to integrate information relating (mainly) to cloned ion channels in a Web environment. This site is in its infancy but, given time, should be an excellent resource. Medical Research Council Centre for Synaptic Plasticity http://www.bris.ac.uk/Depts/Synaptic/ This is the home page of the Medical Research Council’s Centre for Synaptic Plasticity, a joint venture between the MRC and the University of Bristol, UK. The remit of the centre is to advance the current understanding of synaptic plasticity and to specifically target how, where and why the brain modifies synaptic strengths during both normal function and in certain pathological states. The site contains various links to the Centre’s activities, along with pages on glutamate receptors (new pages covering pharmacological tools and transgenic models for glutamate receptors have been added) and URLs to other MRC resources, including the MRC Co-operative on Neuronal Plasticity, Learning and Memory (http://www.cf.ac.uk/plasticity/index.html). Forthcoming events are also advertised, including a Synaptic Plasticity meeting — a satellite to the FENS2000 conference in Brighton, UK (http://www.fens2000.org). Neurotransmitter in Sensory Systems http://www.ucl.ac.uk/~smgxt01/ This is the Neurotransmitter in Sensory Systems home page, compiled by Tom Salt at the Institute of Ophthalmology, UCL, UK. This is an uncomplicated informative site — pages cover current glutamate receptor and nitric oxide/arginine projects, as well as a “beginner’s guide to what goes on in the lab”.
Protease database http://www.merops.co.uk/ The MEROPS site (named after the European Bee-eater) is a large searchable protease database free to academic and government users. Proteases have been placed into ‘families’ based on similarities in protein sequence and structure. Further classification places families into ‘clans’ where there are indications of an evolutionary relationship. Powerful searching for specific proteases can be achieved by name, MEROPS identifier and organism, or by ‘family’ or ‘clan’. Once a protease has been identified, easily accessible links provide extensive additional information, including a summary page, sequences, structures and associated literature. Well laid out links describing the organisation of the database and other useful URLs are also provided.
Of general interest Medical Microbiology http://www.leeds.ac.uk/mbiology/fullproj/proj1.htm Developed as a Leeds University student project, this site contains a review of Medical Microbiology on the Web. For those interested, it also contains a nice ‘history of the Internet’ section. Microbiology Underground… http://www.medmicro.mds.qmw.ac.uk/underground/ The Microbial Underground collection of Web pages covers microbiology, molecular biology and medicine on the Web. Although no longer supported, the site still has many useful URLs. Gordon Research Conferences home page http://www.grc.uri.edu/grc_home.htm This is the home page for the Gordon Research Conferences (GRCs), which promote and support communication and discussion of ideas at the frontiers of biological, chemical and physical sciences. The site contains a database of upcoming (and past) GRCs with information on the conference programme, aims of the conference and how to attend. Conferences are held mainly in the US, although an increasing number are now being held in Europe, Japan and the Pacific Rim. The site also contains extensive advice on proposing and chairing a GRC. “Our Stolen Future” http://www.osf-facts.org/ This is the home page for the authors of the book “Our Stolen Future”, published in 1996, that explores endocrine disruption. The hypothesis is that there are chemicals present in the environment of humans and wildlife that, by virtue of their ability to interact with the endocrine system, are causing a variety of adverse health effects. The site contains many links to existing and new research in this field. “See Thru’ Man” www.indexedvisuals.com This is a searchable online index of stock medical illustrations and visuals. The site contains artists’ drawings and photographs covering a vast array of subjects from DNA helices to “See Thru’ Man”. All images are owned by the artist who created them and cannot be used without permission.
Signalling mechanisms Web alert Martin G Todman* and Philip J Benson† A selection of World Wide Web sites relevant to the reviews published in this issue of Current Opinion in Neurobiology. Addresses *Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Falmer, Brighton, East Sussex BN1 9QG, UK; e-mail: [email protected] † University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK; e-mail: [email protected]; URL: http://www.physiol.ox.ac.uk/~pjb/ Current Opinion in Neurobiology 2000, 10:287
Signalling mechanisms Signalling and gene control resources http://193.175.244.148/intro/overview/sigmech.html This is an example of the network modelling pages available as part of the parent TRANSPATH signal transduction browser, which is in turn a member of the TRANSFAC family of databases (http://transfac.gbf.de/index.html). Together these sites, compiled by the GBF group in Germany, represent a large and searchable resource in signalling and gene control. Much of the information is concentrated on human, mouse and rat, although many molecules and pathways from other organisms are also included. Ion Channel Network http://www.le.ac.uk/csn/ and a mirror-site at http://www.pain.med.umn.edu/csn/ The aim of the Ion Channel Network is to integrate information relating (mainly) to cloned ion channels in a Web environment. This site is in its infancy but, given time, should be an excellent resource. Medical Research Council Centre for Synaptic Plasticity http://www.bris.ac.uk/Depts/Synaptic/ This is the home page of the Medical Research Council’s Centre for Synaptic Plasticity, a joint venture between the MRC and the University of Bristol, UK. The remit of the centre is to advance the current understanding of synaptic plasticity and to specifically target how, where and why the brain modifies synaptic strengths during both normal function and in certain pathological states. The site contains various links to the Centre’s activities, along with pages on glutamate receptors (new pages covering pharmacological tools and transgenic models for glutamate receptors have been added) and URLs to other MRC resources, including the MRC Co-operative on Neuronal Plasticity, Learning and Memory (http://www.cf.ac.uk/plasticity/index.html). Forthcoming events are also advertised, including a Synaptic Plasticity meeting — a satellite to the FENS2000 conference in Brighton, UK (http://www.fens2000.org). Neurotransmitter in Sensory Systems http://www.ucl.ac.uk/~smgxt01/ This is the Neurotransmitter in Sensory Systems home page, compiled by Tom Salt at the Institute of Ophthalmology, UCL, UK. This is an uncomplicated informative site — pages cover current glutamate receptor and nitric oxide/arginine projects, as well as a “beginner’s guide to what goes on in the lab”.
Protease database http://www.merops.co.uk/ The MEROPS site (named after the European Bee-eater) is a large searchable protease database free to academic and government users. Proteases have been placed into ‘families’ based on similarities in protein sequence and structure. Further classification places families into ‘clans’ where there are indications of an evolutionary relationship. Powerful searching for specific proteases can be achieved by name, MEROPS identifier and organism, or by ‘family’ or ‘clan’. Once a protease has been identified, easily accessible links provide extensive additional information, including a summary page, sequences, structures and associated literature. Well laid out links describing the organisation of the database and other useful URLs are also provided.
Of general interest Medical Microbiology http://www.leeds.ac.uk/mbiology/fullproj/proj1.htm Developed as a Leeds University student project, this site contains a review of Medical Microbiology on the Web. For those interested, it also contains a nice ‘history of the Internet’ section. Microbiology Underground… http://www.medmicro.mds.qmw.ac.uk/underground/ The Microbial Underground collection of Web pages covers microbiology, molecular biology and medicine on the Web. Although no longer supported, the site still has many useful URLs. Gordon Research Conferences home page http://www.grc.uri.edu/grc_home.htm This is the home page for the Gordon Research Conferences (GRCs), which promote and support communication and discussion of ideas at the frontiers of biological, chemical and physical sciences. The site contains a database of upcoming (and past) GRCs with information on the conference programme, aims of the conference and how to attend. Conferences are held mainly in the US, although an increasing number are now being held in Europe, Japan and the Pacific Rim. The site also contains extensive advice on proposing and chairing a GRC. “Our Stolen Future” http://www.osf-facts.org/ This is the home page for the authors of the book “Our Stolen Future”, published in 1996, that explores endocrine disruption. The hypothesis is that there are chemicals present in the environment of humans and wildlife that, by virtue of their ability to interact with the endocrine system, are causing a variety of adverse health effects. The site contains many links to existing and new research in this field. “See Thru’ Man” www.indexedvisuals.com This is a searchable online index of stock medical illustrations and visuals. The site contains artists’ drawings and photographs covering a vast array of subjects from DNA helices to “See Thru’ Man”. All images are owned by the artist who created them and cannot be used without permission.